Publications 2024

Foss S, Sakya SA, Aguinagalde L, Lustig M, Shaughnessy J, Cruz AR, Scheepmaker L, Mathiesen L, Ruso-Julve F, Anthi AK, Gjølberg TT, Mester S, Bern M, Evers M, Bratlie DB, Michaelsen TE, Schlothauer T, Sok D, Bhattacharya J, Leusen J, Valerius T, Ram S, Rooijakkers SHM, Sandlie I, Andersen JT (2024)
Human IgG Fc-engineering for enhanced plasma half-life, mucosal distribution and killing of cancer cells and bacteria
Nat Commun, 15 (1), 2007
DOI 10.1038/s41467-024-46321-9, PubMed 38453922

Publications 2023

Gjølberg TT, Wik JA, Johannessen H, Krüger S, Bassi N, Christopoulos PF, Bern M, Foss S, Petrovski G, Moe MC, Haraldsen G, Fosse JH, Skålhegg BS, Andersen JT, Sundlisæter E (2023)
Antibody blockade of Jagged1 attenuates choroidal neovascularization
Nat Commun, 14 (1), 3109
DOI 10.1038/s41467-023-38563-w, PubMed 37253747

Jørstad ØK, Foss S, Gjølberg TT, Mester S, Nyquist-Andersen M, Sivertsen MS, Fossum D, Gleditsch E, Moe MC, Andersen JT (2023)
Pharmaceutical compounding and storage of faricimab in a syringe for intravitreal injection do not impair stability and bi-specific binding properties
Int J Retina Vitreous, 9 (1), 65
DOI 10.1186/s40942-023-00507-3, PubMed 37936232

Lustig M, Chan C, Jansen JHM, Bräutigam M, Kölling MA, Gehlert CL, Baumann N, Mester S, Foss S, Andersen JT, Bastian L, Sondermann P, Peipp M, Burger R, Leusen JHW, Valerius T (2023)
Disruption of the sialic acid/Siglec-9 axis improves antibody-mediated neutrophil cytotoxicity towards tumor cells
Front Immunol, 14, 1178817
DOI 10.3389/fimmu.2023.1178817, PubMed 37346044

Mukadam AS, Miller LVC, Smith AE, Vaysburd M, Sakya SA, Sanford S, Keeling S, Tuck BJ, Katsinelos T, Green C, Skov L, Kaalund SS, Foss S, Mayes K, O'Connell K, Wing M, Knox C, Banbury J, Avezov E, Rowe JB, Goedert M, Andersen JT, James LC, McEwan WA (2023)
Cytosolic antibody receptor TRIM21 is required for effective tau immunotherapy in mouse models
Science, 379 (6639), 1336-1341
DOI 10.1126/science.abn1366, PubMed 36996217

Publications 2022

Foss S, Jonsson A, Bottermann M, Watkinson R, Lode HE, McAdam MB, Michaelsen TE, Sandlie I, James LC, Andersen JT (2022)
Potent TRIM21 and complement-dependent intracellular antiviral immunity requires the IgG3 hinge
Sci Immunol, 7 (70), eabj1640
DOI 10.1126/sciimmunol.abj1640, PubMed 35486676

Gjølberg TT, Frick R, Mester S, Foss S, Grevys A, Høydahl LS, Jørstad ØK, Schlothauer T, Sandlie I, Moe MC, Andersen JT (2022)
Biophysical differences in IgG1 Fc-based therapeutics relate to their cellular handling, interaction with FcRn and plasma half-life
Commun Biol, 5 (1), 832
DOI 10.1038/s42003-022-03787-x, PubMed 35982144

Grevys A, Frick R, Mester S, Flem-Karlsen K, Nilsen J, Foss S, Sand KMK, Emrich T, Fischer JAA, Greiff V, Sandlie I, Schlothauer T, Andersen JT (2022)
Antibody variable sequences have a pronounced effect on cellular transport and plasma half-life
iScience, 25 (2), 103746
DOI 10.1016/j.isci.2022.103746, PubMed 35118359

Mørtberg TV, Zhi H, Vidarsson G, Foss S, Lissenberg-Thunnissen S, Wuhrer M, Michaelsen TE, Skogen B, Stuge TB, Andersen JT, Newman PJ, Ahlen MT (2022)
Prevention of Fetal/Neonatal Alloimmune Thrombocytopenia in Mice: Biochemical and Cell Biological Characterization of Isoforms of a Human Monoclonal Antibody
Immunohorizons, 6 (1), 90-103
DOI 10.4049/immunohorizons.2100097, PubMed 35074850

Zakrzewicz A, Würth C, Beckert B, Feldhoff S, Vanderheyden K, Foss S, Andersen JT, Haard H, Verheesen P, Bobkov V, Tikkanen R (2022)
Stabilization of Keratinocyte Monolayer Integrity in the Presence of Anti-Desmoglein-3 Antibodies through FcRn Blockade with Efgartigimod: Novel Treatment Paradigm for Pemphigus?
Cells, 11 (6)
DOI 10.3390/cells11060942, PubMed 35326398

