Magnar Bjørås
- Research scientist, Group leader; M.Sc.
Publications 2024
Loss of alkyladenine DNA glycosylase alters gene expression in the developing mouse brain and leads to reduced anxiety and improved memory
DNA Repair (Amst), 135, 103632
DOI 10.1016/j.dnarep.2024.103632, PubMed 38280242
Dissecting gene expression networks in the developing hippocampus through the lens of NEIL3 depletion
Prog Neurobiol, 235, 102599
DOI 10.1016/j.pneurobio.2024.102599, PubMed 38522610
The combination of pleconaril, rupintrivir, and remdesivir efficiently inhibits enterovirus infections in vitro, delaying the development of drug-resistant virus variants
Antiviral Res, 224, 105842
DOI 10.1016/j.antiviral.2024.105842, PubMed 38417531
Enhanced glutathione levels confer resistance to apoptotic and ferroptotic programmed cell death in NEIL DNA glycosylase deficient HAP1 cells
Free Radic Biol Med, 213, 470-487
DOI 10.1016/j.freeradbiomed.2024.01.037, PubMed 38301978
Genomic 8-oxoguanine modulates gene transcription independent of its repair by DNA glycosylases OGG1 and MUTYH
Redox Biol, 79, 103461 (in press)
DOI 10.1016/j.redox.2024.103461, PubMed 39662289
Predicting regulatory mutations and their target genes by new computational integrative analysis: A study of follicular lymphoma
Comput Biol Med, 178, 108787
DOI 10.1016/j.compbiomed.2024.108787, PubMed 38901187
Altered Genome-Wide DNA Methylation in the Duodenum of Common Variable Immunodeficiency Patients
J Clin Immunol, 44 (6), 133
DOI 10.1007/s10875-024-01726-5, PubMed 38780872
Publications 2023
Optimized synthesis of polyacrylic acid-coated magnetic nanoparticles for high-efficiency DNA isolation and size selection
RSC Adv, 13 (42), 29109-29120
DOI 10.1039/d3ra04687g, PubMed 37800135
A pan-SARS-CoV-2-specific soluble angiotensin-converting enzyme 2-albumin fusion engineered for enhanced plasma half-life and needle-free mucosal delivery
PNAS Nexus, 2 (12), pgad403
DOI 10.1093/pnasnexus/pgad403, PubMed 38077689
A loss-of-function mutation in human Oxidation Resistance 1 disrupts the spatial-temporal regulation of histone arginine methylation in neurodevelopment
Genome Biol, 24 (1), 216
DOI 10.1186/s13059-023-03037-1, PubMed 37773136
Severely ill COVID-19 patients have altered circulating levels of proteins controlling the epitranscriptome
J Infect, 86 (6), 593-595
DOI 10.1016/j.jinf.2023.03.002, PubMed 36889510
Mitotic chromosome condensation resets chromatin to safeguard transcriptional homeostasis during interphase
Proc Natl Acad Sci U S A, 120 (4), e2210593120
DOI 10.1073/pnas.2210593120, PubMed 36656860
Boosted production of antibodies that neutralized different SARS-CoV-2 variants in a COVID-19 convalescent following messenger RNA vaccination - a case study
Int J Infect Dis, 137, 75-78
DOI 10.1016/j.ijid.2023.10.011, PubMed 37852599
A fast, low-cost, robust and high-throughput method for viral nucleic acid isolation based on NAxtra magnetic nanoparticles
Sci Rep, 13 (1), 11714
DOI 10.1038/s41598-023-38743-0, PubMed 37474666
[Glioblastoma in adults]
Tidsskr Nor Laegeforen, 143 (2)
DOI 10.4045/tidsskr.22.0314, PubMed 36718891
NAxtra magnetic nanoparticles for low-cost, efficient isolation of mammalian DNA and RNA
Sci Rep, 13 (1), 20836
DOI 10.1038/s41598-023-46868-5, PubMed 38012172
Optimization of the Hemolysis Assay for the Assessment of Cytotoxicity
Int J Mol Sci, 24 (3)
DOI 10.3390/ijms24032914, PubMed 36769243
Identifying functional regulatory mutation blocks by integrating genome sequencing and transcriptome data
iScience, 26 (8), 107266
DOI 10.1016/j.isci.2023.107266, PubMed 37520692
Publications 2022
abc4pwm: affinity based clustering for position weight matrices in applications of DNA sequence analysis
BMC Bioinformatics, 23 (1), 83
DOI 10.1186/s12859-022-04615-z, PubMed 35240993
Age- and sex-dependent effects of DNA glycosylase Neil3 on amyloid pathology, adult neurogenesis, and memory in a mouse model of Alzheimer's disease
Free Radic Biol Med, 193 (Pt 2), 685-693
DOI 10.1016/j.freeradbiomed.2022.11.020, PubMed 36395955
Seven classes of antiviral agents
Cell Mol Life Sci, 79 (12), 605
DOI 10.1007/s00018-022-04635-1, PubMed 36436108
DrugVirus.info 2.0: an integrative data portal for broad-spectrum antivirals (BSA) and BSA-containing drug combinations (BCCs)
Nucleic Acids Res, 50 (W1), W272-W275
DOI 10.1093/nar/gkac348, PubMed 35610052
Mono- and combinational drug therapies for global viral pandemic preparedness
iScience, 25 (4), 104112
DOI 10.1016/j.isci.2022.104112, PubMed 35402870
Novel Synergistic Anti-Enteroviral Drug Combinations
Viruses, 14 (9)
DOI 10.3390/v14091866, PubMed 36146673
NEIL3-deficient bone marrow displays decreased hematopoietic capacity and reduced telomere length
Biochem Biophys Rep, 29, 101211
DOI 10.1016/j.bbrep.2022.101211, PubMed 35079641
Lactate receptor HCAR1 regulates neurogenesis and microglia activation after neonatal hypoxia-ischemia
Elife, 11
DOI 10.7554/eLife.76451, PubMed 35942676
Duodenal inflammation in common variable immunodeficiency has altered transcriptional response to viruses
J Allergy Clin Immunol, 151 (3), 767-777
DOI 10.1016/j.jaci.2022.09.029, PubMed 36220400
Immobilization of FeFe-hydrogenase on black TiO2 nanotubes as biocathodes for the hydrogen evolution reaction
Electrochemistry Communications, 135, 107221
DOI 10.1016/j.elecom.2022.107221, PublikaID 419
DNA Repair Mechanisms are Activated in Circulating Lymphocytes of Hospitalized Covid-19 Patients
J Inflamm Res, 15, 6629-6644
DOI 10.2147/JIR.S379331, PubMed 36514358
Mapping of pituitary stress-induced gene regulation connects Nrcam to negative emotions
iScience, 25 (9), 104953
DOI 10.1016/j.isci.2022.104953, PubMed 36060062
Multi-OMICs landscape of SARS-CoV-2-induced host responses in human lung epithelial cells
iScience, 26 (1), 105895
DOI 10.1016/j.isci.2022.105895, PubMed 36590899
Epitranscriptome in Ischemic Cardiovascular Disease: Potential Target for Therapies
