Publications 2024

Chiavelli C, Prapa M, Rovesti G, Silingardi M, Neri G, Pugliese G, Trudu L, Dall'Ora M, Golinelli G, Grisendi G, Vinet J, Bestagno M, Spano C, Papapietro RV, Depenni R, Di Emidio K, Pasetto A, Nascimento Silva D, Feletti A, Berlucchi S, Iaccarino C, Pavesi G, Dominici M (2024)
Autologous anti-GD2 CAR T cells efficiently target primary human glioblastoma
NPJ Precis Oncol, 8 (1), 26
DOI 10.1038/s41698-024-00506-z, PubMed 38302615

Gaimari A, De Lucia A, Nicolini F, Mazzotti L, Maltoni R, Rughi G, Zurlo M, Marchesini M, Juan M, Parras D, Cerchione C, Martinelli G, Bravaccini S, Tettamanti S, Pasetto A, Pasini L, Magnoni C, Gazzola L, Borges de Souza P, Mazza M (2024)
Significant Advancements and Evolutions in Chimeric Antigen Receptor Design
Int J Mol Sci, 25 (22)
DOI 10.3390/ijms252212201, PubMed 39596267

Yan J, Bangalore CR, Nikouyan N, Appelberg S, Silva DN, Yao H, Pasetto A, Weber F, Weber S, Larsson O, Höglund U, Bogdanovic G, Grabbe M, Aleman S, Szekely L, Szakos A, Tuvesson O, Gidlund EK, Cadossi M, Salati S, Tegel H, Hober S, Frelin L, Mirazimi A, Ahlén G et al. (2024)
Distinct roles of vaccine-induced SARS-CoV-2-specific neutralizing antibodies and T cells in protection and disease
Mol Ther, 32 (2), 540-555
DOI 10.1016/j.ymthe.2024.01.007, PubMed 38213030

Publications 2023

Pasetto A, Lu YC (2023)
Editorial: Personalized immunotherapy for cancer
Front Oncol, 13, 1171907
DOI 10.3389/fonc.2023.1171907, PubMed 36959783

Publications 2022

Burm R, Maravelia P, Ahlen G, Ciesek S, Caro Perez N, Pasetto A, Urban S, Van Houtte F, Verhoye L, Wedemeyer H, Johansson M, Frelin L, Sällberg M, Meuleman P (2022)
Novel prime-boost immune-based therapy inhibiting both hepatitis B and D virus infections
Gut, 72 (6), 1186-1195
DOI 10.1136/gutjnl-2022-327216, PubMed 35977815

Kishton RJ, Patel SJ, Decker AE, Vodnala SK, Cam M, Yamamoto TN, Patel Y, Sukumar M, Yu Z, Ji M, Henning AN, Gurusamy D, Palmer DC, Stefanescu RA, Girvin AT, Lo W, Pasetto A, Malekzadeh P, Deniger DC, Wood KC, Sanjana NE, Restifo NP (2022)
Cancer genes disfavoring T cell immunity identified via integrated systems approach
Cell Rep, 40 (5), 111153
DOI 10.1016/j.celrep.2022.111153, PubMed 35926468

Mazzotti L, Gaimari A, Bravaccini S, Maltoni R, Cerchione C, Juan M, Navarro EA, Pasetto A, Nascimento Silva D, Ancarani V, Sambri V, Calabrò L, Martinelli G, Mazza M (2022)
T-Cell Receptor Repertoire Sequencing and Its Applications: Focus on Infectious Diseases and Cancer
Int J Mol Sci, 23 (15)
DOI 10.3390/ijms23158590, PubMed 35955721

Pasetto A, Buggert M (2022)
T-Cell Repertoire Characterization
Methods Mol Biol, 2574, 209-219
DOI 10.1007/978-1-0716-2712-9_9, PubMed 36087203

Silva DN, Chrobok M, Rovesti G, Healy K, Wagner AK, Maravelia P, Gatto F, Mazza M, Mazzotti L, Lohmann V, Sällberg Chen M, Sällberg M, Buggert M, Pasetto A (2022)
Process Development for Adoptive Cell Therapy in Academia: A Pipeline for Clinical-Scale Manufacturing of Multiple TCR-T Cell Products
Front Immunol, 13, 896242
DOI 10.3389/fimmu.2022.896242, PubMed 35784320

