Studies of the interactions of antibodies with their Fc receptors, with a particular focus on the neonatal Fc receptor (FcRn) and its relationship with IgG and albumin. In addition, we are investigating how FcRn acts as a transporter in different cell types of the body. The studies will unravel the basic structural and cellular mechanisms that govern the functions of FcRn. Such knowledge offers opportunities for development of novel drug concepts that will secure improved half-life and biodistribution.
Studies of the mechanisms of infections at different body sites and how humoral immunity fights and restricts infection and virus replication. In particular, we are studying how antibodies contribute to protection against infectious diseases, and how FcRn and tripartite motif containing 21 (TRIM21) take part in cellular protection. Such knowledge can be utilized to develop novel antibody technologies tailored to combat infectious diseases.
Recent publications
Azevedo C, Nilsen J, Grevys A, Nunes R, Andersen JT, Sarmento B(2020) Engineered albumin-functionalized nanoparticles for improved FcRn binding enhance oral delivery of insulin J Control Release(in press) DOI 10.1016/j.jconrel.2020.08.005, PubMed 32771477
Caddy SL, Vaysburd M, Wing M, Foss S, Andersen JT, O'Connell K, Mayes K, Higginson K, Iturriza-Gómara M, Desselberger U, James LC(2020) Intracellular neutralisation of rotavirus by VP6-specific IgG PLoS Pathog, 16(8), e1008732(in press) DOI 10.1371/journal.ppat.1008732, PubMed 32750093
Hubbard JJ, Pyzik M, Rath T, Kozicky LK, Sand KMK, Gandhi AK, Grevys A, Foss S, Menzies SC, Glickman JN, Fiebiger E, Roopenian DC, Sandlie I, Andersen JT, Sly LM, Baker K, Blumberg RS(2020) FcRn is a CD32a coreceptor that determines susceptibility to IgG immune complex-driven autoimmunity J Exp Med, 217(10) DOI 10.1084/jem.20200359, PubMed 32658257