PubMed registered articles Leonardo A. Meza-Zepeda
Publications by Leonardo A. Meza-Zepeda
110 publications found
Publications 2024
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Multi-omics profiling of longitudinal samples reveals early genomic changes in follicular lymphoma
Blood Cancer J, 14 (1), 147
DOI 10.1038/s41408-024-01124-5, PubMed 39191762 -
Evolutionary mode and timing of dissemination of high-grade serous carcinomas
JCI Insight, 9 (3)
DOI 10.1172/jci.insight.170423, PubMed 38175731 -
Systematic analysis of RNA-binding proteins identifies targetable therapeutic vulnerabilities in osteosarcoma
Nat Commun, 15 (1), 2810
DOI 10.1038/s41467-024-47031-y, PubMed 38561347
Publications 2023
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The interplay between neoantigens and immune cells in sarcomas treated with checkpoint inhibition
Front Immunol, 14, 1226445
DOI 10.3389/fimmu.2023.1226445, PubMed 37799721 -
Heritable defects in telomere and mitotic function selectively predispose to sarcomas
Science, 379 (6629), 253-260
DOI 10.1126/science.abj4784, PubMed 36656928 -
Chromosomal instability and a deregulated cell cycle are intrinsic features of high-risk gastrointestinal stromal tumours with a metastatic potential
Mol Oncol, 17 (11), 2432-2450
DOI 10.1002/1878-0261.13514, PubMed 37622176
Publications 2022
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Strategies to inhibit FGFR4 V550L-driven rhabdomyosarcoma
Br J Cancer, 127 (11), 1939-1953
DOI 10.1038/s41416-022-01973-6, PubMed 36097178 -
Validation of a novel risk score to predict early and late recurrence in solitary fibrous tumour
Br J Cancer, 127 (10), 1793-1798
DOI 10.1038/s41416-022-01959-4, PubMed 36030294 -
Mutational analysis and protein profiling predict drug sensitivity in multiple myeloma cell lines
Front Oncol, 12, 1040730
DOI 10.3389/fonc.2022.1040730, PubMed 36523963 -
Improving public cancer care by implementing precision medicine in Norway: IMPRESS-Norway
J Transl Med, 20 (1), 225
DOI 10.1186/s12967-022-03432-5, PubMed 35568909 -
Correction to: Improving public cancer care by implementing precision medicine in Norway: IMPRESS-Norway
J Transl Med, 20 (1), 317
DOI 10.1186/s12967-022-03518-0, PubMed 35841045 -
Clonal evolution after treatment pressure in multiple myeloma: heterogenous genomic aberrations and transcriptomic convergence
Leukemia, 36 (7), 1887-1897
DOI 10.1038/s41375-022-01597-y, PubMed 35643867 -
miR-486-5p expression is regulated by DNA methylation in osteosarcoma
BMC Genomics, 23 (1), 142
DOI 10.1186/s12864-022-08346-6, PubMed 35172717 -
A national precision cancer medicine implementation initiative for Norway
Nat Med, 28 (5), 885-887
DOI 10.1038/s41591-022-01777-4, PubMed 35513529 -
Clonal evolution in primary breast cancers under sequential epirubicin and docetaxel monotherapy
Genome Med, 14 (1), 86
DOI 10.1186/s13073-022-01090-2, PubMed 35948919
Publications 2021
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Comparing the epigenetic landscape in myonuclei purified with a PCM1 antibody from a fast/glycolytic and a slow/oxidative muscle
PLoS Genet, 17 (11), e1009907
DOI 10.1371/journal.pgen.1009907, PubMed 34752468 -
Pembrolizumab in advanced osteosarcoma: results of a single-arm, open-label, phase 2 trial
Cancer Immunol Immunother, 70 (9), 2617-2624
DOI 10.1007/s00262-021-02876-w, PubMed 33580363 -
Clinical and molecular implications of NAB2-STAT6 fusion variants in solitary fibrous tumour
Pathology, 53 (6), 713-719