Publications 2021

Maravelia P, Frelin L, Ni Y, Caro Pérez N, Ahlén G, Jagya N, Verch G, Verhoye L, Pater L, Johansson M, Pasetto A, Meuleman P, Urban S, Sällberg M (2021)
Blocking Entry of Hepatitis B and D Viruses to Hepatocytes as a Novel Immunotherapy for Treating Chronic Infections
J Infect Dis, 223 (1), 128-138
DOI 10.1093/infdis/jiaa036, PubMed 31994701

Maravelia P, Silva DN, Rovesti G, Chrobok M, Stål P, Lu YC, Pasetto A (2021)
Liquid Biopsy in Hepatocellular Carcinoma: Opportunities and Challenges for Immunotherapy
Cancers (Basel), 13 (17)
DOI 10.3390/cancers13174334, PubMed 34503144

Paria BC, Levin N, Lowery FJ, Pasetto A, Deniger DC, Parkhurst MR, Yossef R, Kim SP, Florentin M, Ngo LT, Ray S, Krishna S, Robbins PF, Rosenberg SA (2021)
Rapid Identification and Evaluation of Neoantigen-reactive T-Cell Receptors From Single Cells
J Immunother, 44 (1), 1-8
DOI 10.1097/CJI.0000000000000342, PubMed 33086340

Pasetto A, Lu YC (2021)
Single-Cell TCR and Transcriptome Analysis: An Indispensable Tool for Studying T-Cell Biology and Cancer Immunotherapy
Front Immunol, 12, 689091
DOI 10.3389/fimmu.2021.689091, PubMed 34163487

Publications 2020

Healy K, Pasetto A, Sobkowiak MJ, Soon CF, Cornberg M, Aleman S, Sällberg Chen M (2020)
Chronic Viral Liver Diseases: Approaching the Liver Using T Cell Receptor-Mediated Gene Technologies
Cells, 9 (6)
DOI 10.3390/cells9061471, PubMed 32560123

Pasetto A (2020)
Identification and Clinical Application of Immunological Receptors Targeting Mutated Antigens Expressed by Solid Tumors
Cancers (Basel), 12 (10)
DOI 10.3390/cancers12102818, PubMed 33007884

Sällberg M, Pasetto A (2020)
Liver, Tumor and Viral Hepatitis: Key Players in the Complex Balance Between Tolerance and Immune Activation
Front Immunol, 11, 552
DOI 10.3389/fimmu.2020.00552, PubMed 32292409

Publications 2019

Ahmadzadeh M, Pasetto A, Jia L, Deniger DC, Stevanović S, Robbins PF, Rosenberg SA (2019)
Tumor-infiltrating human CD4⁺ regulatory T cells display a distinct TCR repertoire and exhibit tumor and neoantigen reactivity
Sci Immunol, 4 (31)
DOI 10.1126/sciimmunol.aao4310, PubMed 30635355

Cafri G, Yossef R, Pasetto A, Deniger DC, Lu YC, Parkhurst M, Gartner JJ, Jia L, Ray S, Ngo LT, Jafferji M, Sachs A, Prickett T, Robbins PF, Rosenberg SA (2019)
Memory T cells targeting oncogenic mutations detected in peripheral blood of epithelial cancer patients
Nat Commun, 10 (1), 449
DOI 10.1038/s41467-019-08304-z, PubMed 30683863

Gros A, Tran E, Parkhurst MR, Ilyas S, Pasetto A, Groh EM, Robbins PF, Yossef R, Garcia-Garijo A, Fajardo CA, Prickett TD, Jia L, Gartner JJ, Ray S, Ngo L, Wunderllich JR, Yang JC, Rosenberg SA (2019)
Recognition of human gastrointestinal cancer neoantigens by circulating PD-1+ lymphocytes
J Clin Invest, 129 (11), 4992-5004
DOI 10.1172/JCI127967, PubMed 31609250

Lo W, Parkhurst M, Robbins PF, Tran E, Lu YC, Jia L, Gartner JJ, Pasetto A, Deniger D, Malekzadeh P, Shelton TE, Prickett T, Ray S, Kivitz S, Paria BC, Kriley I, Schrump DS, Rosenberg SA (2019)
Immunologic Recognition of a Shared p53 Mutated Neoantigen in a Patient with Metastatic Colorectal Cancer
Cancer Immunol Res, 7 (4), 534-543
DOI 10.1158/2326-6066.CIR-18-0686, PubMed 30709841

