Lars Eide
- Professor, Group leader; PhD
- +47 23 07 10 62 / 932 41 242
Publications 2024
Global metabolomic profiling of tumor tissue and paired serum samples to identify biomarkers for response to neoadjuvant FOLFIRINOX treatment of human pancreatic cancer
Mol Oncol (in press)
DOI 10.1002/1878-0261.13759, PubMed 39545923
The Effects of the Coating and Aging of Biodegradable Polylactic Acid Membranes on In Vitro Primary Human Retinal Pigment Epithelium Cells
Biomedicines, 12 (5)
DOI 10.3390/biomedicines12050966, PubMed 38790928
Biallelic NDUFA4 Deletion Causes Mitochondrial Complex IV Deficiency in a Patient with Leigh Syndrome
Genes (Basel), 15 (4)
DOI 10.3390/genes15040500, PubMed 38674434
Publications 2023
Retinal Pigment Epithelium Cell Development: Extrapolating Basic Biology to Stem Cell Research
Biomedicines, 11 (2)
DOI 10.3390/biomedicines11020310, PubMed 36830851
Progress in Stem Cells-Based Replacement Therapy for Retinal Pigment Epithelium: In Vitro Differentiation to In Vivo Delivery
Stem Cells Transl Med, 12 (8), 536-552
DOI 10.1093/stcltm/szad039, PubMed 37459045
A loss-of-function mutation in human Oxidation Resistance 1 disrupts the spatial-temporal regulation of histone arginine methylation in neurodevelopment
Genome Biol, 24 (1), 216
DOI 10.1186/s13059-023-03037-1, PubMed 37773136
Fasting and non-fasting plasma levels of monomethyl branched chain fatty acids: Implications for maple syrup urine disease
JIMD Rep, 64 (5), 360-366
DOI 10.1002/jmd2.12380, PubMed 37701324
Publications 2021
NEIL1 and NEIL2 DNA glycosylases modulate anxiety and learning in a cooperative manner in mice
Commun Biol, 4 (1), 1354
DOI 10.1038/s42003-021-02864-x, PubMed 34857879
The small molecule SERCA activator CDN1163 increases energy metabolism in human skeletal muscle cells
Curr Res Pharmacol Drug Discov, 2, 100060
DOI 10.1016/j.crphar.2021.100060, PubMed 34909682
Correction: Mitochondrial DNA Repair through OGG1 Activity Attenuates Breast Cancer Progression and Metastasis
Cancer Res, 81 (11), 3144
DOI 10.1158/0008-5472.CAN-21-1000, PubMed 34087783
Publications 2020
OXR1A, a Coactivator of PRMT5 Regulating Histone Arginine Methylation
Cell Rep, 30 (12), 4165-4178.e7
DOI 10.1016/j.celrep.2020.02.063, PubMed 32209476
Publications 2019
Deterioration of mitochondrial bioenergetics and ultrastructure impairment in skeletal muscle of a transgenic minipig model in the early stages of Huntington's disease
Dis Model Mech, 12 (7)
DOI 10.1242/dmm.038737, PubMed 31278192
Age-Related Oxidative Changes in Primary Porcine Fibroblasts Expressing Mutated Huntingtin
Neurodegener Dis, 19 (1), 22-34
DOI 10.1159/000500091, PubMed 31167196
Publications 2018
Increased nuclear DNA damage precedes mitochondrial dysfunction in peripheral blood mononuclear cells from Huntington's disease patients
Sci Rep, 8 (1), 9817
DOI 10.1038/s41598-018-27985-y, PubMed 29959348
A transgenic minipig model of Huntington's disease shows early signs of behavioral and molecular pathologies
Dis Model Mech, 11 (10)
DOI 10.1242/dmm.035949, PubMed 30254085
Markers of Mitochondrial Metabolism in Tumor Hypoxia, Systemic Inflammation, and Adverse Outcome of Rectal Cancer
Transl Oncol, 12 (1), 76-83
DOI 10.1016/j.tranon.2018.09.010, PubMed 30273860
Publications 2017
Optimization of Storage Temperature for Retention of Undifferentiated Cell Character of Cultured Human Epidermal Cell Sheets
Sci Rep, 7 (1), 8206
