Lars Nilsson
Position: Professor
Phone: +47 22840221

Publications 2013

Gu GJ, Wu D, Lund H, Sunnemark D, Kvist AJ, Milner R, Eckersley S, Nilsson LN, Agerman K, Landegren U, Kamali-Moghaddam M (2013)
Elevated MARK2-dependent phosphorylation of Tau in Alzheimer's disease
J Alzheimers Dis, 33 (3), 699-713
PubMed 23001711

Gumucio A, Lannfelt L, Nilsson LN (2013)
Lack of exon 10 in the murine tau gene results in mild sensorimotor defects with aging
BMC Neurosci, 14, 148
PubMed 24261309

Kalimo H, Lalowski M, Bogdanovic N, Philipson O, Bird TD, Nochlin D, Schellenberg GD, Brundin R, Olofsson T, Soliymani R, Baumann M, Wirths O, Bayer TA, Nilsson LN, Basun H, Lannfelt L, Ingelsson M (2013)
The Arctic AβPP mutation leads to Alzheimer's disease pathology with highly variable topographic deposition of differentially truncated Aβ
Acta Neuropathol Commun, 1, 60
PubMed 24252272

Lillehaug S, Syverstad GH, Nilsson LN, Bjaalie JG, Leergaard TB, Torp R (2013)
Brainwide distribution and variance of amyloid-beta deposits in tg-ArcSwe mice
Neurobiol Aging, 35 (3), 556-64
PubMed 24126157

Lillenes MS, Støen M, Gómez-Muñoz M, Torp R, Günther CC, Nilsson LN, Tønjum T (2013)
Transient OGG1, APE1, PARP1 and Polβ expression in an Alzheimer's disease mouse model
Mech Ageing Dev, 134 (10), 467-77
PubMed 24121118

Magnusson K, Sehlin D, Syvänen S, Svedberg MM, Philipson O, Söderberg L, Tegerstedt K, Holmquist M, Gellerfors P, Tolmachev V, Antoni G, Lannfelt L, Hall H, Nilsson LN (2013)
Specific uptake of an amyloid-β protofibril-binding antibody-tracer in AβPP transgenic mouse brain
J Alzheimers Dis, 37 (1), 29-40
PubMed 23780660

Publications 2012

Zhang X, Wang B, O'Callaghan P, Hjertström E, Jia J, Gong F, Zcharia E, Nilsson LN, Lannfelt L, Vlodavsky I, Lindahl U, Li JP (2012)
Heparanase overexpression impairs inflammatory response and macrophage-mediated clearance of amyloid-β in murine brain
Acta Neuropathol, 124 (4), 465-78
PubMed 22692572

Publications 2011

Lord A, Philipson O, Klingstedt T, Westermark G, Hammarström P, Nilsson KP, Nilsson LN (2011)
Observations in APP bitransgenic mice suggest that diffuse and compact plaques form via independent processes in Alzheimer's disease
Am J Pathol, 178 (5), 2286-98
PubMed 21514441

Philipson O, Lord A, Lalowski M, Soliymani R, Baumann M, Thyberg J, Bogdanovic N, Olofsson T, Tjernberg LO, Ingelsson M, Lannfelt L, Kalimo H, Nilsson LN (2011)
The Arctic amyloid-β precursor protein (AβPP) mutation results in distinct plaques and accumulation of N- and C-truncated Aβ
Neurobiol Aging, 33 (5), 1010.e1-13
PubMed 22118948

Ramberg V, Tracy LM, Samuelsson M, Nilsson LN, Iverfeldt K (2011)
The CCAAT/enhancer binding protein (C/EBP) δ is differently regulated by fibrillar and oligomeric forms of the Alzheimer amyloid-β peptide
J Neuroinflammation, 8, 34
PubMed 21492414

Yang J, Lunde LK, Nuntagij P, Oguchi T, Camassa LM, Nilsson LN, Lannfelt L, Xu Y, Amiry-Moghaddam M, Ottersen OP, Torp R (2011)
Loss of astrocyte polarization in the tg-ArcSwe mouse model of Alzheimer's disease
J Alzheimers Dis, 27 (4), 711-22
PubMed 21891870

