Gunn A. Hildrestrand

  • Researcher; PhD
  • +47 23 01 39 11

Mammalian group

 

Publications 2021

de Sousa MML, Ye J, Luna L, Hildrestrand G, Bjoras K, Scheffler K, Bjoras M (2021)
Impact of Oxidative DNA Damage and the Role of DNA Glycosylases in Neurological Dysfunction
Int. J. Mol. Sci., 22 (23), 12924
DOI 10.3390/ijms222312924

Hildrestrand GA, Rolseth V, Kunath N, Suganthan R, Jensen V, Bugaj AM, Fernandez-Berrocal MS, Sikko SB, Vetlesen S, Kusnierczyk A, Olsen AK, Gutzkow KB, Rowe AD, Wang W, Moldestad O, Syrstad MD, Slupphaug G, Eide L, Klungland A, Saetrom P, Luna L, Ye J, Scheffler K, Bjoras M (2021)
NEIL1 and NEIL2 DNA glycosylases modulate anxiety and learning in a cooperative manner in mice
Commun. Biol., 4 (1), 1354
DOI 10.1038/s42003-021-02864-x

Publications 2020

Yang MY, Lin XL, Segers F, Suganthan R, Hildrestrand GA, Rinholm JE, Aas PA, Sousa MML, Holm S, Bolstad N, Warren D, Berge RK, Johansen RF, Yndestad A, Kristiansen E, Klungland A, Luna L, Eide L, Halvorsen B, Aukrust P, Bjoras M (2020)
OXR1A, a Coactivator of PRMT5 Regulating Histone Arginine Methylation
Cell Reports, 30 (12), 4165-+
DOI 10.1016/j.celrep.2020.02.063

Publications 2017

Olsen MB, Hildrestrand GA, Scheffler K, Vinge LE, Alfsnes K, Palibrk V, Wang JB, Neurauter CG, Luna L, Johansen J, Ogaard JDS, Ohm IK, Slupphaug G, Kusnierczyk A, Fiane AE, Brorson SH, Zhang LL, Gullestad L, Louch WE, Iversen PO, Ostlie I, Klungland A, Christensen G, Sjaastad I, Saetrom P et al. (2017)
NEIL3-Dependent Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture
Cell Reports, 18 (1), 82-92
DOI 10.1016/j.celrep.2016.12.009

Rolseth V, Luna L, Olsen AK, Suganthan R, Scheffler K, Neurauter CG, Esbensen Y, Kusnierczyk A, Hildrestrand GA, Graupner A, Andersen JM, Slupphaug G, Klungland A, Nilsen H, Bjoras M (2017)
No cancer predisposition or increased spontaneous mutation frequencies in NEIL DNA glycosylases-deficient mice
Sci Rep, 7, 4384
DOI 10.1038/s41598-017-04472-4

Publications 2016

Skarpengland T, Holm S, Scheffler K, Gregersen I, Dahl TB, Suganthan R, Segers FM, Ostlie I, Otten JJT, Luna L, Ketelhuth DFJ, Lundberg AM, Neurauter CG, Hildrestrand G, Skjelland M, Bjorndal B, Svardal AM, Iversen PO, Hedin U, Nygard S, Olstad OK, Krohg-Sorensen K, Slupphaug G, Eide L, Kusnierczyk A et al. (2016)
Neil3-dependent base excision repair regulates lipid metabolism and prevents atherosclerosis in Apoe-deficient mice
Sci Rep, 6, 28337
DOI 10.1038/srep28337

Publications 2015

Bjorge MD, Hildrestrand GA, Scheffler K, Suganthan R, Rolseth V, Kusnierczyk A, Rowe AD, Vagbo CB, Vetlesen S, Eide L, Slupphaug G, Nakabeppu Y, Bredy TW, Klungland A, Bjoras M (2015)
Synergistic Actions of Ogg1 and Mutyh DNA Glycosylases Modulate Anxiety-like Behavior in Mice
Cell Reports, 13 (12), 2671-2678
DOI 10.1016/j.celrep.2015.12.001