DOI 10.1016/j.pathol.2020.11.010, PubMed 33745702 -
Discovery of novel candidates for anti-liposarcoma therapies by medium-scale high-throughput drug screening
PLoS One, 16 (3), e0248140
DOI 10.1371/journal.pone.0248140, PubMed 33690666 -
Integrating Anatomical, Molecular and Clinical Risk Factors in Gastrointestinal Stromal Tumor of the Stomach
Ann Surg Oncol, 28 (11), 6837-6845
DOI 10.1245/s10434-021-09605-8, PubMed 33651216 -
Rapid genome editing by CRISPR-Cas9-POLD3 fusion
Elife, 10
DOI 10.7554/eLife.75415, PubMed 34898428 -
The expressed mutational landscape of microsatellite stable colorectal cancers
Genome Med, 13 (1), 142
DOI 10.1186/s13073-021-00955-2, PubMed 34470667
Publications 2020
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Accurate 3-gene-signature for early diagnosis of liposarcoma progression
Clin Sarcoma Res, 10, 4
DOI 10.1186/s13569-020-0126-1, PubMed 32158531 -
Mutational dynamics and immune evasion in diffuse large B-cell lymphoma explored in a relapse-enriched patient series
Blood Adv, 4 (9), 1859-1866
DOI 10.1182/bloodadvances.2019001325, PubMed 32374878
Publications 2019
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ctDNA detected by ddPCR reveals changes in tumour load in metastatic malignant melanoma treated with bevacizumab
Sci Rep, 9 (1), 17471
DOI 10.1038/s41598-019-53917-5, PubMed 31767937 -
Remodeling of secretory lysosomes during education tunes functional potential in NK cells
Nat Commun, 10 (1), 514
DOI 10.1038/s41467-019-08384-x, PubMed 30705279 -
Preclinical Evaluation of the Pan-FGFR Inhibitor LY2874455 in FRS2-Amplified Liposarcoma
Cells, 8 (2)
DOI 10.3390/cells8020189, PubMed 30795553 -
Cell-free DNA in blood as a noninvasive insight into the sarcoma genome
Mol Aspects Med, 72, 100827
DOI 10.1016/j.mam.2019.10.004, PubMed 31703948 -
Diagnostic Profiling of the Human Public IgM Repertoire With Scalable Mimotope Libraries
Front Immunol, 10, 2796
DOI 10.3389/fimmu.2019.02796, PubMed 31849974
Publications 2018
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Patterns of genomic evolution in advanced melanoma
Nat Commun, 9 (1), 2665
DOI 10.1038/s41467-018-05063-1, PubMed 29991680 -
Preclinical Evaluation of Vemurafenib as Therapy for BRAFV600E Mutated Sarcomas
Int J Mol Sci, 19 (4)
DOI 10.3390/ijms19040969, PubMed 29570692 -
Evaluation of commercial DNA and RNA extraction methods for high-throughput sequencing of FFPE samples
PLoS One, 13 (5), e0197456
DOI 10.1371/journal.pone.0197456, PubMed 29771965 -
Multifocal Primary Prostate Cancer Exhibits High Degree of Genomic Heterogeneity
Eur Urol, 75 (3), 498-505
DOI 10.1016/j.eururo.2018.08.009, PubMed 30181068 -
Noninvasive Detection of ctDNA Reveals Intratumor Heterogeneity and Is Associated with Tumor Burden in Gastrointestinal Stromal Tumor
Mol Cancer Ther, 17 (11), 2473-2480
DOI 10.1158/1535-7163.MCT-18-0174, PubMed 30097488 -
Sample-Index Misassignment Impacts Tumour Exome Sequencing
Sci Rep, 8 (1), 5307
DOI 10.1038/s41598-018-23563-4, PubMed 29593270
Publications 2017
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Multi-omics of 34 colorectal cancer cell lines - a resource for biomedical studies
Mol Cancer, 16 (1), 116
DOI 10.1186/s12943-017-0691-y, PubMed 28683746 -
Corrigendum: Sumoylation of Rap1 mediates the recruitment of TFIID to promote transcription of ribosomal protein genes
Genome Res, 27 (2), 334
DOI 10.1101/gr.218370.116, PubMed 28148563 -
Analysis of the miR-34 family functions in breast cancer reveals annotation error of miR-34b