Publications 2010

Blom ES, Wang Y, Skoglund L, Hansson AC, Ubaldi M, Lourdusamy A, Sommer WH, Mielke M, Hyman BT, Heilig M, Lannfelt L, Nilsson LN, Ingelsson M (2010)
Increased mRNA Levels of TCF7L2 and MYC of the Wnt Pathway in Tg-ArcSwe Mice and Alzheimer's Disease Brain
Int J Alzheimers Dis, 2011, 936580
PubMed 21234373

Codita A, Gumucio A, Lannfelt L, Gellerfors P, Winblad B, Mohammed AH, Nilsson LN (2010)
Impaired behavior of female tg-ArcSwe APP mice in the IntelliCage: A longitudinal study
Behav Brain Res, 215 (1), 83-94
PubMed 20615433

Hånell A, Clausen F, Björk M, Jansson K, Philipson O, Nilsson LN, Hillered L, Weinreb PH, Lee D, McIntosh TK, Gimbel DA, Strittmatter SM, Marklund N (2010)
Genetic deletion and pharmacological inhibition of Nogo-66 receptor impairs cognitive outcome after traumatic brain injury in mice
J Neurotrauma, 27 (7), 1297-309
PubMed 20486800

Israelsson C, Bengtsson H, Lobell A, Nilsson LN, Kylberg A, Isaksson M, Wootz H, Lannfelt L, Kullander K, Hillered L, Ebendal T (2010)
Appearance of Cxcl10-expressing cell clusters is common for traumatic brain injury and neurodegenerative disorders
Eur J Neurosci, 31 (5), 852-63
PubMed 20374285

Kamali-Moghaddam M, Pettersson FE, Wu D, Englund H, Darmanis S, Lord A, Tavoosidana G, Sehlin D, Gustafsdottir S, Nilsson LN, Lannfelt L, Landegren U (2010)
Sensitive detection of Aβ protofibrils by proximity ligation--relevance for Alzheimer's disease
BMC Neurosci, 11, 124
PubMed 20923550

Lannfelt L, Pettersson FE, Nilsson LN (2010)
Translating research on brain aging into public health: a new type of immunotherapy for Alzheimer's disease
Nutr Rev, 68 Suppl 2, S128-34
PubMed 21091946

Philipson O, Lord A, Gumucio A, O'Callaghan P, Lannfelt L, Nilsson LN (2010)
Animal models of amyloid-beta-related pathologies in Alzheimer's disease
FEBS J, 277 (6), 1389-409
PubMed 20136653

Publications 2009

Ingelsson M, Basun H, Pettersson FE, Kilander L, Nilsson LN, Lannfelt L (2009)
[Rare mutations aim toward future treatment]
Lakartidningen, 106 (20), 1396-400
PubMed 19585838

Lord A, Englund H, Söderberg L, Tucker S, Clausen F, Hillered L, Gordon M, Morgan D, Lannfelt L, Pettersson FE, Nilsson LN (2009)
Amyloid-beta protofibril levels correlate with spatial learning in Arctic Alzheimer's disease transgenic mice
FEBS J, 276 (4), 995-1006
PubMed 19215301

Lord A, Gumucio A, Englund H, Sehlin D, Sundquist VS, Söderberg L, Möller C, Gellerfors P, Lannfelt L, Pettersson FE, Nilsson LN (2009)
An amyloid-beta protofibril-selective antibody prevents amyloid formation in a mouse model of Alzheimer's disease
Neurobiol Dis, 36 (3), 425-34
PubMed 19703562

Philipson O, Lannfelt L, Nilsson LN (2009)
Genetic and pharmacological evidence of intraneuronal Abeta accumulation in APP transgenic mice
FEBS Lett, 583 (18), 3021-6
PubMed 19683527

Publications 2008

O'Callaghan P, Sandwall E, Li JP, Yu H, Ravid R, Guan ZZ, van Kuppevelt TH, Nilsson LN, Ingelsson M, Hyman BT, Kalimo H, Lindahl U, Lannfelt L, Zhang X (2008)
Heparan sulfate accumulation with Abeta deposits in Alzheimer's disease and Tg2576 mice is contributed by glial cells
Brain Pathol, 18 (4), 548-61
PubMed 18422760

Philipson O, Hammarström P, Nilsson KP, Portelius E, Olofsson T, Ingelsson M, Hyman BT, Blennow K, Lannfelt L, Kalimo H, Nilsson LN (2008)
A highly insoluble state of Abeta similar to that of Alzheimer's disease brain is found in Arctic APP transgenic mice
Neurobiol Aging, 30 (9), 1393-405
PubMed 18192084