Stroke, 53 (6), 2114-2122
DOI 10.1161/STROKEAHA.121.037581, PubMed 35240858
Antiviral Immunoglobulins of Chicken Egg Yolk for Potential Prevention of SARS-CoV-2 Infection
Viruses, 14 (10)
DOI 10.3390/v14102121, PubMed 36298676
Publications 2021
Non-flipping DNA glycosylase AlkD scans DNA without formation of a stable interrogation complex
Commun Biol, 4 (1), 876
DOI 10.1038/s42003-021-02400-x, PubMed 34267321
Increased p53 signaling impairs neural differentiation in HUWE1-promoted intellectual disabilities
Cell Rep Med, 2 (4), 100240
DOI 10.1016/j.xcrm.2021.100240, PubMed 33948573
Impact of Oxidative DNA Damage and the Role of DNA Glycosylases in Neurological Dysfunction
Int J Mol Sci, 22 (23)
DOI 10.3390/ijms222312924, PubMed 34884729
NEIL1 and NEIL2 DNA glycosylases modulate anxiety and learning in a cooperative manner in mice
Commun Biol, 4 (1), 1354
DOI 10.1038/s42003-021-02864-x, PubMed 34857879
Nafamostat-Interferon-α Combination Suppresses SARS-CoV-2 Infection In Vitro and In Vivo by Cooperatively Targeting Host TMPRSS2
Viruses, 13 (9)
DOI 10.3390/v13091768, PubMed 34578348
Synergistic Interferon-Alpha-Based Combinations for Treatment of SARS-CoV-2 and Other Viral Infections
Viruses, 13 (12)
DOI 10.3390/v13122489, PubMed 34960758
Active Components of Commonly Prescribed Medicines Affect Influenza A Virus-Host Cell Interaction: A Pilot Study
Viruses, 13 (8)
DOI 10.3390/v13081537, PubMed 34452402
NEIL3-deficiency increases gut permeability and contributes to a pro-atherogenic metabolic phenotype
Sci Rep, 11 (1), 19749
DOI 10.1038/s41598-021-98820-0, PubMed 34611194
Screening of FDA-Approved Drugs Using a MERS-CoV Clinical Isolate from South Korea Identifies Potential Therapeutic Options for COVID-19
Viruses, 13 (4)
DOI 10.3390/v13040651, PubMed 33918958
Endonuclease V Regulates Atherosclerosis Through C-C Motif Chemokine Ligand 2-Mediated Monocyte Infiltration
J Am Heart Assoc, 10 (14), e020656
DOI 10.1161/JAHA.120.020656, PubMed 34259011
DNA repair enzyme NEIL3 enables a stable neural representation of space by shaping transcription in hippocampal neurons
iScience, 24 (12), 103470
DOI 10.1016/j.isci.2021.103470, PubMed 34988395
Epitope-resolved profiling of the SARS-CoV-2 antibody response identifies cross-reactivity with endemic human coronaviruses
Cell Rep Med, 2 (1), 100189
DOI 10.1016/j.xcrm.2020.100189, PubMed 33495758
Antimicrobial resistance: A challenge awaiting the post-COVID-19 era
Int J Infect Dis, 111, 322-325
DOI 10.1016/j.ijid.2021.09.003, PubMed 34508864
Insight into ALKBH8-related intellectual developmental disability based on the first pathogenic missense variant
Hum Genet, 141 (2), 209-215
DOI 10.1007/s00439-021-02391-z, PubMed 34757492
Synthesis and antimicrobial activities of chitosan/polypropylene carbonate-based nanoparticles
RSC Adv, 11 (17), 10121-10129
DOI 10.1039/d0ra09257f, PubMed 35423476
DNA glycosylase Neil3 regulates vascular smooth muscle cell biology during atherosclerosis development
Atherosclerosis, 324, 123-132
DOI 10.1016/j.atherosclerosis.2021.02.023, PubMed 33714552
Loss of Mediator complex subunit 13 (MED13) promotes resistance to alkylation through cyclin D1 upregulation
Nucleic Acids Res, 49 (3), 1470-1484
DOI 10.1093/nar/gkaa1289, PubMed 33444446
ALKBH3 partner ASCC3 mediates P-body formation and selective clearance of MMS-induced 1-methyladenosine and 3-methylcytosine from mRNA
J Transl Med, 19 (1), 287
DOI 10.1186/s12967-021-02948-6, PubMed 34217309
In situ cofactor regeneration enables selective CO2 reduction in a stable and efficient enzymatic photoelectrochemical cell
Appl. Catal. B-Environ., 296, 120349
DOI 10.1016/j.apcatb.2021.120349
High performance and toxicity assessment of Ta3N5 nanotubes for photoelectrochemical water splitting
Catal. Today, 361, 57-62
DOI 10.1016/j.cattod.2019.12.031
Publications 2020
Discovery and development of safe-in-man broad-spectrum antiviral agents
Int J Infect Dis, 93, 268-276
DOI 10.1016/j.ijid.2020.02.018, PubMed 32081774
Structural basis for substrate and product recognition in human phosphoglucomutase-1 (PGM1) isoform 2, a member of the α-D-phosphohexomutase superfamily
Sci Rep, 10 (1), 5656
DOI 10.1038/s41598-020-62548-0, PubMed 32221390
Nobel Prize for discovering how cells adapt to changing oxygen levels
Tidsskr. Nor. Laegeforen., 140 (1), 8
Antibiotic-induced DNA damage results in a controlled loss of pH homeostasis and genome instability
Sci Rep, 10 (1), 19422
DOI 10.1038/s41598-020-76426-2, PubMed 33173044
HMST-Seq-Analyzer: A new python tool for differential methylation and hydroxymethylation analysis in various DNA methylation sequencing data
Comput Struct Biotechnol J, 18, 2877-2889
DOI 10.1016/j.csbj.2020.09.038, PubMed 33163148
Chemical, Physical and Biological Triggers of Evolutionary Conserved Bcl-xL-Mediated Apoptosis
Cancers (Basel), 12 (6)
DOI 10.3390/cancers12061694, PubMed 32630560
Identification and Tracking of Antiviral Drug Combinations
Viruses, 12 (10)
DOI 10.3390/v12101178, PubMed 33080984
Potential Antiviral Options against SARS-CoV-2 Infection
Viruses, 12 (6)
DOI 10.3390/v12060642, PubMed 32545799
Deletion of Endonuclease V suppresses chemically induced hepatocellular carcinoma
Nucleic Acids Res, 48 (8), 4463-4479
DOI 10.1093/nar/gkaa115, PubMed 32083667
Epitope-resolved profiling of the SARS-CoV-2 antibody response identifies cross-reactivity with an endemic human CoV
bioRxiv
DOI 10.1101/2020.07.27.222943, PubMed 32743570
Genetic diversity and drug resistance pattern of Mycobacterium tuberculosis strains isolated from pulmonary tuberculosis patients in the Benishangul Gumuz region and its surroundings, Northwest Ethiopia
PLoS One, 15 (4), e0231320
DOI 10.1371/journal.pone.0231320, PubMed 32267877
Absence of NLRP3 Inflammasome in Hematopoietic Cells Reduces Adverse Remodeling After Experimental Myocardial Infarction
JACC Basic Transl Sci, 5 (12), 1210-1224
DOI 10.1016/j.jacbts.2020.09.013, PubMed 33426377
