Our main focus has been on repair of endogenous DNA base lesion repair mechanisms and genome stability. We have made major contributions to characterization of many new DNA repair enzymes from bacteria, yeast and mammalian. Our group has solved the atomic 3D-structure of many DNA-protein complexes revealing several new mechanisms of DNA base damage recognition and catalysis. We have also established research on the role of DNA base lesion repair in neurodegeneration, cognition and behavior, which is a new direction in the DNA repair field revealing novel functions beyond canonical DNA. Furthermore, we have established collaborations with clinicians to study the impact of DNA base lesion repair on diseases such as infections, heart failure, rare neurodegenerative disorders and cancer.
Mapping of pituitary stress-induced gene regulation connects Nrcam to negative emotions
iScience, 25 (9), 104953
Lactate receptor HCAR1 regulates neurogenesis and microglia activation after neonatal hypoxia-ischemia
Mechanical coupling of supracellular stress amplification and tissue fluidization during exit from quiescence
Proc Natl Acad Sci U S A, 119 (32), e2201328119