Kirsten Skarstad's research group: DNA Replication and Chromosome Dynamics
Group leader
DNA replication is the process by which an organism's DNA is copied to produce an identical or nearly identical copy of itself. This fundamental biological process is essential for the transmission of genetic information from one generation to the next and for the growth, development, and maintenance of living organisms. However, the intricate machinery responsible for DNA replication is often confronted by various challenges as it navigates the chromosome. These obstacles can lead to stalling or, in severe cases, a complete breakdown of the replication apparatus, resulting in the creation of lethal double-strand breaks that necessitate repair for the cell's survival.
In bacteria, such breakdowns can be triggered by the presence of antibiotics or other genotoxic substances, and some of the ensuing repair processes unfortunately lead to the emergence and acquisition of antibiotic resistance. Our research focuses on proteins involved in bacterial stress responses, DNA replication and repair processes, aiming to unearth new insights into bacterial survival and antimicrobial resistance mechanisms. In a wider perspective the aim of the group is to use this knowledge to combat disease. We seek to identify novel targets and pathways that can be instrumental for the development of antibiotic treatments, thereby contributing to the ongoing battle against antibiotic-resistant bacterial infections.
The Skarstad group collaborates closely with the Bjørås group and the two groups have several inter-linked projects.
Skarstad group and associated members from the Bjørås group.