Peptides containing the PCNA interacting motif APIM bind to the β-clamp and inhibit bacterial growth and mutagenesis
Nucleic Acids Res, 48 (10), 5540-5554
DOI 10.1093/nar/gkaa278, PubMed 32347931
PML Regulates the Epidermal Differentiation Complex and Skin Morphogenesis during Mouse Embryogenesis
Genes (Basel), 11 (10)
DOI 10.3390/genes11101130, PubMed 32992884
N6-methyladenosine in RNA of atherosclerotic plaques: An epitranscriptomic signature of human carotid atherosclerosis
Biochem Biophys Res Commun, 533 (4), 631-637
DOI 10.1016/j.bbrc.2020.09.057, PubMed 33004177
Parp3 promotes astrocytic differentiation through a tight regulation of Nox4-induced ROS and mTorc2 activation
Cell Death Dis, 11 (11), 954
DOI 10.1038/s41419-020-03167-5, PubMed 33159039
IGAP-integrative genome analysis pipeline reveals new gene regulatory model associated with nonspecific TF-DNA binding affinity
Comput Struct Biotechnol J, 18, 1270-1286
DOI 10.1016/j.csbj.2020.05.024, PubMed 32612751
DNA glycosylase Neil2 contributes to genomic responses in the spleen during clinical prion disease
Free Radic Biol Med, 152, 348-354
DOI 10.1016/j.freeradbiomed.2020.03.030, PubMed 32259578
OXR1A, a Coactivator of PRMT5 Regulating Histone Arginine Methylation
Cell Rep, 30 (12), 4165-4178.e7
DOI 10.1016/j.celrep.2020.02.063, PubMed 32209476
Publications 2019
Publisher Correction: Breaking the speed limit with multimode fast scanning of DNA by Endonuclease V
Nat Commun, 10 (1), 1991
DOI 10.1038/s41467-019-10070-x, PubMed 31024006
Additive manufacturing of laminar flow cells for single-molecule experiments
Sci Rep, 9 (1), 16784
DOI 10.1038/s41598-019-53151-z, PubMed 31727950
Novel Antiviral Activities of Obatoclax, Emetine, Niclosamide, Brequinar, and Homoharringtonine
Viruses, 11 (10)
DOI 10.3390/v11100964, PubMed 31635418
Complex alternative splicing of human Endonuclease V mRNA, but evidence for only a single protein isoform
PLoS One, 14 (11), e0225081
DOI 10.1371/journal.pone.0225081, PubMed 31703097
[Nobel Prize for discovery of how cells adapt to changing oxygen level]
Tidsskr Nor Laegeforen, 139 (1)
DOI 10.4045/tidsskr.19.0764, PubMed 31948215
Common Nodes of Virus-Host Interaction Revealed Through an Integrated Network Analysis
Front Immunol, 10, 2186
DOI 10.3389/fimmu.2019.02186, PubMed 31636628
Generation of a Mouse Model Lacking the Non-Homologous End-Joining Factor Mri/Cyren
Biomolecules, 9 (12)
DOI 10.3390/biom9120798, PubMed 31795137
Expanding the activity spectrum of antiviral agents
Drug Discov Today, 24 (5), 1224-1228
DOI 10.1016/j.drudis.2019.04.006, PubMed 30980905
The DNA modification N6-methyl-2'-deoxyadenosine (m6dA) drives activity-induced gene expression and is required for fear extinction
Nat Neurosci, 22 (4), 534-544
DOI 10.1038/s41593-019-0339-x, PubMed 30778148
Alkyladenine DNA glycosylase associates with transcription elongation to coordinate DNA repair with gene expression
Nat Commun, 10 (1), 5460
DOI 10.1038/s41467-019-13394-w, PubMed 31784530
Diverse functions of DNA glycosylases processing oxidative base lesions in brain
DNA Repair (Amst), 81, 102665
DOI 10.1016/j.dnarep.2019.102665, PubMed 31327582
High performance and toxicity assessment of Ta3N5 nanotubes for photoelectrochemical water splitting
Catalysis Today, 0, 1-6 (in press)
DOI 10.1016/j.cattod.2019.12.031, PublikaID 337
Neuromodulatory Effect of NLRP3 and ASC in Neonatal Hypoxic Ischemic Encephalopathy
Neonatology, 115 (4), 355-362
DOI 10.1159/000497200, PubMed 30909283
Histone Methylations Define Neural Stem/Progenitor Cell Subtypes in the Mouse Subventricular Zone
Mol Neurobiol, 57 (2), 997-1008
DOI 10.1007/s12035-019-01777-5, PubMed 31654318
Publications 2018
Breaking the speed limit with multimode fast scanning of DNA by Endonuclease V
Nat Commun, 9 (1), 5381
DOI 10.1038/s41467-018-07797-4, PubMed 30568191
Excision of the doubly methylated base N4,5-dimethylcytosine from DNA by Escherichia coli Nei and Fpg proteins
Philos Trans R Soc Lond B Biol Sci, 373 (1748)
DOI 10.1098/rstb.2017.0337, PubMed 29685966
Increased nuclear DNA damage precedes mitochondrial dysfunction in peripheral blood mononuclear cells from Huntington's disease patients
Sci Rep, 8 (1), 9817
DOI 10.1038/s41598-018-27985-y, PubMed 29959348
A transgenic minipig model of Huntington's disease shows early signs of behavioral and molecular pathologies
Dis Model Mech, 11 (10)
DOI 10.1242/dmm.035949, PubMed 30254085
Publisher Correction: Impaired oxidative stress response characterizes HUWE1-promoted X-linked intellectual disability
Sci Rep, 8 (1), 6010
DOI 10.1038/s41598-018-24189-2, PubMed 29651030
Normal development of mice lacking PAXX, the paralogue of XRCC4 and XLF
FEBS Open Bio, 8 (3), 426-434
DOI 10.1002/2211-5463.12381, PubMed 29511619
Novel activities of safe-in-human broad-spectrum antiviral agents
Antiviral Res, 154, 174-182
DOI 10.1016/j.antiviral.2018.04.016, PubMed 29698664
Ythdf2-mediated m6A mRNA clearance modulates neural development in mice
Genome Biol, 19 (1), 69
DOI 10.1186/s13059-018-1436-y, PubMed 29855337
Stress Resilience of Spermatozoa and Blood Mononuclear Cells without Prion Protein
Front Mol Biosci, 5, 1
DOI 10.3389/fmolb.2018.00001, PubMed 29417049
Neonatal Ogg1/Mutyh knockout mice have altered inflammatory gene response compared to wildtype mice in the brain and lung after hypoxia-reoxygenation
J Perinat Med, 47 (1), 114-124
DOI 10.1515/jpm-2018-0172, PubMed 30020889
A Systems Approach to Study Immuno- and Neuro-Modulatory Properties of Antiviral Agents
Viruses, 10 (8)
DOI 10.3390/v10080423, PubMed 30103549
Publications 2017
Integrative whole-genome sequence analysis reveals roles of regulatory mutations in BCL6 and BCL2 in follicular lymphoma
Sci Rep, 7 (1), 7040
DOI 10.1038/s41598-017-07226-4, PubMed 28765546
Monitoring of the spatial and temporal dynamics of BER/SSBR pathway proteins, including MYH, UNG2, MPG, NTH1 and NEIL1-3, during DNA replication
Nucleic Acids Res, 45 (14), 8291-8301