Publications 2007

Englund H, Sehlin D, Johansson AS, Nilsson LN, Gellerfors P, Paulie S, Lannfelt L, Pettersson FE (2007)
Sensitive ELISA detection of amyloid-beta protofibrils in biological samples
J Neurochem, 103 (1), 334-45
PubMed 17623042

Nilsson KP, Aslund A, Berg I, Nyström S, Konradsson P, Herland A, Inganäs O, Stabo-Eeg F, Lindgren M, Westermark GT, Lannfelt L, Nilsson LN, Hammarström P (2007)
Imaging distinct conformational states of amyloid-beta fibrils in Alzheimer's disease using novel luminescent probes
ACS Chem Biol, 2 (8), 553-60
PubMed 17672509

Sahlin C, Lord A, Magnusson K, Englund H, Almeida CG, Greengard P, Nyberg F, Gouras GK, Lannfelt L, Nilsson LN (2007)
The Arctic Alzheimer mutation favors intracellular amyloid-beta production by making amyloid precursor protein less available to alpha-secretase
J Neurochem, 101 (3), 854-62
PubMed 17448150

Sahlin C, Pettersson FE, Nilsson LN, Lannfelt L, Johansson AS (2007)
Docosahexaenoic acid stimulates non-amyloidogenic APP processing resulting in reduced Abeta levels in cellular models of Alzheimer's disease
Eur J Neurosci, 26 (4), 882-9
PubMed 17714184

Publications 2005

Ingelsson M, Nilsson L, Basun H, Aquilonius SM, Lannfelt L (2005)
[Conformationally altered proteins cause neurodegenerative diseases]
Lakartidningen, 102 (47), 3542-3, 3545-6, 3549 passim
PubMed 16408392

Lord A, Kalimo H, Eckman C, Zhang XQ, Lannfelt L, Nilsson LN (2005)
The Arctic Alzheimer mutation facilitates early intraneuronal Abeta aggregation and senile plaque formation in transgenic mice
Neurobiol Aging, 27 (1), 67-77
PubMed 16298242

Stenh C, Englund H, Lord A, Johansson AS, Almeida CG, Gellerfors P, Greengard P, Gouras GK, Lannfelt L, Nilsson LN (2005)
Amyloid-beta oligomers are inefficiently measured by enzyme-linked immunosorbent assay
Ann Neurol, 58 (1), 147-50
PubMed 15984012

Publications 2004

Costa DA, Nilsson LN, Bales KR, Paul SM, Potter H (2004)
Apolipoprotein is required for the formation of filamentous amyloid, but not for amorphous Abeta deposition, in an AbetaPP/PS double transgenic mouse model of Alzheimer's disease
J Alzheimers Dis, 6 (5), 509-14
PubMed 15505373

Leighty RE, Nilsson LN, Potter H, Costa DA, Low MA, Bales KR, Paul SM, Arendash GW (2004)
Use of multimetric statistical analysis to characterize and discriminate between the performance of four Alzheimer's transgenic mouse lines differing in Abeta deposition
Behav Brain Res, 153 (1), 107-21
PubMed 15219712

Nilsson LN, Arendash GW, Leighty RE, Costa DA, Low MA, Garcia MF, Cracciolo JR, Rojiani A, Wu X, Bales KR, Paul SM, Potter H (2004)
Cognitive impairment in PDAPP mice depends on ApoE and ACT-catalyzed amyloid formation
Neurobiol Aging, 25 (9), 1153-67
PubMed 15312961

Publications 2001

Nilsson LN, Bales KR, DiCarlo G, Gordon MN, Morgan D, Paul SM, Potter H (2001)
Alpha-1-antichymotrypsin promotes beta-sheet amyloid plaque deposition in a transgenic mouse model of Alzheimer's disease
J Neurosci, 21 (5), 1444-51
PubMed 11222634

Nilsson LN, Das S, Potter H (2001)
Effect of cytokines, dexamethasone and the A/T-signal peptide polymorphism on the expression of alpha(1)-antichymotrypsin in astrocytes: significance for Alzheimer's disease
Neurochem Int, 39 (5-6), 361-70
PubMed 11578771

