Publications
Publications published since 2003 from OUS - Unit for Cell Signalling (Krauss)
92 publications found
Publications 2024
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Acoustic Wave-Induced Stroboscopic Optical Mechanotyping of Adherent Cells
Adv Sci (Weinh), 11 (16), e2307929
DOI 10.1002/advs.202307929, PubMed 38417124 -
Development of a Smart Wireless Multisensor Platform for an Optogenetic Brain Implant
Sensors (Basel), 24 (2)
DOI 10.3390/s24020575, PubMed 38257668 -
Cell identity dynamics and insight into insulin secretagogues when employing stem cell-derived islets for disease modeling
Front Bioeng Biotechnol, 12, 1392575
DOI 10.3389/fbioe.2024.1392575, PubMed 38933536 -
Glucose Concentration in Regulating Induced Pluripotent Stem Cells Differentiation Toward Insulin-Producing Cells
Transpl Int, 37, 11900
DOI 10.3389/ti.2024.11900, PubMed 38304198 -
The effects of TGF-β-induced activation and starvation of vitamin A and palmitic acid on human stem cell-derived hepatic stellate cells
Stem Cell Res Ther, 15 (1), 223
DOI 10.1186/s13287-024-03852-8, PubMed 39044210
Publications 2023
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Adipose-Derived Stromal Cells Preserve Pancreatic Islet Function in a Transplantable 3D Bioprinted Scaffold
Adv Healthc Mater, 12 (32), e2300640
DOI 10.1002/adhm.202300640, PubMed 37781993 -
Pump-less, recirculating organ-on-a-chip (rOoC) platform
Lab Chip, 23 (4), 591-608
DOI 10.1039/d2lc00919f, PubMed 36655405 -
Characterization of Mechanical and Cellular Effects of Rhythmic Vertical Vibrations on Adherent Cell Cultures
Bioengineering (Basel), 10 (7)
DOI 10.3390/bioengineering10070811, PubMed 37508838 -
Mass spectrometry reveals that oxysterols are secreted from non-alcoholic fatty liver disease induced organoids
J Steroid Biochem Mol Biol, 232, 106355
DOI 10.1016/j.jsbmb.2023.106355, PubMed 37380087 -
Quantitative chemometric phenotyping of three-dimensional liver organoids by Raman spectral imaging
Cell Rep Methods, 3 (4), 100440
DOI 10.1016/j.crmeth.2023.100440, PubMed 37159662 -
Simultaneous LC-MS determination of glucose regulatory peptides secreted by stem cell-derived islet organoids
Electrophoresis, 44 (21-22), 1682-1697
DOI 10.1002/elps.202300095, PubMed 37574258 -
A Mouse Model for the Rapid and Binomial Assessment of Putative WNT/β-Catenin Signalling Inhibitors
Biomedicines, 11 (10)
DOI 10.3390/biomedicines11102719, PubMed 37893093 -
Characterization of human stem cell-derived hepatic stellate cells and liver sinusoidal endothelial cells during extended in vitro culture
Front Bioeng Biotechnol, 11, 1223737
DOI 10.3389/fbioe.2023.1223737, PubMed 37560536
Publications 2022
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The Tankyrase Inhibitor OM-153 Demonstrates Antitumor Efficacy and a Therapeutic Window in Mouse Models
Cancer Res Commun, 2 (4), 233-245
DOI 10.1158/2767-9764.CRC-22-0027, PubMed 36873622 -
Academic User View: Organ-on-a-Chip Technology
Biosensors (Basel), 12 (2)
DOI 10.3390/bios12020126, PubMed 35200386 -
"Organ-in-a-Column" Coupled On-line with Liquid Chromatography-Mass Spectrometry
Anal Chem, 94 (50), 17677-17684
DOI 10.1021/acs.analchem.2c04530, PubMed 36484723 -
A trio of biological rhythms and their relevance in rhythmic mechanical stimulation of cell cultures
Front Psychol, 13, 867191
DOI 10.3389/fpsyg.2022.867191, PubMed 35967633 -
Globally Accessible Distributed Data Sharing (GADDS): a decentralized FAIR platform to facilitate data sharing in the life sciences
Bioinformatics, 38 (15), 3812-3817
DOI 10.1093/bioinformatics/btac362, PubMed 35639939
Publications 2021
