Publications by Tom Eirik Mollnes

626 publications found

Publications 2024

1. Andersson LI, Sjöström DJ, Quach HQ, Hägerström K, Hurler L, Kajdácsi E, Cervenak L, Prohászka Z, Toonen EJM, Mohlin C, Mollnes TE, Sandgren P, Tjernberg I, Nilsson PH (2024)
   Storage of Transfusion Platelet Concentrates Is Associated with Complement Activation and Reduced Ability of Platelets to Respond to Protease-Activated Receptor-1 and Thromboxane A2 Receptor
   Int J Mol Sci, 25 (2)
   DOI 10.3390/ijms25021091, PubMed 38256162
2. Barratt-Due A, Pettersen K, Børresdatter-Dahl T, Holter JC, Grønli RH, Dyrhol-Riise AM, Lerum TV, Holten AR, Tonby K, Trøseid M, Skjønsberg OH, Granerud BK, Heggelund L, Kildal AB, Schjalm C, Aaløkken TM, Aukrust P, Ueland T, Mollnes TE, Halvorsen B, NOR‐Solidarity study groupThe Norwegian SARS‐CoV‐2 study group (2024)
   Escalated complement activation during hospitalization is associated with higher risk of 60-day mortality in SARS-CoV-2-infected patients
   J Intern Med, 296 (1), 80-92
   DOI 10.1111/joim.13783, PubMed 38539241
3. Clarke GJB, Skandsen T, Zetterberg H, Follestad T, Einarsen CE, Vik A, Mollnes TE, Pischke SE, Blennow K, Håberg AK (2024)
   Longitudinal Associations Between Persistent Post-Concussion Symptoms and Blood Biomarkers of Inflammation and CNS-Injury After Mild Traumatic Brain Injury
   J Neurotrauma, 41 (7-8), 862-878
   DOI 10.1089/neu.2023.0419, PubMed 38117157
4. Fageräng B, Cyranka L, Schjalm C, McAdam KE, Larsen CS, Heinzelbecker J, Gedde-Dahl T, Würzner R, Espevik T, Tjønnfjord GE, Garred P, Barratt-Due A, Tvedt THA, Mollnes TE (2024)
   The function of the complement system remains fully intact throughout the course of allogeneic stem cell transplantation
   Front Immunol, 15, 1422370
   DOI 10.3389/fimmu.2024.1422370, PubMed 38938578
5. Fageräng B, Götz MP, Cyranka L, Lau C, Nilsson PH, Mollnes TE, Garred P (2024)
   The Inflammatory Response Induced by Aspergillus fumigatus Conidia Is Dependent on Complement Activation: Insight from a Whole Blood Model
   J Innate Immun, 16 (1), 324-336
   DOI 10.1159/000539368, PubMed 38768576
6. Fageräng B, Lau C, Mc Adam KE, Schjalm C, Christiansen D, Garred P, Nilsson PH, Mollnes TE (2024)
   A novel selective leukocyte depletion human whole blood model reveals the specific roles of monocytes and granulocytes in the cytokine response to Escherichia coli
   J Leukoc Biol, 115 (4), 647-663
   DOI 10.1093/jleuko/qiad151, PubMed 38057165
7. Farbu BH, Lydersen S, Mohus RM, Ueland T, Mollnes TE, Klepstad P, Langeland H (2024)
   The detrimental effects of intestinal injury mediated by inflammation are limited in cardiac arrest patients: A prospective cohort study
   Resusc Plus, 18, 100639
   DOI 10.1016/j.resplu.2024.100639, PubMed 38666252
8. Førde JL, Alhourani A, Carey T, Arbab A, Fladmark KE, Skrede S, Mollnes TE, Herfindal L, Hagland HR (2024)
   Impact of the Graphene Production Methods Sonication and Microfluidization on In Vitro and In Vivo Toxicity, Macrophage Response, and Complement Activation
   ACS Omega, 9 (39), 40468-40476
   DOI 10.1021/acsomega.4c03189, PubMed 39372034
9. Jørgensen SF, Macpherson ME, Bjørnetrø T, Holm K, Kummen M, Rashidi A, Michelsen AE, Lekva T, Halvorsen B, Trøseid M, Mollnes TE, Berge RK, Yndestad A, Ueland T, Karlsen TH, Aukrust P, Hov JR, Fevang B (2024)
   Retraction Note: Rifaximin alters gut microbiota profile, but does not affect systemic inflammation - a randomized controlled trial in common variable immunodeficiency
   Sci Rep, 14 (1), 3704
   DOI 10.1038/s41598-024-54117-6, PubMed 38355714
10. Kristiansen S, Jarmund AH, Hilmo J, Mollnes TE, Leth-Olsen M, Nyrnes SA, Nilsen BA, Grønli RH, Faldaas BO, Storm B, Espenes A, Nielsen EW (2024)
    Femoral Nailing in a Porcine Model Causes Bone Marrow Emboli in the Lungs and Systemic Emboli in the Heart and Brain
    JB JS Open Access, 9 (1)
    DOI 10.2106/JBJS.OA.23.00128, PubMed 38419616
11. Kristiansen S, Storm BS, Emblem ÅE, Grønli RH, Pettersen K, Hilmo J, Jarmund AH, Leth-Olsen M, Nyrnes SA, Nilsen BA, Nielsen EW, Mollnes TE (2024)
    Femoral nailing associated with bone marrow emboli in pigs induced a specific increase in blood IL-6 and broad inflammatory responses in the heart and lungs
    Front Immunol, 15, 1396800
    DOI 10.3389/fimmu.2024.1396800, PubMed 39100680
12. Marsh PL, Moore EE, Moore HB, Bunch CM, Aboukhaled M, Condon SM, Al-Fadhl MD, Thomas SJ, Larson JR, Bower CW, Miller CB, Pearson ML, Twilling CL, Reser DW, Kim GS, Troyer BM, Yeager D, Thomas SG, Srikureja DP, Patel SS, Añón SL, Thomas AV, Miller JB, Van Ryn DE, Pamulapati SV et al. (2024)
    Corrigendum: Iatrogenic air embolism: pathoanatomy, thromboinflammation, endotheliopathy, and therapies
    Front Immunol, 15, 1378003
    DOI 10.3389/fimmu.2024.1378003, PubMed 38380313
13. Mert Ü, Groven RVM, Greven J, He Z, Mahmoud MA, van Griensven M, Huber-Lang M, Mollnes TE, Rosado Balmayor E, Horst K, Hildebrand F (2024)
    Damage Control Orthopaedics Induced Less Trauma-Induced Coagulopathy than Early Total Care in a Porcine Polytrauma Model
    Eur Surg Res, 65 (1), 115-122
    DOI 10.1159/000541399, PubMed 39348804
14. Nygaard-Odeh K, Soloy-Nilsen H, Kristiansen MG, Brekke OL, Mollnes TE, Berk M, Bramness JG, Oiesvold T (2024)
    Cytokines in hepatitis C-infected patients with or without opioid maintenance therapy
    Acta Neuropsychiatr, 1-7 (in press)
    DOI 10.1017/neu.2023.56, PubMed 38173235
15. Roos J, Zinngrebe J, Huber-Lang M, Lupu L, Schmidt MA, Strobel H, Westhoff MA, Stifel U, Gebhard F, Wabitsch M, Mollnes TE, Debatin KM, Halbgebauer R, Fischer-Posovszky P (2024)
    Trauma-associated extracellular histones mediate inflammation via a MYD88-IRAK1-ERK signaling axis and induce lytic cell death in human adipocytes
    Cell Death Dis, 15 (4), 285
    DOI 10.1038/s41419-024-06676-9, PubMed 38653969
16. Volstad KB, Pripp AH, Ludviksen JA, Stiris T, Saugstad OD, Mollnes TE, Andresen JH (2024)
    No Short-Term Effect of Low-Dose Nicotine on Inflammation after Global Hypoxia in Newborn Piglets
    Neonatology, 1-10 (in press)
    DOI 10.1159/000541217, PubMed 39317175
17. Weiss MG, de Jong AM, Seegert H, Moeslund N, Maassen H, Schjalm C, de Boer E, Leuvenink H, Mollnes TE, Eijken M, Keller AK, Dijkstra G, Jespersen B, Pischke SE (2024)
    Activation of the Innate Immune System in Brain-Dead Donors Can Be Reduced by Luminal Intestinal Preservation During Organ Procurement Surgery - A Porcine Model
    Transpl Int, 37, 13569
    DOI 10.3389/ti.2024.13569, PubMed 39544322
18. Zhou N, Groven RVM, Horst K, Mert Ü, Greven J, Mollnes TE, Huber-Lang M, van Griensven M, Hildebrand F, Balmayor ER (2024)
    Pulmonary miRNA expression after polytrauma depends on the surgical invasiveness and displays an anti-inflammatory pattern by the combined inhibition of C5 and CD14
    Front Immunol, 15, 1402571
    DOI 10.3389/fimmu.2024.1402571, PubMed 39267761

Publications 2023

1. Askarian F, Tsai CM, Cordara G, Zurich RH, Bjånes E, Golten O, Vinther Sørensen H, Kousha A, Meier A, Chikwati E, Bruun JA, Ludviksen JA, Choudhury B, Trieu D, Davis S, Edvardsen PKT, Mollnes TE, Liu GY, Krengel U, Conrad DJ, Vaaje-Kolstad G, Nizet V (2023)
   Immunization with lytic polysaccharide monooxygenase CbpD induces protective immunity against Pseudomonas aeruginosa pneumonia
   Proc Natl Acad Sci U S A, 120 (30), e2301538120
   DOI 10.1073/pnas.2301538120, PubMed 37459522
2. Bayly-Jones C, Ho BHT, Lau C, Leung EWW, D'Andrea L, Lupton CJ, Ekkel SM, Venugopal H, Whisstock JC, Mollnes TE, Spicer BA, Dunstone MA (2023)
   The neoepitope of the complement C5b-9 Membrane Attack Complex is formed by proximity of adjacent ancillary regions of C9
   Commun Biol, 6 (1), 42
   DOI 10.1038/s42003-023-04431-y, PubMed 36639734
3. Bjerkhaug AU, Granslo HN, Cavanagh JP, Høiland I, Ludviksen JK, Lau C, Espevik T, Mollnes TE, Klingenberg C (2023)
   Dual inhibition of complement C5 and CD14 attenuates inflammation in a cord blood model
   Pediatr Res, 94 (2), 512-519
   DOI 10.1038/s41390-023-02489-2, PubMed 36725909
4. Chaban V, de Boer E, McAdam KE, Vaage J, Mollnes TE, Nilsson PH, Pischke SE, Islam R (2023)
   Escherichia coli-induced inflammatory responses are temperature-dependent in human whole blood ex vivo
   Mol Immunol, 157, 70-77
   DOI 10.1016/j.molimm.2023.03.006, PubMed 37001293
5. Cyranka L, Mariegaard I, Skjødt MO, Bayarri-Olmos R, Mollnes TE, Garred P, Rosbjerg A (2023)
   Functional Analysis of a Novel Complement C5a Receptor 1-Blocking Monoclonal Antibody
   J Innate Immun, 15 (1), 836-849
   DOI 10.1159/000535084, PubMed 37952515
6. Førde JL, Herfindal L, Myhr KM, Torkildsen Ø, Mollnes TE, Skrede S (2023)
   Ocrelizumab and ofatumumab, but not rituximab, trigger complement induction in vitro
   Int Immunopharmacol, 124 (Pt B), 111021
   DOI 10.1016/j.intimp.2023.111021, PubMed 37816262
7. Gerogianni A, Bal M, Mohlin C, Woodruff TM, Lambris JD, Mollnes TE, Sjöström DJ, Nilsson PH (2023)
   In vitro evaluation of iron oxide nanoparticle-induced thromboinflammatory response using a combined human whole blood and endothelial cell model
   Front Immunol, 14, 1101387
   DOI 10.3389/fimmu.2023.1101387, PubMed 37081885
8. Gramstad OR, Schjalm C, Mollnes TE, Nielsen EW (2023)
   Increased thromboinflammatory load in hereditary angioedema
   Clin Exp Immunol, 214 (2), 170-181
   DOI 10.1093/cei/uxad091, PubMed 37561062
9. Grover SP, Snir O, Hindberg K, Englebert TM, Braekkan SK, Morelli VM, Jensen SB, Wolberg AS, Mollnes TE, Ueland T, Mackman N, Hansen JB (2023)
   High plasma levels of C1-inhibitor are associated with lower risk of future venous thromboembolism
   J Thromb Haemost, 21 (7), 1849-1860
   DOI 10.1016/j.jtha.2023.03.024, PubMed 37003465
10. Heldal TF, Åsberg A, Ueland T, Reisæter AV, Pischke SE, Mollnes TE, Aukrust P, Reinholt F, Hartmann A, Heldal K, Jenssen TG (2023)
    Systemic inflammation early after kidney transplantation is associated with long-term graft loss: a cohort study
    Front Immunol, 14, 1253991
    DOI 10.3389/fimmu.2023.1253991, PubMed 37849758
11. Horst K, Mollnes TE, Huber-Lang M, Hildebrand F (2023)
    Editorial: Organ cross talk and its impact on the clinical course in multiple trauma and critical illness
    Front Immunol, 14, 1195371
    DOI 10.3389/fimmu.2023.1195371, PubMed 37090701
12. Marsh PL, Moore EE, Moore HB, Bunch CM, Aboukhaled M, Condon SM, Al-Fadhl MD, Thomas SJ, Larson JR, Bower CW, Miller CB, Pearson ML, Twilling CL, Reser DW, Kim GS, Troyer BM, Yeager D, Thomas SG, Srikureja DP, Patel SS, Añón SL, Thomas AV, Miller JB, Van Ryn DE, Pamulapati SV et al. (2023)
    Iatrogenic air embolism: pathoanatomy, thromboinflammation, endotheliopathy, and therapies
    Front Immunol, 14, 1230049
    DOI 10.3389/fimmu.2023.1230049, PubMed 37795086
13. Maassen H, Venema LH, Weiss MG, Huijink TM, Hofker HS, Keller AK, Mollnes TE, Eijken M, Pischke SE, Jespersen B, van Goor H, Leuvenink HGD (2023)
    H₂S-Enriched Flush out Does Not Increase Donor Organ Quality in a Porcine Kidney Perfusion Model
    Antioxidants (Basel), 12 (3)
    DOI 10.3390/antiox12030749, PubMed 36978997
14. Rydenfelt K, Kjøsen G, Horneland R, Krey Ludviksen J, Jenssen TG, Line PD, Tønnessen TI, Mollnes TE, Haugaa H, Pischke SE (2023)
    Local Postoperative Graft Inflammation in Pancreas Transplant Patients With Early Graft Thrombosis
    Transplant Direct, 10 (1), e1567
    DOI 10.1097/TXD.0000000000001567, PubMed 38094132
15. Rydenfelt K, Kjøsen G, Horneland R, Ludviksen JK, Jenssen TG, Line PD, Tønnessen TI, Mollnes TE, Haugaa H, Pischke SE (2023)
    Thromboinflammatory response is increased in pancreas transplant alone versus simultaneous pancreas-kidney transplantation and early pancreas graft thrombosis is associated with complement activation
    Front Immunol, 14, 1044444
    DOI 10.3389/fimmu.2023.1044444, PubMed 37063904
16. Sandvig HV, Aam S, Alme KN, Askim T, Beyer MK, Ellekjær H, Ihle-Hansen H, Lydersen S, Mollnes TE, Munthe-Kaas R, Næss H, Saltvedt I, Seljeseth YM, Thingstad P, Wethal T, Knapskog AB (2023)
    Plasma Inflammatory Biomarkers Are Associated With Poststroke Cognitive Impairment: The Nor-COAST Study
    Stroke, 54 (5), 1303-1311
    DOI 10.1161/STROKEAHA.122.041965, PubMed 37026459
17. Selvakumar J, Havdal LB, Drevvatne M, Brodwall EM, Lund Berven L, Stiansen-Sonerud T, Einvik G, Leegaard TM, Tjade T, Michelsen AE, Mollnes TE, Lund-Johansen F, Holmøy T, Zetterberg H, Blennow K, Sandler CX, Cvejic E, Lloyd AR, Wyller VBB (2023)
    Prevalence and Characteristics Associated With Post-COVID-19 Condition Among Nonhospitalized Adolescents and Young Adults
    JAMA Netw Open, 6 (3), e235763
    DOI 10.1001/jamanetworkopen.2023.5763, PubMed 36995712
18. Sikkeland LIB, Ueland T, Lund MB, Durheim MT, Mollnes TE (2023)
    A role for the terminal C5-C9 complement pathway in idiopathic pulmonary fibrosis
    Front Med (Lausanne), 10, 1236495
    DOI 10.3389/fmed.2023.1236495, PubMed 37621463
19. Skjeflo EW, Evensen LH, Jensen SB, Latysheva N, Michelsen A, Ueland T, Brækkan SK, Hindberg K, Snir O, Mollnes TE, Hansen JB (2023)
    Complement factors B, D, C3bBbP and risk of future venous thromboembolism
    Clin Immunol, 249, 109278
    DOI 10.1016/j.clim.2023.109278, PubMed 36894046
20. Soloey-Nilsen H, Nygaard-Odeh K, Kristiansen MG, Kvig EI, Brekke OL, Mollnes TE, Berk M, Reitan SK, Oiesvold T (2023)
    Transdiagnostic Associations between Anger Hostility and Chemokine Interferon-gamma Inducible Protein 10
    Clin Psychopharmacol Neurosci, 22 (2), 285-294
    DOI 10.9758/cpn.23.1091, PubMed 38627075
21. Sommen SL, Havdal LB, Selvakumar J, Einvik G, Leegaard TM, Lund-Johansen F, Michelsen AE, Mollnes TE, Stiansen-Sonerud T, Tjade T, Wyller VBB, Berven LL (2023)
    Inflammatory markers and pulmonary function in adolescents and young adults 6 months after mild COVID-19
    Front Immunol, 13, 1081718
    DOI 10.3389/fimmu.2022.1081718, PubMed 36685555
22. Thorgersen EB, Asvall J, Schjalm C, McAdam KE, Bruland ØS, Larsen SG, Mollnes TE (2023)
    Effect of Intraperitoneal ²²⁴Radium-Labelled Microparticles on Compartmentalized Inflammation After Cytoreductive Surgery and Hypertherm Intraperitoneal Chemotherapy
    Technol Cancer Res Treat, 22, 15330338231192902
    DOI 10.1177/15330338231192902, PubMed 37574949
23. Wang B, Wöhler A, Greven J, Salzmann RJS, Keller CM, Tertel T, Zhao Q, Mert Ü, Horst K, Lupu L, Huber-Lang M, van Griensven M, Mollnes TE, Schaaf S, Schwab R, Strassburg CP, Schmidt-Wolf IGH, Giebel B, Hildebrand F, Lukacs-Kornek V, Willms AG, Kornek MT (2023)
    Liquid Biopsy in Organ Damage: small extracellular vesicle chip-based assessment of polytrauma
    Front Immunol, 14, 1279496
    DOI 10.3389/fimmu.2023.1279496, PubMed 38035093