DOI 10.1093/nar/gkx476, PubMed 28575236
Impaired oxidative stress response characterizes HUWE1-promoted X-linked intellectual disability
Sci Rep, 7 (1), 15050
DOI 10.1038/s41598-017-15380-y, PubMed 29118367
Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1
Nat Commun, 8, 15557
DOI 10.1038/ncomms15557, PubMed 28534495
NEIL3-Dependent Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture
Cell Rep, 18 (1), 82-92
DOI 10.1016/j.celrep.2016.12.009, PubMed 28052262
Glycosylated Chromogranin A in Heart Failure: Implications for Processing and Cardiomyocyte Calcium Homeostasis
Circ Heart Fail, 10 (2)
DOI 10.1161/CIRCHEARTFAILURE.116.003675, PubMed 28209766
Metabolism and DNA repair shape a specific modification pattern in mitochondrial DNA
Mitochondrion, 40, 16-28
DOI 10.1016/j.mito.2017.09.002, PubMed 28893634
No cancer predisposition or increased spontaneous mutation frequencies in NEIL DNA glycosylases-deficient mice
Sci Rep, 7 (1), 4384
DOI 10.1038/s41598-017-04472-4, PubMed 28663564
Novel UCHL1 mutations reveal new insights into ubiquitin processing
Hum Mol Genet, 26 (6), 1031-1040
DOI 10.1093/hmg/ddw391, PubMed 28007905
Novel UCHL1 mutations reveal new insights into ubiquitin processing
Hum Mol Genet, 26 (6), 1217-1218
DOI 10.1093/hmg/ddx072, PubMed 28334853
8-oxoguanine DNA glycosylase (Ogg1) controls hepatic gluconeogenesis
DNA Repair (Amst), 61, 56-62
DOI 10.1016/j.dnarep.2017.11.008, PubMed 29207315
Synthetic lethality between murine DNA repair factors XLF and DNA-PKcs is rescued by inactivation of Ku70
DNA Repair (Amst), 57, 133-138
DOI 10.1016/j.dnarep.2017.07.008, PubMed 28759779
TORC1 Inhibits GSK3-Mediated Elo2 Phosphorylation to Regulate Very Long Chain Fatty Acid Synthesis and Autophagy
Cell Rep, 18 (8), 2073-2074
DOI 10.1016/j.celrep.2017.02.020, PubMed 28228270
Publications 2016
N-Acetylcysteine Amide Exerts Possible Neuroprotective Effects in Newborn Pigs after Perinatal Asphyxia
Neonatology, 111 (1), 12-21
DOI 10.1159/000447255, PubMed 27497671
Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition
Nature, 537 (7621), 548-552
DOI 10.1038/nature19360, PubMed 27626377
Neil3 induced neurogenesis protects against prion disease during the clinical phase
Sci Rep, 6, 37844
DOI 10.1038/srep37844, PubMed 27886261
Mutually exclusive RNA secondary structures regulate translation initiation of DinQ in Escherichia coli
RNA, 22 (11), 1739-1749
DOI 10.1261/rna.058461.116, PubMed 27651528
Regulation of Human Endonuclease V Activity and Relocalization to Cytoplasmic Stress Granules
J Biol Chem, 291 (41), 21786-21801
DOI 10.1074/jbc.M116.730911, PubMed 27573237
Crystal structure and MD simulation of mouse EndoV reveal wedge motif plasticity in this inosine-specific endonuclease
Sci Rep, 6, 24979
DOI 10.1038/srep24979, PubMed 27108838
PML regulates neuroprotective innate immunity and neuroblast commitment in a hypoxic-ischemic encephalopathy model
Cell Death Dis, 7 (7), e2320
DOI 10.1038/cddis.2016.223, PubMed 27468695
Efficient and Reliable Production of Vectors for the Study of the Repair, Mutagenesis, and Phenotypic Consequences of Defined DNA Damage Lesions in Mammalian Cells
PLoS One, 11 (6), e0158581
DOI 10.1371/journal.pone.0158581, PubMed 27362559
3CAPS - a structural AP-site analogue as a tool to investigate DNA base excision repair
Nucleic Acids Res, 44 (5), 2187-98
DOI 10.1093/nar/gkv1520, PubMed 26733580
Enhanced base excision repair capacity in carotid atherosclerosis may protect nuclear DNA but not mitochondrial DNA
Free Radic Biol Med, 97, 386-397
DOI 10.1016/j.freeradbiomed.2016.07.001, PubMed 27381496
Neil3-dependent base excision repair regulates lipid metabolism and prevents atherosclerosis in Apoe-deficient mice
Sci Rep, 6, 28337
DOI 10.1038/srep28337, PubMed 27328939
Publications 2015
Synergistic Actions of Ogg1 and Mutyh DNA Glycosylases Modulate Anxiety-like Behavior in Mice
Cell Rep, 13 (12), 2671-8
DOI 10.1016/j.celrep.2015.12.001, PubMed 26711335
Structural basis for incision at deaminated adenines in DNA and RNA by endonuclease V
Prog Biophys Mol Biol, 117 (2-3), 134-142
DOI 10.1016/j.pbiomolbio.2015.03.005, PubMed 25824682
Susceptibility to infections, without concomitant hyper-IgE, reported in 1976, is caused by hypomorphic mutation in the phosphoglucomutase 3 (PGM3) gene
Clin Immunol, 161 (2), 366-72
DOI 10.1016/j.clim.2015.10.002, PubMed 26482871
Secretoneurin is a novel prognostic cardiovascular biomarker associated with cardiomyocyte calcium handling
J Am Coll Cardiol, 65 (4), 339-351
DOI 10.1016/j.jacc.2014.10.065, PubMed 25634832
An in vitro Study of Protein Adsorption to Biocompatible Coatings
Stud Health Technol Inform, 211, 166-71
DOI 10.3233/978-1-61499-516-6-166, PubMed 25980864
Genetic variants in the DNA repair gene NEIL3 and the risk of myocardial infarction in a nested case-control study. The HUNT Study
DNA Repair (Amst), 28, 21-7
DOI 10.1016/j.dnarep.2015.01.013, PubMed 25703835
Uracil-DNA Glycosylase UNG Promotes Tet-mediated DNA Demethylation
J Biol Chem, 291 (2), 731-8
DOI 10.1074/jbc.M115.693861, PubMed 26620559
Transcriptome analysis of human OXR1 depleted cells reveals its role in regulating the p53 signaling pathway
Sci Rep, 5, 17409
DOI 10.1038/srep17409, PubMed 26616534
Publications 2014
Inosine in DNA and RNA
Curr Opin Genet Dev, 26, 116-23
DOI 10.1016/j.gde.2014.07.008, PubMed 25173738
Extending serum half-life of albumin by engineering neonatal Fc receptor (FcRn) binding
J Biol Chem, 289 (19), 13492-502
DOI 10.1074/jbc.M114.549832, PubMed 24652290
Mitochondrial DNA damage and repair during ischemia-reperfusion injury of the heart
J Mol Cell Cardiol, 78, 9-22
DOI 10.1016/j.yjmcc.2014.11.010, PubMed 25446179
Development of DinQ from Escherichia coli as an anti-cell-envelope antibiotic
Int J Antimicrob Agents, 45 (2), 196-7
DOI 10.1016/j.ijantimicag.2014.10.005, PubMed 25465525
New carbocyclic nucleosides: synthesis of carbocyclic pseudoisocytidine and its analogs