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Thermoplastic Elastomer (TPE)-Poly(Methyl Methacrylate) (PMMA) Hybrid Devices for Active Pumping PDMS-Free Organ-on-a-Chip Systems
Biosensors (Basel), 11 (5)
DOI 10.3390/bios11050162, PubMed 34069506 -
Development of a 1,2,4-Triazole-Based Lead Tankyrase Inhibitor: Part II
J Med Chem, 64 (24), 17936-17949
DOI 10.1021/acs.jmedchem.1c01264, PubMed 34878777 -
Identification of response signatures for tankyrase inhibitor treatment in tumor cell lines
iScience, 24 (7), 102807
DOI 10.1016/j.isci.2021.102807, PubMed 34337362 -
The Adenoviral E1B-55k Protein Present in HEK293 Cells Mediates Abnormal Accumulation of Key WNT Signaling Proteins in Large Cytoplasmic Aggregates
Genes (Basel), 12 (12)
DOI 10.3390/genes12121920, PubMed 34946869 -
Electromembrane Extraction and Mass Spectrometry for Liver Organoid Drug Metabolism Studies
Anal Chem, 93 (7), 3576-3585
DOI 10.1021/acs.analchem.0c05082, PubMed 33534551
Publications 2020
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Pancreas-on-a-Chip Technology for Transplantation Applications
Curr Diab Rep, 20 (12), 72
DOI 10.1007/s11892-020-01357-1, PubMed 33206261 -
A Small-Molecule Tankyrase Inhibitor Reduces Glioma Stem Cell Proliferation and Sphere Formation
Cancers (Basel), 12 (6)
DOI 10.3390/cancers12061630, PubMed 32575464 -
Correction: Towards dual inhibitors of the MET kinase and WNT signaling pathway; design, synthesis and biological evaluation
RSC Adv, 10 (9), 4927
DOI 10.1039/d0ra90007a, PubMed 35503286 -
Sjögren syndrome/scleroderma autoantigen 1 is a direct Tankyrase binding partner in cancer cells
Commun Biol, 3 (1), 123
DOI 10.1038/s42003-020-0851-2, PubMed 32170109 -
Tankyrase inhibition ameliorates lipid disorder via suppression of PGC-1α PARylation in db/db mice
Int J Obes (Lond), 44 (8), 1691-1702
DOI 10.1038/s41366-020-0573-z, PubMed 32317752 -
Preclinical Lead Optimization of a 1,2,4-Triazole Based Tankyrase Inhibitor
J Med Chem, 63 (13), 6834-6846
DOI 10.1021/acs.jmedchem.0c00208, PubMed 32511917 -
Tankyrase inhibition sensitizes melanoma to PD-1 immune checkpoint blockade in syngeneic mouse models
Commun Biol, 3 (1), 196
DOI 10.1038/s42003-020-0916-2, PubMed 32332858
Publications 2019
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EU-OPENSCREEN: A Novel Collaborative Approach to Facilitate Chemical Biology
SLAS Discov, 24 (3), 398-413
DOI 10.1177/2472555218816276, PubMed 30616481 -
3D cell culture models and organ-on-a-chip: Meet separation science and mass spectrometry
Electrophoresis, 41 (1-2), 56-64
DOI 10.1002/elps.201900170, PubMed 31544246 -
MEK Inhibition Induces Canonical WNT Signaling through YAP in KRAS Mutated HCT-15 Cells, and a Cancer Preventive FOXO3/FOXM1 Ratio in Combination with TNKS Inhibition
Cancers (Basel), 11 (2)
DOI 10.3390/cancers11020164, PubMed 30717152
Publications 2018
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The tankyrase inhibitor G007-LK inhibits small intestine LGR5+ stem cell proliferation without altering tissue morphology
Biol Res, 51 (1), 3
DOI 10.1186/s40659-017-0151-6, PubMed 29316982 -
Ultracentrifugation versus kit exosome isolation: nanoLC-MS and other tools reveal similar performance biomarkers, but also contaminations
Future Sci OA, 5 (1), FSO359
DOI 10.4155/fsoa-2018-0088, PubMed 30652024
Publications 2017
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Discovery of a Novel Series of Tankyrase Inhibitors by a Hybridization Approach
J Med Chem, 60 (24), 10013-10025
DOI 10.1021/acs.jmedchem.7b00883, PubMed 29155568 -
5-FU resistant EMT-like pancreatic cancer cells are hypersensitive to photochemical internalization of the novel endoglin-targeting immunotoxin CD105-saporin