Publications 2022

1. Bugge E, Wynn R, Mollnes TE, Reitan SK, Lapid M, Grønli OK (2022)
   C-reactive protein levels and depression in older and younger adults - A study of 19,947 individuals. The Tromsø study
   Brain Behav Immun Health, 27, 100571
   DOI 10.1016/j.bbih.2022.100571, PubMed 36583067
2. Damoah CE, Snir O, Hindberg K, Garred P, Ludviksen JK, Brækkan SK, Morelli VM, Mollnes TE, Hansen JB, INVENT Consortium (2022)
   High Levels of Complement Activating Enzyme MASP-2 Are Associated With the Risk of Future Incident Venous Thromboembolism
   Arterioscler Thromb Vasc Biol, 42 (9), 1186-1197
   DOI 10.1161/ATVBAHA.122.317746, PubMed 35861070
3. de Boer E, Sokolova M, Quach HQ, McAdam KE, Götz MP, Chaban V, Vaage J, Fageräng B, Woodruff TM, Garred P, Nilsson PH, Mollnes TE, Pischke SE (2022)
   Synthetic Oligodeoxynucleotide CpG Motifs Activate Human Complement through Their Backbone Structure and Induce Complement-Dependent Cytokine Release
   J Immunol, 209 (9), 1760-1767
   DOI 10.4049/jimmunol.2101191, PubMed 36104112
4. Emblem Å, Knutsen E, Jørgensen TE, Fure H, Johansen SD, Brekke OL, Mollnes TE, Karlsen BO (2022)
   Blood Transcriptome Analysis of Septic Patients Reveals a Long Non-Coding Alu-RNA in the Complement C5a Receptor 1 Gene
   Noncoding RNA, 8 (2)
   DOI 10.3390/ncrna8020024, PubMed 35447887
5. Gerogianni A, Dimitrov JD, Zarantonello A, Poillerat V, Chonat S, Sandholm K, McAdam KE, Ekdahl KN, Mollnes TE, Mohlin C, Roumenina LT, Nilsson PH (2022)
   Heme Interferes With Complement Factor I-Dependent Regulation by Enhancing Alternative Pathway Activation
   Front Immunol, 13, 901876
   DOI 10.3389/fimmu.2022.901876, PubMed 35935964
6. Habberstad R, Aass N, Mollnes TE, Damås JK, Brunelli C, Rossi R, Garcia-Alonso E, Kaasa S, Klepstad P (2022)
   Inflammatory Markers and Radiotherapy Response in Patients With Painful Bone Metastases
   J Pain Symptom Manage, 64 (4), 330-339
   DOI 10.1016/j.jpainsymman.2022.06.018, PubMed 35803553
7. Heldal TF, Åsberg A, Ueland T, Reisaeter AV, Pischke SE, Mollnes TE, Aukrust P, Hartmann A, Heldal K, Jenssen T (2022)
   Inflammation in the early phase after kidney transplantation is associated with increased long-term all-cause mortality
   Am J Transplant, 22 (8), 2016-2027
   DOI 10.1111/ajt.17047, PubMed 35352462
8. Jager NM, Venema LH, Arykbaeva AS, Meter-Arkema AH, Ottens PJ, van Kooten C, Mollnes TE, Alwayn IPJ, Leuvenink HGD, Pischke SE, PROPER study consortium (2022)
   Complement Is Activated During Normothermic Machine Perfusion of Porcine and Human Discarded Kidneys
   Front Immunol, 13, 831371
   DOI 10.3389/fimmu.2022.831371, PubMed 35911712
9. Johnson C, Quach HQ, Lau C, Ekholt K, Espevik T, Woodruff TM, Pischke SE, Mollnes TE, Nilsson PH (2022)
   Thrombin Differentially Modulates the Acute Inflammatory Response to Escherichia coli and Staphylococcus aureus in Human Whole Blood
   J Immunol, 208 (12), 2771-2778
   DOI 10.4049/jimmunol.2101033, PubMed 35675954
10. Landsem A, Emblem Å, Lau C, Christiansen D, Gerogianni A, Karlsen BO, Mollnes TE, Nilsson PH, Brekke OL (2022)
    Complement C3b contributes to Escherichia coli-induced platelet aggregation in human whole blood
    Front Immunol, 13, 1020712
    DOI 10.3389/fimmu.2022.1020712, PubMed 36591264
11. Lund Berven L, Selvakumar J, Havdal L, Stiansen-Sonerud T, Einvik G, Leegaard TM, Tjade T, Michelsen AE, Mollnes TE, Wyller VBB (2022)
    Inflammatory Markers, Pulmonary Function, and Clinical Symptoms in Acute COVID-19 Among Non-Hospitalized Adolescents and Young Adults
    Front Immunol, 13, 837288
    DOI 10.3389/fimmu.2022.837288, PubMed 35222429
12. Lupu L, Horst K, Greven J, Mert Ü, Ludviksen JAK, Pettersen K, Lau C, Li Y, Palmer A, Qin K, Zhang X, Mayer B, van Griensven M, Huber-Lang M, Hildebrand F, Mollnes TE (2022)
    Simultaneous C5 and CD14 inhibition limits inflammation and organ dysfunction in pig polytrauma
    Front Immunol, 13, 952267
    DOI 10.3389/fimmu.2022.952267, PubMed 36059503
13. Medeiros PMC, Schjalm C, Christiansen D, Sokolova M, Pischke SE, Würzner R, Mollnes TE, Barratt-Due A (2022)
    Vitamin C, Hydrocortisone, and the Combination Thereof Significantly Inhibited Two of Nine Inflammatory Markers Induced by Escherichia Coli But Not by Staphylococcus Aureus - When Incubated in Human Whole Blood
    Shock, 57 (1), 72-80
    DOI 10.1097/SHK.0000000000001834, PubMed 34265830
14. Mollnes TE, Storm BS, Brekke OL, Nilsson PH, Lambris JD (2022)
    Application of the C3 inhibitor compstatin in a human whole blood model designed for complement research - 20 years of experience and future perspectives
    Semin Immunol, 59, 101604
    DOI 10.1016/j.smim.2022.101604, PubMed 35570131
15. Nguyen THP, Hokstad I, Fagerland MW, Mollnes TE, Hollan I, Feinberg MW, Hjeltnes G, Eilertsen GØ, Mikkelsen K, Agewall S (2022)
    Antirheumatic therapy is associated with reduced complement activation in rheumatoid arthritis
    PLoS One, 17 (2), e0264628
    DOI 10.1371/journal.pone.0264628, PubMed 35213675
16. Nielsen EW, Miller Y, Brekke OL, Grond J, Duong AH, Fure H, Ludviksen JK, Pettersen K, Reubsaet L, Solberg R, Johansen HT, Mollnes TE (2022)
    A Novel Porcine Model of Ischemia-Reperfusion Injury After Cross-Clamping the Thoracic Aorta Revealed Substantial Cardiopulmonary, Thromboinflammatory and Biochemical Changes Without Effect of C1-Inhibitor Treatment
    Front Immunol, 13, 852119
    DOI 10.3389/fimmu.2022.852119, PubMed 35432333
17. Quach HQ, Johnson C, Ekholt K, Islam R, Mollnes TE, Nilsson PH (2022)
    Platelet-Depletion of Whole Blood Reveals That Platelets Potentiate the Release of IL-8 From Leukocytes Into Plasma in a Thrombin-Dependent Manner
    Front Immunol, 13, 865386
    DOI 10.3389/fimmu.2022.865386, PubMed 35444648
18. Soloey-Nilsen H, Nygaard-Odeh K, Kristiansen MG, Brekke OL, Mollnes TE, Reitan SK, Oiesvold T (2022)
    Association between brain-derived neurotropic factor (BDNF), high-sensitivity C-reactive protein (hs-CRP) and psychiatric symptoms in medicated and unmedicated patients
    BMC Psychiatry, 22 (1), 84
    DOI 10.1186/s12888-022-03744-2, PubMed 35114967
19. Storjord E, Airila-Månsson S, Karlsen K, Madsen M, Dahl JA, Landsem A, Fure H, Ludviksen JK, Fjøse JØ, Dickey AK, Karlsen BO, Waage Nielsen E, Mollnes TE, Brekke OL (2022)
    Dental and Periodontal Health in Acute Intermittent Porphyria
    Life (Basel), 12 (8)
    DOI 10.3390/life12081270, PubMed 36013449
20. Storm BS, Ludviksen JK, Christiansen D, Fure H, Pettersen K, Landsem A, Nilsen BA, Dybwik K, Braaten T, Nielsen EW, Mollnes TE (2022)
    Venous Air Embolism Activates Complement C3 Without Corresponding C5 Activation and Trigger Thromboinflammation in Pigs
    Front Immunol, 13, 839632
    DOI 10.3389/fimmu.2022.839632, PubMed 35371063
21. Torp MK, Ranheim T, Schjalm C, Hjorth M, Heiestad CM, Dalen KT, Nilsson PH, Mollnes TE, Pischke SE, Lien E, Vaage J, Yndestad A, Stensløkken KO (2022)
    Intracellular Complement Component 3 Attenuated Ischemia-Reperfusion Injury in the Isolated Buffer-Perfused Mouse Heart and Is Associated With Improved Metabolic Homeostasis
    Front Immunol, 13, 870811
    DOI 10.3389/fimmu.2022.870811, PubMed 35432387