Tetrahedron Lett., 55 (27), 3713-3716
DOI 10.1016/j.tetlet.2014.05.030
Dissection of the neonatal Fc receptor (FcRn)-albumin interface using mutagenesis and anti-FcRn albumin-blocking antibodies
J Biol Chem, 289 (24), 17228-39
DOI 10.1074/jbc.M113.522565, PubMed 24764301
The distribution of DNA damage is defined by region-specific susceptibility to DNA damage formation rather than repair differences
DNA Repair (Amst), 18, 44-51
DOI 10.1016/j.dnarep.2014.03.003, PubMed 24685126
Genome instability in Maple Syrup Urine Disease correlates with impaired mitochondrial biogenesis
Metabolism, 63 (8), 1063-70
DOI 10.1016/j.metabol.2014.05.003, PubMed 24928662
PGM3 mutations cause a congenital disorder of glycosylation with severe immunodeficiency and skeletal dysplasia
Am J Hum Genet, 95 (1), 96-107
DOI 10.1016/j.ajhg.2014.05.007, PubMed 24931394
Addressing RNA integrity to determine the impact of mitochondrial DNA mutations on brain mitochondrial function with age
PLoS One, 9 (5), e96940
DOI 10.1371/journal.pone.0096940, PubMed 24819950
Human OXR1 maintains mitochondrial DNA integrity and counteracts hydrogen peroxide-induced oxidative stress by regulating antioxidant pathways involving p21
Free Radic Biol Med, 77, 41-8
DOI 10.1016/j.freeradbiomed.2014.09.003, PubMed 25236744
Cockayne Syndrome group B protein stimulates NEIL2 DNA glycosylase activity
Mech Ageing Dev, 135, 1-14
DOI 10.1016/j.mad.2013.12.008, PubMed 24406253
Publications 2013
A new family of proteins related to the HEAT-like repeat DNA glycosylases with affinity for branched DNA structures
J Struct Biol, 183 (1), 66-75
DOI 10.1016/j.jsb.2013.04.007, PubMed 23623903
Novel Deletion Mutation Identified in a Patient with Late-Onset Combined Methylmalonic Acidemia and Homocystinuria, cblC Type
JIMD Rep, 11, 79-85
DOI 10.1007/8904_2013_225, PubMed 23580368
Tiling array study of MNNG treated Escherichia coli reveals a widespread transcriptional response
Sci Rep, 3, 3053
DOI 10.1038/srep03053, PubMed 24157950
Accelerated clinical course of prion disease in mice compromised in repair of oxidative DNA damage
Free Radic Biol Med, 68, 1-7
DOI 10.1016/j.freeradbiomed.2013.11.013, PubMed 24296244
Base excision repair
Cold Spring Harb Perspect Biol, 5 (4), a012583
DOI 10.1101/cshperspect.a012583, PubMed 23545420
Human NEIL3 is mainly a monofunctional DNA glycosylase removing spiroimindiohydantoin and guanidinohydantoin
DNA Repair (Amst), 12 (12), 1159-64
DOI 10.1016/j.dnarep.2013.04.026, PubMed 23755964
Loss of Neil3, the major DNA glycosylase activity for removal of hydantoins in single stranded DNA, reduces cellular proliferation and sensitizes cells to genotoxic stress
Biochim Biophys Acta, 1833 (5), 1157-64
DOI 10.1016/j.bbamcr.2012.12.024, PubMed 23305905
Structural basis of DNA loop recognition by endonuclease V
Structure, 21 (2), 257-65
DOI 10.1016/j.str.2012.12.007, PubMed 23313664
Genotype-phenotype analysis of S326C OGG1 polymorphism: a risk factor for oxidative pathologies
Free Radic Biol Med, 63, 401-9
DOI 10.1016/j.freeradbiomed.2013.05.031, PubMed 23726996
Endonuclease V cleaves at inosines in RNA
Nat Commun, 4, 2271
DOI 10.1038/ncomms3271, PubMed 23912683
Single transmembrane peptide DinQ modulates membrane-dependent activities
PLoS Genet, 9 (2), e1003260
DOI 10.1371/journal.pgen.1003260, PubMed 23408903
Ginsenoside Rd promotes glutamate clearance by up-regulating glial glutamate transporter GLT-1 via PI3K/AKT and ERK1/2 pathways
Front Pharmacol, 4, 152
DOI 10.3389/fphar.2013.00152, PubMed 24376419
TORC1 inhibits GSK3-mediated Elo2 phosphorylation to regulate very long chain fatty acid synthesis and autophagy
Cell Rep, 5 (4), 1036-46
DOI 10.1016/j.celrep.2013.10.024, PubMed 24239358
Publications 2012
Structure-based mutagenesis reveals the albumin-binding site of the neonatal Fc receptor
Nat Commun, 3, 610
DOI 10.1038/ncomms1607, PubMed 22215085
Fumarylacetoacetate inhibits the initial step of the base excision repair pathway: implication for the pathogenesis of tyrosinemia type I
J Inherit Metab Dis, 36 (5), 773-8
DOI 10.1007/s10545-012-9556-0, PubMed 23138988
Cdc28 kinase activity regulates the basal transcription machinery at a subset of genes
Proc Natl Acad Sci U S A, 109 (26), 10450-5
DOI 10.1073/pnas.1200067109, PubMed 22689984
Sculpting of DNA at abasic sites by DNA glycosylase homolog mag2
Structure, 21 (1), 154-166
DOI 10.1016/j.str.2012.11.004, PubMed 23245849
The human homolog of Escherichia coli endonuclease V is a nucleolar protein with affinity for branched DNA structures
PLoS One, 7 (11), e47466
DOI 10.1371/journal.pone.0047466, PubMed 23139746
Structure and function of the human sperm-specific isoform of protein kinase A (PKA) catalytic subunit Cα2
J Struct Biol, 178 (3), 300-10
DOI 10.1016/j.jsb.2012.03.013, PubMed 22504716
Silver nanoparticles induce premutagenic DNA oxidation that can be prevented by phytochemicals from Gentiana asclepiadea
Mutagenesis, 27 (6), 759-69
DOI 10.1093/mutage/ges046, PubMed 22940646
The human base excision repair enzyme SMUG1 directly interacts with DKC1 and contributes to RNA quality control
Mol Cell, 49 (2), 339-45
DOI 10.1016/j.molcel.2012.11.010, PubMed 23246433
The Schizosaccharomyces pombe AlkB homolog Abh1 exhibits AP lyase activity but no demethylase activity
DNA Repair (Amst), 11 (5), 453-62
DOI 10.1016/j.dnarep.2012.01.014, PubMed 22365419
The arsenic-based cure of acute promyelocytic leukemia promotes cytoplasmic sequestration of PML and PML/RARA through inhibition of PML body recycling
Blood, 120 (4), 847-57
DOI 10.1182/blood-2011-10-388496, PubMed 22692509
Neil1 is a genetic modifier of somatic and germline CAG trinucleotide repeat instability in R6/1 mice
Hum Mol Genet, 21 (22), 4939-47
DOI 10.1093/hmg/dds337, PubMed 22914735
Release from quiescence stimulates the expression of human NEIL3 under the control of the Ras dependent ERK-MAP kinase pathway
DNA Repair (Amst), 11 (4), 401-9
