Publications 2021

Danielsen TK, Sadredini M, Manotheepan R, Aronsen JM, Frisk M, Hansen MH, Andressen KW, Hougen K, Levy FO, Louch WE, Sejersted OM, Sjaastad I, Stokke MK (2021)
Exercise Training Stabilizes RyR2-Dependent Ca2+ Release in Post-infarction Heart Failure
Front. Cardiovasc. Med., 7, 623922
DOI 10.3389/fcvm.2020.623922

Publications 2020

Jang W, Adams CE, Liu H, Zhang C, Levy FO, Andressen KW, Lambert NA (2020)
An inactive receptor-G protein complex maintains the dynamic range of agonist-induced signaling
Proc. Natl. Acad. Sci. U. S. A., 117 (48), 30755-30762
DOI 10.1073/pnas.2010801117

Publications 2019

Calamera G, Li D, Ulsund AH, Kim JJ, Neely OC, Moltzau LR, Bjornerem M, Paterson D, Kim C, Levy FO, Andressen KW (2019)
FRET-based cyclic GMP biosensors measure low cGMP concentrations in cardiomyocytes and neurons
Commun. Biol., 2, 394
DOI 10.1038/s42003-019-0641-x

Ulsund AH, Dahl M, Frimurer TM, Manfra O, Schwartz TW, Levy FO, Andressen KW (2019)
Preassociation between the 5-HT7 serotonin receptor and G protein G(s): molecular determinants and association with low potency activation of adenylyl cyclase
Faseb J., 33 (3), 3870-3886
DOI 10.1096/fj.201800805RR

Publications 2018

Andressen KW, Ulsund AH, Krobert KA, Lohse MJ, Bunemann M, Levy FO (2018)
Related GPCRs couple differently to G(s): preassociation between G protein and 5-HT7 serotonin receptor reveals movement of Gas upon receptor activation
Faseb J., 32 (2), 1059-1069
DOI 10.1096/fj.201700486R

Publications 2017

Meier S, Andressen KW, Aronsen JM, Sjaastad I, Hougen K, Skomedal T, Osnes JB, Qvigstad E, Levy FO, Moltzau LR (2017)
PDE3 inhibition by C-type natriuretic peptide-induced cGMP enhances cAMP-mediated signaling in both non-failing and failing hearts
Eur. J. Pharmacol., 812, 174-183
DOI 10.1016/j.ejphar.2017.07.014

Publications 2016

Olberg DE, Bauer N, Andressen KW, Hjornevik T, Cumming P, Levy FO, Klaveness J, Haraldsen I, Sutcliffe JL (2016)
Brain penetrant small molecule F-18-GnRH receptor (GnRH-R) antagonists: Synthesis and preliminary positron emission tomography imaging in rats
Nucl. Med. Biol., 43 (8), 478-489
DOI 10.1016/j.nucmedbio.2016.05.003

Publications 2015

Andressen KW, Manfra O, Brevik CH, Ulsund AH, Vanhoenacker P, Levy FO, Krobert KA (2015)
The atypical antipsychotics clozapine and olanzapine promote down-regulation and display functional selectivity at human 5-HT7 receptors
Br. J. Pharmacol., 172 (15), 3846-3860
DOI 10.1111/bph.13169

Impellizzeri AAR, Pappalardo M, Basile L, Manfra O, Andressen KW, Krobert KA, Messina A, Levy FO, Guccione S (2015)
Identification of essential residues for binding and activation in the human 5-HT7(a) serotonin receptor by molecular modeling and site-directed mutagenesis
Front. Behav. Neurosci., 9, 92
DOI 10.3389/fnbeh.2015.00092

Manfra O, Van Craenenbroeck K, Skieterska K, Frimurer T, Schwartz TW, Levy FO, Andressen KW (2015)
Downregulation of 5-HT7 Serotonin Receptors by the Atypical Antipsychotics Clozapine and Olanzapine. Role of Motifs in the C-Terminal Domain and Interaction with GASP-1
ACS Chem. Neurosci., 6 (7), 1206-1218
DOI 10.1021/cn500339p

Olberg DE, Hausner SH, Bauer N, Klaveness J, Indrevoll B, Andressen KW, Dahl M, Levy FO, Sutcliffe JL, Haraldsen I (2015)
Radiosynthesis of high affinity fluorine-18 labeled GnRH peptide analogues: in vitro studies and in vivo assessment of brain uptake in rats
MedChemComm, 6 (4), 708-714
DOI 10.1039/c4md00486h

Orstavik O, Manfra O, Andressen KW, Andersen GO, Skomedal T, Osnes JB, Levy FO, Krobert KA (2015)
The Inotropic Effect of the Active Metabolite of Levosimendan, OR-1896, Is Mediated through Inhibition of PDE3 in Rat Ventricular Myocardium
PLoS One, 10 (3), e0115547
DOI 10.1371/journal.pone.0115547