Malekzadeh P, Pasetto A, Robbins PF, Parkhurst MR, Paria BC, Jia L, Gartner JJ, Hill V, Yu Z, Restifo NP, Sachs A, Tran E, Lo W, Somerville RP, Rosenberg SA, Deniger DC (2019)
Neoantigen screening identifies broad TP53 mutant immunogenicity in patients with epithelial cancers
J Clin Invest, 129 (3), 1109-1114
DOI 10.1172/JCI123791, PubMed 30714987

Parkhurst MR, Robbins PF, Tran E, Prickett TD, Gartner JJ, Jia L, Ivey G, Li YF, El-Gamil M, Lalani A, Crystal JS, Sachs A, Groh E, Ray S, Ngo LT, Kivitz S, Pasetto A, Yossef R, Lowery FJ, Goff SL, Lo W, Cafri G, Deniger DC, Malekzadeh P, Ahmadzadeh M et al. (2019)
Unique Neoantigens Arise from Somatic Mutations in Patients with Gastrointestinal Cancers
Cancer Discov, 9 (8), 1022-1035
DOI 10.1158/2159-8290.CD-18-1494, PubMed 31164343

Pasetto A, Ahlén G, Sällberg M (2019)
Editorial: HBV-the naked truth?
Aliment Pharmacol Ther, 50 (8), 963-964
DOI 10.1111/apt.15428, PubMed 31591767

Publications 2018

Deniger DC, Pasetto A, Robbins PF, Gartner JJ, Prickett TD, Paria BC, Malekzadeh P, Jia L, Yossef R, Langhan MM, Wunderlich JR, Danforth DN, Somerville RPT, Rosenberg SA (2018)
T-cell Responses to TP53 "Hotspot" Mutations and Unique Neoantigens Expressed by Human Ovarian Cancers
Clin Cancer Res, 24 (22), 5562-5573
DOI 10.1158/1078-0432.CCR-18-0573, PubMed 29853601

Yossef R, Tran E, Deniger DC, Gros A, Pasetto A, Parkhurst MR, Gartner JJ, Prickett TD, Cafri G, Robbins PF, Rosenberg SA (2018)
Enhanced detection of neoantigen-reactive T cells targeting unique and shared oncogenes for personalized cancer immunotherapy
JCI Insight, 3 (19)
DOI 10.1172/jci.insight.122467, PubMed 30282837

Zacharakis N, Chinnasamy H, Black M, Xu H, Lu YC, Zheng Z, Pasetto A, Langhan M, Shelton T, Prickett T, Gartner J, Jia L, Trebska-McGowan K, Somerville RP, Robbins PF, Rosenberg SA, Goff SL, Feldman SA (2018)
Immune recognition of somatic mutations leading to complete durable regression in metastatic breast cancer
Nat Med, 24 (6), 724-730
DOI 10.1038/s41591-018-0040-8, PubMed 29867227

Publications 2017

Balasiddaiah A, Davanian H, Aleman S, Pasetto A, Frelin L, Sällberg M, Lohmann V, Koh S, Bertoletti A, Chen M (2017)
Hepatitis C Virus-Specific T Cell Receptor mRNA-Engineered Human T Cells: Impact of Antigen Specificity on Functional Properties
J Virol, 91 (9)
DOI 10.1128/JVI.00010-17, PubMed 28228595

Stevanović S, Pasetto A, Helman SR, Gartner JJ, Prickett TD, Howie B, Robins HS, Robbins PF, Klebanoff CA, Rosenberg SA, Hinrichs CS (2017)
Landscape of immunogenic tumor antigens in successful immunotherapy of virally induced epithelial cancer
Science, 356 (6334), 200-205
DOI 10.1126/science.aak9510, PubMed 28408606

Publications 2016

Deniger DC, Kwong ML, Pasetto A, Dudley ME, Wunderlich JR, Langhan MM, Lee CR, Rosenberg SA (2016)
A Pilot Trial of the Combination of Vemurafenib with Adoptive Cell Therapy in Patients with Metastatic Melanoma
Clin Cancer Res, 23 (2), 351-362
DOI 10.1158/1078-0432.CCR-16-0906, PubMed 28093487

Deniger DC, Pasetto A, Tran E, Parkhurst MR, Cohen CJ, Robbins PF, Cooper LJ, Rosenberg SA (2016)
Stable, Nonviral Expression of Mutated Tumor Neoantigen-specific T-cell Receptors Using the Sleeping Beauty Transposon/Transposase System
Mol Ther, 24 (6), 1078-1089
DOI 10.1038/mt.2016.51, PubMed 26945006