Publications 2021

1. Alme KN, Askim T, Assmus J, Mollnes TE, Naik M, Næss H, Saltvedt I, Ueland PM, Ulvik A, Knapskog AB (2021)
   Investigating novel biomarkers of immune activation and modulation in the context of sedentary behaviour: a multicentre prospective ischemic stroke cohort study
   BMC Neurol, 21 (1), 318
   DOI 10.1186/s12883-021-02343-0, PubMed 34399717
2. Alme KN, Ulvik A, Askim T, Assmus J, Mollnes TE, Naik M, Næss H, Saltvedt I, Ueland PM, Knapskog AB (2021)
   Neopterin and kynurenic acid as predictors of stroke recurrence and mortality: a multicentre prospective cohort study on biomarkers of inflammation measured three months after ischemic stroke
   BMC Neurol, 21 (1), 476
   DOI 10.1186/s12883-021-02498-w, PubMed 34879833
3. Askarian F, Uchiyama S, Masson H, Sørensen HV, Golten O, Bunæs AC, Mekasha S, Røhr ÅK, Kommedal E, Ludviksen JA, Arntzen MØ, Schmidt B, Zurich RH, van Sorge NM, Eijsink VGH, Krengel U, Mollnes TE, Lewis NE, Nizet V, Vaaje-Kolstad G (2021)
   The lytic polysaccharide monooxygenase CbpD promotes Pseudomonas aeruginosa virulence in systemic infection
   Nat Commun, 12 (1), 1230
   DOI 10.1038/s41467-021-21473-0, PubMed 33623002
4. Chaban V, Nakstad ER, Stær-Jensen H, Schjalm C, Seljeflot I, Vaage J, Lundqvist C, Benth JŠ, Sunde K, Mollnes TE, Andersen GØ, Pischke SE (2021)
   Complement activation is associated with poor outcome after out-of-hospital cardiac arrest
   Resuscitation, 166, 129-136
   DOI 10.1016/j.resuscitation.2021.05.038, PubMed 34126135
5. Debler L, Palmer A, Braumüller S, Klohs B, Mollnes TE, Holzmann K, Huber-Lang M, Halbgebauer R (2021)
   Hemorrhagic Shock Induces a Rapid Transcriptomic Shift of the Immune Balance in Leukocytes after Experimental Multiple Injury
   Mediators Inflamm, 2021, 6654318
   DOI 10.1155/2021/6654318, PubMed 33574730
6. Fevang B, Wyller VBB, Mollnes TE, Pedersen M, Asprusten TT, Michelsen A, Ueland T, Otterdal K (2021)
   Lasting Immunological Imprint of Primary Epstein-Barr Virus Infection With Associations to Chronic Low-Grade Inflammation and Fatigue
   Front Immunol, 12, 715102
   DOI 10.3389/fimmu.2021.715102, PubMed 34987499
7. Garred P, Tenner AJ, Mollnes TE (2021)
   Therapeutic Targeting of the Complement System: From Rare Diseases to Pandemics
   Pharmacol Rev, 73 (2), 792-827
   DOI 10.1124/pharmrev.120.000072, PubMed 33687995
8. Grimnes G, Bhoelan S, Hindberg K, Davids M, Nieuwdorp M, Mollnes TE, Michelsen AE, Ueland T, Brækkan SK, Hansen JB, Tichelaar V (2021)
   Impact of a Vancomycin-Induced Shift of the Gut Microbiome in a Gram-Negative Direction on Plasma Factor VIII:C Levels: Results from a Randomized Controlled Trial
   Thromb Haemost, 122 (4), 540-551
   DOI 10.1055/s-0041-1733906, PubMed 34428832
9. Holt MF, Michelsen AE, Shahini N, Bjørkelund E, Bendz CH, Massey RJ, Schjalm C, Halvorsen B, Broch K, Ueland T, Gullestad L, Nilsson PH, Aukrust P, Mollnes TE, Louwe MC (2021)
   The Alternative Complement Pathway Is Activated Without a Corresponding Terminal Pathway Activation in Patients With Heart Failure
   Front Immunol, 12, 800978
   DOI 10.3389/fimmu.2021.800978, PubMed 35003128
10. Islam R, Islam MM, Nilsson PH, Mohlin C, Hagen KT, Paschalis EI, Woods RL, Bhowmick SC, Dohlman CH, Espevik T, Chodosh J, Gonzalez-Andrades M, Mollnes TE (2021)
    Combined blockade of complement C5 and TLR co-receptor CD14 synergistically inhibits pig-to-human corneal xenograft induced innate inflammatory responses
    Acta Biomater, 127, 169-179
    DOI 10.1016/j.actbio.2021.03.047, PubMed 33785451
11. Langeland H, Damås JK, Mollnes TE, Ludviksen JK, Ueland T, Michelsen AE, Løberg M, Bergum D, Nordseth T, Skjærvold NK, Klepstad P (2021)
    The inflammatory response is related to circulatory failure after out-of-hospital cardiac arrest: A prospective cohort study
    Resuscitation, 170, 115-125
    DOI 10.1016/j.resuscitation.2021.11.026, PubMed 34838662
12. Macpherson A, Laabei M, Ahdash Z, Graewert MA, Birtley JR, Schulze ME, Crennell S, Robinson SA, Holmes B, Oleinikovas V, Nilsson PH, Snowden J, Ellis V, Mollnes TE, Deane CM, Svergun D, Lawson AD, van den Elsen JM (2021)
    The allosteric modulation of complement C5 by knob domain peptides
    Elife, 10
    DOI 10.7554/eLife.63586, PubMed 33570492
13. Nilsson PH, Johnson C, Quach QH, Macpherson A, Durrant O, Pischke SE, Fure H, Landsem A, Bergseth G, Schjalm C, Haugaard-Kedström LM, Huber-Lang M, van den Elsen J, Brekke OL, Mollnes TE (2021)
    A Conformational Change of Complement C5 Is Required for Thrombin-Mediated Cleavage, Revealed by a Novel Ex Vivo Human Whole Blood Model Preserving Full Thrombin Activity
    J Immunol, 207 (6), 1641-1651
    DOI 10.4049/jimmunol.2001471, PubMed 34380648
14. Nilsson PH, Pettersen K, Oppermann M, Skjeflo EW, Fure H, Christiansen D, Mollnes TE (2021)
    Quantification of Porcine Complement Activation Fragment C3a by a Neoepitope-Based Enzyme-Linked Immunosorbent Assay
    Methods Mol Biol, 2227, 51-59
    DOI 10.1007/978-1-0716-1016-9_5, PubMed 33847930
15. Niyonzima N, Rahman J, Kunz N, West EE, Freiwald T, Desai JV, Merle NS, Gidon A, Sporsheim B, Lionakis MS, Evensen K, Lindberg B, Skagen K, Skjelland M, Singh P, Haug M, Ruseva MM, Kolev M, Bibby J, Marshall O, O'Brien B, Deeks N, Afzali B, Clark RJ, Woodruff TM et al. (2021)
    Mitochondrial C5aR1 activity in macrophages controls IL-1β production underlying sterile inflammation
    Sci Immunol, 6 (66), eabf2489
    DOI 10.1126/sciimmunol.abf2489, PubMed 34932384
16. Pethő Á, Piecha D, Mészáros T, Urbanics R, Moore C, Canaud B, Rosivall L, Mollnes TE, Steppan S, Szénási G, Szebeni J, Dézsi L (2021)
    A porcine model of hemodialyzer reactions: roles of complement activation and rinsing back of extracorporeal blood
    Ren Fail, 43 (1), 1609-1620
    DOI 10.1080/0886022X.2021.2007127, PubMed 34882053
17. Rognes IN, Pischke SE, Ottestad W, Røislien J, Berg JP, Johnson C, Eken T, Mollnes TE (2021)
    Increased complement activation 3 to 6 h after trauma is a predictor of prolonged mechanical ventilation and multiple organ dysfunction syndrome: a prospective observational study
    Mol Med, 27 (1), 35
    DOI 10.1186/s10020-021-00286-3, PubMed 33832430
18. Sharifi S, Islam MM, Sharifi H, Islam R, Huq TN, Nilsson PH, Mollnes TE, Tran KD, Patzer C, Dohlman CH, Patra HK, Paschalis EI, Gonzalez-Andrades M, Chodosh J (2021)
    Electron Beam Sterilization of Poly(Methyl Methacrylate)-Physicochemical and Biological Aspects
    Macromol Biosci, 21 (4), e2000379
    DOI 10.1002/mabi.202000379, PubMed 33624923
19. Sharifi S, Islam MM, Sharifi H, Islam R, Koza D, Reyes-Ortega F, Alba-Molina D, Nilsson PH, Dohlman CH, Mollnes TE, Chodosh J, Gonzalez-Andrades M (2021)
    Tuning gelatin-based hydrogel towards bioadhesive ocular tissue engineering applications
    Bioact Mater, 6 (11), 3947-3961
    DOI 10.1016/j.bioactmat.2021.03.042, PubMed 33937594
20. Skjeflo EW, Brækkan SK, Ludviksen JK, Snir O, Hindberg K, Mollnes TE, Hansen JB (2021)
    Elevated plasma concentration of complement factor C5 is associated with risk of future venous thromboembolism
    Blood, 138 (21), 2129-2137
    DOI 10.1182/blood.2021010822, PubMed 34339498
21. Skovdahl HK, Gopalakrishnan S, Svendsen TD, Granlund AVB, Bakke I, Ginbot ZG, Thorsvik S, Flatberg A, Sporsheim B, Ostrop J, Mollnes TE, Sandvik AK, Bruland T (2021)
    Patient Derived Colonoids as Drug Testing Platforms-Critical Importance of Oxygen Concentration
    Front Pharmacol, 12, 679741
    DOI 10.3389/fphar.2021.679741, PubMed 34054553
22. Storm BS, Christiansen D, Fure H, Ludviksen JK, Lau C, Lambris JD, Woodruff TM, Brekke OL, Braaten T, Nielsen EW, Mollnes TE (2021)
    Air Bubbles Activate Complement and Trigger Hemostasis and C3-Dependent Cytokine Release Ex Vivo in Human Whole Blood
    J Immunol, 207 (11), 2828-2840
    DOI 10.4049/jimmunol.2100308, PubMed 34732467
23. Storm BS, Halvorsen PS, Skulstad H, Dybwik K, Schjalm C, Christiansen D, Wisløff-Aase K, Fosse E, Braaten T, Nielsen EW, Mollnes TE (2021)
    Open chest and pericardium facilitate transpulmonary passage of venous air emboli
    Acta Anaesthesiol Scand, 65 (5), 648-655
    DOI 10.1111/aas.13796, PubMed 33595102
24. Sundnes O, Ottestad W, Schjalm C, Lundbäck P, la Cour Poulsen L, Mollnes TE, Haraldsen G, Eken T (2021)
    Rapid systemic surge of IL-33 after severe human trauma: a prospective observational study
    Mol Med, 27 (1), 29
    DOI 10.1186/s10020-021-00288-1, PubMed 33771098
25. Thomas AM, Chaban V, Pischke SE, Orrem HL, Bosnes V, Sunde K, Seljeflot I, Lundqvist C, Nakstad ER, Andersen GØ, Schjalm C, Mollnes TE, Barratt-Due A (2021)
    Complement ratios C3bc/C3 and sC5b-9/C5 do not increase the sensitivity of detecting acute complement activation systemically
    Mol Immunol, 141, 273-279
    DOI 10.1016/j.molimm.2021.11.016, PubMed 34906905
26. Thorgersen EB, Asvall J, Frøysnes IS, Schjalm C, Larsen SG, Dueland S, Andersson Y, Fodstad Ø, Mollnes TE, Flatmark K (2021)
    Increased Local Inflammatory Response to MOC31PE Immunotoxin After Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy
    Ann Surg Oncol, 28 (9), 5252-5262
    DOI 10.1245/s10434-021-10022-0, PubMed 34019185
27. Wiker HG, Mollnes TE, Garred P, Bjune G, Bjorvatn B (2021)
    Morten Harboe (1929-2021), one of the founders of Scandinavian Journal of Immunology OBITUARY
    Scand. J. Immunol., 94 (1), e13054
    DOI 10.1111/sji.13054
28. Witczak BJ, Pischke SE, Reisæter AV, Midtvedt K, Ludviksen JK, Heldal K, Jenssen T, Hartmann A, Åsberg A, Mollnes TE (2021)
    Elevated Terminal C5b-9 Complement Complex 10 Weeks Post Kidney Transplantation Was Associated With Reduced Long-Term Patient and Kidney Graft Survival
    Front Immunol, 12, 738927
    DOI 10.3389/fimmu.2021.738927, PubMed 34759922
29. Würzner R, Tedesco F, Garred P, Mollnes TE, Truedsson L, Turner MW, Sommarin Y, Wieslander J, Daha MR (2021)
    Memories of Bob Sim-Genius Complementologist and Cheerful Travel Companion
    Viruses, 13 (6)
    DOI 10.3390/v13061068, PubMed 34199701
30. Zhu GH, Azharuddin M, Islam R, Rahmoune H, Deb S, Kanji U, Das J, Osterrieth J, Aulakh P, Ibrahim-Hashi H, Manchanda R, Nilsson PH, Mollnes TE, Bhattacharyya M, Islam MM, Hinkula J, Slater NKH, Patra HK (2021)
    Innate Immune Invisible Ultrasmall Gold Nanoparticles-Framework for Synthesis and Evaluation
    ACS Appl Mater Interfaces, 13 (20), 23410-23422
    DOI 10.1021/acsami.1c02834, PubMed 33978409