J Exp Clin Cancer Res, 36 (1), 187
DOI 10.1186/s13046-017-0662-6, PubMed 29258566 -
Combining HIC, SEC, and IEX with Fluorescence Polarization for Drug Target Discovery
LC GC Eur., 30 (5), 232-239
Publications 2016
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Mass spectrometric detection of 27-hydroxycholesterol in breast cancer exosomes
J Steroid Biochem Mol Biol, 169, 22-28
DOI 10.1016/j.jsbmb.2016.02.006, PubMed 26877254 -
Versatile, sensitive liquid chromatography mass spectrometry - Implementation of 10 μm OT columns suitable for small molecules, peptides and proteins
Sci Rep, 6, 37507
DOI 10.1038/srep37507, PubMed 27897190 -
Comparison of commercial nanoliquid chromatography columns for fast, targeted mass spectrometry-based proteomics
Future Sci OA, 2 (2), FSO119
DOI 10.4155/fsoa-2016-0014, PubMed 28031966
Publications 2015
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Development and structural analysis of adenosine site binding tankyrase inhibitors
Bioorg Med Chem Lett, 26 (2), 328-333
DOI 10.1016/j.bmcl.2015.12.018, PubMed 26706174 -
Meis2 is essential for cranial and cardiac neural crest development
BMC Dev Biol, 15, 40
DOI 10.1186/s12861-015-0093-6, PubMed 26545946 -
Structure, Dynamics, and Functionality of Tankyrase Inhibitor-Induced Degradasomes
Mol Cancer Res, 13 (11), 1487-501
DOI 10.1158/1541-7786.MCR-15-0125, PubMed 26124443 -
The PARsylation activity of tankyrase in adipose tissue modulates systemic glucose metabolism in mice
Diabetologia, 59 (3), 582-91
DOI 10.1007/s00125-015-3815-1, PubMed 26631215
Publications 2014
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Tankyrases: structure, function and therapeutic implications in cancer
Curr Pharm Des, 20 (41), 6472-88
DOI 10.2174/1381612820666140630101525, PubMed 24975604 -
Open tubular lab-on-column/mass spectrometry for targeted proteomics of nanogram sample amounts
PLoS One, 9 (9), e106881
DOI 10.1371/journal.pone.0106881, PubMed 25222838 -
The novel EpCAM-targeting monoclonal antibody 3-17I linked to saporin is highly cytotoxic after photochemical internalization in breast, pancreas and colon cancer cell lines
MAbs, 6 (4), 1038-50
DOI 10.4161/mabs.28207, PubMed 24525727 -
Implications of targeted genomic disruption of β-catenin in BxPC-3 pancreatic adenocarcinoma cells
PLoS One, 9 (12), e115496
DOI 10.1371/journal.pone.0115496, PubMed 25536063 -
Highly automated nano-LC/MS-based approach for thousand cell-scale quantification of side chain-hydroxylated oxysterols
J Lipid Res, 55 (7), 1531-6
DOI 10.1194/jlr.D048801, PubMed 24792927 -
Metabolites in vertebrate Hedgehog signaling
Biochem Biophys Res Commun, 446 (3), 669-74
DOI 10.1016/j.bbrc.2014.01.087, PubMed 24486313
Publications 2013
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A novel tankyrase small-molecule inhibitor suppresses APC mutation-driven colorectal tumor growth
Cancer Res, 73 (10), 3132-44
DOI 10.1158/0008-5472.CAN-12-4562, PubMed 23539443 -
Tankyrases as drug targets
FEBS J, 280 (15), 3576-93
DOI 10.1111/febs.12320, PubMed 23648170 -
Trans fat can be a hidden health risk
Tidsskr Nor Laegeforen, 133 (17), 1844-7
DOI 10.4045/tidsskr.12.1395, PubMed 24042300 -
Luciferase assay to study the activity of a cloned promoter DNA fragment
Methods Mol Biol, 977, 65-78
DOI 10.1007/978-1-62703-284-1_6, PubMed 23436354 -
The tankyrase-specific inhibitor JW74 affects cell cycle progression and induces apoptosis and differentiation in osteosarcoma cell lines
Cancer Med, 3 (1), 36-46
DOI 10.1002/cam4.170, PubMed 24403055 -