Potter H, Wefes IM, Nilsson LN (2001)
The inflammation-induced pathological chaperones ACT and apo-E are necessary catalysts of Alzheimer amyloid formation
Neurobiol Aging, 22 (6), 923-30
PubMed 11755000

Publications 1999

Rogers JT, Leiter LM, McPhee J, Cahill CM, Zhan SS, Potter H, Nilsson LN (1999)
Translation of the alzheimer amyloid precursor protein mRNA is up-regulated by interleukin-1 through 5'-untranslated region sequences
J Biol Chem, 274 (10), 6421-31
PubMed 10037734

Publications 1998

Nilsson L, Rogers J, Potter H (1998)
The essential role of inflammation and induced gene expression in the pathogenic pathway of Alzheimer's disease
Front Biosci, 3, d436-46
PubMed 9545438

Publications 1997

Nilsson L, Folkesson R (1997)
Coexistence of somatostatin receptor subtypes in the human neuroblastoma cell line LA-N-2
FEBS Lett, 401 (1), 83-8
PubMed 9003811

Norlander T, Nilsson L, Rivero C, Midvedt T, Lidegran M, Carlsöö B, Stierna P (1997)
Effects of experimental Mycoplasma pulmonis infection on sensory neuropeptides and airway mucosa in the rat
Eur Respir J, 10 (10), 2334-42
PubMed 9387962

Publications 1996

Van Setten GB, Nilsson L, Hahne S, Johnston JA, Kvanta A, Gandy SE, Näslund J, Nordstedt C (1996)
Beta-amyloid protein protein precursor expression in lacrimal glands and tear fluid
Invest Ophthalmol Vis Sci, 37 (13), 2585-93
PubMed 8977472

Publications 1995

Nilsson L, Bergström L, Meyersson G, Påhlman S, Winblad B, Folkesson R (1995)
Somatostatinergic phenotype markers in the human neuroblastoma cell-line LA-N-2
FEBS Lett, 372 (1), 88-92
PubMed 7556650

Nilsson L, Mohammed AK, Henriksson BG, Winblad B, Bergström L (1995)
Influence of place learning on somatostatin levels in the rat brain following environmental deprivation
Regul Pept, 58 (1-2), 11-8
PubMed 8570855

Publications 1994

Gether U, Nilsson L, Lowe JA, Schwartz TW (1994)
Specific residues at the top of transmembrane segment V and VI of the neurokinin-1 receptor involved in binding of the nonpeptide antagonist CP 96,345 [corrected]
J Biol Chem, 269 (39), 23959-64
PubMed 7929043

Publications 1993

Bogdanovic N, Islam A, Nilsson L, Bergström L, Winblad B, Adem A (1993)
Effects of nucleus basalis lesion on muscarinic receptor subtypes
Exp Brain Res, 97 (2), 225-32
PubMed 8150042

Bogdanovic N, Nilsson L, Adem A, Winblad B, Bergström L (1993)
Decrease of somatostatin receptor binding in the rat cerebral cortex after ibotenic acid lesion of the nucleus basalis magnocellularis: a quantitative autoradiographic study
Brain Res, 628 (1-2), 31-8
PubMed 8313162

Nilsson L, Mohammed AK, Henriksson BG, Folkesson R, Winblad B, Bergström L (1993)
Environmental influence on somatostatin levels and gene expression in the rat brain
Brain Res, 628 (1-2), 93-8
PubMed 7906186

Publications 1991

Bergström L, Garlind A, Nilsson L, Alafuzoff I, Fowler CJ, Winblad B, Cowburn RF (1991)
Regional distribution of somatostatin receptor binding and modulation of adenylyl cyclase activity in Alzheimer's disease brain
J Neurol Sci, 105 (2), 225-33
PubMed 1684616

Cowburn RF, Fowler CJ, Garlind A, Alafuzoff I, Nilsson L, Winblad B, Bergström L (1991)
Somatostatin receptors and the modulation of adenylyl cyclase activity in Alzheimer's disease
J Neurol Neurosurg Psychiatry, 54 (8), 748-9
PubMed 1658238

Nilsson L, Winblad B, Volkmann I, Alafuzoff I, Bergström L (1991)
Characterization and quantification of (125)I-bolton hunter substance P binding sites in human brain
Neurochem Int, 18 (3), 399-404
PubMed 20504717