The fight against doping


Research aims

Yvette Dehnes<br>Group leader
Yvette Dehnes
Group leader
The World Anti-Doping Agency (WADA) has been created by governments and the Olympic family in order to harmonize and organize the world-wide fight against doping. As one of the 33 WADA-accredited laboratories around the world the Norwegian Doping Control Laboratory at Aker Hospital is obliged to both render analytical service to anti-doping agencies like Antidoping Norway, and to be engaged in research promoting the development of methodologies in analytical chemistry for the detection of doping agents and prohibited methods as well as the identification of novel doping trends and pharmacological studies on doping agents and methods. Although the laboratory’s main focus is on the analytical service to anti-doping organizations, WADA requires at least 7 % of the total budget to be spent on anti-doping research.

Current projects

  • Determination of peptide-based doping agents in blood based on dried blood spots (DBS)
  • Synthesis of anabolic steroid metabolites by liver microsomes
  • Beta2 adrenoreceptor agonists and elite athletes: Blood and urinary concentrations of terbutaline, formoterol, salmeterol and procaterol in asthmatic and non-asthmatic subjects
  • Chemical synthesis of anabolic steroid Phase II metabolites
  • Determination of peptidic drugs using LC-MS/MS
  • Transfer of the analysis of large peptides and proteins to a LC-MS platform
  • Characterization of erythropoietin (EPO) produced in liver, a potential source to atypical EPO profiles in doping samples

Contact information
Group leader
Yvette Dehnes
Norwegian Doping Control Laboratory
Department of Pharmacology
Tel: +47 22894914