Quantitative Analyses and Kinetic Modelling in Nuclear Medicine

Caroline Stokke
Group leader

Functional and molecular imaging modalities are state-of-art technologies for in vivo assessment of pathology, and important tools in basic medical research. Nuclear medicine can facilitate early diagnosis and evaluation of therapy response. Especially, molecular radionuclide therapy allows for quantitative theranostic imaging and dose-effect evaluation.

The group collaborates closely with the Department for Nuclear Medicine in establishing novel methods and radiopharmaceuticals. Due to the recent advancement in nuclear medicine technology, medical physics play a significant role in the cross-disciplinary research team. The research group is responsible for quantitative measurements and advanced image analyses in various clinical studies.

The group focuses on

  • Quantitative PET imaging and pharmacokinetic modelling
  • Dosimetry and treatment planning for molecular radiotherapies (theranostics)
  • Implementation of novel methods and processing techniques for nuclear medicine imaging
  • Clinical and preclinical functional neuroimaging 

Research projects

  • Theranostics: Dose-effects for a novel 177-Lu based treatment of non-Hodgkin lymphoma (South-Eastern Norway Regional Health Authority Grant, 2017-2020, PI Stokke), Feasibility of quantitative 90-Y PET/CT for Selective Internal Radiation Therapy, Dosimetry-based treatment planning of 131-I therapy
  • Neuroimaging: The Human Opioid System - prediction of risk and treatment effects in addiction and persistent pain (South-Eastern Norway Regional Health Authority Grant, PI Hjørnevik), 18F-Flutemetamol PET/CT for the diagnosis of Alzheimer’s disease
  • Cardiac imaging: PET/CT assessment in candidates for cardiac resynchronisation therapy
  • Oncological assessment: Quantitative PET parameters as predictors for patient outcome (part of different lymphoma trials), development of radiomics feature software, and various technical projects related to image reconstruction and analyses

Contact information
Group Leader Caroline Stokke, PhD, Assoc. Prof., Dep of Diagnostic Physics, carsto@ous-hf.no, (0047) 98685214