Structural basis and SAR for G007-LK, a lead stage 1,2,4-triazole based specific tankyrase 1/2 inhibitor
J Med Chem, 56 (7), 3012-23
DOI 10.1021/jm4000566, PubMed 23473363 -
Wnt/beta-catenin signaling and small molecule inhibitors
Curr Pharm Des, 19 (4), 634-64
DOI 10.2174/138161213804581837, PubMed 23016862
Publications 2012
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Recent Advances in Wnt/beta-Catenin Pathway Small-Molecule Inhibitors
Annu. Rep. Med. Chem., 47, 393-409
DOI 10.1016/B978-0-12-396492-2.00026-6 -
High sensitivity measurements of active oxysterols with automated filtration/filter backflush-solid phase extraction-liquid chromatography-mass spectrometry
J Chromatogr A, 1255, 291-7
DOI 10.1016/j.chroma.2012.02.002, PubMed 22410154 -
Mouse Tcf3 represses canonical Wnt signaling by either competing for β-catenin binding or through occupation of DNA-binding sites
Mol Cell Biochem, 365 (1-2), 53-63
DOI 10.1007/s11010-012-1243-9, PubMed 22270545 -
A novel tankyrase inhibitor decreases canonical Wnt signaling in colon carcinoma cells and reduces tumor growth in conditional APC mutant mice
Cancer Res, 72 (11), 2822-32
DOI 10.1158/0008-5472.CAN-11-3336, PubMed 22440753
Publications 2011
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In vitro differentiation of mouse embryonic stem cells into neurons of the dorsal forebrain
Cell Mol Neurobiol, 31 (5), 715-27
DOI 10.1007/s10571-011-9669-2, PubMed 21424551 -
Characterization and functional analysis of the 5'-flanking promoter region of the mouse Tcf3 gene
Mol Cell Biochem, 360 (1-2), 289-99
DOI 10.1007/s11010-011-1068-y, PubMed 21935611 -
Novel synthetic antagonists of canonical Wnt signaling inhibit colorectal cancer cell growth
Cancer Res, 71 (1), 197-205
DOI 10.1158/0008-5472.CAN-10-1282, PubMed 21199802
Publications 2010
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A Distinct Slow-Cycling Cancer Stem-like Subpopulation of Pancreatic Adenocarcinoma Cells is maintained in Vivo
Cancers (Basel), 2 (4), 2011-25
DOI 10.3390/cancers2042011, PubMed 24281215 -
A Distinct Slow-Cycling Cancer Stem-like Subpopulation of Pancreatic Adenocarcinoma Cells is maintained in Vivo
Cancers, 2 (4), 2011-2025
DOI 10.3390/cancers2042011, PublikaID 116 -
Analysis of illegitimate genomic integration mediated by zinc-finger nucleases: implications for specificity of targeted gene correction
BMC Mol Biol, 11, 35
DOI 10.1186/1471-2199-11-35, PubMed 20459736 -
Hedgehog antagonists cyclopamine and dihydroveratramine can be mistaken for each other in Veratrum album
J Pharm Biomed Anal, 53 (3), 497-502
DOI 10.1016/j.jpba.2010.05.024, PubMed 20646889 -
Hedgehog antagonist cyclopamine isomerizes to less potent forms when acidified
J Pharm Biomed Anal, 52 (5), 707-13
DOI 10.1016/j.jpba.2010.02.017, PubMed 20236786
Publications 2009
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Characterization and functional analysis of a slow cycling stem cell-like subpopulation in pancreas adenocarcinoma
Clin Exp Metastasis, 26 (7), 611-23
DOI 10.1007/s10585-009-9260-0, PubMed 19421880 -
Inhibition of canonical Wnt signaling promotes gliogenesis in P0-NSCs
Biochem Biophys Res Commun, 386 (4), 628-33
DOI 10.1016/j.bbrc.2009.06.084, PubMed 19545542
Publications 2008
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Cellular responses to targeted genomic sequence modification using single-stranded oligonucleotides and zinc-finger nucleases
DNA Repair (Amst), 8 (3), 298-308
DOI 10.1016/j.dnarep.2008.11.011, PubMed 19071233 -
Effect of canonical Wnt inhibition in the neurogenic cortex, hippocampus, and premigratory dentate gyrus progenitor pool
Dev Dyn, 237 (7), 1799-811