DOI 10.1038/s41598-017-08586-7, PubMed 28811665
Constitutive MAP-kinase activation suppresses germline apoptosis in NTH-1 DNA glycosylase deficient C. elegans
DNA Repair (Amst), 61, 46-55
DOI 10.1016/j.dnarep.2017.11.009, PubMed 29202295
Metabolic reprogramming is associated with flavopiridol resistance in prostate cancer DU145 cells
Sci Rep, 7 (1), 5081
DOI 10.1038/s41598-017-05086-6, PubMed 28698547
Correction: MtDNA depleted PC3 cells exhibit Warburg effect and cancer stem cell features
Oncotarget, 8 (4), 7208-7213
DOI 10.18632/oncotarget.14800, PubMed 28179591
Metabolism and DNA repair shape a specific modification pattern in mitochondrial DNA
Mitochondrion, 40, 16-28
DOI 10.1016/j.mito.2017.09.002, PubMed 28893634
8-oxoguanine DNA glycosylase (Ogg1) controls hepatic gluconeogenesis
DNA Repair (Amst), 61, 56-62
DOI 10.1016/j.dnarep.2017.11.008, PubMed 29207315
Publications 2016
Blood removal therapy in hereditary hemochromatosis induces a stress response resulting in improved genome integrity
Transfusion, 56 (6), 1435-41
DOI 10.1111/trf.13588, PubMed 27045387
Anti-proliferative Properties of miR-20b and miR-363 from the miR-106a-363 Cluster on Human Carcinoma Cells
Microrna, 5 (1), 19-35
DOI 10.2174/2211536605666160322151813, PubMed 27001184
MtDNA depleted PC3 cells exhibit Warburg effect and cancer stem cell features
Oncotarget, 7 (26), 40297-40313
DOI 10.18632/oncotarget.9610, PubMed 27248169
Pitfalls in mitochondrial epigenetics
Mitochondrial DNA A DNA Mapp Seq Anal, 28 (5), 762-768
DOI 10.1080/24701394.2016.1180514, PubMed 27246961
Enhanced base excision repair capacity in carotid atherosclerosis may protect nuclear DNA but not mitochondrial DNA
Free Radic Biol Med, 97, 386-397
DOI 10.1016/j.freeradbiomed.2016.07.001, PubMed 27381496
Neil3-dependent base excision repair regulates lipid metabolism and prevents atherosclerosis in Apoe-deficient mice
Sci Rep, 6, 28337
DOI 10.1038/srep28337, PubMed 27328939
Short-Term Differentiation of Glioblastoma Stem Cells Induces Hypoxia Tolerance
Neurochem Res, 41 (7), 1545-58
DOI 10.1007/s11064-016-1868-2, PubMed 26915110
Palmitate promotes inflammatory responses and cellular senescence in cardiac fibroblasts
Biochim Biophys Acta Mol Cell Biol Lipids, 1862 (2), 234-245
DOI 10.1016/j.bbalip.2016.11.003, PubMed 27845246
Quantification of DNA Damage by Real-Time qPCR
Methods Mol Biol, 1351, 27-32
DOI 10.1007/978-1-4939-3040-1_3, PubMed 26530672
Publications 2015
Synergistic Actions of Ogg1 and Mutyh DNA Glycosylases Modulate Anxiety-like Behavior in Mice
Cell Rep, 13 (12), 2671-8
DOI 10.1016/j.celrep.2015.12.001, PubMed 26711335
Impaired dynamics and function of mitochondria caused by mtDNA toxicity leads to heart failure
Am J Physiol Heart Circ Physiol, 309 (3), H434-49
DOI 10.1152/ajpheart.00253.2014, PubMed 26055793
Analysis of mitochondrial DNA and RNA integrity by a real-time qPCR-based method
Methods Mol Biol, 1264, 97-106
DOI 10.1007/978-1-4939-2257-4_10, PubMed 25631007
Transcriptome analysis of human OXR1 depleted cells reveals its role in regulating the p53 signaling pathway
Sci Rep, 5, 17409
DOI 10.1038/srep17409, PubMed 26616534
Mitochondrial DNA Repair through OGG1 Activity Attenuates Breast Cancer Progression and Metastasis
Cancer Res, 76 (1), 30-4
DOI 10.1158/0008-5472.CAN-15-0692, PubMed 26586787
Publications 2014
Mitochondrial DNA damage and repair during ischemia-reperfusion injury of the heart
J Mol Cell Cardiol, 78, 9-22