Publications 2020

1. Berg LK, Goll R, Fagerli E, Ludviksen JK, Fure H, Moen OS, Sørbye SW, Mollnes TE, Florholmen J (2020)
   Intestinal inflammatory profile shows increase in a diversity of biomarkers in irritable bowel syndrome
   Scand J Gastroenterol, 55 (5), 537-542
   DOI 10.1080/00365521.2020.1754455, PubMed 32329383
2. Chaban V, Clarke GJB, Skandsen T, Islam R, Einarsen CE, Vik A, Damås JK, Mollnes TE, Håberg AK, Pischke SE (2020)
   Systemic Inflammation Persists the First Year after Mild Traumatic Brain Injury: Results from the Prospective Trondheim Mild Traumatic Brain Injury Study
   J Neurotrauma, 37 (19), 2120-2130
   DOI 10.1089/neu.2019.6963, PubMed 32326805
3. Ehrnström B, Kojen JF, Giambelluca M, Ryan L, Moen SH, Hu Z, Yin H, Mollnes TE, Damås JK, Espevik T, Stenvik J (2020)
   TLR8 and complement C5 induce cytokine release and thrombin activation in human whole blood challenged with Gram-positive bacteria
   J Leukoc Biol, 107 (4), 673-683
   DOI 10.1002/JLB.3A0120-114R, PubMed 32083344
4. Grinde D, Øverland T, Lima K, Schjalm C, Mollnes TE, Abrahamsen TG (2020)
   Complement Activation in 22q11.2 Deletion Syndrome
   J Clin Immunol, 40 (3), 515-523
   DOI 10.1007/s10875-020-00766-x, PubMed 32152940
5. Holter JC, Pischke SE, de Boer E, Lind A, Jenum S, Holten AR, Tonby K, Barratt-Due A, Sokolova M, Schjalm C, Chaban V, Kolderup A, Tran T, Tollefsrud Gjølberg T, Skeie LG, Hesstvedt L, Ormåsen V, Fevang B, Austad C, Müller KE, Fladeby C, Holberg-Petersen M, Halvorsen B, Müller F, Aukrust P et al. (2020)
   Systemic complement activation is associated with respiratory failure in COVID-19 hospitalized patients
   Proc Natl Acad Sci U S A, 117 (40), 25018-25025
   DOI 10.1073/pnas.2010540117, PubMed 32943538
6. Hovland A, Retterstøl K, Mollnes TE, Halvorsen B, Aukrust P, Lappegård KT (2020)
   Anti-inflammatory effects of non-statin low-density lipoprotein cholesterol-lowering drugs: an unused potential?
   Scand Cardiovasc J, 54 (5), 274-279
   DOI 10.1080/14017431.2020.1775878, PubMed 32500743
7. Jøntvedt Jørgensen M, Holter JC, Christensen EE, Schjalm C, Tonby K, Pischke SE, Jenum S, Skeie LG, Nur S, Lind A, Opsand H, Enersen TB, Grøndahl R, Hermann A, Dudman S, Muller F, Ueland T, Mollnes TE, Aukrust P, Heggelund L, Holten AR, Dyrhol-Riise AM (2020)
   Increased interleukin-6 and macrophage chemoattractant protein-1 are associated with respiratory failure in COVID-19
   Sci Rep, 10 (1), 21697
   DOI 10.1038/s41598-020-78710-7, PubMed 33303843
8. Keshari RS, Silasi R, Popescu NI, Regmi G, Chaaban H, Lambris JD, Lupu C, Mollnes TE, Lupu F (2020)
   CD14 inhibition improves survival and attenuates thrombo-inflammation and cardiopulmonary dysfunction in a baboon model of Escherichia coli sepsis
   J Thromb Haemost, 19 (2), 429-443
   DOI 10.1111/jth.15162, PubMed 33174372
9. Lau C, McAdam MB, Bergseth G, Grevys A, Bruun JA, Ludviksen JK, Fure H, Espevik T, Moen A, Andersen JT, Mollnes TE (2020)
   NHDL, a recombinant V_L/V_H hybrid antibody control for IgG2/4 antibodies
   MAbs, 12 (1), 1686319
   DOI 10.1080/19420862.2019.1686319, PubMed 31671278
10. Lipcsey M, Tenhunen J, Pischke SE, Kuitunen A, Flaatten H, De Geer L, Sjölin J, Frithiof R, Chew MS, Bendel S, Kawati R, Larsson A, Mollnes TE, Tønnessen TI, Rubertsson S (2020)
    Endotoxin Removal in Septic Shock with the Alteco LPS Adsorber Was Safe But Showed no Benefit Compared to Placebo in the Double-Blind Randomized Controlled Trial-the Asset Study
    Shock, 54 (2), 224-231
    DOI 10.1097/SHK.0000000000001503, PubMed 31880758
11. Macpherson ME, Hov JR, Ueland T, Dahl TB, Kummen M, Otterdal K, Holm K, Berge RK, Mollnes TE, Trøseid M, Halvorsen B, Aukrust P, Fevang B, Jørgensen SF (2020)
    Gut Microbiota-Dependent Trimethylamine N-Oxide Associates With Inflammation in Common Variable Immunodeficiency
    Front Immunol, 11, 574500
    DOI 10.3389/fimmu.2020.574500, PubMed 33042155
12. Mollnes TE, Huber-Lang M (2020)
    Complement in sepsis-when science meets clinics
    FEBS Lett, 594 (16), 2621-2632
    DOI 10.1002/1873-3468.13881, PubMed 32621378
13. Niyonzima N, Bakke SS, Gregersen I, Holm S, Sandanger Ø, Orrem HL, Sporsheim B, Ryan L, Kong XY, Dahl TB, Skjelland M, Sørensen KK, Rokstad AM, Yndestad A, Latz E, Gullestad L, Andersen GØ, Damås JK, Aukrust P, Mollnes TE, Halvorsen B, Espevik T (2020)
    Cholesterol crystals use complement to increase NLRP3 signaling pathways in coronary and carotid atherosclerosis
    EBioMedicine, 60, 102985
    DOI 10.1016/j.ebiom.2020.102985, PubMed 32927275
14. Pedersen H, Jensen RK, Jensen JMB, Fox R, Pedersen DV, Olesen HG, Hansen AG, Christiansen D, Mazarakis SMM, Lojek N, Hansen P, Gadeberg TAF, Zarantonello A, Laursen NS, Mollnes TE, Johnson MB, Stevens B, Thiel S, Andersen GR (2020)
    A Complement C3-Specific Nanobody for Modulation of the Alternative Cascade Identifies the C-Terminal Domain of C3b as Functional in C5 Convertase Activity
    J Immunol, 205 (8), 2287-2300
    DOI 10.4049/jimmunol.2000752, PubMed 32938727
15. Shahini N, Schjalm C, Nilsson PH, Holt MF, Øgaard JDS, Lien E, Ahmed MS, Attramadal H, Aukrust P, Yndestad A, Mollnes TE, Louwe MC (2020)
    Complement component C3 and the TLR co-receptor CD14 are not involved in angiotensin II induced cardiac remodelling
    Biochem Biophys Res Commun, 523 (4), 867-873
    DOI 10.1016/j.bbrc.2020.01.018, PubMed 31955888
16. Sharifi S, Islam MM, Sharifi H, Islam R, Nilsson PH, Dohlman CH, Mollnes TE, Paschalis EI, Chodosh J (2020)
    Sputter Deposition of Titanium on Poly(Methyl Methacrylate) Enhances Corneal Biocompatibility
    Transl Vis Sci Technol, 9 (13), 41
    DOI 10.1167/tvst.9.13.41, PubMed 33442495
17. Storjord E, Henno LT, Mollnes TE, Brekke OL (2020)
    Analysis of cytokines
    Tidsskr. Nor. Laegeforen., 140 (1), 71
18. Storjord E, Hennø LT, Mollnes TE, Brekke OL (2020)
    Analysis of cytokines
    Tidsskr Nor Laegeforen, 140 (1)
    DOI 10.4045/tidsskr.18.0961, PubMed 31948201
19. Storm BS, Christiansen D, Mollnes TE, Nielsen EW (2020)
    Avoiding ambient air in test tubes during incubations of human whole-blood minimizes complement background activation
    J Immunol Methods, 487, 112876
    DOI 10.1016/j.jim.2020.112876, PubMed 33031792
20. Ueland NL, Ludvigsen JK, Hellerud BC, Mollnes TE, Skjeflo EW (2020)
    Choice of immunoassay to evaluate porcine cytokine levels
    Vet Immunol Immunopathol, 230, 110129
    DOI 10.1016/j.vetimm.2020.110129, PubMed 33059181
21. Ueland T, Heggelund L, Lind A, Holten AR, Tonby K, Michelsen AE, Jenum S, Jørgensen MJ, Barratt-Due A, Skeie LG, Nordøy I, Aanensen Fraz MS, Quist-Paulsen E E, Pischke SE, Johal SK, Hesstvedt L, Bogen M, Fevang B, Halvorsen B, Müller F, Bekken GK, Mollnes TE, Dudman S, Aukrust P, Dyrhol-Riise AM et al. (2020)
    Elevated plasma sTIM-3 levels in patients with severe COVID-19
    J Allergy Clin Immunol, 147 (1), 92-98
    DOI 10.1016/j.jaci.2020.09.007, PubMed 32971109
22. van den Heuvel LP, van de Kar NCAJ, Duineveld C, Sarlea A, van der Velden TJAM, Liebrand WTB, van Kraaij S, Schjalm C, Bouwmeester R, Wetzels JFM, Mollnes TE, Volokhina EB (2020)
    The complement component C5 is not responsible for the alternative pathway activity in rabbit erythrocyte hemolytic assays during eculizumab treatment
    Cell Mol Immunol, 17 (6), 653-655
    DOI 10.1038/s41423-020-0406-y, PubMed 32210393
23. Zhang J, Song L, Pedersen DV, Li A, Lambris JD, Andersen GR, Mollnes TE, Ma YJ, Garred P (2020)
    Soluble collectin-12 mediates C3-independent docking of properdin that activates the alternative pathway of complement
    Elife, 9
    DOI 10.7554/eLife.60908, PubMed 32909942
24. Østvik AE, Svendsen TD, Granlund AVB, Doseth B, Skovdahl HK, Bakke I, Thorsvik S, Afroz W, Walaas GA, Mollnes TE, Gustafsson BI, Sandvik AK, Bruland T (2020)
    Intestinal Epithelial Cells Express Immunomodulatory ISG15 During Active Ulcerative Colitis and Crohn's Disease
    J Crohns Colitis, 14 (7), 920-934
    DOI 10.1093/ecco-jcc/jjaa022, PubMed 32020185

Publications 2019

1. Brekke OL, Christiansen D, Kisserli A, Fure H, Dahl JA, Donvito B, Reveil B, Ludviksen JK, Tabary T, Mollnes TE, Cohen JHM (2019)
   Key role of the number of complement receptor 1 on erythrocytes for binding of Escherichia coli to erythrocytes and for leukocyte phagocytosis and oxidative burst in human whole blood
   Mol Immunol, 114, 139-148
   DOI 10.1016/j.molimm.2019.07.014, PubMed 31352230
2. Bugge E, Wynn R, Mollnes TE, Reitan SK, Lapid MI, Gronli OK (2019)
   Corrigendum to "Changes in cytokines during treatment of elderly, hospitalized psychiatric patients-A naturalistic study" [Psychoneuroendocrinology, 108C (2019), 135-139]
   Psychoneuroendocrinology, 109, 104427
   DOI 10.1016/j.psyneuen.2019.104427, PubMed 31537376
3. Bugge E, Wynn R, Mollnes TE, Reitan SK, Lapid MI, Grønli OK (2019)
   Changes in cytokines during treatment of elderly, hospitalized psychiatric patients - a naturalistic study
   Psychoneuroendocrinology, 108, 135-139
   DOI 10.1016/j.psyneuen.2019.06.014, PubMed 31276906
4. Cedzyński M, Thielens NM, Mollnes TE, Vorup-Jensen T (2019)
   Editorial: The Role of Complement in Health and Disease
   Front Immunol, 10, 1869
   DOI 10.3389/fimmu.2019.01869, PubMed 31440250
5. Dahm AEA, Jacobsen EM, Wik HS, Jacobsen AF, Mollnes TE, Kanse SM, Sandset PM (2019)
   Elevated Complement C3 and C4 Levels are Associated with Postnatal Pregnancy-Related Venous Thrombosis
   Thromb Haemost, 119 (9), 1481-1488
   DOI 10.1055/s-0039-1692426, PubMed 31254974
6. Granslo HN, Aarag Fredheim EG, Esaiassen E, Christophersen L, Jensen PØ, Mollnes TE, Moser C, Flaegstad T, Klingenberg C, Cavanagh JP (2019)
   The synthetic antimicrobial peptide LTX21 induces inflammatory responses in a human whole blood model and a murine peritoneum model
   APMIS, 127 (6), 475-483
   DOI 10.1111/apm.12946, PubMed 30916807
7. Gravastrand CS, Steinkjer B, Halvorsen B, Landsem A, Skjelland M, Jacobsen EA, Woodruff TM, Lambris JD, Mollnes TE, Brekke OL, Espevik T, Rokstad AMA (2019)
   Cholesterol Crystals Induce Coagulation Activation through Complement-Dependent Expression of Monocytic Tissue Factor
   J Immunol, 203 (4), 853-863
   DOI 10.4049/jimmunol.1900503, PubMed 31270150
8. Hagve M, Gjessing PF, Hole MJ, Jansen KM, Fuskevåg OM, Mollnes TE, Larsen TS, Irtun Ø (2019)
   Perioperative Infusion of Glucagon-Like Peptide-1 Prevents Insulin Resistance After Surgical Trauma in Female Pigs
   Endocrinology, 160 (12), 2892-2902
   DOI 10.1210/en.2019-00374, PubMed 31589305
9. Hardersen R, Enebakk T, Christiansen D, Ludviksen JK, Mollnes TE, Lappegård KT, Hovland A (2019)
   Comparison of cytokine changes in three different lipoprotein apheresis systems in an ex vivo whole blood model
   J Clin Apher, 35 (2), 104-116
   DOI 10.1002/jca.21765, PubMed 31782556
10. Hokstad I, Deyab G, Wang Fagerland M, Lyberg T, Hjeltnes G, Førre Ø, Agewall S, Mollnes TE, Hollan I (2019)
    Tumor necrosis factor inhibitors are associated with reduced complement activation in spondylarthropathies: An observational study
    PLoS One, 14 (7), e0220079
    DOI 10.1371/journal.pone.0220079, PubMed 31335881
11. Holt MF, Seim BE, Øgaard J, Olsen MB, Woldbæk PR, Kvitting JP, Aukrust P, Yndestad A, Mollnes TE, Nilsson PH, Louwe MC, Ranheim T (2019)
    Selective and marked decrease of complement receptor C5aR2 in human thoracic aortic aneurysms: a dysregulation with potential inflammatory effects
    Open Heart, 6 (2), e001098
    DOI 10.1136/openhrt-2019-001098, PubMed 31798913
12. Høiland II, Liang RA, Braekkan SK, Pettersen K, Ludviksen JK, Latysheva N, Snir O, Ueland T, Hindberg K, Mollnes TE, Hansen JB (2019)
    Complement activation assessed by the plasma terminal complement complex and future risk of venous thromboembolism
    J Thromb Haemost, 17 (6), 934-943
    DOI 10.1111/jth.14438, PubMed 30920726
13. Islam MM, Sharifi R, Mamodaly S, Islam R, Nahra D, Abusamra DB, Hui PC, Adibnia Y, Goulamaly M, Paschalis EI, Cruzat A, Kong J, Nilsson PH, Argüeso P, Mollnes TE, Chodosh J, Dohlman CH, Gonzalez-Andrades M (2019)
    Effects of gamma radiation sterilization on the structural and biological properties of decellularized corneal xenografts
    Acta Biomater, 96, 330-344
    DOI 10.1016/j.actbio.2019.07.002, PubMed 31284096
14. Jørgensen SF, Macpherson ME, Bjørnetrø T, Holm K, Kummen M, Rashidi A, Michelsen AE, Lekva T, Halvorsen B, Trøseid M, Mollnes TE, Berge RK, Yndestad A, Ueland T, Karlsen TH, Aukrust P, Hov JR, Fevang B (2019)
    Rifaximin alters gut microbiota profile, but does not affect systemic inflammation - a randomized controlled trial in common variable immunodeficiency
    Sci Rep, 9 (1), 167 (Retracted)
    DOI 10.1038/s41598-018-35367-7, PubMed 30655568
15. Kozma GT, Mészáros T, Vashegyi I, Fülöp T, Örfi E, Dézsi L, Rosivall L, Bavli Y, Urbanics R, Mollnes TE, Barenholz Y, Szebeni J (2019)
    Pseudo-anaphylaxis to Polyethylene Glycol (PEG)-Coated Liposomes: Roles of Anti-PEG IgM and Complement Activation in a Porcine Model of Human Infusion Reactions
    ACS Nano, 13 (8), 9315-9324
    DOI 10.1021/acsnano.9b03942, PubMed 31348638
16. Liang RA, Høiland II, Ueland T, Aukrust P, Snir O, Hindberg K, Braekkan SK, Garred P, Mollnes TE, Hansen JB (2019)
    Plasma levels of mannose-binding lectin and future risk of venous thromboembolism
    J Thromb Haemost, 17 (10), 1661-1669
    DOI 10.1111/jth.14539, PubMed 31220397
17. Macpherson ME, Halvorsen B, Yndestad A, Ueland T, Mollnes TE, Berge RK, Rashidi A, Otterdal K, Gregersen I, Kong XY, Holven KB, Aukrust P, Fevang B, Jørgensen SF (2019)
    Impaired HDL Function Amplifies Systemic Inflammation in Common Variable Immunodeficiency
    Sci Rep, 9 (1), 9427
    DOI 10.1038/s41598-019-45861-1, PubMed 31263122
18. Mastellos DC, Blom AM, Connolly ES, Daha MR, Geisbrecht BV, Ghebrehiwet B, Gros P, Hajishengallis G, Holers VM, Huber-Lang M, Kinoshita T, Mollnes TE, Montgomery RA, Morgan BP, Nilsson B, Pio R, Ricklin D, Risitano AM, Taylor RP, Mantovani A, Ioannidis JPA, Lambris JD (2019)
    'Stealth' corporate innovation: an emerging threat for therapeutic drug development
    Nat Immunol, 20 (11), 1409-1413
    DOI 10.1038/s41590-019-0503-1, PubMed 31562490
19. Mastellos DC, Blom AM, Connolly ES, Daha MR, Geisbrecht BV, Ghebrehiwet B, Gros P, Hajishengallis G, Holers VM, Huber-Lang M, Kinoshita T, Mollnes TE, Montgomery RA, Morgan BP, Nilsson B, Pio R, Ricklin D, Risitano AM, Taylor RP, Mantovani A, Ioannidis JPA, Lambris JD (2019)
    Author Correction: 'Stealth' corporate innovation: an emerging threat for therapeutic drug development
    Nat Immunol, 20 (11), 1556
    DOI 10.1038/s41590-019-0531-x, PubMed 31605100
20. Ottestad W, Rognes IN, Pischke SE, Mollnes TE, Andersson U, Eken T (2019)
    Biphasic Release of the Alarmin High Mobility Group Box 1 Protein Early After Trauma Predicts Poor Clinical Outcome
    Crit Care Med, 47 (8), e614-e622
    DOI 10.1097/CCM.0000000000003800, PubMed 31162203
21. Pischke SE, Hestenes S, Johansen HT, Fure H, Bugge JF, Espinoza A, Skulstad H, Edvardsen T, Fosse E, Mollnes TE, Halvorsen PS, Nielsen EW (2019)
    Sepsis causes right ventricular myocardial inflammation independent of pulmonary hypertension in a porcine sepsis model
    PLoS One, 14 (6), e0218624
    DOI 10.1371/journal.pone.0218624, PubMed 31247004
22. Shahini N, Ueland T, Auensen A, Michelsen AE, Ludviksen JK, Hussain AI, Pettersen KI, Aakhus S, Espeland T, Lunde IG, Kirschfink M, Nilsson PH, Mollnes TE, Gullestad L, Aukrust P, Yndestad A, Louwe MC (2019)
    Increased Complement Factor B and Bb Levels Are Associated with Mortality in Patients with Severe Aortic Stenosis
    J Immunol, 203 (7), 1973-1980
    DOI 10.4049/jimmunol.1801244, PubMed 31492744
23. Siljan WW, Holter JC, Michelsen AE, Nymo SH, Lauritzen T, Oppen K, Husebye E, Ueland T, Mollnes TE, Aukrust P, Heggelund L (2019)
    Inflammatory biomarkers are associated with aetiology and predict outcomes in community-acquired pneumonia: results of a 5-year follow-up cohort study
    ERJ Open Res, 5 (1)
    DOI 10.1183/23120541.00014-2019, PubMed 30863773
24. Skjeflo EW, Christiansen D, Landsem A, Stenvik J, Woodruff TM, Espevik T, Nielsen EW, Mollnes TE (2019)
    Phagocytosis of live and dead Escherichia coli and Staphylococcus aureus in human whole blood is markedly reduced by combined inhibition of C5aR1 and CD14
    Mol Immunol, 112, 131-139
    DOI 10.1016/j.molimm.2019.03.014, PubMed 31102985
25. Thomas AM, Gerogianni A, McAdam MB, Fløisand Y, Lau C, Espevik T, Nilsson PH, Mollnes TE, Barratt-Due A (2019)
    Complement Component C5 and TLR Molecule CD14 Mediate Heme-Induced Thromboinflammation in Human Blood
    J Immunol, 203 (6), 1571-1578
    DOI 10.4049/jimmunol.1900047, PubMed 31413105
26. Thorgersen EB, Barratt-Due A, Haugaa H, Harboe M, Pischke SE, Nilsson PH, Mollnes TE (2019)
    The Role of Complement in Liver Injury, Regeneration, and Transplantation
    Hepatology, 70 (2), 725-736
    DOI 10.1002/hep.30508, PubMed 30653682