Publications 2013

Rolseth V, Krokeide SZ, Kunke D, Neurauter CG, Suganthan R, Sejersted Y, Hildrestrand GA, Bjoras M, Luna L (2013)
Loss of Neil3, the major DNA glycosylase activity for removal of hydantoins in single stranded DNA, reduces cellular proliferation and sensitizes cells to genotoxic stress
Biochim. Biophys. Acta-Mol. Cell Res., 1833 (5), 1157-1164
DOI 10.1016/j.bbamcr.2012.12.024

Publications 2012

Mollersen L, Rowe AD, Illuzzi JL, Hildrestrand GA, Gerhold KJ, Tveteras L, Bjolgerud A, Wilson DM, Bjoras M, Klungland A (2012)
Neil1 is a genetic modifier of somatic and germline CAG trinucleotide repeat instability in R6/1 mice
Hum. Mol. Genet., 21 (22), 4939-4947
DOI 10.1093/hmg/dds337

Regnell CE, Hildrestrand GA, Sejersted Y, Medin T, Moldestad O, Rolseth V, Krokeide SZ, Suganthan R, Luna L, Bjoras M, Bergersen LH (2012)
Hippocampal Adult Neurogenesis Is Maintained by Neil3-Dependent Repair of Oxidative DNA Lesions in Neural Progenitor Cells
Cell Reports, 2 (3), 503-510
DOI 10.1016/j.celrep.2012.08.008

Publications 2011

Sejersted Y, Hildrestrand GA, Kunke D, Rolseth V, Krokeide SZ, Neurauter CG, Suganthan R, Atneosen-Asegg M, Fleming AM, Saugstad OD, Burrows CJ, Luna L, Bjoras M (2011)
Endonuclease VIII-like 3 (Neil3) DNA glycosylase promotes neurogenesis induced by hypoxia-ischemia
Proc. Natl. Acad. Sci. U. S. A., 108 (46), 18802-18807
DOI 10.1073/pnas.1106880108

Publications 2009

Hildrestrand GA (2009)
Intracellular localization and expression patterns of DNAglycosylases and their activities in murine and human stem cells
In Series of dissertations submitted to the Faculty of Medicine, University of Oslo, Unipub, Oslo, no. 783, 1 b. (flere pag.)
BIBSYS 092931499, ISBN 978-82-8072-792-3

Hildrestrand GA, Duggal S, Bjoras M, Luna L, Brinchmann JE (2009)
Modulation of DNA glycosylase activities in mesenchymal stem cells
Exp. Cell Res., 315 (15), 2558-2567
DOI 10.1016/j.yexcr.2009.05.017

Hildrestrand GA, Neurauter CG, Diep DB, Castellanos CG, Krauss S, Bjoras M, Luna L (2009)
Expression patterns of Neil3 during embryonic brain development and neoplasia
BMC Neurosci., 10, 45
DOI 10.1186/1471-2202-10-45

Publications 2007

Hildrestrand GA, Diep DB, Kunke D, Bolstad N, Bjoras M, Krauss S, Luna L (2007)
The capacity to remove 8-oxoG is enhanced in newborn neural stem/progenitor cells and decreases in juvenile mice and upon cell differentiation
DNA Repair, 6 (6), 723-732
DOI 10.1016/j.dnarep.2006.12.008

Hildrestrand GA, Rolseth V, Bjoras M, Luna L (2007)
Human NEIL1 localizes with the centrosomes and condensed chromosomes during mitosis
DNA Repair, 6 (10), 1425-1433
DOI 10.1016/j.dnarep.2007.04.008

Publications 2000

Hildrestrand GA (2000)
Atlantic salmon (Salmo salar) estrogen receptor β: cloning and characterization of a partial cDNA
[G.A. Hildrestrand], Bergen, VI, 92 bl.
BIBSYS 001250345