DOI 10.1002/dvdy.21586, PubMed 18521945
Publications 2007
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The capacity to remove 8-oxoG is enhanced in newborn neural stem/progenitor cells and decreases in juvenile mice and upon cell differentiation
DNA Repair (Amst), 6 (6), 723-32
DOI 10.1016/j.dnarep.2006.12.008, PubMed 17236821 -
Abnormal lens morphogenesis and ectopic lens formation in the absence of beta-catenin function
Genesis, 45 (4), 157-68
DOI 10.1002/dvg.20277, PubMed 17410548 -
A dynamic gradient of Wnt signaling controls initiation of neurogenesis in the mammalian cortex and cellular specification in the hippocampus
Dev Biol, 311 (1), 223-37
DOI 10.1016/j.ydbio.2007.08.038, PubMed 17916349 -
Kv1.1 null mice have enlarged hippocampus and ventral cortex
BMC Neurosci, 8, 10
DOI 10.1186/1471-2202-8-10, PubMed 17250763
Publications 2006
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Wnt-mediated down-regulation of Sp1 target genes by a transcriptional repressor Sp5
J Biol Chem, 282 (2), 1225-37
DOI 10.1074/jbc.M605851200, PubMed 17090534 -
N-cadherin mediates cortical organization in the mouse brain
Dev Biol, 304 (1), 22-33
DOI 10.1016/j.ydbio.2006.12.014, PubMed 17222817
Publications 2005
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Effects of canonical Wnt signaling on dorso-ventral specification of the mouse telencephalon
Dev Biol, 279 (1), 155-68
DOI 10.1016/j.ydbio.2004.12.010, PubMed 15708565 -
Gamma-glutamylcysteine synthetase and L-buthionine-(S,R)-sulfoximine: a new selection strategy for gene-transduced neural and hematopoietic stem/progenitor cells
Hum Gene Ther, 16 (6), 711-24
DOI 10.1089/hum.2005.16.711, PubMed 15960602 -
The cellular fate of cortical progenitors is not maintained in neurosphere cultures
Mol Cell Neurosci, 30 (3), 388-97
DOI 10.1016/j.mcn.2005.08.003, PubMed 16150605 -
Implications of cell cycle progression on functional sequence correction by short single-stranded DNA oligonucleotides
Gene Ther, 12 (6), 546-51
DOI 10.1038/sj.gt.3302454, PubMed 15674399 -
Genomic sequence correction by single-stranded DNA oligonucleotides: role of DNA synthesis and chemical modifications of the oligonucleotide ends
J Gene Med, 7 (12), 1534-44
DOI 10.1002/jgm.804, PubMed 16025558
Publications 2004
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Characterisation of the Wnt antagonists and their response to conditionally activated Wnt signalling in the developing mouse forebrain
Brain Res Dev Brain Res, 153 (2), 261-70
DOI 10.1016/j.devbrainres.2004.09.008, PubMed 15527894 -
The study of the mechanism of binding of human ML1A melatonin receptor ligands using molecular modeling
Dokl Biochem Biophys, 394, 49-52
DOI 10.1023/b:dobi.0000017154.54595.0e, PubMed 15116569 -
Continuing role for mouse Numb and Numbl in maintaining progenitor cells during cortical neurogenesis
Nat Neurosci, 7 (8), 803-11
DOI 10.1038/nn1289, PubMed 15273690 -
Efficient expansion and gene transduction of mouse neural stem/progenitor cells on recombinant fibronectin
Neuroscience, 124 (4), 823-30
DOI 10.1016/j.neuroscience.2003.11.030, PubMed 15026123
Publications 2003
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Targeted disruption of mouse Dach1 results in postnatal lethality
Dev Dyn, 226 (1), 139-44
DOI 10.1002/dvdy.10210, PubMed 12508235 -
Role of beta-catenin in the developing cortical and hippocampal neuroepithelium
Neuroscience, 122 (1), 129-43
DOI 10.1016/s0306-4522(03)00519-0, PubMed 14596855 -
Branched oligonucleotides induce in vivo gene conversion of a mutated EGFP reporter
Gene Ther, 10 (21), 1830-40
DOI 10.1038/sj.gt.3302079, PubMed 12960973