Publications 2018

1. Askarian F, Lapek JD, Dongre M, Tsai CM, Kumaraswamy M, Kousha A, Valderrama JA, Ludviksen JA, Cavanagh JP, Uchiyama S, Mollnes TE, Gonzalez DJ, Wai SN, Nizet V, Johannessen M (2018)
   Staphylococcus aureus Membrane-Derived Vesicles Promote Bacterial Virulence and Confer Protective Immunity in Murine Infection Models
   Front Microbiol, 9, 262
   DOI 10.3389/fmicb.2018.00262, PubMed 29515544
2. Bjerre A, Bergseth G, Ludviksen JK, Stokke A, Bosnes V, Karpman D, Mollnes TE (2018)
   Clinical and Complement Long-Term Follow-Up of a Pediatric Patient with C3 Mutation-Related Atypical Hemolytic Uremic Syndrome
   Case Rep Nephrol, 2018, 3810249
   DOI 10.1155/2018/3810249, PubMed 30662780
3. Bugge E, Wynn R, Mollnes TE, Reitan SK, Grønli OK (2018)
   Cytokine profiles and diagnoses in elderly, hospitalized psychiatric patients
   BMC Psychiatry, 18 (1), 315
   DOI 10.1186/s12888-018-1900-y, PubMed 30261848
4. Gaya da Costa M, Poppelaars F, van Kooten C, Mollnes TE, Tedesco F, Würzner R, Trouw LA, Truedsson L, Daha MR, Roos A, Seelen MA (2018)
   Age and Sex-Associated Changes of Complement Activity and Complement Levels in a Healthy Caucasian Population
   Front Immunol, 9, 2664
   DOI 10.3389/fimmu.2018.02664, PubMed 30515158
5. Gaarden TL, Engedal K, Benth JŠ, Larsen M, Lorentzen B, Mollnes TE, Bjølseth TM, Castellheim A (2018)
   Exploration of 27 plasma immune markers: a cross-sectional comparison of 64 old psychiatric inpatients having unipolar major depression and 18 non-depressed old persons
   BMC Geriatr, 18 (1), 149
   DOI 10.1186/s12877-018-0836-x, PubMed 29940870
6. Habberstad R, Frøseth TCS, Aass N, Abramova T, Baas T, Mørkeset ST, Caraceni A, Laird B, Boland JW, Rossi R, Garcia-Alonso E, Stensheim H, Loge JH, Hjermstad MJ, Bjerkeset E, Bye A, Lund JÅ, Solheim TS, Vagnildhaug OM, Brunelli C, Damås JK, Mollnes TE, Kaasa S, Klepstad P (2018)
   The Palliative Radiotherapy and Inflammation Study (PRAIS) - protocol for a longitudinal observational multicenter study on patients with cancer induced bone pain
   BMC Palliat Care, 17 (1), 110
   DOI 10.1186/s12904-018-0362-9, PubMed 30266081
7. Hardersen R, Enebakk T, Christiansen D, Bergseth G, Brekke OL, Mollnes TE, Lappegård KT, Hovland A (2018)
   Granulocyte and monocyte CD11b expression during plasma separation is dependent on complement factor 5 (C5) - an ex vivo study with blood from a C5-deficient individual
   APMIS, 126 (4), 342-352
   DOI 10.1111/apm.12821, PubMed 29575196
8. Høiland II, Liang RA, Hindberg K, Latysheva N, Brekke OL, Mollnes TE, Hansen JB (2018)
   Associations between complement pathways activity, mannose-binding lectin, and odds of unprovoked venous thromboembolism
   Thromb Res, 169, 50-56
   DOI 10.1016/j.thromres.2018.06.019, PubMed 30015228
9. Kleveland O, Ueland T, Kunszt G, Bratlie M, Yndestad A, Broch K, Holte E, Ryan L, Amundsen BH, Bendz B, Aakhus S, Espevik T, Halvorsen B, Mollnes TE, Wiseth R, Gullestad L, Aukrust P, Damås JK (2018)
   Interleukin-6 receptor inhibition with tocilizumab induces a selective and substantial increase in plasma IP-10 and MIP-1β in non-ST-elevation myocardial infarction
   Int J Cardiol, 271, 1-7
   DOI 10.1016/j.ijcard.2018.04.136, PubMed 29961572
10. Landsem A, Fure H, Krey Ludviksen J, Christiansen D, Lau C, Mathisen M, Bergseth G, Nymo S, Lappegård KT, Woodruff TM, Espevik T, Mollnes TE, Brekke OL (2018)
    Complement component 5 does not interfere with physiological hemostasis but is essential for Escherichia coli-induced coagulation accompanied by Toll-like receptor 4
    Clin Exp Immunol, 196 (1), 97-110
    DOI 10.1111/cei.13240, PubMed 30444525
11. Langeland H, Bergum D, Løberg M, Bjørnstad K, Damås JK, Mollnes TE, Skjærvold NK, Klepstad P (2018)
    Transitions Between Circulatory States After Out-of-Hospital Cardiac Arrest: Protocol for an Observational, Prospective Cohort Study
    JMIR Res Protoc, 7 (1), e17
    DOI 10.2196/resprot.8558, PubMed 29351897
12. Orrem HL, Nilsson PH, Pischke SE, Grindheim G, Garred P, Seljeflot I, Husebye T, Aukrust P, Yndestad A, Andersen GØ, Barratt-Due A, Mollnes TE (2018)
    Acute heart failure following myocardial infarction: complement activation correlates with the severity of heart failure in patients developing cardiogenic shock
    ESC Heart Fail, 5 (3), 292-301
    DOI 10.1002/ehf2.12266, PubMed 29424484
13. Orrem HL, Nilsson PH, Pischke SE, Kleveland O, Yndestad A, Ekholt K, Damås JK, Espevik T, Bendz B, Halvorsen B, Gregersen I, Wiseth R, Andersen GØ, Ueland T, Gullestad L, Aukrust P, Barratt-Due A, Mollnes TE (2018)
    IL-6 Receptor Inhibition by Tocilizumab Attenuated Expression of C5a Receptor 1 and 2 in Non-ST-Elevation Myocardial Infarction
    Front Immunol, 9, 2035
    DOI 10.3389/fimmu.2018.02035, PubMed 30258440
14. Orrem HL, Shetelig C, Ueland T, Limalanathan S, Nilsson PH, Husebye T, Aukrust P, Seljeflot I, Hoffmann P, Eritsland J, Mollnes TE, Andersen GØ, Yndestad A (2018)
    Soluble IL-1 receptor 2 is associated with left ventricular remodelling in patients with ST-elevation myocardial infarction
    Int J Cardiol, 268, 187-192
    DOI 10.1016/j.ijcard.2018.05.032, PubMed 29853279
15. Quist-Paulsen E, Aukrust P, Kran AB, Dunlop O, Ormaasen V, Stiksrud B, Midttun Ø, Ueland T, Ueland PM, Mollnes TE, Dyrhol-Riise AM (2018)
    High neopterin and IP-10 levels in cerebrospinal fluid are associated with neurotoxic tryptophan metabolites in acute central nervous system infections
    J Neuroinflammation, 15 (1), 327
    DOI 10.1186/s12974-018-1366-3, PubMed 30470234
16. Siljan WW, Holter JC, Nymo SH, Husebye E, Ueland T, Skattum L, Bosnes V, Garred P, Frøland SS, Mollnes TE, Aukrust P, Heggelund L (2018)
    Low Levels of Immunoglobulins and Mannose-Binding Lectin Are Not Associated With Etiology, Severity, or Outcome in Community-Acquired Pneumonia
    Open Forum Infect Dis, 5 (2), ofy002
    DOI 10.1093/ofid/ofy002, PubMed 29410975
17. Skjeflo EW, Christiansen D, Fure H, Ludviksen JK, Woodruff TM, Espevik T, Nielsen EW, Brekke OL, Mollnes TE (2018)
    Staphylococcus aureus-induced complement activation promotes tissue factor-mediated coagulation
    J Thromb Haemost, 16 (5), 905-918
    DOI 10.1111/jth.13979, PubMed 29437288
18. Skovdahl HK, Damås JK, Granlund AVB, Østvik AE, Doseth B, Bruland T, Mollnes TE, Sandvik AK (2018)
    C-C Motif Ligand 20 (CCL20) and C-C Motif Chemokine Receptor 6 (CCR6) in Human Peripheral Blood Mononuclear Cells: Dysregulated in Ulcerative Colitis and a Potential Role for CCL20 in IL-1β Release
    Int J Mol Sci, 19 (10)
    DOI 10.3390/ijms19103257, PubMed 30347808
19. Skaare H, Svensson M, Jenssen T, Åsberg A, Schmidt EB, Chandra A, Ueland T, Mollnes TE, Hartmann A, Eide IA (2018)
    Plasma n-6 Polyunsaturated Fatty Acid Levels and Survival in Renal Transplantation
    J Ren Nutr, 28 (5), 333-339
    DOI 10.1053/j.jrn.2018.02.008, PubMed 29703632
20. Thomas AM, Schjalm C, Nilsson PH, Lindenskov PHH, Rørtveit R, Solberg R, Saugstad OD, Berglund MM, Strömberg P, Lau C, Espevik T, Jansen JH, Castellheim A, Mollnes TE, Barratt-Due A (2018)
    Combined Inhibition of C5 and CD14 Attenuates Systemic Inflammation in a Piglet Model of Meconium Aspiration Syndrome
    Neonatology, 113 (4), 322-330
    DOI 10.1159/000486542, PubMed 29486477
21. Wendelbo Ø, Opheim EN, Hervig T, Felli Lunde TH, Bruserud Ø, Mollnes TE, Reikvam H (2018)
    Cytokine profiling and post-transfusion haemoglobin increment in patients with haematological diseases
    Vox Sang, 113 (7), 657-668
    DOI 10.1111/vox.12703, PubMed 30159896
22. Wolf-Grosse S, Mollnes TE, Ali S, Stenvik J, Nilsen AM (2018)
    Iron oxide nanoparticles enhance Toll-like receptor-induced cytokines in a particle size- and actin-dependent manner in human blood
    Nanomedicine (Lond), 13 (14), 1773-1785
    DOI 10.2217/nnm-2017-0362, PubMed 30084726

