Project group leader Jørgen Wesche:

Cancer cell migration and metastasis

 
  J. Wesche
J. Wesche

Cell migration is an important function for many cells. However, the ability of cells to migrate can transform a localized benign tumor to a metastatic and deadly cancer. In the process of metastasis, individual cells detach from the primary tumor and start to migrate to invade either nearby tissue or to enter lymphatic vessels or the bloodstream and then colonize in distant organs.

A deeper understanding of the process of cell migration may lead to new therapeutic strategies for the inhibition of tumor cell invasion. Importantly, the identification of new proteins involved in cancer cell migration could provide new targets for drug intervention in metastatic cancers.

 

Coworkers:


Ellen M. Haugsten

Elisa Fiorito

 

 

Selected publications:

Haugsten EM, Brech A, Liestøl K, Norman JC, Wesche J (2014)
Photoactivation approaches reveal a role for Rab11 in FGFR4 recycling and signalling
Traffic, 15 (6), 665-83 

Nadratowska-Wesolowska B, Haugsten EM, Zakrzewska M, Jakimowicz P, Zhen Y, Pajdzik D, Wesche J, Wiedlocha A (2013)
RSK2 regulates endocytosis of FGF receptor 1 by phosphorylation on serine 789
Oncogene, 33 (40), 4823-36

Oppelt A, Lobert VH, Haglund K, Mackey AM, Rameh LE, Liestøl K, Schink KO, Pedersen NM, Wenzel EM, Haugsten EM, Brech A, Rusten TE, Stenmark H, Wesche J (2012)
Production of phosphatidylinositol 5-phosphate via PIKfyve and MTMR3 regulates cell migration
EMBO Rep, 14 (1), 57-64

Lobert VH, Brech A, Pedersen NM, Wesche J, Oppelt A, Malerød L, Stenmark H (2010)
Ubiquitination of alpha 5 beta 1 integrin controls fibroblast migration through lysosomal degradation of fibronectin-integrin complexes
Dev Cell, 19 (1), 148-59

Haugsten, E.M., Malecki, J., Bjørklund, S.M.S., Olsnes, S., Wesche, J. (2008).
Ubiquitination of FGFR1 Is Required for Its Intracellular Sorting but Not for Its Endocytosis.
Mol Biol Cell. 2008 Aug;19(8):3390-403


Haugsten, E. M. Sorensen, V. Brech, A. Olsnes, S. Wesche, J. (2005)
Different intracellular trafficking of FGF1 endocytosed by the four homologous FGF receptors
J Cell Sci 118:3869-81



Total publication list

Our research is supported by The Norwegian Cancer Society:



Contact information:
Email: Jorgen.Wesche@rr-research.no
Department of Molecular Cell Biology, Institute for Cancer Research
The Norwegian Radium Hospital, Montebello, 0379 Oslo, Norway
Phone +47 22 78 19 31 (Wesche), Switchboard: +47 22 93 40 00