Sci Rep, 7 (1), 9655
DOI 10.1038/s41598-017-10189-1, PubMed 28848235 -
High number of kinome-mutations in non-small cell lung cancer is associated with reduced immune response and poor relapse-free survival
Int J Cancer, 141 (1), 184-190
DOI 10.1002/ijc.30726, PubMed 28387924 -
Use of liquid biopsies to monitor disease progression in a sarcoma patient: a case report
BMC Cancer, 17 (1), 29
DOI 10.1186/s12885-016-2992-8, PubMed 28061772 -
Monitoring multiple myeloma by quantification of recurrent mutations in serum
Haematologica, 102 (7), 1266-1272
DOI 10.3324/haematol.2016.160564, PubMed 28385781 -
Multilevel genomics of colorectal cancers with microsatellite instability-clinical impact of JAK1 mutations and consensus molecular subtype 1
Genome Med, 9 (1), 46
DOI 10.1186/s13073-017-0434-0, PubMed 28539123
Publications 2016
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Genome Analysis of Osteosarcoma Progression Samples Identifies FGFR1 Overexpression as a Potential Treatment Target and CHM as a Candidate Tumor Suppressor Gene
PLoS One, 11 (9), e0163859
DOI 10.1371/journal.pone.0163859, PubMed 27685995 -
TP53 Mutation Spectrum in Smokers and Never Smoking Lung Cancer Patients
Front Genet, 7, 85
DOI 10.3389/fgene.2016.00085, PubMed 27242894 -
Preclinical evaluation of potential therapeutic targets in dedifferentiated liposarcoma
Oncotarget, 7 (34), 54583-54595
DOI 10.18632/oncotarget.10518, PubMed 27409346 -
Unscrambling the genomic chaos of osteosarcoma reveals extensive transcript fusion, recurrent rearrangements and frequent novel TP53 aberrations
Oncotarget, 7 (5), 5273-88
DOI 10.18632/oncotarget.6567, PubMed 26672768 -
VOLIN and KJON-Two novel hyperdiploid myeloma cell lines
Genes Chromosomes Cancer, 55 (11), 890-901
DOI 10.1002/gcc.22388, PubMed 27311012
Publications 2015
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Sumoylation of Rap1 mediates the recruitment of TFIID to promote transcription of ribosomal protein genes
Genome Res, 25 (6), 897-906
DOI 10.1101/gr.185793.114, PubMed 25800674 -
Identification of novel fusion genes in lung cancer using breakpoint assembly of transcriptome sequencing data
Genome Biol, 16 (1), 7
DOI 10.1186/s13059-014-0558-0, PubMed 25650807 -
Genomic landscape of liposarcoma
Oncotarget, 6 (40), 42429-44
DOI 10.18632/oncotarget.6464, PubMed 26643872 -
Translocational renal cell carcinoma (t(6;11)(p21;q12) with transcription factor EB (TFEB) amplification and an integrated precision approach: a case report
J Med Case Rep, 9, 281
DOI 10.1186/s13256-015-0749-7, PubMed 26654961 -
BRAF V600E mutation in early-stage multiple myeloma: good response to broad acting drugs and no relation to prognosis
Blood Cancer J, 5 (3), e299
DOI 10.1038/bcj.2015.24, PubMed 25794135 -
Metabolic reprogramming of metastatic breast cancer and melanoma by let-7a microRNA
Oncotarget, 6 (4), 2451-65
DOI 10.18632/oncotarget.3235, PubMed 25669981
Publications 2014
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Reexpression of LSAMP inhibits tumor growth in a preclinical osteosarcoma model
Mol Cancer, 13, 93
DOI 10.1186/1476-4598-13-93, PubMed 24885297 -
Performance comparison of four exome capture systems for deep sequencing
BMC Genomics, 15 (1), 449
DOI 10.1186/1471-2164-15-449, PubMed 24912484 -
The architecture and evolution of cancer neochromosomes
Cancer Cell, 26 (5), 653-67
DOI 10.1016/j.ccell.2014.09.010, PubMed 25517748 -
The regulatory landscape of osteogenic differentiation
Stem Cells, 32 (10), 2780-93
DOI 10.1002/stem.1759, PubMed 24898411 -