Publications 2017

1. Bakke SS, Aune MH, Niyonzima N, Pilely K, Ryan L, Skjelland M, Garred P, Aukrust P, Halvorsen B, Latz E, Damås JK, Mollnes TE, Espevik T (2017)
   Cyclodextrin Reduces Cholesterol Crystal-Induced Inflammation by Modulating Complement Activation
   J Immunol, 199 (8), 2910-2920
   DOI 10.4049/jimmunol.1700302, PubMed 28855312
2. Fiane KKH, Dahle G, Bendz B, Halvorsen PS, Abdelnoor M, Mollnes TE, Fosse E (2017)
   Reduced inflammatory response by transcatheter, as compared to surgical aortic valve replacement
   Scand Cardiovasc J, 52 (1), 43-50
   DOI 10.1080/14017431.2017.1416157, PubMed 29233022
3. Gravastrand C, Hamad S, Fure H, Steinkjer B, Ryan L, Oberholzer J, Lambris JD, Lacík I, Mollnes TE, Espevik T, Brekke OL, Rokstad AM (2017)
   Alginate microbeads are coagulation compatible, while alginate microcapsules activate coagulation secondary to complement or directly through FXII
   Acta Biomater, 58, 158-167
   DOI 10.1016/j.actbio.2017.05.052, PubMed 28576714
4. Gustavsen A, Skattum L, Bergseth G, Lorentzen B, Floisand Y, Bosnes V, Mollnes TE, Barratt-Due A (2017)
   Effect on mother and child of eculizumab given before caesarean section in a patient with severe antiphospholipid syndrome: A case report
   Medicine (Baltimore), 96 (11), e6338
   DOI 10.1097/MD.0000000000006338, PubMed 28296762
5. Harboe M, Johnson C, Nymo S, Ekholt K, Schjalm C, Lindstad JK, Pharo A, Hellerud BC, Nilsson Ekdahl K, Mollnes TE, Nilsson PH (2017)
   Properdin binding to complement activating surfaces depends on initial C3b deposition
   Proc Natl Acad Sci U S A, 114 (4), E534-E539
   DOI 10.1073/pnas.1612385114, PubMed 28069958
6. Hellerud BC, Orrem HL, Dybwik K, Pischke SE, Baratt-Due A, Castellheim A, Fure H, Bergseth G, Christiansen D, Nunn MA, Espevik T, Lau C, Brandtzæg P, Nielsen EW, Mollnes TE (2017)
   Combined inhibition of C5 and CD14 efficiently attenuated the inflammatory response in a porcine model of meningococcal sepsis
   J Intensive Care, 5, 21
   DOI 10.1186/s40560-017-0217-0, PubMed 28261486
7. Hennø LT, Storjord E, Christiansen D, Bergseth G, Ludviksen JK, Fure H, Barene S, Nielsen EW, Mollnes TE, Brekke OL (2017)
   Effect of the anticoagulant, storage time and temperature of blood samples on the concentrations of 27 multiplex assayed cytokines - Consequences for defining reference values in healthy humans
   Cytokine, 97, 86-95
   DOI 10.1016/j.cyto.2017.05.014, PubMed 28595117
8. Keshari RS, Silasi R, Popescu NI, Patel MM, Chaaban H, Lupu C, Coggeshall KM, Mollnes TE, DeMarco SJ, Lupu F (2017)
   Inhibition of complement C5 protects against organ failure and reduces mortality in a baboon model of Escherichia coli sepsis
   Proc Natl Acad Sci U S A, 114 (31), E6390-E6399
   DOI 10.1073/pnas.1706818114, PubMed 28720697
9. Nilsson PH, Thomas AM, Bergseth G, Gustavsen A, Volokhina EB, van den Heuvel LP, Barratt-Due A, Mollnes TE (2017)
   Eculizumab-C5 complexes express a C5a neoepitope in vivo: Consequences for interpretation of patient complement analyses
   Mol Immunol, 89, 111-114
   DOI 10.1016/j.molimm.2017.05.021, PubMed 28610663
10. Paunas TIF, Finne K, Leh S, Marti HP, Mollnes TE, Berven F, Vikse BE (2017)
    Glomerular abundance of complement proteins characterized by proteomic analysis of laser-captured microdissected glomeruli associates with progressive disease in IgA nephropathy
    Clin Proteomics, 14, 30
    DOI 10.1186/s12014-017-9165-x, PubMed 28814945
11. Pischke SE, Gustavsen A, Orrem HL, Egge KH, Courivaud F, Fontenelle H, Despont A, Bongoni AK, Rieben R, Tønnessen TI, Nunn MA, Scott H, Skulstad H, Barratt-Due A, Mollnes TE (2017)
    Complement factor 5 blockade reduces porcine myocardial infarction size and improves immediate cardiac function
    Basic Res Cardiol, 112 (3), 20
    DOI 10.1007/s00395-017-0610-9, PubMed 28258298
12. Ricklin D, Barratt-Due A, Mollnes TE (2017)
    Complement in clinical medicine: Clinical trials, case reports and therapy monitoring
    Mol Immunol, 89, 10-21
    DOI 10.1016/j.molimm.2017.05.013, PubMed 28576323
13. Shahini N, Michelsen AE, Nilsson PH, Ekholt K, Gullestad L, Broch K, Dahl CP, Aukrust P, Ueland T, Mollnes TE, Yndestad A, Louwe MC (2017)
    The alternative complement pathway is dysregulated in patients with chronic heart failure
    Sci Rep, 7, 42532
    DOI 10.1038/srep42532, PubMed 28195242
14. Shields KJ, Mollnes TE, Eidet JR, Mikkelsen K, Almdahl SM, Bottazzi B, Lyberg T, Manzi S, Ahearn JM, Hollan I (2017)
    Plasma complement and vascular complement deposition in patients with coronary artery disease with and without inflammatory rheumatic diseases
    PLoS One, 12 (3), e0174577
    DOI 10.1371/journal.pone.0174577, PubMed 28362874
15. Siljan WW, Holter JC, Nymo SH, Husebye E, Ueland T, Aukrust P, Mollnes TE, Heggelund L (2017)
    Cytokine responses, microbial aetiology and short-term outcome in community-acquired pneumonia
    Eur J Clin Invest, 48 (1)
    DOI 10.1111/eci.12865, PubMed 29171871
16. Wibroe PP, Anselmo AC, Nilsson PH, Sarode A, Gupta V, Urbanics R, Szebeni J, Hunter AC, Mitragotri S, Mollnes TE, Moghimi SM (2017)
    Bypassing adverse injection reactions to nanoparticles through shape modification and attachment to erythrocytes
    Nat Nanotechnol, 12 (6), 589-594
    DOI 10.1038/nnano.2017.47, PubMed 28396605
17. Wolf-Grosse S, Rokstad AM, Ali S, Lambris JD, Mollnes TE, Nilsen AM, Stenvik J (2017)
    Iron oxide nanoparticles induce cytokine secretion in a complement-dependent manner in a human whole blood model
    Int J Nanomedicine, 12, 3927-3940
    DOI 10.2147/IJN.S136453, PubMed 28579778
18. Wyller VB, Nguyen CB, Ludviksen JA, Mollnes TE (2017)
    Transforming growth factor beta (TGF-β) in adolescent chronic fatigue syndrome
    J Transl Med, 15 (1), 245
    DOI 10.1186/s12967-017-1350-1, PubMed 29202780

Publications 2016

1. Aresvik DM, Lima K, Øverland T, Mollnes TE, Abrahamsen TG (2016)
   Increased Levels of Interferon-Inducible Protein 10 (IP-10) in 22q11.2 Deletion Syndrome
   Scand J Immunol, 83 (3), 188-94
   DOI 10.1111/sji.12406, PubMed 26708691
2. Barratt-Due A, Fløisand Y, Orrem HL, Kvam AK, Holme PA, Bergseth G, Tjønnfjord GE, Mollnes TE (2016)
   Complement activation is a crucial pathogenic factor in catastrophic antiphospholipid syndrome
   Rheumatology (Oxford), 55 (7), 1337-9
   DOI 10.1093/rheumatology/kew040, PubMed 27105662
3. Barratt-Due A, Pischke SE, Nilsson PH, Espevik T, Mollnes TE (2016)
   Dual inhibition of complement and Toll-like receptors as a novel approach to treat inflammatory diseases-C3 or C5 emerge together with CD14 as promising targets
   J Leukoc Biol, 101 (1), 193-204
   DOI 10.1189/jlb.3VMR0316-132R, PubMed 27581539
4. Eide IA, Åsberg A, Svensson M, Ueland T, Mollnes TE, Hartmann A, Bjerve KS, Michelsen A, Aukrust P, Christensen JH, Schmidt EB, Jenssen T (2016)
   Plasma Levels of Marine n-3 Fatty Acids Are Inversely Correlated With Proinflammatory Markers sTNFR1 and IL-6 in Renal Transplant Recipients
   J Ren Nutr, 27 (3), 161-168
   DOI 10.1053/j.jrn.2016.09.008, PubMed 27838193
5. Garabet L, Gilboe IM, Mowinckel MC, Jacobsen AF, Mollnes TE, Sandset PM, Jacobsen EM (2016)
   Antiphospholipid Antibodies are Associated with Low Levels of Complement C3 and C4 in Patients with Systemic Lupus Erythematosus
   Scand J Immunol, 84 (2), 95-9
   DOI 10.1111/sji.12445, PubMed 27135178
6. Gustavsen A, Nymo S, Landsem A, Christiansen D, Ryan L, Husebye H, Lau C, Pischke SE, Lambris JD, Espevik T, Mollnes TE (2016)
   Combined Inhibition of Complement and CD14 Attenuates Bacteria-Induced Inflammation in Human Whole Blood More Efficiently Than Antagonizing the Toll-like Receptor 4-MD2 Complex
   J Infect Dis, 214 (1), 140-50
   DOI 10.1093/infdis/jiw100, PubMed 26977050
7. Hestad KA, Engedal K, Whist JE, Aukrust P, Farup PG, Mollnes TE, Ueland T (2016)
   Patients with depression display cytokine levels in serum and cerebrospinal fluid similar to patients with diffuse neurological symptoms without a defined diagnosis
   Neuropsychiatr Dis Treat, 12, 817-22
   DOI 10.2147/NDT.S101925, PubMed 27110115
8. Jørgensen SF, Trøseid M, Kummen M, Anmarkrud JA, Michelsen AE, Osnes LT, Holm K, Høivik ML, Rashidi A, Dahl CP, Vesterhus M, Halvorsen B, Mollnes TE, Berge RK, Moum B, Lundin KE, Fevang B, Ueland T, Karlsen TH, Aukrust P, Hov JR (2016)
   Altered gut microbiota profile in common variable immunodeficiency associates with levels of lipopolysaccharide and markers of systemic immune activation
   Mucosal Immunol, 9 (6), 1455-1465
   DOI 10.1038/mi.2016.18, PubMed 26982597
9. Landsem A, Fure H, Mollnes TE, Nielsen EW, Brekke OL (2016)
   C1-inhibitor efficiently delays clot development in normal human whole blood and inhibits Escherichia coli-induced coagulation measured by thromboelastometry
   Thromb Res, 143, 63-70
   DOI 10.1016/j.thromres.2016.04.024, PubMed 27197075
10. Lappegård KT, Enebakk T, Thunhaug H, Ludviksen JK, Mollnes TE, Hovland A (2016)
    LDL apheresis activates the complement system and the cytokine network, whereas PCSK9 inhibition with evolocumab induces no inflammatory response
    J Clin Lipidol, 10 (6), 1481-1487
    DOI 10.1016/j.jacl.2016.09.001, PubMed 27919366
11. Niyonzima N, Halvorsen B, Sporsheim B, Garred P, Aukrust P, Mollnes TE, Espevik T (2016)
    Complement activation by cholesterol crystals triggers a subsequent cytokine response
    Mol Immunol, 84, 43-50
    DOI 10.1016/j.molimm.2016.09.019, PubMed 27692470
12. Nymo S, Gustavsen A, Nilsson PH, Lau C, Espevik T, Mollnes TE (2016)
    Human Endothelial Cell Activation by Escherichia coli and Staphylococcus aureus Is Mediated by TNF and IL-1β Secondarily to Activation of C5 and CD14 in Whole Blood
    J Immunol, 196 (5), 2293-9
    DOI 10.4049/jimmunol.1502220, PubMed 26800874
13. Otterdal K, Portillo A, Astrup E, Ludviksen J, Davì G, Holm S, Santilli F, Vitale G, Raoult D, Olano JP, Schjalm C, Halvorsen B, Oteo JA, Mollnes TE, Aukrust P, Nilsson PH (2016)
    High serum CXCL10 in Rickettsia conorii infection is endothelial cell mediated subsequent to whole blood activation
    Cytokine, 83, 269-274
    DOI 10.1016/j.cyto.2016.05.006, PubMed 27180202
14. Otterdal K, Portillo A, Astrup E, Ludviksen JK, Schjalm C, Raoult D, Olano JP, Halvorsen B, Oteo JA, Aukrust P, Mollnes TE, Nilsson PH (2016)
    Rickettsia conorii is a potent complement activator in vivo and combined inhibition of complement and CD14 is required for attenuation of the cytokine response ex vivo
    Clin Microbiol Infect, 22 (8), 734.e1-6
    DOI 10.1016/j.cmi.2016.05.010, PubMed 27217049
15. Pilely K, Rosbjerg A, Genster N, Gal P, Pál G, Halvorsen B, Holm S, Aukrust P, Bakke SS, Sporsheim B, Nervik I, Niyonzima N, Bartels ED, Stahl GL, Mollnes TE, Espevik T, Garred P (2016)
    Cholesterol Crystals Activate the Lectin Complement Pathway via Ficolin-2 and Mannose-Binding Lectin: Implications for the Progression of Atherosclerosis
    J Immunol, 196 (12), 5064-74
    DOI 10.4049/jimmunol.1502595, PubMed 27183610
16. Siljan WW, Holter JC, Nymo SH, Schjalm C, Müller F, Jenum PA, Husebye E, Ueland T, Aukrust P, Mollnes TE, Heggelund L (2016)
    Circulating cell-free DNA is elevated in community-acquired bacterial pneumonia and predicts short-term outcome
    J Infect, 73 (4), 383-6
    DOI 10.1016/j.jinf.2016.07.011, PubMed 27452197
17. Smedbråten J, Mjøen G, Hartmann A, Åsberg A, Rollag H, Mollnes TE, Sandvik L, Fagerland MW, Thiel S, Sagedal S (2016)
    Low level of MAp44, an inhibitor of the lectin complement pathway, and long-term graft and patient survival; a cohort study of 382 kidney recipients
    BMC Nephrol, 17 (1), 148
    DOI 10.1186/s12882-016-0373-9, PubMed 27760523
18. Smedbråten J, Sagedal S, Åsberg A, Hartmann A, Rollag H, Mjøen G, Fagerland MW, Hansen SW, Mollnes TE, Thiel S (2016)
    Collectin Liver 1 and Collectin Kidney 1 of the Lectin Complement Pathway Are Associated With Mortality After Kidney Transplantation
    Am J Transplant, 17 (1), 265-271
    DOI 10.1111/ajt.13933, PubMed 27341702
19. Stiksrud B, Lorvik KB, Kvale D, Mollnes TE, Ueland PM, Trøseid M, Taskén K, Dyrhol-Riise AM (2016)
    Plasma IP-10 Is Increased in Immunological NonResponders and Associated With Activated Regulatory T Cells and Persisting Low CD4 Counts
    J Acquir Immune Defic Syndr, 73 (2), 138-48
    DOI 10.1097/QAI.0000000000001080, PubMed 27632144
20. Storjord E, Dahl JA, Landsem A, Fure H, Ludviksen JK, Goldbeck-Wood S, Karlsen BO, Berg KS, Mollnes TE, W Nielsen E, Brekke OL (2016)
    Systemic inflammation in acute intermittent porphyria: a case-control study
    Clin Exp Immunol, 187 (3), 466-479
    DOI 10.1111/cei.12899, PubMed 27859020
21. Stylianou E, Ueland T, Borchsenius F, Michelsen AE, Øvstebø R, Mollnes TE, Skjønsberg OH, Aukrust P (2016)
    Specific allergen immunotherapy: effect on IgE, IgG4 and chemokines in patients with allergic rhinitis
    Scand J Clin Lab Invest, 76 (2), 118-27
    DOI 10.3109/00365513.2015.1110856, PubMed 26878875
22. Ørning P, Hoem KS, Coron AE, Skjåk-Bræk G, Mollnes TE, Brekke OL, Espevik T, Rokstad AM (2016)
    Alginate microsphere compositions dictate different mechanisms of complement activation with consequences for cytokine release and leukocyte activation
    J Control Release, 229, 58-69
    DOI 10.1016/j.jconrel.2016.03.021, PubMed 26993426

