Deo Prakash Pandey's project group: Targeting tumors of central nervous system
The main goal of our research is to advance the understanding of molecular mechanisms contributing to cancer and to identify and characterize novel dependencies which can be used to target cancer in patients. For a cancer model, we focus on tumors of central nervous systems which are some of the worst malignancies that afflict mankind. Glioblastoma multiforme (GBM) is the most prevalent and aggressive malignant tumor of the central nervous system. Glioblastoma is rapidly fatal and with the current treatment regimes, the median overall survival is less than 15 months for GBM patients, therefore advances in translational and basic scientific understanding of processes in GBM are needed.
We use clinically relevant mouse in vivo and in vitro GBM models to study gliomagenesis and validate our findings in the primary human glioma neural stem (GNS) cells derived from GBM patients. The mouse and human GBM cellular models are derived from neural stem cells and the characterization of genes required for their proliferation is a major focus of our research.
Deo Prakash Pandey, PhD
Dept of Microbiology Oslo University Hospital Rikshospitalet
PO Box 4950 Nydalen NO-0424 Oslo, Norway
Tel: +47 23074063 (O), +47 48595077 (M)Tel: +47 907 68 382
E-mail: email@example.com (OUH), firstname.lastname@example.org