Generation and characterization of an immortalized human mesenchymal stromal cell line
Stem Cells Dev, 23 (19), 2377-89
DOI 10.1089/scd.2013.0599, PubMed 24857590
Publications 2013
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Genome-wide map of quantified epigenetic changes during in vitro chondrogenic differentiation of primary human mesenchymal stem cells
BMC Genomics, 14, 105
DOI 10.1186/1471-2164-14-105, PubMed 23414147 -
IR/IGF1R signaling as potential target for treatment of high-grade osteosarcoma
BMC Cancer, 13, 245
DOI 10.1186/1471-2407-13-245, PubMed 23688189 -
Functional characterisation of osteosarcoma cell lines and identification of mRNAs and miRNAs associated with aggressive cancer phenotypes
Br J Cancer, 109 (8), 2228-36
DOI 10.1038/bjc.2013.549, PubMed 24064976 -
Common fusion transcripts identified in colorectal cancer cell lines by high-throughput RNA sequencing
Transl Oncol, 6 (5), 546-53
DOI 10.1593/tlo.13457, PubMed 24151535 -
Rapid gene expression changes in peripheral blood lymphocytes upon practice of a comprehensive yoga program
PLoS One, 8 (4), e61910
DOI 10.1371/journal.pone.0061910, PubMed 23613970 -
Deep Sequencing the MicroRNA Transcriptome in Colorectal Cancer
PLoS One, 8 (6), e66165
DOI 10.1371/journal.pone.0066165, PubMed 23824282
Publications 2012
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Human ALKBH4 interacts with proteins associated with transcription
PLoS One, 7 (11), e49045
DOI 10.1371/journal.pone.0049045, PubMed 23145062 -
Cdc28 kinase activity regulates the basal transcription machinery at a subset of genes
Proc Natl Acad Sci U S A, 109 (26), 10450-5
DOI 10.1073/pnas.1200067109, PubMed 22689984 -
Integrative analysis reveals relationships of genetic and epigenetic alterations in osteosarcoma
PLoS One, 7 (11), e48262
DOI 10.1371/journal.pone.0048262, PubMed 23144859 -
Identification of osteosarcoma driver genes by integrative analysis of copy number and gene expression data
Genes Chromosomes Cancer, 51 (7), 696-706
DOI 10.1002/gcc.21956, PubMed 22454324 -
Modulation of the osteosarcoma expression phenotype by microRNAs
PLoS One, 7 (10), e48086
DOI 10.1371/journal.pone.0048086, PubMed 23133552 -
Correlation of TP53 and MDM2 genotypes with response to therapy in sarcoma
Cancer, 119 (5), 1013-22
DOI 10.1002/cncr.27837, PubMed 23165797 -
Epithelial-microbial crosstalk in polymeric Ig receptor deficient mice
Eur J Immunol, 42 (11), 2959-70
DOI 10.1002/eji.201242543, PubMed 22865203 -
[Genome sequencing for personalized cancer treatment]
Tidsskr Nor Laegeforen, 132 (21), 2406-8
DOI 10.4045/tidsskr.12.0784, PubMed 23160594
Publications 2011
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Multiple chromosomal monosomies are characteristic of giant cell ependymoma
Hum Pathol, 42 (12), 2042-6
DOI 10.1016/j.humpath.2011.02.012, PubMed 21683982 -
Genome wide single cell analysis of chemotherapy resistant metastatic cells in a case of gastroesophageal adenocarcinoma
BMC Cancer, 11, 455
DOI 10.1186/1471-2407-11-455, PubMed 22014070 -
Preclinical xenograft models of human sarcoma show nonrandom loss of aberrations
Cancer, 118 (2), 558-70
DOI 10.1002/cncr.26276, PubMed 21713766 -
mRNA expression profiles of primary high-grade central osteosarcoma are preserved in cell lines and xenografts
BMC Med Genomics, 4, 66
DOI 10.1186/1755-8794-4-66, PubMed 21933437 -
Depletion of murine intestinal microbiota: effects on gut mucosa and epithelial gene expression
PLoS One, 6 (3), e17996
