The Laboratory is studying the cellular processes and molecular interplay underlying the functions of the two most abundant proteins in blood, albumin and IgG. By combining structural and biophysical approaches with cellular and in vivo studies, we use the insights to design novel albumin and antibody molecules with improved functions. 

 The group is an associated member of the Centre for Excellence Centre for Immune Regulation (CIR)

Guest Frontiers Topic Editor:  The neonatal Fc receptor (FcRn): From Biology to Therapi

• Studies of the interactions of antibodies with their Fc receptors, with a particular focus on the neonatal Fc receptor (FcRn) and its relationship with IgG and albumin. In addition, we are investigating how FcRn acts as a transporter in different cell types of the body. The studies will unravel the basic structural and cellular mechanisms that govern the functions of FcRn. Such knowledge offers opportunities for development of novel drug concepts that will secure improved half-life and biodistribution.
• Studies of the mechanisms of infections at different body sites and how humoral immunity fights and restricts infection and virus replication. In particular, we are studying how antibodies contribute to protection against infectious diseases, and how FcRn and tripartite motif containing 21 (TRIM21) take part in cellular protection. Such knowledge can be utilized to develop novel antibody technologies tailored to combat infectious diseases.

Group leader

Jan Terje Andersen
Department of Immunology Tel: +4795159223 E-mail: j.t.andersen@medisin.uio.no

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