Zakrzewicz A, Würth C, Beckert B, Feldhoff S, Vanderheyden K, Foss S, Andersen JT, Haard H, Verheesen P, Bobkov V, Tikkanen R (2022)
Correction: Zakrzewicz et al. Stabilization of Keratinocyte Monolayer Integrity in the Presence of Anti-Desmoglein-3 Antibodies through FcRn Blockade with Efgartigimod: Novel Treatment Paradigm for Pemphigus? Cells 2022, 11, 942
Cells, 11 (10)
DOI 10.3390/cells11101700, PubMed 35626757

Publications 2020

Bern M, Nilsen J, Ferrarese M, Sand KMK, Gjølberg TT, Lode HE, Davidson RJ, Camire RM, Bækkevold ES, Foss S, Grevys A, Dalhus B, Wilson J, Høydahl LS, Christianson GJ, Roopenian DC, Schlothauer T, Michaelsen TE, Moe MC, Lombardi S, Pinotti M, Sandlie I, Branchini A, Andersen JT (2020)
An engineered human albumin enhances half-life and transmucosal delivery when fused to protein-based biologics
Sci Transl Med, 12 (565)
DOI 10.1126/scitranslmed.abb0580, PubMed 33055243

Caddy SL, Vaysburd M, Papa G, Wing M, O'Connell K, Stoycheva D, Foss S, Terje Andersen J, Oxenius A, James LC (2020)
Viral nucleoprotein antibodies activate TRIM21 and induce T cell immunity
EMBO J, 40 (5), e106228
DOI 10.15252/embj.2020106228, PubMed 33258165

Caddy SL, Vaysburd M, Wing M, Foss S, Andersen JT, O'Connell K, Mayes K, Higginson K, Iturriza-Gómara M, Desselberger U, James LC (2020)
Intracellular neutralisation of rotavirus by VP6-specific IgG
PLoS Pathog, 16 (8), e1008732
DOI 10.1371/journal.ppat.1008732, PubMed 32750093

Hubbard JJ, Pyzik M, Rath T, Kozicky LK, Sand KMK, Gandhi AK, Grevys A, Foss S, Menzies SC, Glickman JN, Fiebiger E, Roopenian DC, Sandlie I, Andersen JT, Sly LM, Baker K, Blumberg RS (2020)
FcRn is a CD32a coreceptor that determines susceptibility to IgG immune complex-driven autoimmunity
J Exp Med, 217 (10)
DOI 10.1084/jem.20200359, PubMed 32658257

Publications 2019

Bottermann M, Foss S, Caddy SL, Clift D, van Tienen LM, Vaysburd M, Cruickshank J, O'Connell K, Clark J, Mayes K, Higginson K, Lode HE, McAdam MB, Sandlie I, Andersen JT, James LC (2019)
Complement C4 Prevents Viral Infection through Capsid Inactivation
Cell Host Microbe, 25 (4), 617-629.e7
DOI 10.1016/j.chom.2019.02.016, PubMed 30926239

Foss S, Bottermann M, Jonsson A, Sandlie I, James LC, Andersen JT (2019)
TRIM21-From Intracellular Immunity to Therapy
Front Immunol, 10, 2049
DOI 10.3389/fimmu.2019.02049, PubMed 31555278

Labzin LI, Bottermann M, Rodriguez-Silvestre P, Foss S, Andersen JT, Vaysburd M, Clift D, James LC (2019)
Antibody and DNA sensing pathways converge to activate the inflammasome during primary human macrophage infection
EMBO J, 38 (21), e101365
DOI 10.15252/embj.2018101365, PubMed 31468569

Lode HE, Gjølberg TT, Foss S, Sivertsen MS, Brustugun J, Andersson Y, Jørstad ØK, Moe MC, Andersen JT (2019)
A new method for pharmaceutical compounding and storage of anti-VEGF biologics for intravitreal use in silicone oil-free prefilled plastic syringes
Sci Rep, 9 (1), 18021
DOI 10.1038/s41598-019-54226-7, PubMed 31792234

Publications 2018

Bottermann M, Foss S, van Tienen LM, Vaysburd M, Cruickshank J, O'Connell K, Clark J, Mayes K, Higginson K, Hirst JC, McAdam MB, Slodkowicz G, Hutchinson E, Kozik P, Andersen JT, James LC (2018)
TRIM21 mediates antibody inhibition of adenovirus-based gene delivery and vaccination
Proc Natl Acad Sci U S A, 115 (41), 10440-10445
DOI 10.1073/pnas.1806314115, PubMed 30209217

Grevys A, Nilsen J, Sand KMK, Daba MB, Øynebråten I, Bern M, McAdam MB, Foss S, Schlothauer T, Michaelsen TE, Christianson GJ, Roopenian DC, Blumberg RS, Sandlie I, Andersen JT (2018)
A human endothelial cell-based recycling assay for screening of FcRn targeted molecules
Nat Commun, 9 (1), 621
DOI 10.1038/s41467-018-03061-x, PubMed 29434196

