Tove Lekva
- Scientist; PhD
Publications 2024
PCSK1N as a tumor size marker and an ER stress response protein in corticotroph pituitary adenomas
J Clin Endocrinol Metab (in press)
DOI 10.1210/clinem/dgae643, PubMed 39288010
Toxoplasma gondii infection associated with inflammasome activation and neuronal injury
Sci Rep, 14 (1), 5327
DOI 10.1038/s41598-024-55887-9, PubMed 38438515
Canonical notch activation in patients with scrub typhus: association with organ dysfunction and poor outcome
Infection, 52 (4), 1357-1365
DOI 10.1007/s15010-024-02192-2, PubMed 38502427
Long-term depot specific changes in adipose tissue after treatment of acromegaly
Eur J Endocrinol, 190 (3), K37-K42
DOI 10.1093/ejendo/lvae016, PubMed 38401530
Retraction Note: Rifaximin alters gut microbiota profile, but does not affect systemic inflammation - a randomized controlled trial in common variable immunodeficiency
Sci Rep, 14 (1), 3704
DOI 10.1038/s41598-024-54117-6, PubMed 38355714
The long non-coding RPPH1 is decreased in leukocytes and increased in plasma from women developing pre-eclampsia†
Biol Reprod, 111 (2), 427-435
DOI 10.1093/biolre/ioae069, PubMed 38685609
C-C Motif Ligand 7 (CCL7) and C-C Motif Chemokine Receptor 3 (CCR3) dysregulation in patients with scrub typhus and association with mortality
J Infect Dis (in press)
DOI 10.1093/infdis/jiae401, PubMed 39190223
High dose statin treatment reduces circulating Dickkopf-1 following acute myocardial infarction
Int J Cardiol, 406, 132035
DOI 10.1016/j.ijcard.2024.132035, PubMed 38604450
Cellular adhesion molecules in drug-naïve and previously medicated patients with schizophrenia-spectrum disorders
Schizophr Res, 267, 223-229
DOI 10.1016/j.schres.2024.03.029, PubMed 38574562
Publications 2023
Endocortical Trabecularization in Acromegaly: The Cause for the Paradoxically Increased Vertebral Fracture Risk?
JBMR Plus, 7 (10), e10787
DOI 10.1002/jbm4.10787, PubMed 37808394
Elevated Systemic Levels of Markers Reflecting Intestinal Barrier Dysfunction and Inflammasome Activation Are Correlated in Severe Mental Illness
Schizophr Bull, 49 (3), 635-645
DOI 10.1093/schbul/sbac191, PubMed 36462169
Increased ferroptosis in leukocytes from preeclamptic women involving the long non-coding taurine upregulated gene 1 (TUG1)
J Intern Med, 295 (2), 181-195
DOI 10.1111/joim.13732, PubMed 37870937
Platelet and mitochondrial RNA is decreased in plasma-derived extracellular vesicles in women with preeclampsia-an exploratory study
BMC Med, 21 (1), 458
DOI 10.1186/s12916-023-03178-x, PubMed 37996819
Metabolic profiling of pregnancies complicated by preeclampsia: A longitudinal study
Acta Obstet Gynecol Scand, 102 (3), 334-343
DOI 10.1111/aogs.14505, PubMed 36647289
Maternal metabolic profiling across body mass index groups: An exploratory longitudinal study
Acta Obstet Gynecol Scand, 103 (3), 540-550
DOI 10.1111/aogs.14750, PubMed 38083835
Publications 2022
Plasma Levels of the Cytokines B Cell-Activating Factor (BAFF) and A Proliferation-Inducing Ligand (APRIL) in Schizophrenia, Bipolar, and Major Depressive Disorder: A Cross Sectional, Multisite Study
Schizophr Bull, 48 (1), 37-46
DOI 10.1093/schbul/sbab106, PubMed 34499169
Serum amyloid A1 and pregnancy zone protein in pregnancy complications and correlation with markers of placental dysfunction
Am J Obstet Gynecol MFM, 5 (1), 100794
DOI 10.1016/j.ajogmf.2022.100794, PubMed 36334725
Maternal body mass index and placental weight: a role for fetal insulin, maternal insulin and leptin
J Endocrinol Invest, 45 (11), 2105-2121
DOI 10.1007/s40618-022-01842-2, PubMed 35781790
Markers of cellular senescence is associated with persistent pulmonary pathology after COVID-19 infection
Infect Dis (Lond), 54 (12), 918-923
DOI 10.1080/23744235.2022.2113135, PubMed 35984738
Multi-ancestry genome-wide association study of gestational diabetes mellitus highlights genetic links with type 2 diabetes
Hum Mol Genet, 31 (19), 3377-3391