DOI 10.1016/j.yjmcc.2014.11.010, PubMed 25446179
Serum albumin and HCO3- regulate separate pools of ATP in human spermatozoa
Hum Reprod, 29 (5), 918-30
DOI 10.1093/humrep/deu028, PubMed 24578478
The distribution of DNA damage is defined by region-specific susceptibility to DNA damage formation rather than repair differences
DNA Repair (Amst), 18, 44-51
DOI 10.1016/j.dnarep.2014.03.003, PubMed 24685126
Genome instability in Maple Syrup Urine Disease correlates with impaired mitochondrial biogenesis
Metabolism, 63 (8), 1063-70
DOI 10.1016/j.metabol.2014.05.003, PubMed 24928662
Addressing RNA integrity to determine the impact of mitochondrial DNA mutations on brain mitochondrial function with age
PLoS One, 9 (5), e96940
DOI 10.1371/journal.pone.0096940, PubMed 24819950
Human OXR1 maintains mitochondrial DNA integrity and counteracts hydrogen peroxide-induced oxidative stress by regulating antioxidant pathways involving p21
Free Radic Biol Med, 77, 41-8
DOI 10.1016/j.freeradbiomed.2014.09.003, PubMed 25236744
Publications 2013
Mitochondrial DNA integrity changes with age but does not correlate with learning performance in honey bees
Exp Gerontol, 49, 12-8
DOI 10.1016/j.exger.2013.10.013, PubMed 24211425
Accelerated clinical course of prion disease in mice compromised in repair of oxidative DNA damage
Free Radic Biol Med, 68, 1-7
DOI 10.1016/j.freeradbiomed.2013.11.013, PubMed 24296244
Alteration of mitochondrial function and insulin sensitivity in primary mouse skeletal muscle cells isolated from transgenic and knockout mice: role of ogg1
Endocrinology, 154 (8), 2640-9
DOI 10.1210/en.2013-1076, PubMed 23748360
Publications 2011
Lack of the DNA glycosylases MYH and OGG1 in the cancer prone double mutant mouse does not increase mitochondrial DNA mutagenesis
DNA Repair (Amst), 11 (3), 278-85
DOI 10.1016/j.dnarep.2011.12.001, PubMed 22209780
Exogenous pyruvate accelerates glycolysis and promotes capacitation in human spermatozoa
Hum Reprod, 26 (12), 3249-63
DOI 10.1093/humrep/der317, PubMed 21946930
Human cytomegalovirus infection increases mitochondrial biogenesis
Mitochondrion, 11 (6), 935-45
DOI 10.1016/j.mito.2011.08.008, PubMed 21907833
Mitochondrial DNA damage level determines neural stem cell differentiation fate
J Neurosci, 31 (26), 9746-51
DOI 10.1523/JNEUROSCI.0852-11.2011, PubMed 21715639
Publications 2010
Four novel mutations identified in Norwegian patients result in intermittent maple syrup urine disease when combined with the R301C mutation
Mol Genet Metab, 100 (4), 324-32
DOI 10.1016/j.ymgme.2010.04.017, PubMed 20570198
Mitochondrial DNA toxicity in forebrain neurons causes apoptosis, neurodegeneration, and impaired behavior
Mol Cell Biol, 30 (6), 1357-67
DOI 10.1128/MCB.01149-09, PubMed 20065039
Mitochondrial DNA integrity is essential for mitochondrial maturation during differentiation of neural stem cells
Stem Cells, 28 (12), 2195-204
DOI 10.1002/stem.542, PubMed 20954243
Publications 2009
Accumulation of mitochondrial DNA damage and bioenergetic dysfunction in CSB defective cells
FEBS J, 276 (10), 2811-21
DOI 10.1111/j.1742-4658.2009.07004.x, PubMed 19389114
Accumulation of 8-oxoguanine in liver DNA during hyperoxic resuscitation of newborn mice
Pediatr Res, 66 (5), 533-8
DOI 10.1203/PDR.0b013e3181ba1a42, PubMed 19668103
Up-regulation of myocardial DNA base excision repair activities in experimental heart failure
Mutat Res, 666 (1-2), 32-8