Publications 2015

1. Asprusten TT, Fagermoen E, Sulheim D, Skovlund E, Sørensen Ø, Mollnes TE, Wyller VB (2015)
   Study findings challenge the content validity of the Canadian Consensus Criteria for adolescent chronic fatigue syndrome
   Acta Paediatr, 104 (5), 498-503
   DOI 10.1111/apa.12950, PubMed 25640602
2. Berg A, Otterdal K, Patel S, Gonca M, David C, Dalen I, Nymo S, Nilsson M, Nordling S, Magnusson PU, Ueland T, Prato M, Giribaldi G, Mollnes TE, Aukrust P, Langeland N, Nilsson PH (2015)
   Complement Activation Correlates With Disease Severity and Contributes to Cytokine Responses in Plasmodium falciparum Malaria
   J Infect Dis, 212 (11), 1835-40
   DOI 10.1093/infdis/jiv283, PubMed 25980034
3. Bergstrøm B, Aune MH, Awuh JA, Kojen JF, Blix KJ, Ryan L, Flo TH, Mollnes TE, Espevik T, Stenvik J (2015)
   TLR8 Senses Staphylococcus aureus RNA in Human Primary Monocytes and Macrophages and Induces IFN-β Production via a TAK1-IKKβ-IRF5 Signaling Pathway
   J Immunol, 195 (3), 1100-11
   DOI 10.4049/jimmunol.1403176, PubMed 26085680
4. Blom AM, Österborg A, Mollnes TE, Okroj M (2015)
   Antibodies reactive to cleaved sites in complement proteins enable highly specific measurement of soluble markers of complement activation
   Mol Immunol, 66 (2), 164-70
   DOI 10.1016/j.molimm.2015.02.029, PubMed 25795308
5. Egge KH, Barratt-Due A, Nymo S, Lindstad JK, Pharo A, Lau C, Espevik T, Thorgersen EB, Mollnes TE (2015)
   The anti-inflammatory effect of combined complement and CD14 inhibition is preserved during escalating bacterial load
   Clin Exp Immunol, 181 (3), 457-67
   DOI 10.1111/cei.12645, PubMed 25907631
6. Egge KH, Thorgersen EB, Pischke SE, Lindstad JK, Pharo A, Bongoni AK, Rieben R, Nunn MA, Barratt-Due A, Mollnes TE (2015)
   Organ inflammation in porcine Escherichia coli sepsis is markedly attenuated by combined inhibition of C5 and CD14
   Immunobiology, 220 (8), 999-1005
   DOI 10.1016/j.imbio.2015.04.002, PubMed 25956456
7. Fretland AA, Sokolov A, Postriganova N, Kazaryan AM, Pischke SE, Nilsson PH, Rognes IN, Bjornbeth BA, Fagerland MW, Mollnes TE, Edwin B (2015)
   Inflammatory Response After Laparoscopic Versus Open Resection of Colorectal Liver Metastases: Data From the Oslo-CoMet Trial
   Medicine (Baltimore), 94 (42), e1786
   DOI 10.1097/MD.0000000000001786, PubMed 26496309
8. Hein E, Munthe-Fog L, Thiara AS, Fiane AE, Mollnes TE, Garred P (2015)
   Heparin-coated cardiopulmonary bypass circuits selectively deplete the pattern recognition molecule ficolin-2 of the lectin complement pathway in vivo
   Clin Exp Immunol, 179 (2), 294-9
   DOI 10.1111/cei.12446, PubMed 25174443
9. Hellerud BC, Olstad OK, Nielsen EW, Trøseid AM, Skadberg Ø, Thorgersen EB, Vege Å, Mollnes TE, Brandtzæg P (2015)
   Massive Organ Inflammation in Experimental and in Clinical Meningococcal Septic Shock
   Shock, 44 (5), 458-69
   DOI 10.1097/SHK.0000000000000441, PubMed 26473439
10. Hovland A, Jonasson L, Garred P, Yndestad A, Aukrust P, Lappegård KT, Espevik T, Mollnes TE (2015)
    The complement system and toll-like receptors as integrated players in the pathophysiology of atherosclerosis
    Atherosclerosis, 241 (2), 480-94
    DOI 10.1016/j.atherosclerosis.2015.05.038, PubMed 26086357
11. Huang S, Engberg AE, Jonsson N, Sandholm K, Nicholls IA, Mollnes TE, Fromell K, Nilsson B, Ekdahl KN (2015)
    Reciprocal relationship between contact and complement system activation on artificial polymers exposed to whole human blood
    Biomaterials, 77, 111-9
    DOI 10.1016/j.biomaterials.2015.10.067, PubMed 26584351
12. Haakonsen Lindenskov PH, Castellheim A, Saugstad OD, Mollnes TE (2015)
    Meconium aspiration syndrome: possible pathophysiological mechanisms and future potential therapies
    Neonatology, 107 (3), 225-230
    DOI 10.1159/000369373, PubMed 25721501
13. Khan F, Pharo A, Lindstad JK, Mollnes TE, Tønnessen TI, Pischke SE (2015)
    Effect of Perfusion Fluids on Recovery of Inflammatory Mediators in Microdialysis
    Scand J Immunol, 82 (5), 467-75
    DOI 10.1111/sji.12332, PubMed 26099791
14. Landsem A, Fure H, Christiansen D, Nielsen EW, Østerud B, Mollnes TE, Brekke OL (2015)
    The key roles of complement and tissue factor in Escherichia coli-induced coagulation in human whole blood
    Clin Exp Immunol, 182 (1), 81-9
    DOI 10.1111/cei.12663, PubMed 26241501
15. Lappegård KT, Bjerre A, Tjønnfjord GE, Mollnes TE (2015)
    Therapeutic complement inhibition – from experimental to clinical medicine
    Tidsskr Nor Laegeforen, 135 (19), 1745-9
    DOI 10.4045/tidsskr.15.0049, PubMed 26486669
16. Lappegård KT, Bjørnstad H, Mollnes TE, Hovland A (2015)
    Effect of Cardiac Resynchronization Therapy on Inflammation in Congestive Heart Failure: A Review
    Scand J Immunol, 82 (3), 191-8
    DOI 10.1111/sji.12328, PubMed 26099323
17. Lau C, Nygård S, Fure H, Olstad OK, Holden M, Lappegård KT, Brekke OL, Espevik T, Hovig E, Mollnes TE (2015)
    CD14 and complement crosstalk and largely mediate the transcriptional response to Escherichia coli in human whole blood as revealed by DNA microarray
    PLoS One, 10 (2), e0117261
    DOI 10.1371/journal.pone.0117261, PubMed 25706641
18. Lau C, Olstad OK, Holden M, Nygård S, Fure H, Lappegård KT, Brekke OL, Espevik T, Hovig E, Mollnes TE (2015)
    Gene expression profiling of Gram-negative bacteria-induced inflammation in human whole blood: The role of complement and CD14-mediated innate immune response
    Genom Data, 5, 176-83
    DOI 10.1016/j.gdata.2015.05.019, PubMed 26484252
19. Meroni PL, Macor P, Durigutto P, De Maso L, Gerosa M, Ferraresso M, Borghi MO, Mollnes TE, Tedesco F (2015)
    Complement activation in antiphospholipid syndrome and its inhibition to prevent rethrombosis after arterial surgery
    Blood, 127 (3), 365-7
    DOI 10.1182/blood-2015-09-672139, PubMed 26644452
20. Neupane SP, Lien L, Ueland T, Mollnes TE, Aukrust P, Bramness JG (2015)
    Serum brain-derived neurotrophic factor levels in relation to comorbid depression and cytokine levels in Nepalese men with alcohol-use disorders
    Alcohol, 49 (5), 471-8
    DOI 10.1016/j.alcohol.2015.01.012, PubMed 25873205
21. Nilsson B, Ekdahl KN, Kemper C, Mollnes TE (2015)
    Preface. 15th European Meeting on Complement in Human Disease 2015, Uppsala, Sweden
    Mol Immunol, 67 (1), 1-2
    DOI 10.1016/j.molimm.2015.04.006, PubMed 25934434
22. Niyonzima N, Samstad EO, Aune MH, Ryan L, Bakke SS, Rokstad AM, Wright SD, Damås JK, Mollnes TE, Latz E, Espevik T (2015)
    Reconstituted High-Density Lipoprotein Attenuates Cholesterol Crystal-Induced Inflammatory Responses by Reducing Complement Activation
    J Immunol, 195 (1), 257-64
    DOI 10.4049/jimmunol.1403044, PubMed 26026058
23. Prebensen C, Ueland T, Michelsen AE, Lind A, Pettersen FO, Mollnes TE, Aukrust P, Dyrhol-Riise AM, Kvale D (2015)
    High MIP-1β Levels in Plasma Predict Long-Term Immunological Nonresponse to Suppressive Antiretroviral Therapy in HIV Infection
    J Acquir Immune Defic Syndr, 69 (4), 395-402
    DOI 10.1097/QAI.0000000000000617, PubMed 26115437
24. Skjeflo EW, Sagatun C, Dybwik K, Aam S, Urving SH, Nunn MA, Fure H, Lau C, Brekke OL, Huber-Lang M, Espevik T, Barratt-Due A, Nielsen EW, Mollnes TE (2015)
    Combined inhibition of complement and CD14 improved outcome in porcine polymicrobial sepsis
    Crit Care, 19, 415
    DOI 10.1186/s13054-015-1129-9, PubMed 26612199
25. Smedbråten YV, Sagedal S, Mjøen G, Hartmann A, Fagerland MW, Rollag H, Mollnes TE, Thiel S (2015)
    High ficolin-3 level at the time of transplantation is an independent risk factor for graft loss in kidney transplant recipients
    Transplantation, 99 (4), 791-6
    DOI 10.1097/TP.0000000000000422, PubMed 25222012
26. Volokhina EB, Bergseth G, van de Kar NC, van den Heuvel LP, Mollnes TE (2015)
    Eculizumab treatment efficiently prevents C5 cleavage without C5a generation in vivo
    Blood, 126 (2), 278-9
    DOI 10.1182/blood-2015-03-637645, PubMed 26160188
27. Volokhina EB, van de Kar NC, Bergseth G, van der Velden TJ, Westra D, Wetzels JF, van den Heuvel LP, Mollnes TE (2015)
    Sensitive, reliable and easy-performed laboratory monitoring of eculizumab therapy in atypical hemolytic uremic syndrome
    Clin Immunol, 160 (2), 237-43
    DOI 10.1016/j.clim.2015.05.018, PubMed 26111482
28. Volokhina EB, Westra D, van der Velden TJ, van de Kar NC, Mollnes TE, van den Heuvel LP (2015)
    Complement activation patterns in atypical haemolytic uraemic syndrome during acute phase and in remission
    Clin Exp Immunol, 181 (2), 306-13
    DOI 10.1111/cei.12426, PubMed 25079699
29. Wergeland I, Pullar N, Assmus J, Ueland T, Tonby K, Feruglio S, Kvale D, Damås JK, Aukrust P, Mollnes TE, Dyrhol-Riise AM (2015)
    IP-10 differentiates between active and latent tuberculosis irrespective of HIV status and declines during therapy
    J Infect, 70 (4), 381-91
    DOI 10.1016/j.jinf.2014.12.019, PubMed 25597826
30. Wyller VB, Reme SE, Mollnes TE (2015)
    Chronic fatigue syndrome/myalgic encephalo-myelitis--pathophysiology, diagnosis and treatment
    Tidsskr Nor Laegeforen, 135 (23-24), 2172-5
    DOI 10.4045/tidsskr.15.1180, PubMed 26674040
31. Würzner R, Tedesco F, Garred P, Mollnes TE, Truedsson L, Turner MW, Sommarin Y, Wieslander J, Sim RB (2015)
    European Union funded project on the development of a whole complement deficiency screening ELISA-A story of success and an exceptional manager: Mohamed R. Daha
    Mol Immunol, 68 (1), 63-6
    DOI 10.1016/j.molimm.2015.05.003, PubMed 26006049

Publications 2014

1. Berg A, Patel S, Gonca M, David C, Otterdal K, Ueland T, Dalen I, Kvaløy JT, Mollnes TE, Aukrust P, Langeland N (2014)
   Cytokine network in adults with falciparum Malaria and HIV-1: increased IL-8 and IP-10 levels are associated with disease severity
   PLoS One, 9 (12), e114480
   DOI 10.1371/journal.pone.0114480, PubMed 25503583
2. Bergseth G, Ludviksen JK, Kirschfink M, Giclas PC, Nilsson B, Mollnes TE (2014)
   An international serum standard for application in assays to detect human complement activation products (vol 56, pg 232, 2013)
   Mol. Immunol., 60 (2), 115
   DOI 10.1016/j.molimm.2014.04.008
3. Bisschops LL, van der Hoeven JG, Mollnes TE, Hoedemaekers CW (2014)
   Seventy-two hours of mild hypothermia after cardiac arrest is associated with a lowered inflammatory response during rewarming in a prospective observational study
   Crit Care, 18 (5), 546
   DOI 10.1186/s13054-014-0546-5, PubMed 25304549
4. Blom AM, Volokhina EB, Fransson V, Strömberg P, Berghard L, Viktorelius M, Mollnes TE, López-Trascasa M, van den Heuvel LP, Goodship TH, Marchbank KJ, Okroj M (2014)
   A novel method for direct measurement of complement convertases activity in human serum
   Clin Exp Immunol, 178 (1), 142-53
   DOI 10.1111/cei.12388, PubMed 24853370
5. Engberg AE, Nilsson PH, Huang S, Fromell K, Hamad OA, Mollnes TE, Rosengren-Holmberg JP, Sandholm K, Teramura Y, Nicholls IA, Nilsson B, Ekdahl KN (2014)
   Prediction of inflammatory responses induced by biomaterials in contact with human blood using protein fingerprint from plasma
   Biomaterials, 36, 55-65
   DOI 10.1016/j.biomaterials.2014.09.011, PubMed 25292422
6. Hallstensen RF, Bergseth G, Foss S, Jæger S, Gedde-Dahl T, Holt J, Christiansen D, Lau C, Brekke OL, Armstrong E, Stefanovic V, Andersen JT, Sandlie I, Mollnes TE (2014)
   Eculizumab treatment during pregnancy does not affect the complement system activity of the newborn
   Immunobiology, 220 (4), 452-9
   DOI 10.1016/j.imbio.2014.11.003, PubMed 25468724
7. Huber-Lang M, Barratt-Due A, Pischke SE, Sandanger Ø, Nilsson PH, Nunn MA, Denk S, Gaus W, Espevik T, Mollnes TE (2014)
   Double blockade of CD14 and complement C5 abolishes the cytokine storm and improves morbidity and survival in polymicrobial sepsis in mice
   J Immunol, 192 (11), 5324-31
   DOI 10.4049/jimmunol.1400341, PubMed 24790148
8. Lappegård KT, Garred P, Jonasson L, Espevik T, Aukrust P, Yndestad A, Mollnes TE, Hovland A (2014)
   A vital role for complement in heart disease
   Mol Immunol, 61 (2), 126-34
   DOI 10.1016/j.molimm.2014.06.036, PubMed 25037633
9. Lind A, Brekke K, Pettersen FO, Mollnes TE, Trøseid M, Kvale D (2014)
   A parameter for IL-10 and TGF-ß mediated regulation of HIV-1 specific T cell activation provides novel information and relates to progression markers
   PLoS One, 9 (1), e85604
   DOI 10.1371/journal.pone.0085604, PubMed 24416431
10. Neupane SP, Lien L, Martinez P, Aukrust P, Ueland T, Mollnes TE, Hestad K, Bramness JG (2014)
    High frequency and intensity of drinking may attenuate increased inflammatory cytokine levels of major depression in alcohol-use disorders
    CNS Neurosci Ther, 20 (10), 898-904
    DOI 10.1111/cns.12303, PubMed 24995667
11. Nymo S, Niyonzima N, Espevik T, Mollnes TE (2014)
    Cholesterol crystal-induced endothelial cell activation is complement-dependent and mediated by TNF
    Immunobiology, 219 (10), 786-92
    DOI 10.1016/j.imbio.2014.06.006, PubMed 25053140
12. Ostvik AE, Granlund Av, Gustafsson BI, Torp SH, Espevik T, Mollnes TE, Damås JK, Sandvik AK (2014)
    Mucosal toll-like receptor 3-dependent synthesis of complement factor B and systemic complement activation in inflammatory bowel disease
    Inflamm Bowel Dis, 20 (6), 995-1003
    DOI 10.1097/MIB.0000000000000035, PubMed 24739633
13. Owen EP, Würzner R, Leisegang F, Rizkallah P, Whitelaw A, Simpson J, Thomas AD, Harris CL, Giles JL, Hellerud BC, Mollnes TE, Morgan BP, Potter PC, Orren A (2014)
    A complement C5 gene mutation, c.754G>A:p.A252T, is common in the Western Cape, South Africa and found to be homozygous in seven percent of Black African meningococcal disease cases
    Mol Immunol, 64 (1), 170-6
    DOI 10.1016/j.molimm.2014.11.010, PubMed 25534848
14. Samstad EO, Niyonzima N, Nymo S, Aune MH, Ryan L, Bakke SS, Lappegård KT, Brekke OL, Lambris JD, Damås JK, Latz E, Mollnes TE, Espevik T (2014)
    Cholesterol crystals induce complement-dependent inflammasome activation and cytokine release
    J Immunol, 192 (6), 2837-45
    DOI 10.4049/jimmunol.1302484, PubMed 24554772
15. Skjeflo EW, Christiansen D, Espevik T, Nielsen EW, Mollnes TE (2014)
    Combined inhibition of complement and CD14 efficiently attenuated the inflammatory response induced by Staphylococcus aureus in a human whole blood model
    J Immunol, 192 (6), 2857-64
    DOI 10.4049/jimmunol.1300755, PubMed 24516199
16. Wyller VB, Sørensen Ø, Sulheim D, Fagermoen E, Ueland T, Mollnes TE (2014)
    Plasma cytokine expression in adolescent chronic fatigue syndrome
    Brain Behav Immun, 46, 80-6
    DOI 10.1016/j.bbi.2014.12.025, PubMed 25555530