DOI 10.1093/hmg/ddac050, PubMed 35220425
Systemic Cell Adhesion Molecules in Severe Mental Illness: Potential Role of Intercellular CAM-1 in Linking Peripheral and Neuroinflammation
Biol Psychiatry, 93 (2), 187-196
DOI 10.1016/j.biopsych.2022.06.029, PubMed 36182530
Respiratory dysfunction three months after severe COVID-19 is associated with gut microbiota alterations
J Intern Med, 291 (6), 801-812
DOI 10.1111/joim.13458, PubMed 35212063
Publications 2021
Circulating HLA-G and its association with cardiovascular markers in pregnancy
J Reprod Immunol, 146, 103331
DOI 10.1016/j.jri.2021.103331, PubMed 34030048
Dysregulated non-coding telomerase RNA component and associated exonuclease XRN1 in leucocytes from women developing preeclampsia-possible link to enhanced senescence
Sci Rep, 11 (1), 19735
DOI 10.1038/s41598-021-99140-z, PubMed 34611223
Author Correction: Dysregulated non-coding telomerase RNA component and associated exonuclease XRN1 in leucocytes from women developing preeclampsia-possible link to enhanced senescence
Sci Rep, 11 (1), 22572
DOI 10.1038/s41598-021-00917-z, PubMed 34782619
Identifying women with gestational diabetes based on maternal characteristics: an analysis of four Norwegian prospective studies
BMC Pregnancy Childbirth, 21 (1), 615
DOI 10.1186/s12884-021-04086-9, PubMed 34496778
Low CETP activity and unique composition of large VLDL and small HDL in women giving birth to small-for-gestational age infants
Sci Rep, 11 (1), 6213
DOI 10.1038/s41598-021-85777-3, PubMed 33737686
Increased circulating IL-18 levels in severe mental disorders indicate systemic inflammasome activation
Brain Behav Immun, 99, 299-306
DOI 10.1016/j.bbi.2021.10.017, PubMed 34758379
Secreted Wnt antagonists in scrub typhus
PLoS Negl Trop Dis, 15 (4), e0009185
DOI 10.1371/journal.pntd.0009185, PubMed 33914733
Publications 2020
YKL-40 (Chitinase-3-Like Protein 1) Serum Levels in Aortic Stenosis
Circ Heart Fail, 13 (10), e006643
DOI 10.1161/CIRCHEARTFAILURE.119.006643, PubMed 32962417
Distinct Pattern of Endoplasmic Reticulum Protein Processing and Extracellular Matrix Proteins in Functioning and Silent Corticotroph Pituitary Adenomas
Cancers (Basel), 12 (10)
DOI 10.3390/cancers12102980, PubMed 33066652
Pregnancy and postpartum levels of circulating maternal sHLA-G in preeclampsia
J Reprod Immunol, 143, 103249
DOI 10.1016/j.jri.2020.103249, PubMed 33254097
Distinct patterns of soluble leukocyte activation markers are associated with etiology and outcomes in precapillary pulmonary hypertension
Sci Rep, 10 (1), 18540
DOI 10.1038/s41598-020-75654-w, PubMed 33122779
Multiplex Analysis of Circulating Maternal Cardiovascular Biomarkers Comparing Preeclampsia Subtypes
Hypertension, 75 (6), 1513-1522
DOI 10.1161/HYPERTENSIONAHA.119.14580, PubMed 32336238
Changes in maternal blood glucose and lipid concentrations during pregnancy differ by maternal body mass index and are related to birthweight: A prospective, longitudinal study of healthy pregnancies
PLoS One, 15 (6), e0232749
DOI 10.1371/journal.pone.0232749, PubMed 32574162
Elevated levels of the secreted wingless agonist R-spondin 3 in preeclamptic pregnancies
J Hypertens, 38 (7), 1347-1354
DOI 10.1097/HJH.0000000000002362, PubMed 31990902
Elevated Cholesteryl Ester Transfer Protein Activity Early in Pregnancy Predicts Prediabetes 5 Years Later
J Clin Endocrinol Metab, 105 (3)
DOI 10.1210/clinem/dgz119, PubMed 31665383
Reduced levels of circulating adhesion molecules in adolescents with early-onset psychosis
NPJ Schizophr, 6 (1), 20
DOI 10.1038/s41537-020-00112-5, PubMed 32811840
Publications 2019
Hip Structure Analyses in Acromegaly: Decrease of Cortical Bone Thickness After Treatment: A Longitudinal Cohort Study
JBMR Plus, 3 (12), e10240
DOI 10.1002/jbm4.10240, PubMed 31844828
Rifaximin alters gut microbiota profile, but does not affect systemic inflammation - a randomized controlled trial in common variable immunodeficiency