DOI 10.1371/journal.pone.0017996, PubMed 21445311 -
Adipocyte differentiation of human bone marrow-derived stromal cells is modulated by microRNA-155, microRNA-221, and microRNA-222
Stem Cells Dev, 21 (6), 873-83
DOI 10.1089/scd.2010.0503, PubMed 21756067
Publications 2010
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Genomic alterations reveal potential for higher grade transformation in follicular lymphoma and confirm parallel evolution of tumor cell clones
Blood, 116 (9), 1489-97
DOI 10.1182/blood-2010-03-272278, PubMed 20505157 -
Identification of target genes for wild type and truncated HMGA2 in mesenchymal stem-like cells
BMC Cancer, 10, 329
DOI 10.1186/1471-2407-10-329, PubMed 20576167 -
DNA copy number changes in human malignant fibrous histiocytomas by array comparative genomic hybridisation
PLoS One, 5 (11), e15378
DOI 10.1371/journal.pone.0015378, PubMed 21085701 -
Evaluation of high-resolution microarray platforms for genomic profiling of bone tumours
BMC Res Notes, 3, 223
DOI 10.1186/1756-0500-3-223, PubMed 20691109 -
Molecular characterization of commonly used cell lines for bone tumor research: a trans-European EuroBoNet effort
Genes Chromosomes Cancer, 49 (1), 40-51
DOI 10.1002/gcc.20717, PubMed 19787792
Publications 2009
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LSAMP, a novel candidate tumor suppressor gene in human osteosarcomas, identified by array comparative genomic hybridization
Genes Chromosomes Cancer, 48 (8), 679-93
DOI 10.1002/gcc.20675, PubMed 19441093 -
Upregulation of stem cell genes in multidrug resistant K562 leukemia cells
Leuk Res, 33 (10), 1379-85
DOI 10.1016/j.leukres.2009.03.028, PubMed 19394083 -
OH-2, a hyperdiploid myeloma cell line without an IGH translocation, has a complex translocation juxtaposing MYC near MAFB and the IGK locus
Leuk Res, 33 (12), 1670-7
DOI 10.1016/j.leukres.2009.03.001, PubMed 19395026
Publications 2008
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DNA copy number changes in high-grade malignant peripheral nerve sheath tumors by array CGH
Mol Cancer, 7, 48
DOI 10.1186/1476-4598-7-48, PubMed 18522746 -
Early-onset lymphoma and extensive embryonic apoptosis in two domain-specific Fen1 mice mutants
Cancer Res, 68 (12), 4571-9
DOI 10.1158/0008-5472.CAN-08-0168, PubMed 18559501 -
Array-CGH fine mapping of minor and cryptic HR-CGH detected genomic imbalances in 80 out of 590 patients with abnormal development
Eur J Hum Genet, 16 (11), 1318-28
DOI 10.1038/ejhg.2008.78, PubMed 18461090 -
GeneCount: genome-wide calculation of absolute tumor DNA copy numbers from array comparative genomic hybridization data
Genome Biol, 9 (5), R86
DOI 10.1186/gb-2008-9-5-r86, PubMed 18500990 -
High-resolution analysis of genetic stability of human adipose tissue stem cells cultured to senescence
J Cell Mol Med, 12 (2), 553-63
DOI 10.1111/j.1582-4934.2007.00146.x, PubMed 18419597 -
Chromosomal aberrations in head and neck squamous cell carcinomas in Norwegian and Sudanese populations by array comparative genomic hybridization
Oncol Rep, 20 (4), 825-43
DOI 10.3892/or_00000080, PubMed 18813824
Publications 2007
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Lymphomas can develop from B cells chronically helped by idiotype-specific T cells
J Exp Med, 204 (5), 1181-91
DOI 10.1084/jem.20061220, PubMed 17485509
Publications 2006
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Array comparative genomic hybridization reveals distinct DNA copy number differences between gastrointestinal stromal tumors and leiomyosarcomas