Høydahl LS, Richter L, Frick R, Snir O, Gunnarsen KS, Landsverk OJB, Iversen R, Jeliazkov JR, Gray JJ, Bergseng E, Foss S, Qiao SW, Lundin KEA, Jahnsen J, Jahnsen FL, Sandlie I, Sollid LM, Løset GÅ (2018)
Plasma Cells Are the Most Abundant Gluten Peptide MHC-expressing Cells in Inflamed Intestinal Tissues From Patients With Celiac Disease
Gastroenterology, 156 (5), 1428-1439.e10
DOI 10.1053/j.gastro.2018.12.013, PubMed 30593798

Sivertsen MS, Jørstad ØK, Grevys A, Foss S, Moe MC, Andersen JT (2018)
Pharmaceutical compounding of aflibercept in prefilled syringes does not affect structural integrity, stability or VEGF and Fc binding properties
Sci Rep, 8 (1), 2101
DOI 10.1038/s41598-018-20525-8, PubMed 29391560

Publications 2017

Bottermann M, Lode HE, Watkinson RE, Foss S, Sandlie I, Andersen JT, James LC (2017)
Corrigendum: Antibody-antigen kinetics constrain intracellular humoral immunity
Sci Rep, 7, 45418
DOI 10.1038/srep45418, PubMed 28382939

Publications 2016

Bottermann M, Lode HE, Watkinson RE, Foss S, Sandlie I, Andersen JT, James LC (2016)
Antibody-antigen kinetics constrain intracellular humoral immunity
Sci Rep, 6, 37457
DOI 10.1038/srep37457, PubMed 27881870

Foss S, Watkinson RE, Grevys A, McAdam MB, Bern M, Høydahl LS, Dalhus B, Michaelsen TE, Sandlie I, James LC, Andersen JT (2016)
TRIM21 Immune Signaling Is More Sensitive to Antibody Affinity Than Its Neutralization Activity
J Immunol, 196 (8), 3452-3459
DOI 10.4049/jimmunol.1502601, PubMed 26962230

Publications 2015

Foss S, Grevys A, Sand KMK, Bern M, Blundell P, Michaelsen TE, Pleass RJ, Sandlie I, Andersen JT (2015)
Enhanced FcRn-dependent transepithelial delivery of IgG by Fc-engineering and polymerization
J Control Release, 223, 42-52
DOI 10.1016/j.jconrel.2015.12.033, PubMed 26718855

Foss S, Watkinson R, Sandlie I, James LC, Andersen JT (2015)
TRIM21: a cytosolic Fc receptor with broad antibody isotype specificity
Immunol Rev, 268 (1), 328-39
DOI 10.1111/imr.12363, PubMed 26497531

Grevys A, Bern M, Foss S, Bratlie DB, Moen A, Gunnarsen KS, Aase A, Michaelsen TE, Sandlie I, Andersen JT (2015)
Fc Engineering of Human IgG1 for Altered Binding to the Neonatal Fc Receptor Affects Fc Effector Functions
J Immunol, 194 (11), 5497-508
DOI 10.4049/jimmunol.1401218, PubMed 25904551

Publications 2014

Hallstensen RF, Bergseth G, Foss S, Jæger S, Gedde-Dahl T, Holt J, Christiansen D, Lau C, Brekke OL, Armstrong E, Stefanovic V, Andersen JT, Sandlie I, Mollnes TE (2014)
Eculizumab treatment during pregnancy does not affect the complement system activity of the newborn
Immunobiology, 220 (4), 452-9
DOI 10.1016/j.imbio.2014.11.003, PubMed 25468724

Sand KM, Dalhus B, Christianson GJ, Bern M, Foss S, Cameron J, Sleep D, Bjørås M, Roopenian DC, Sandlie I, Andersen JT (2014)
Dissection of the neonatal Fc receptor (FcRn)-albumin interface using mutagenesis and anti-FcRn albumin-blocking antibodies
J Biol Chem, 289 (24), 17228-39
DOI 10.1074/jbc.M113.522565, PubMed 24764301

Publications 2013

Andersen JT, Gonzalez-Pajuelo M, Foss S, Landsverk OJ, Pinto D, Szyroki A, de Haard HJ, Saunders M, Vanlandschoot P, Sandlie I (2013)
Selection of nanobodies that target human neonatal Fc receptor
Sci Rep, 3, 1118
DOI 10.1038/srep01118, PubMed 23346375

Publications 2012

Andersen JT, Foss S, Kenanova VE, Olafsen T, Leikfoss IS, Roopenian DC, Wu AM, Sandlie I (2012)
Anti-carcinoembryonic antigen single-chain variable fragment antibody variants bind mouse and human neonatal Fc receptor with different affinities that reveal distinct cross-species differences in serum half-life
J Biol Chem, 287 (27), 22927-37
DOI 10.1074/jbc.M112.355131, PubMed 22570488