DOI 10.1016/j.dnarep.2012.01.007, PubMed 22365498
Hallmarks of processivity in glycoside hydrolases from crystallographic and computational studies of the Serratia marcescens chitinases
J Biol Chem, 287 (43), 36322-30
DOI 10.1074/jbc.M112.402149, PubMed 22952223
The chromatin remodeling factor SMARCB1 forms a complex with human cytomegalovirus proteins UL114 and UL44
PLoS One, 7 (3), e34119
DOI 10.1371/journal.pone.0034119, PubMed 22479537
Hippocampal adult neurogenesis is maintained by Neil3-dependent repair of oxidative DNA lesions in neural progenitor cells
Cell Rep, 2 (3), 503-10
DOI 10.1016/j.celrep.2012.08.008, PubMed 22959434
Oxygenation of the newborn: a molecular approach
Neonatology, 101 (4), 315-25
DOI 10.1159/000337345, PubMed 22940621
Identification and characterization of novel mutations in the human gene encoding the catalytic subunit Calpha of protein kinase A (PKA)
PLoS One, 7 (4), e34838
DOI 10.1371/journal.pone.0034838, PubMed 22514673
Biochemical mapping of human NEIL1 DNA glycosylase and AP lyase activities
DNA Repair (Amst), 11 (9), 766-73
DOI 10.1016/j.dnarep.2012.07.002, PubMed 22858590
Publications 2011
Separation-of-function mutants unravel the dual-reaction mode of human 8-oxoguanine DNA glycosylase
Structure, 19 (1), 117-27
DOI 10.1016/j.str.2010.09.023, PubMed 21220122
Lack of the DNA glycosylases MYH and OGG1 in the cancer prone double mutant mouse does not increase mitochondrial DNA mutagenesis
DNA Repair (Amst), 11 (3), 278-85
DOI 10.1016/j.dnarep.2011.12.001, PubMed 22209780
DNA alkylation lesions and their repair in human cells: modification of the comet assay with 3-methyladenine DNA glycosylase (AlkD)
Toxicol Lett, 208 (1), 76-81
DOI 10.1016/j.toxlet.2011.10.005, PubMed 22019460
Schizosaccharomyces pombe Ofd2 is a nuclear 2-oxoglutarate and iron dependent dioxygenase interacting with histones
PLoS One, 6 (9), e25188
DOI 10.1371/journal.pone.0025188, PubMed 21949882
Modeling the impact of mitochondrial DNA damage in forebrain neurons and beyond
Mech Ageing Dev, 132 (8-9), 424-8
DOI 10.1016/j.mad.2011.02.006, PubMed 21354441
AP endonuclease independent repair of abasic sites in Schizosaccharomyces pombe
Nucleic Acids Res, 40 (5), 2000-9
DOI 10.1093/nar/gkr933, PubMed 22084197
Endonuclease VIII-like 3 (Neil3) DNA glycosylase promotes neurogenesis induced by hypoxia-ischemia
Proc Natl Acad Sci U S A, 108 (46), 18802-7
DOI 10.1073/pnas.1106880108, PubMed 22065741
Characterization of the chitinolytic machinery of Enterococcus faecalis V583 and high-resolution structure of its oxidative CBM33 enzyme
J Mol Biol, 416 (2), 239-54
DOI 10.1016/j.jmb.2011.12.033, PubMed 22210154
Mitochondrial DNA damage level determines neural stem cell differentiation fate
J Neurosci, 31 (26), 9746-51
DOI 10.1523/JNEUROSCI.0852-11.2011, PubMed 21715639
The ada operon of Mycobacterium tuberculosis encodes two DNA methyltransferases for inducible repair of DNA alkylation damage
DNA Repair (Amst), 10 (6), 595-602
DOI 10.1016/j.dnarep.2011.03.007, PubMed 21570366
A chemical-genetic screen to unravel the genetic network of CDC28/CDK1 links ubiquitin and Rad6-Bre1 to cell cycle progression
Proc Natl Acad Sci U S A, 108 (46), 18748-53
DOI 10.1073/pnas.1115885108, PubMed 22042866
Publications 2010
Caenorhabditis elegans NDX-4 is a MutT-type enzyme that contributes to genomic stability
DNA Repair (Amst), 10 (2), 176-87
DOI 10.1016/j.dnarep.2010.10.009, PubMed 21111690
Four novel mutations identified in Norwegian patients result in intermittent maple syrup urine disease when combined with the R301C mutation
Mol Genet Metab, 100 (4), 324-32
DOI 10.1016/j.ymgme.2010.04.017, PubMed 20570198
Calprotectin (S100A8/S100A9) and myeloperoxidase: co-regulators of formation of reactive oxygen species
Toxins (Basel), 2 (1), 95-115
DOI 10.3390/toxins2010095, PubMed 22069549
Reduced expression of DNA glycosylases in post-hypoxic newborn pigs undergoing therapeutic hypothermia
Brain Res, 1363, 198-205
DOI 10.1016/j.brainres.2010.09.080, PubMed 20883672
Autophagy contributes to therapy-induced degradation of the PML/RARA oncoprotein
Blood, 116 (13), 2324-31
DOI 10.1182/blood-2010-01-261040, PubMed 20574048
The G157C mutation in the Escherichia coli sliding clamp specifically affects initiation of replication
Mol Microbiol, 79 (2), 433-46
DOI 10.1111/j.1365-2958.2010.07453.x, PubMed 21219462
Schizosaccharomyces pombe encodes a mutated AP endonuclease 1
DNA Repair (Amst), 10 (3), 296-305
DOI 10.1016/j.dnarep.2010.11.014, PubMed 21193357
Tiling array analysis of UV treated Escherichia coli predicts novel differentially expressed small peptides
PLoS One, 5 (12), e15356
DOI 10.1371/journal.pone.0015356, PubMed 21203457
Mitochondrial DNA integrity is essential for mitochondrial maturation during differentiation of neural stem cells
Stem Cells, 28 (12), 2195-204
DOI 10.1002/stem.542, PubMed 20954243
Publications 2009
Structures of endonuclease V with DNA reveal initiation of deaminated adenine repair
Nat Struct Mol Biol, 16 (2), 138-43
DOI 10.1038/nsmb.1538, PubMed 19136958
DNA base repair--recognition and initiation of catalysis
FEMS Microbiol Rev, 33 (6), 1044-78
DOI 10.1111/j.1574-6976.2009.00188.x, PubMed 19659577
Catalytically impaired hMYH and NEIL1 mutant proteins identified in patients with primary sclerosing cholangitis and cholangiocarcinoma
Carcinogenesis, 30 (7), 1147-54
DOI 10.1093/carcin/bgp118, PubMed 19443904
Modulation of DNA glycosylase activities in mesenchymal stem cells
Exp Cell Res, 315 (15), 2558-67
DOI 10.1016/j.yexcr.2009.05.017, PubMed 19477173
Expression patterns of Neil3 during embryonic brain development and neoplasia
BMC Neurosci, 10, 45
DOI 10.1186/1471-2202-10-45, PubMed 19426544
Accumulation of 8-oxoguanine in liver DNA during hyperoxic resuscitation of newborn mice
Pediatr Res, 66 (5), 533-8
DOI 10.1203/PDR.0b013e3181ba1a42, PubMed 19668103
DNA binding kinetics of two response regulators, PlnC and PlnD, from the bacteriocin regulon of Lactobacillus plantarum C11