Publications 2013

1. Auråen H, Mollnes TE, Bjørtuft Ø, Bakkan PA, Geiran O, Kongerud J, Fiane A, Holm AM (2013)
   Multiorgan procurement increases systemic inflammation in brain dead donors
   Clin Transplant, 27 (4), 613-8
   DOI 10.1111/ctr.12175, PubMed 23803161
2. Barratt-Due A, Thorgersen EB, Egge K, Pischke S, Sokolov A, Hellerud BC, Lindstad JK, Pharo A, Bongoni AK, Rieben R, Nunn M, Scott H, Mollnes TE (2013)
   Combined inhibition of complement C5 and CD14 markedly attenuates inflammation, thrombogenicity, and hemodynamic changes in porcine sepsis
   J Immunol, 191 (2), 819-27
   DOI 10.4049/jimmunol.1201909, PubMed 23761634
3. Bergseth G, Ludviksen JK, Kirschfink M, Giclas PC, Nilsson B, Mollnes TE (2013)
   An international serum standard for application in assays to detect human complement activation products
   Mol Immunol, 56 (3), 232-9
   DOI 10.1016/j.molimm.2013.05.221, PubMed 23787367
4. Brekke OL, Waage C, Christiansen D, Fure H, Qu H, Lambris JD, Østerud B, Nielsen EW, Mollnes TE (2013)
   The effects of selective complement and CD14 inhibition on the E. coli-induced tissue factor mRNA upregulation, monocyte tissue factor expression, and tissue factor functional activity in human whole blood
   Adv Exp Med Biol, 735, 123-36
   DOI 10.1007/978-1-4614-4118-2_8, PubMed 23402023
5. Egge KH, Thorgersen EB, Lindstad JK, Pharo A, Lambris JD, Barratt-Due A, Mollnes TE (2013)
   Post challenge inhibition of C3 and CD14 attenuates Escherichia coli-induced inflammation in human whole blood
   Innate Immun, 20 (1), 68-77
   DOI 10.1177/1753425913482993, PubMed 23669326
6. Ehrnthaller C, Huber-Lang M, Nilsson P, Bindl R, Redeker S, Recknagel S, Rapp A, Mollnes T, Amling M, Gebhard F, Ignatius A (2013)
   Complement C3 and C5 deficiency affects fracture healing
   PLoS One, 8 (11), e81341
   DOI 10.1371/journal.pone.0081341, PubMed 24260573
7. Gregersen I, Skjelland M, Holm S, Holven KB, Krogh-Sørensen K, Russell D, Askevold ET, Dahl CP, Ørn S, Gullestad L, Mollnes TE, Ueland T, Aukrust P, Halvorsen B (2013)
   Increased systemic and local interleukin 9 levels in patients with carotid and coronary atherosclerosis
   PLoS One, 8 (8), e72769
   DOI 10.1371/journal.pone.0072769, PubMed 24023645
8. Hamre H, Zeller B, Kanellopoulos A, Ruud E, Fosså SD, Loge JH, Aukrust P, Halvorsen B, Mollnes TE, Kiserud CE (2013)
   Serum cytokines and chronic fatigue in adults surviving after childhood leukemia and lymphoma
   Brain Behav Immun, 30, 80-7
   DOI 10.1016/j.bbi.2013.01.006, PubMed 23333795
9. Happonen KE, Saxne T, Jacobsson L, Sturfelt G, Rönnelid J, Mollnes TE, Heinegård D, Turesson C, Blom AM (2013)
   COMP-C3b complexes in rheumatoid arthritis with severe extraarticular manifestations
   J Rheumatol, 40 (12), 2001-5
   DOI 10.3899/jrheum.130613, PubMed 24187101
10. Haugaa H, Almaas R, Thorgersen EB, Foss A, Line PD, Sanengen T, Bergmann GB, Ohlin P, Waelgaard L, Grindheim G, Pischke SE, Mollnes TE, Tønnessen TI (2013)
    Clinical experience with microdialysis catheters in pediatric liver transplants
    Liver Transpl, 19 (3), 305-14
    DOI 10.1002/lt.23578, PubMed 23193034
11. Landsem A, Nielsen EW, Fure H, Christiansen D, Ludviksen JK, Lambris JD, Østerud B, Mollnes TE, Brekke OL (2013)
    C1-inhibitor efficiently inhibits Escherichia coli-induced tissue factor mRNA up-regulation, monocyte tissue factor expression and coagulation activation in human whole blood
    Clin Exp Immunol, 173 (2), 217-29
    DOI 10.1111/cei.12098, PubMed 23607270
12. Lappegård KT, Hovland A, Pop GA, Mollnes TE (2013)
    Atrial fibrillation: inflammation in disguise?
    Scand J Immunol, 78 (2), 112-9
    DOI 10.1111/sji.12061, PubMed 23672430
13. Lau C, Gunnarsen KS, Høydahl LS, Andersen JT, Berntzen G, Pharo A, Lindstad JK, Ludviksen JK, Brekke OL, Barratt-Due A, Nielsen EW, Stokes CR, Espevik T, Sandlie I, Mollnes TE (2013)
    Chimeric anti-CD14 IGG2/4 Hybrid antibodies for therapeutic intervention in pig and human models of inflammation
    J Immunol, 191 (9), 4769-77
    DOI 10.4049/jimmunol.1301653, PubMed 24062486
14. Mollnes TE, Nilsson PH (2013)
    Letter to editor
    J Clin Biochem Nutr, 52 (3), 253-4
    DOI 10.3164/jcbn.52-3_LtoE, PubMed 23704816
15. Prohászka Z, Munthe-Fog L, Ueland T, Gombos T, Yndestad A, Förhécz Z, Skjoedt MO, Pozsonyi Z, Gustavsen A, Jánoskuti L, Karádi I, Gullestad L, Dahl CP, Askevold ET, Füst G, Aukrust P, Mollnes TE, Garred P (2013)
    Association of ficolin-3 with severity and outcome of chronic heart failure
    PLoS One, 8 (4), e60976
    DOI 10.1371/journal.pone.0060976, PubMed 23596511
16. Salvesen B, Curstedt T, Mollnes TE, Saugstad OD (2013)
    Effects of Natural versus Synthetic Surfactant with SP-B and SP-C Analogs in a Porcine Model of Meconium Aspiration Syndrome
    Neonatology, 105 (2), 128-35
    DOI 10.1159/000356065, PubMed 24356240
17. Schejbel L, Fadnes D, Permin H, Lappegård KT, Garred P, Mollnes TE (2013)
    Primary complement C5 deficiencies - molecular characterization and clinical review of two families
    Immunobiology, 218 (10), 1304-10
    DOI 10.1016/j.imbio.2013.04.021, PubMed 23743184
18. Thorgersen EB, Pischke SE, Barratt-Due A, Fure H, Lindstad JK, Pharo A, Hellerud BC, Mollnes TE (2013)
    Systemic CD14 inhibition attenuates organ inflammation in porcine Escherichia coli sepsis
    Infect Immun, 81 (9), 3173-81
    DOI 10.1128/IAI.00390-13, PubMed 23774598
19. van Vuuren BJ, Bergseth G, Mollnes TE, Shaw AM (2013)
    Electroluminescent TCC, C3dg and fB/Bb epitope assays for profiling complement cascade activation in vitro using an activated complement serum calibration standard
    J Immunol Methods, 402 (1-2), 50-6
    DOI 10.1016/j.jim.2013.11.010, PubMed 24287422
20. Øvstebø R, Hellum M, Aass HC, Trøseid AM, Brandtzaeg P, Mollnes TE, Henriksson CE (2013)
    Microparticle-associated tissue factor activity is reduced by inhibition of the complement protein 5 in Neisseria meningitidis-exposed whole blood
    Innate Immun, 20 (5), 552-60
    DOI 10.1177/1753425913502099, PubMed 24051102

Publications 2012

1. Almaas R, Hankø E, Mollnes TE, Rootwelt T (2012)
   Dexamethasone reduces bilirubin-induced toxicity and IL-8 and MCP-1 release in human NT2-N neurons
   Brain Res, 1458, 12-7
   DOI 10.1016/j.brainres.2012.04.007, PubMed 22546346
2. Barratt-Due A, Pischke SE, Brekke OL, Thorgersen EB, Nielsen EW, Espevik T, Huber-Lang M, Mollnes TE (2012)
   Bride and groom in systemic inflammation--the bells ring for complement and Toll in cooperation
   Immunobiology, 217 (11), 1047-56
   DOI 10.1016/j.imbio.2012.07.019, PubMed 22964230
3. Barratt-Due A, Sokolov A, Gustavsen A, Hellerud BC, Egge K, Pischke SE, Lindstad JK, Pharo A, Castellheim A, Thorgersen EB, Mollnes TE (2012)
   Polyvalent immunoglobulin significantly attenuated the formation of IL-1β in Escherichia coli-induced sepsis in pigs
   Immunobiology, 218 (5), 683-9
   DOI 10.1016/j.imbio.2012.08.268, PubMed 22947599
4. Bisschops LL, Hoedemaekers CW, Mollnes TE, van der Hoeven JG (2012)
   Rewarming after hypothermia after cardiac arrest shifts the inflammatory balance
   Crit Care Med, 40 (4), 1136-42
   DOI 10.1097/CCM.0b013e3182377050, PubMed 22020246
5. Christiansen D, Brekke OL, Stenvik J, Lambris JD, Espevik T, Mollnes TE (2012)
   Differential effect of inhibiting MD-2 and CD14 on LPS- versus whole E. coli bacteria-induced cytokine responses in human blood
   Adv Exp Med Biol, 946, 237-51
   DOI 10.1007/978-1-4614-0106-3_14, PubMed 21948372
6. Granslo HN, Klingenberg C, Fredheim EA, Acharya G, Mollnes TE, Flægstad T (2012)
   Staphylococcus epidermidis biofilms induce lower complement activation in neonates as compared with adults
   Pediatr Res, 73 (3), 294-300
   DOI 10.1038/pr.2012.193, PubMed 23232670
7. Harboe M, Garred P, Lindstad JK, Pharo A, Müller F, Stahl GL, Lambris JD, Mollnes TE (2012)
   The role of properdin in zymosan- and Escherichia coli-induced complement activation
   J Immunol, 189 (5), 2606-13
   DOI 10.4049/jimmunol.1200269, PubMed 22851705
8. Haugaa H, Thorgersen EB, Pharo A, Boberg KM, Foss A, Line PD, Sanengen T, Almaas R, Grindheim G, Waelgaard L, Pischke SE, Mollnes TE, Inge Tønnessen T (2012)
   Inflammatory markers sampled by microdialysis catheters distinguish rejection from ischemia in liver grafts
   Liver Transpl, 18 (12), 1421-9
   DOI 10.1002/lt.23503, PubMed 22767413
9. Hovland A, Hardersen R, Nielsen EW, Enebakk T, Christiansen D, Ludviksen JK, Mollnes TE, Lappegård KT (2012)
   Complement profile and activation mechanisms by different LDL apheresis systems
   Acta Biomater, 8 (6), 2288-96
   DOI 10.1016/j.actbio.2012.02.017, PubMed 22373816
10. Hovland A, Lappegård KT, Mollnes TE (2012)
    LDL apheresis and inflammation--implications for atherosclerosis
    Scand J Immunol, 76 (3), 229-36
    DOI 10.1111/j.1365-3083.2012.02734.x, PubMed 22670805
11. Håugaa H, Thorgersen EB, Pharo A, Boberg KM, Foss A, Line PD, Sanengen T, Almaas R, Grindheim G, Pischke SE, Mollnes TE, Tønnessen TI (2012)
    Early bedside detection of ischemia and rejection in liver transplants by microdialysis
    Liver Transpl, 18 (7), 839-49
    DOI 10.1002/lt.23425, PubMed 22407878
12. Kvarnström A, Sokolov A, Swartling T, Kurlberg G, Mollnes TE, Bengtsson A (2012)
    Alternative pathway activation of complement in laparoscopic and open rectal surgery
    Scand J Immunol, 76 (1), 49-53
    DOI 10.1111/j.1365-3083.2012.02702.x, PubMed 22486843
13. Rokstad AM, Brekke OL, Steinkjer B, Ryan L, Kolláriková G, Strand BL, Skjåk-Bræk G, Lambris JD, Lacík I, Mollnes TE, Espevik T (2012)
    The induction of cytokines by polycation containing microspheres by a complement dependent mechanism
    Biomaterials, 34 (3), 621-30
    DOI 10.1016/j.biomaterials.2012.10.012, PubMed 23103159
14. Rødland EK, Ueland T, Bjørnsen S, Sagen EL, Dahl CP, Naalsund A, Mollnes TE, Brosstad FR, Müller F, Aukrust P, Frøland SS (2012)
    Systemic biomarkers of inflammation and haemostasis in patients with chronic necrotizing pulmonary aspergillosis
    BMC Infect Dis, 12, 144
    DOI 10.1186/1471-2334-12-144, PubMed 22731696
15. Sokolov A, Hellerud BC, Johannessen EA, Mollnes TE (2012)
    Inflammatory response induced by candidate biomaterials of an implantable microfabricated sensor
    J Biomed Mater Res A, 100 (5), 1142-50
    DOI 10.1002/jbm.a.34054, PubMed 22337626
16. Sokolov A, Hellerud BC, Tønnessen TI, Johannessen EA, Mollnes TE (2012)
    Activation of coagulation and platelets by candidate membranes of implantable devices in a whole blood model without soluble anticoagulant
    J Biomed Mater Res A, 101 (2), 575-81
    DOI 10.1002/jbm.a.34348, PubMed 22949225
17. Ørn S, Ueland T, Manhenke C, Sandanger Ø, Godang K, Yndestad A, Mollnes TE, Dickstein K, Aukrust P (2012)
    Increased interleukin-1β levels are associated with left ventricular hypertrophy and remodelling following acute ST segment elevation myocardial infarction treated by primary percutaneous coronary intervention
    J Intern Med, 272 (3), 267-76
    DOI 10.1111/j.1365-2796.2012.02517.x, PubMed 22243053