Publications 2014

Brudeli B, Navaratnarajah M, Andressen KW, Manfra O, Moltzau LR, Nilsen NO, Levy FO, Klaveness J (2014)
Discovery and pharmacological profile of new hydrophilic 5-HT4 receptor antagonists
Bioorg. Med. Chem. Lett., 24 (18), 4598-4602
DOI 10.1016/j.bmcl.2014.06.083

Kilander MBC, Petersen J, Andressen KW, Ganji RS, Levy FO, Schuster J, Dahl N, Bryja V, Schulte G (2014)
Disheveled regulates precoupling of heterotrimeric G proteins to Frizzled 6
Faseb J., 28 (5), 2293-2305
DOI 10.1096/fj.13-246363

Olberg DE, Andressen KW, Levy FO, Klaveness J, Haraldsen I, Sutcliffe JL (2014)
Synthesis and in vitro evaluation of small-molecule [F-18] labeled gonadotropin-releasing hormone (GnRH) receptor antagonists as potential PET imaging agents for GnRH receptor expression
Bioorg. Med. Chem. Lett., 24 (7), 1846-1850
DOI 10.1016/j.bmcl.2014.02.002

Publications 2013

Brudeli B, Andressen KW, Moltzau LR, Nilsen NO, Levy FO, Klaveness J (2013)
Acidic biphenyl derivatives: Synthesis and biological activity of a new series of potent 5-HT4 receptor antagonists
Bioorg. Med. Chem., 21 (22), 7134-7145
DOI 10.1016/j.bmc.2013.09.004

Brudeli B, Moltzau LR, Nguyen CHT, Andressen KW, Nilsen NO, Levy FO, Klaveness J (2013)
Synthesis and pharmacological properties of a new hydrophilic and orally bioavailable 5-HT4 antagonist
Eur. J. Med. Chem., 64, 629-637
DOI 10.1016/j.ejmech.2013.03.060

Gellynck E, Heyninck K, Andressen KW, Haegeman G, Levy FO, Vanhoenacker P, Van Craenenbroeck K (2013)
The serotonin 5-HT7 receptors: two decades of research
Exp. Brain Res., 230 (4), 555-568
DOI 10.1007/s00221-013-3694-y

Publications 2012

Gellynck E, Andressen KW, Lintermans B, Haegeman G, Levy FO, Vanhoenacker P, Van Craenenbroeck K (2012)
Biochemical and pharmacological study of N-linked glycosylation of the human serotonin 5-HT7(a) receptor
FEBS J., 279 (11), 1994-2003
DOI 10.1111/j.1742-4658.2012.08581.x

Publications 2010

Brudeli B, Moltzau LR, Andressen KW, Krobert KA, Klaveness J, Levy FO (2010)
Synthesis and pharmacological properties of novel hydrophilic 5-HT4 receptor antagonists
Bioorg. Med. Chem., 18 (24), 8600-8613
DOI 10.1016/j.bmc.2010.10.011

Publications 2008

Afzal F, Andressen KW, Mork HK, Aronsen JM, Sjaastad I, Dahl CP, Skomedal T, Levy FO, Osnes JB, Qvigstad E (2008)
5-HT4-elicited positive inotropic response is mediated by cAMP and regulated by PDE3 in failing rat and human cardiac ventricles
Br. J. Pharmacol., 155 (7), 1005-1014
DOI 10.1038/bjp.2008.339

Andressen KW (2008)
The 5-HT₇ serotonin receptor: G protein preassociation and functional selectivity
In Series of dissertations submitted to the Faculty of Medicine, University of Oslo, Unipub, Oslo, no. 601, 1 b. (flere pag.)
BIBSYS 080299229, ISBN 978-82-8072-747-3

Gellynck E, Laenen K, Andressen KW, Lintermans B, De Martelaere K, Matthys A, Levy FO, Haegeman G, Vanhoenacker P, Van Craenenbroeck K (2008)
Cloning, genomic organization and functionality of 5-HT7 receptor splice variants from mouse brain
Gene, 426 (1-2), 23-31
DOI 10.1016/j.gene.2008.08.011

Ngai J, Methi T, Andressen KW, Levy FO, Torgersen KM, Vang T, Wettschureck N, Tasken K (2008)
The heterotrimeric G-protein alpha-subunit G alpha q regulates TCR-mediated immune responses through an Lck-dependent pathway
Eur. J. Immunol., 38 (11), 3208-3218
DOI 10.1002/eji.200838195

Publications 2007

Vinge LE, Andressen KW, Attramadal T, Andersen GO, Ahmed MS, Peppel K, Koch WJ, Freedman NJ, Levy FO, Skomedal T, Osnes JB, Attramadal H (2007)
Substrate specificities of G protein-coupled receptor kinase-2 and -3 at cardiac myocyte receptors provide basis for distinct roles in regulation of myocardial function
Mol. Pharmacol., 72 (3), 582-591
DOI 10.1124/mol.107.035766

Publications 2002

Andressen KW (2002)
Constitutive activity of 5-HT₄ and 5-HT₇ serotonin receptors and modification of signalling through endogenous G<ind>s coupled receptors in HEK292 cells
J.W. Andressen, Oslo, 2 bl. 69 s.
BIBSYS 020703104