DOI 10.1016/j.mrfmmm.2009.03.008, PubMed 19481677
Publications 2007
Mutations in the RAD27 and SGS1 genes differentially affect the chronological and replicative lifespan of yeast cells growing on glucose and glycerol
FEMS Yeast Res, 7 (6), 848-59
DOI 10.1111/j.1567-1364.2007.00248.x, PubMed 17506834
Publications 2005
Culture of adult mouse neurons
Biotechniques, 38 (1), 99-104
DOI 10.2144/05381RR02, PubMed 15679091
Publications 2004
Mutant huntingtin impairs axonal trafficking in mammalian neurons in vivo and in vitro
Mol Cell Biol, 24 (18), 8195-209
DOI 10.1128/MCB.24.18.8195-8209.2004, PubMed 15340079
Base J, found in nuclear DNA of Trypanosoma brucei, is not a target for DNA glycosylases
DNA Repair (Amst), 3 (2), 145-54
DOI 10.1016/j.dnarep.2003.10.009, PubMed 14706348
Publications 2003
Incision at hypoxanthine residues in DNA by a mammalian homologue of the Escherichia coli antimutator enzyme endonuclease V
Nucleic Acids Res, 31 (14), 3893-900
DOI 10.1093/nar/gkg472, PubMed 12853604
Reversible inactivation of E. coli endonuclease III via modification of its [4Fe-4S] cluster by nitric oxide
DNA Repair (Amst), 2 (7), 809-17
DOI 10.1016/s1568-7864(03)00065-x, PubMed 12826281
Publications 2001
Repair of 8-oxodeoxyguanosine lesions in mitochondrial dna depends on the oxoguanine dna glycosylase (OGG1) gene and 8-oxoguanine accumulates in the mitochondrial dna of OGG1-defective mice
Cancer Res, 61 (14), 5378-81
PubMed 11454679
Overexpression of endonuclease III protects Escherichia coli mutants defective in alkylation repair against lethal effects of methylmethanesulphonate
FEBS Lett, 491 (1-2), 59-62
DOI 10.1016/s0014-5793(01)02156-1, PubMed 11226419
Human endonuclease III acts preferentially on DNA damage opposite guanine residues in DNA
Biochemistry, 40 (22), 6653-9
DOI 10.1021/bi0028901, PubMed 11380260
Publications 2000
Base removers and strand scissors: different strategies employed in base excision and strand incision at modified base residues in DNA
Cold Spring Harb Symp Quant Biol, 65, 135-42
DOI 10.1101/sqb.2000.65.135, PubMed 12760028
Publications 1999
The Saccharomyces cerevisiae homologues of endonuclease III from Escherichia coli, Ntg1 and Ntg2, are both required for efficient repair of spontaneous and induced oxidative DNA damage in yeast
Mol Cell Biol, 19 (5), 3779-87
DOI 10.1128/MCB.19.5.3779, PubMed 10207101
Genes and enzymes for the removal of oxidative DNA base damage
ALFRED BENZON SYMP S, 44, 272-283
Publications 1996
Base excision of DNA damage by DNA glycosylases containing the helix-hairpin-helix domain
Biotechnology Centre of Oslo, University of Oslo, Oslo, 1 b. (flere pag.)
BIBSYS 971092192, ISBN 82-90934-51-3
Base excision of oxidative purine and pyrimidine DNA damage in Saccharomyces cerevisiae by a DNA glycosylase with sequence similarity to endonuclease III from Escherichia coli
Proc Natl Acad Sci U S A, 93 (20), 10735-40
DOI 10.1073/pnas.93.20.10735, PubMed 8855249
Publications 1995
Oxidation of thymine to 5-formyluracil in DNA: mechanisms of formation, structural implications, and base excision by human cell free extracts
Biochemistry, 34 (45), 14758-64
DOI 10.1021/bi00045a017, PubMed 7578084
The base excision repair pathway
Trends Biochem Sci, 20 (10), 391-7
DOI 10.1016/s0968-0004(00)89086-6, PubMed 8533150
Publications 1992
Cloning and expression of a rat brain L-glutamate transporter
Nature, 360 (6403), 464-7
DOI 10.1038/360464a0, PubMed 1448170