Every day all cells in all organisms are challenged with agents that damage the DNA which may lead to mutations or cell death. To protect themselves against such treats, cells express hundreds of proteins that are engaged in detection and removal of DNA damage. Defects in these processes are associated with cancer, neurological disease and premature aging. During the last years, the role of DNA repair in disease progression has been more and more acknowledged, however a complete picture has not yet been drawn. Our aim is to increase the knowledge of processes that are involved in keeping our genetic material error free by the use of simple model organisms as bacteria and yeast in addition to higher eukaryotic systems. Results obtained in such organisms are often directly transferable to mammalian organisms. Our recent research has revealed that one of the anticipated “DNA repair” proteins rather is active on modified RNA. The focus of the group has therefor shifted to study RNA and various aspects of RNA metabolism with emphasis on the enzyme Endonuclease V.
Epitranscriptome in Ischemic Cardiovascular Disease: Potential Target for Therapies
Stroke, 53 (6), 2114-2122
Endonuclease V Regulates Atherosclerosis Through C-C Motif Chemokine Ligand 2-Mediated Monocyte Infiltration
J Am Heart Assoc, 10 (14), e020656
N6-methyladenosine in RNA of atherosclerotic plaques: An epitranscriptomic signature of human carotid atherosclerosis
Biochem Biophys Res Commun, 533 (4), 631-637