BMC Biochem, 10, 17
DOI 10.1186/1471-2091-10-17, PubMed 19519894
Up-regulation of myocardial DNA base excision repair activities in experimental heart failure
Mutat Res, 666 (1-2), 32-8
DOI 10.1016/j.mrfmmm.2009.03.008, PubMed 19481677
Publications 2008
Bacteriocins (meningocins) in Norwegian isolates of Neisseria meningitidis: possible role in the course of a meningococcal epidemic
APMIS, 116 (5), 333-44
DOI 10.1111/j.1600-0463.2008.00850.x, PubMed 18452423
Dissection of the molecular defects caused by pathogenic mutations in the DNA repair factor XPC
Mol Cell Biol, 28 (23), 7225-35
DOI 10.1128/MCB.00781-08, PubMed 18809580
DNA apurinic-apyrimidinic site binding and excision by endonuclease IV
Nat Struct Mol Biol, 15 (5), 515-22
DOI 10.1038/nsmb.1414, PubMed 18408731
Expression and purification of NEIL3, a human DNA glycosylase homolog
Protein Expr Purif, 65 (2), 160-4
DOI 10.1016/j.pep.2008.11.014, PubMed 19121397
Characterization of human cytomegalovirus uracil DNA glycosylase (UL114) and its interaction with polymerase processivity factor (UL44)
J Mol Biol, 381 (2), 276-88
DOI 10.1016/j.jmb.2008.05.028, PubMed 18599070
Widespread distribution of DNA glycosylases removing oxidative DNA lesions in human and rodent brains
DNA Repair (Amst), 7 (9), 1578-88
DOI 10.1016/j.dnarep.2008.06.007, PubMed 18603019
Base excision repair activities in organotypic hippocampal slice cultures exposed to oxygen and glucose deprivation
DNA Repair (Amst), 7 (6), 869-78
DOI 10.1016/j.dnarep.2008.02.009, PubMed 18406215
Overexpression of the LexA-regulated tisAB RNA in E. coli inhibits SOS functions; implications for regulation of the SOS response
Nucleic Acids Res, 36 (19), 6249-59
DOI 10.1093/nar/gkn633, PubMed 18832374
Publications 2007
The outer membrane secretin PilQ from Neisseria meningitidis binds DNA
Microbiology (Reading), 153 (Pt 5), 1593-1603
DOI 10.1099/mic.0.2006/004200-0, PubMed 17464074
Structural insight into repair of alkylated DNA by a new superfamily of DNA glycosylases comprising HEAT-like repeats
Nucleic Acids Res, 35 (7), 2451-9
DOI 10.1093/nar/gkm039, PubMed 17395642
Genetic interactions of DNA repair pathways in the pathogen Neisseria meningitidis
J Bacteriol, 189 (15), 5728-37
DOI 10.1128/JB.00161-07, PubMed 17513474
The capacity to remove 8-oxoG is enhanced in newborn neural stem/progenitor cells and decreases in juvenile mice and upon cell differentiation
DNA Repair (Amst), 6 (6), 723-32
DOI 10.1016/j.dnarep.2006.12.008, PubMed 17236821
Human NEIL1 localizes with the centrosomes and condensed chromosomes during mitosis
DNA Repair (Amst), 6 (10), 1425-33
DOI 10.1016/j.dnarep.2007.04.008, PubMed 17556049
OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells
Nature, 447 (7143), 447-52
DOI 10.1038/nature05778, PubMed 17450122
Publications 2006
A new protein superfamily includes two novel 3-methyladenine DNA glycosylases from Bacillus cereus, AlkC and AlkD
Mol Microbiol, 59 (5), 1602-9
DOI 10.1111/j.1365-2958.2006.05044.x, PubMed 16468998
New functions of XPC in the protection of human skin cells from oxidative damage
EMBO J, 25 (18), 4305-15
DOI 10.1038/sj.emboj.7601277, PubMed 16957781
Human cytomegalovirus infection modulates DNA base excision repair in fibroblast cells
Virology, 348 (2), 389-97
DOI 10.1016/j.virol.2006.01.001, PubMed 16476462
Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage
EMBO J, 25 (14), 3389-97
DOI 10.1038/sj.emboj.7601219, PubMed 16858410
18S rDNA polymerase chain reaction and sequencing in onychomycosis diagnostics
Acta Derm Venereol, 86 (3), 223-6
DOI 10.2340/00015555-0077, PubMed 16710579
Publications 2005
Biochemical characterization and DNA repair pathway interactions of Mag1-mediated base excision repair in Schizosaccharomyces pombe
Nucleic Acids Res, 33 (3), 1123-31
DOI 10.1093/nar/gki259, PubMed 15722486
Impaired base excision repair and accumulation of oxidative base lesions in CD4+ T cells of HIV-infected patients
Blood, 105 (12), 4730-5
DOI 10.1182/blood-2004-11-4272, PubMed 15705786
Antimutator role of DNA glycosylase MutY in pathogenic Neisseria species
J Bacteriol, 187 (8), 2801-9
DOI 10.1128/JB.187.8.2801-2809.2005, PubMed 15805527
Dynamic relocalization of hOGG1 during the cell cycle is disrupted in cells harbouring the hOGG1-Cys326 polymorphic variant
Nucleic Acids Res, 33 (6), 1813-24
DOI 10.1093/nar/gki325, PubMed 15800211
Product inhibition and magnesium modulate the dual reaction mode of hOgg1
DNA Repair (Amst), 4 (3), 381-7
DOI 10.1016/j.dnarep.2004.11.002, PubMed 15661661
Publications 2004
A general role of the DNA glycosylase Nth1 in the abasic sites cleavage step of base excision repair in Schizosaccharomyces pombe
Nucleic Acids Res, 32 (17), 5119-25
DOI 10.1093/nar/gkh851, PubMed 15452279
Substrate specificities of bacterial and human AlkB proteins
Nucleic Acids Res, 32 (11), 3456-61
DOI 10.1093/nar/gkh655, PubMed 15229293
The Bacillus subtilis counterpart of the mammalian 3-methyladenine DNA glycosylase has hypoxanthine and 1,N6-ethenoadenine as preferred substrates
J Biol Chem, 279 (14), 13601-6
DOI 10.1074/jbc.M314277200, PubMed 14729667
Publications 2003
Influence of DNA torsional rigidity on excision of 7,8-dihydro-8-oxo-2'-deoxyguanosine in the presence of opposing abasic sites by human OGG1 protein
Nucleic Acids Res, 31 (7), 1897-903
DOI 10.1093/nar/gkg289, PubMed 12655006
WRN interacts physically and functionally with the recombination mediator protein RAD52
J Biol Chem, 278 (38), 36476-86
DOI 10.1074/jbc.M303885200, PubMed 12750383
Comparative analysis of 8-oxoG:C, 8-oxoG:A, A:C and C:C DNA repair in extracts from wild type or 8-oxoG DNA glycosylase deficient mammalian and bacterial cells
DNA Repair (Amst), 2 (6), 707-18
DOI 10.1016/s1568-7864(03)00041-7, PubMed 12767349
Base excision repair activities required for yeast to attain a full chronological life span
Aging Cell, 2 (2), 93-104
