Welcome to Per Medbøe Thorsby's research group:

Biochemical endocrinology and metabolism research group

 
Group leader<br>Per M. Thorsby
Group leader
Per M. Thorsby

The aim of this research group is to explore metabolic aberrations in endocrine diseases for the identification and validation of new biomarkers.

Background

Endocrine and metabolic diseases such as diabetes, thyroid diseases, adrenal diseases and osteoporosis are major causes of morbidity and mortality.
The challenges are to identify persons at risk, implement therapeutic and preventive measures and monitor effects of these actions.
Adequate diagnostics and follow-up of treatment depend heavily on biomarkers in blood, urine, tears and saliva.
We use transcriptomic, proteomic and metabolomic approaches in close collaboration with the Dept of Endocrinology, OUS.

Prodects: 

Finding new biomarkers:

  • Diabetes:
    • Proteomic / metabolomic profiling of  human insulin producing cells aiming at discovering biomarkers for cell mas / function
    • Posttranslational modification of albumin in diabetes and late complications of diabetes
  • Thyroid disease:
    • Prospective evaluation of biomarkers of tear fluid in Graves ophtalmopathy
    • Metabolomic profiling of tear fluid in Graves ophtalmopathy

Basal studies:

  • Functional studies of genetic modifications in thyroid hormone resistance
  • Proteomic / metabolomic profiling of human fat tissue
  • Proteomic / metabolomic profiling of human bone marrow
  • Gene expression of  vitamin D stimulated insulin producing cells
  • Metabolomic profiling of hyperglycemic clamp in humans
  • Proteomic profiling of CSF in narcolepsy

Other projects:

  • Influence of estrogen supplementations on cortisol measurements in humans
  • Steroid profiling in congenital adrenal hyperplasia

Contact information

Per Medbøe Thorsby, Hormone Laboratory, Department of Medical Biochemistry,
Tel: + 47 23 03 30 43/ + 47 22 89 47 08 E-mail: pertho@ous-hf.no