Gros A, Parkhurst MR, Tran E, Pasetto A, Robbins PF, Ilyas S, Prickett TD, Gartner JJ, Crystal JS, Roberts IM, Trebska-McGowan K, Wunderlich JR, Yang JC, Rosenberg SA (2016)
Prospective identification of neoantigen-specific lymphocytes in the peripheral blood of melanoma patients
Nat Med, 22 (4), 433-8
DOI 10.1038/nm.4051, PubMed 26901407

Parkhurst M, Gros A, Pasetto A, Prickett T, Crystal JS, Robbins P, Rosenberg SA (2016)
Isolation of T-Cell Receptors Specifically Reactive with Mutated Tumor-Associated Antigens from Tumor-Infiltrating Lymphocytes Based on CD137 Expression
Clin Cancer Res, 23 (10), 2491-2505
DOI 10.1158/1078-0432.CCR-16-2680, PubMed 27827318

Pasetto A, Gros A, Robbins PF, Deniger DC, Prickett TD, Matus-Nicodemos R, Douek DC, Howie B, Robins H, Parkhurst MR, Gartner J, Trebska-McGowan K, Crystal JS, Rosenberg SA (2016)
Tumor- and Neoantigen-Reactive T-cell Receptors Can Be Identified Based on Their Frequency in Fresh Tumor
Cancer Immunol Res, 4 (9), 734-43
DOI 10.1158/2326-6066.CIR-16-0001, PubMed 27354337

Prickett TD, Crystal JS, Cohen CJ, Pasetto A, Parkhurst MR, Gartner JJ, Yao X, Wang R, Gros A, Li YF, El-Gamil M, Trebska-McGowan K, Rosenberg SA, Robbins PF (2016)
Durable Complete Response from Metastatic Melanoma after Transfer of Autologous T Cells Recognizing 10 Mutated Tumor Antigens
Cancer Immunol Res, 4 (8), 669-78
DOI 10.1158/2326-6066.CIR-15-0215, PubMed 27312342

Tran E, Robbins PF, Lu YC, Prickett TD, Gartner JJ, Jia L, Pasetto A, Zheng Z, Ray S, Groh EM, Kriley IR, Rosenberg SA (2016)
T-Cell Transfer Therapy Targeting Mutant KRAS in Cancer
N Engl J Med, 375 (23), 2255-2262
DOI 10.1056/NEJMoa1609279, PubMed 27959684

Publications 2013

Holmström F, Pasetto A, Nähr V, Brass A, Kriegs M, Hildt E, Broderick KE, Chen M, Ahlén G, Frelin L (2013)
A synthetic codon-optimized hepatitis C virus nonstructural 5A DNA vaccine primes polyfunctional CD8+ T cell responses in wild-type and NS5A-transgenic mice
J Immunol, 190 (3), 1113-24
DOI 10.4049/jimmunol.1201497, PubMed 23284053

Knudsen ML, Johansson DX, Kostic L, Nordström EK, Tegerstedt K, Pasetto A, Applequist SE, Ljungberg K, Sirard JC, Liljeström P (2013)
The adjuvant activity of alphavirus replicons is enhanced by incorporating the microbial molecule flagellin into the replicon
PLoS One, 8 (6), e65964
DOI 10.1371/journal.pone.0065964, PubMed 23785460

Pasetto A, Aleman S, Chen M (2013)
Functional attributes of responding T cells in HCV infection: the recent advances in engineering functional antiviral T cells
Arch Immunol Ther Exp (Warsz), 62 (1), 23-30
DOI 10.1007/s00005-013-0248-8, PubMed 23955531

Publications 2012

Pasetto A, Frelin L, Aleman S, Holmström F, Brass A, Ahlén G, Brenndörfer ED, Lohmann V, Bartenschlager R, Sällberg M, Bertoletti A, Chen M (2012)
TCR-redirected human T cells inhibit hepatitis C virus replication: hepatotoxic potential is linked to antigen specificity and functional avidity
J Immunol, 189 (9), 4510-9
DOI 10.4049/jimmunol.1201613, PubMed 23024278

Publications 2011

Pasetto A, Frelin L, Brass A, Yasmeen A, Koh S, Lohmann V, Bartenschlager R, Magalhaes I, Maeurer M, Sällberg M, Chen M (2011)
Generation of T-cell receptors targeting a genetically stable and immunodominant cytotoxic T-lymphocyte epitope within hepatitis C virus non-structural protein 3
J Gen Virol, 93 (Pt 2), 247-258
DOI 10.1099/vir.0.037903-0, PubMed 22071510