DOI 10.1046/j.1474-9728.2003.00041.x, PubMed 12882322
Incision at hypoxanthine residues in DNA by a mammalian homologue of the Escherichia coli antimutator enzyme endonuclease V
Nucleic Acids Res, 31 (14), 3893-900
DOI 10.1093/nar/gkg472, PubMed 12853604
Limited repair of 8-hydroxy-7,8-dihydroguanine residues in human testicular cells
Nucleic Acids Res, 31 (4), 1351-63
DOI 10.1093/nar/gkg216, PubMed 12582255
A new Schizosaccharomyces pombe base excision repair mutant, nth1, reveals overlapping pathways for repair of DNA base damage
Mol Microbiol, 48 (2), 465-80
DOI 10.1046/j.1365-2958.2003.03440.x, PubMed 12675805
Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA
Nature, 421 (6925), 859-63
DOI 10.1038/nature01363, PubMed 12594517
Publications 2002
Methylpurine DNA glycosylase of the hyperthermophilic archaeon Archaeoglobus fulgidus
Biochemistry, 41 (42), 12697-705
DOI 10.1021/bi020334w, PubMed 12379112
Reciprocal "flipping" underlies substrate recognition and catalytic activation by the human 8-oxo-guanine DNA glycosylase
J Mol Biol, 317 (2), 171-7
DOI 10.1006/jmbi.2002.5400, PubMed 11902834
Human OGG1 undergoes serine phosphorylation and associates with the nuclear matrix and mitotic chromatin in vivo
Nucleic Acids Res, 30 (11), 2349-57
DOI 10.1093/nar/30.11.2349, PubMed 12034821
Human DNA glycosylases of the bacterial Fpg/MutM superfamily: an alternative pathway for the repair of 8-oxoguanine and other oxidation products in DNA
Nucleic Acids Res, 30 (22), 4926-36
DOI 10.1093/nar/gkf618, PubMed 12433996
Reconstitution of the base excision repair pathway for 7,8-dihydro-8-oxoguanine with purified human proteins
Nucleic Acids Res, 30 (10), 2124-30
DOI 10.1093/nar/30.10.2124, PubMed 12000832
Publications 2001
Highly efficient base excision repair (BER) in human and rat male germ cells
Nucleic Acids Res, 29 (8), 1781-90
DOI 10.1093/nar/29.8.1781, PubMed 11292851
Publications 2000
Cell-cycle regulation, intracellular sorting and induced overexpression of the human NTH1 DNA glycosylase involved in removal of formamidopyrimidine residues from DNA
Mutat Res, 460 (2), 95-104
DOI 10.1016/s0921-8777(00)00015-x, PubMed 10882850
Brain hypoplasia caused by exposure to trichlorfon and dichlorvos during development can be ascribed to DNA alkylation damage and inhibition of DNA alkyltransferase repair
Neurotoxicology, 21 (1-2), 165-73
PubMed 10794396
Base removers and strand scissors: different strategies employed in base excision and strand incision at modified base residues in DNA
Cold Spring Harb Symp Quant Biol, 65, 135-42
DOI 10.1101/sqb.2000.65.135, PubMed 12760028
Publications 1999
The Saccharomyces cerevisiae homologues of endonuclease III from Escherichia coli, Ntg1 and Ntg2, are both required for efficient repair of spontaneous and induced oxidative DNA damage in yeast
Mol Cell Biol, 19 (5), 3779-87
DOI 10.1128/MCB.19.5.3779, PubMed 10207101
Genes and enzymes for the removal of oxidative DNA base damage
ALFRED BENZON SYMP S, 44, 272-283
Publications 1998
Production, isolation and purification of bacteriocins expressed by two strains of Neisseria meningitidis
APMIS, 106 (12), 1181-7
DOI 10.1111/j.1699-0463.1998.tb00275.x, PubMed 10052727
Effects of chemical-induced DNA damage on male germ cells
Arch Toxicol Suppl, 20, 151-60
DOI 10.1007/978-3-642-46856-8_14, PubMed 9442290
Inducible expression of the GLT-1 glutamate transporter in a CHO cell line selected for low endogenous glutamate uptake (vol 422, pg 339, 1998)
FEBS Lett., 427 (1), 152
DOI 10.1016/S0014-5793(98)00345-7
Inducible expression of the GLT-1 glutamate transporter in a CHO cell line selected for low endogenous glutamate uptake
FEBS Lett, 422 (3), 339-42
DOI 10.1016/s0014-5793(98)00036-2, PubMed 9498811
Publications 1997
Opposite base-dependent reactions of a human base excision repair enzyme on DNA containing 7,8-dihydro-8-oxoguanine and abasic sites
EMBO J, 16 (20), 6314-22
DOI 10.1093/emboj/16.20.6314, PubMed 9321410
DNA damage induced by 3-chloro-4-(dichloromethyl)-5-hydroxy-2[5H]-furanone (MX) in HL-60 cells and purified DNA in vitro
Mutat Res, 390 (1-2), 171-8
DOI 10.1016/s0165-1218(97)00016-5, PubMed 9150766
Publications 1996
Cloning and expression of a neuronal rat brain glutamate transporter
Brain Res Mol Brain Res, 36 (1), 163-8
DOI 10.1016/0169-328x(95)00279-2, PubMed 9011753
Base excision of oxidative purine and pyrimidine DNA damage in Saccharomyces cerevisiae by a DNA glycosylase with sequence similarity to endonuclease III from Escherichia coli
Proc Natl Acad Sci U S A, 93 (20), 10735-40
DOI 10.1073/pnas.93.20.10735, PubMed 8855249
Publications 1995
Purification and properties of the alkylation repair DNA glycosylase encoded the MAG gene from Saccharomyces cerevisiae
Biochemistry, 34 (14), 4577-82
DOI 10.1021/bi00014a010, PubMed 7718559
The base excision repair pathway
Trends Biochem Sci, 20 (10), 391-7
DOI 10.1016/s0968-0004(00)89086-6, PubMed 8533150
Publications 1994
Increased removal of 3-alkyladenine reduces the frequencies of hprt mutations induced by methyl- and ethylmethanesulfonate in Chinese hamster fibroblast cells
Nucleic Acids Res, 22 (9), 1670-4
DOI 10.1093/nar/22.9.1670, PubMed 8202370
Differential expression of two glial glutamate transporters in the rat brain: an in situ hybridization study
Eur J Neurosci, 6 (6), 936-42
DOI 10.1111/j.1460-9568.1994.tb00587.x, PubMed 7952280
Publications 1993
Excision of 3-methylguanine from alkylated DNA by 3-methyladenine DNA glycosylase I of Escherichia coli
Nucleic Acids Res, 21 (9), 2045-9
DOI 10.1093/nar/21.9.2045, PubMed 8502545
Publications 1992
Cloning and expression of a rat brain L-glutamate transporter
Nature, 360 (6403), 464-7
DOI 10.1038/360464a0, PubMed 1448170
Publications 1990
Cloning and expression in Escherichia coli of a gene for an alkylbase DNA glycosylase from Saccharomyces cerevisiae; a homologue to the bacterial alkA gene
EMBO J, 9 (13), 4563-8
DOI 10.1002/j.1460-2075.1990.tb07909.x, PubMed 2265619