Sci Rep, 9 (1), 167 (Retracted)
DOI 10.1038/s41598-018-35367-7, PubMed 30655568
Adipokines and macrophage markers during pregnancy-Possible role for sCD163 in prediction and progression of gestational diabetes mellitus
Diabetes Metab Res Rev, 35 (3), e3114
DOI 10.1002/dmrr.3114, PubMed 30548982
Increased interleukin 18 activity in adolescents with early-onset psychosis is associated with cortisol and depressive symptoms
Psychoneuroendocrinology, 112, 104513
DOI 10.1016/j.psyneuen.2019.104513, PubMed 31761332
Publications 2018
Prediction of Gestational Diabetes Mellitus and Pre-diabetes 5 Years Postpartum using 75 g Oral Glucose Tolerance Test at 14-16 Weeks' Gestation
Sci Rep, 8 (1), 13392
DOI 10.1038/s41598-018-31614-z, PubMed 30190548
Genetic determinants of glucose levels in pregnancy: genetic risk scores analysis and GWAS in the Norwegian STORK cohort
Eur J Endocrinol, 179 (6), 363-372
DOI 10.1530/EJE-18-0478, PubMed 30324795
Circulating delta-like Notch ligand 1 is correlated with cardiac allograft vasculopathy and suppressed in heart transplant recipients on everolimus-based immunosuppression
Am J Transplant, 19 (4), 1050-1060
DOI 10.1111/ajt.15141, PubMed 30312541
Publications 2017
Wnt5a is elevated in heart failure and affects cardiac fibroblast function
J Mol Med (Berl), 95 (7), 767-777
DOI 10.1007/s00109-017-1529-1, PubMed 28357477
Gene expression profiling of fast- and slow-growing non-functioning gonadotroph pituitary adenomas
Eur J Endocrinol, 178 (3), 295-307
DOI 10.1530/EJE-17-0702, PubMed 29259037
A Study of TNF Pathway Activation in Schizophrenia and Bipolar Disorder in Plasma and Brain Tissue
Schizophr Bull, 43 (4), 881-890
DOI 10.1093/schbul/sbw183, PubMed 28049760
Leptin and adiponectin as predictors of cardiovascular risk after gestational diabetes mellitus
Cardiovasc Diabetol, 16 (1), 5
DOI 10.1186/s12933-016-0492-4, PubMed 28068986
CXC chemokine ligand 16 is increased in gestational diabetes mellitus and preeclampsia and associated with lipoproteins in gestational diabetes mellitus at 5 years follow-up
Diab Vasc Dis Res, 14 (6), 525-533
DOI 10.1177/1479164117728011, PubMed 28856928
Large Reduction in Adiponectin During Pregnancy Is Associated With Large-for-Gestational-Age Newborns
J Clin Endocrinol Metab, 102 (7), 2552-2559
DOI 10.1210/jc.2017-00289, PubMed 28460045
The Notch Ligands DLL1 and Periostin Are Associated with Symptom Severity and Diastolic Function in Dilated Cardiomyopathy
J Cardiovasc Transl Res, 10 (4), 401-410
DOI 10.1007/s12265-017-9748-y, PubMed 28474304
Publications 2016
Gene expression in term placentas is regulated more by spinal or epidural anesthesia than by late-onset preeclampsia or gestational diabetes mellitus
Sci Rep, 6, 29715
DOI 10.1038/srep29715, PubMed 27405415
Low circulating pentraxin 3 levels in pregnancy is associated with gestational diabetes and increased apoB/apoA ratio: a 5-year follow-up study
Cardiovasc Diabetol, 15, 23
DOI 10.1186/s12933-016-0345-1, PubMed 26842615
Impact of Systemic Inflammation on the Progression of Gestational Diabetes Mellitus
Curr Diab Rep, 16 (4), 26
DOI 10.1007/s11892-016-0715-9, PubMed 26879309
Selection and validation of reliable reference genes for RT-qPCR analysis in a large cohort of pituitary adenomas
Mol Cell Endocrinol, 437, 183-189
DOI 10.1016/j.mce.2016.08.030, PubMed 27561203
Publications 2015
Alternative splicing of placental lactogen (CSH2) in somatotroph pituitary adenomas
Neuro Endocrinol Lett, 36 (2), 136-42
PubMed 26071582
β-cell dysfunction in women with previous gestational diabetes is associated with visceral adipose tissue distribution
Eur J Endocrinol, 173 (1), 63-70
DOI 10.1530/EJE-15-0153, PubMed 25877991
Aortic Stiffness and Cardiovascular Risk in Women with Previous Gestational Diabetes Mellitus
PLoS One, 10 (8), e0136892
DOI 10.1371/journal.pone.0136892, PubMed 26309121
Publications 2014
Cytokine network in scrub typhus: high levels of interleukin-8 are associated with disease severity and mortality