Cancer Res, 66 (18), 8984-93
DOI 10.1158/0008-5472.CAN-06-1972, PubMed 16982739 -
DNA damage responses in cell cycle G2 phase and mitosis--tracking and targeting
Anticancer Res, 26 (3A), 1909-16
PubMed 16827124 -
Gain of chromosome 6p is an infrequent cause of increased PIM1 expression in B-cell non-Hodgkin's lymphomas
Leukemia, 20 (3), 539-42
DOI 10.1038/sj.leu.2404094, PubMed 16437153
Publications 2005
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Translocation t(14;18) and gain of chromosome 18/BCL2: effects on BCL2 expression and apoptosis in B-cell non-Hodgkin's lymphomas
Leukemia, 19 (12), 2313-23
DOI 10.1038/sj.leu.2403954, PubMed 16193090 -
Mapping and characterization of the amplicon near APOA2 in 1q23 in human sarcomas by FISH and array CGH
Mol Cancer, 4, 39
DOI 10.1186/1476-4598-4-39, PubMed 16274472
Publications 2004
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Lessons from genetic profiling in soft tissue sarcomas
Acta Orthop Scand Suppl, 75 (311), 35-50
DOI 10.1080/00016470410001708310, PubMed 15188664 -
Amplification of chromosome 1 sequences in lipomatous tumors and other sarcomas
Int J Cancer, 109 (3), 363-9
DOI 10.1002/ijc.11716, PubMed 14961574 -
M-CGH: analysing microarray-based CGH experiments
BMC Bioinformatics, 5, 74
DOI 10.1186/1471-2105-5-74, PubMed 15189572
Publications 2002
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Positional cloning identifies a novel cyclophilin as a candidate amplified oncogene in 1q21
Oncogene, 21 (14), 2261-9
DOI 10.1038/sj.onc.1205339, PubMed 11948409 -
Analyses of single-copy Arabidopsis T-DNA-transformed lines show that the presence of vector backbone sequences, short inverted repeats and DNA methylation is not sufficient or necessary for the induction of transgene silencing
Nucleic Acids Res, 30 (20), 4556-66
DOI 10.1093/nar/gkf568, PubMed 12384603
Publications 2001
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A well-differentiated liposarcoma with a new type of chromosome 12-derived markers
Cancer Genet Cytogenet, 131 (1), 13-8
DOI 10.1016/s0165-4608(01)00516-7, PubMed 11734312 -
Amplification and overexpression of PRUNE in human sarcomas and breast carcinomas-a possible mechanism for altering the nm23-H1 activity
Oncogene, 20 (47), 6881-90
DOI 10.1038/sj.onc.1204874, PubMed 11687967 -
Dedifferentiation of a well-differentiated liposarcoma to a highly malignant metastatic osteosarcoma: amplification of 12q14 at all stages and gain of 1q22-q24 associated with metastases
Cancer Genet Cytogenet, 125 (2), 100-11
DOI 10.1016/s0165-4608(00)00369-1, PubMed 11369052 -
Ectopic sequences from truncated HMGIC in liposarcomas are derived from various amplified chromosomal regions
Genes Chromosomes Cancer, 31 (3), 264-73
DOI 10.1002/gcc.1143, PubMed 11391797
Publications 1999
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Expression of a novel factor in human breast cancer cells with metastatic potential
Cancer Res, 59 (18), 4675-80
PubMed 10493524
Publications 1998
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Molecular characterization of a novel amplicon at 1q21-q22 frequently observed in human sarcomas
Br J Cancer, 78 (4), 495-503
DOI 10.1038/bjc.1998.521, PubMed 9716033
Publications 1997
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HMGIC, the gene for an architectural transcription factor, is amplified and rearranged in a subset of human sarcomas
Oncogene, 14 (24), 2935-41
DOI 10.1038/sj.onc.1201135, PubMed 9205100