PLoS Negl Trop Dis, 8 (2), e2648
DOI 10.1371/journal.pntd.0002648, PubMed 24516677
Increased endothelial and macrophage markers are associated with disease severity and mortality in scrub typhus
J Infect, 69 (5), 462-9
DOI 10.1016/j.jinf.2014.06.018, PubMed 24995849
Increased serum and bone matrix levels of the secreted Wnt antagonist DKK-1 in patients with growth hormone deficiency in response to growth hormone treatment
J Clin Endocrinol Metab, 100 (2), 736-43
DOI 10.1210/jc.2014-2912, PubMed 25459913
Publications 2013
Expression of SSTR2a, but not of SSTRs 1, 3, or 5 in somatotroph adenomas assessed by monoclonal antibodies was reduced by octreotide and correlated with the acute and long-term effects of octreotide
J Clin Endocrinol Metab, 98 (11), E1730-9
DOI 10.1210/jc.2013-2145, PubMed 24092823
Different levels of various glucocorticoid-regulated genes in corticotroph adenomas
Endocrine, 44 (1), 220-7
DOI 10.1007/s12020-012-9871-0, PubMed 23315031
Umbilical cord levels of sclerostin, placental weight, and birth weight are predictors of total bone mineral content in neonates
Eur J Endocrinol, 168 (3), 371-8
DOI 10.1530/EJE-12-0531, PubMed 23221033
Attenuated RORC expression in the presence of EMT progression in somatotroph adenomas following treatment with somatostatin analogs is associated with poor clinical recovery
PLoS One, 8 (6), e66927
DOI 10.1371/journal.pone.0066927, PubMed 23825587
Epithelial splicing regulator protein 1 and alternative splicing in somatotroph adenomas
Endocrinology, 154 (9), 3331-43
DOI 10.1210/en.2013-1051, PubMed 23825128
Thioredoxin interacting protein is a potential regulator of glucose and energy homeostasis in endogenous Cushing's syndrome
PLoS One, 8 (5), e64247
DOI 10.1371/journal.pone.0064247, PubMed 23691179
Effect of high-intensity interval training on progression of cardiac allograft vasculopathy
J Heart Lung Transplant, 32 (11), 1073-80
DOI 10.1016/j.healun.2013.06.023, PubMed 23906899
Publications 2012
A complex interaction between Rickettsia conorii and Dickkopf-1--potential role in immune evasion mechanisms in endothelial cells
PLoS One, 7 (9), e43638
DOI 10.1371/journal.pone.0043638, PubMed 23028464
Gene expression profiling identifies ESRP1 as a potential regulator of epithelial mesenchymal transition in somatotroph adenomas from a large cohort of patients with acromegaly
J Clin Endocrinol Metab, 97 (8), E1506-14
DOI 10.1210/jc.2012-1760, PubMed 22585092
TXNIP is highly regulated in bone biopsies from patients with endogenous Cushing's syndrome and related to bone turnover
Eur J Endocrinol, 166 (6), 1039-48
DOI 10.1530/EJE-11-1082, PubMed 22450549
High-intensity interval training improves peak oxygen uptake and muscular exercise capacity in heart transplant recipients
Am J Transplant, 12 (11), 3134-42
DOI 10.1111/j.1600-6143.2012.04221.x, PubMed 22900793
Adipocytes as a source of increased circulating levels of nicotinamide phosphoribosyltransferase/visfatin in active acromegaly
J Clin Endocrinol Metab, 97 (4), 1355-62
DOI 10.1210/jc.2011-2417, PubMed 22319029
Publications 2011
Activin A levels are associated with abnormal glucose regulation in patients with myocardial infarction: potential counteracting effects of activin A on inflammation
Diabetes, 60 (5), 1544-51
DOI 10.2337/db10-1493, PubMed 21464440
Reduced levels of E-cadherin correlate with progression of corticotroph pituitary tumours
Clin Endocrinol (Oxf), 75 (6), 811-8
DOI 10.1111/j.1365-2265.2011.04109.x, PubMed 21595730
Increased serum and bone matrix levels of transforming growth factor {beta}1 in patients with GH deficiency in response to GH treatment
Eur J Endocrinol, 165 (3), 393-400
DOI 10.1530/EJE-11-0442, PubMed 21653735
Publications 2010
The expression of E-cadherin in somatotroph pituitary adenomas is related to tumor size, invasiveness, and somatostatin analog response
J Clin Endocrinol Metab, 95 (5), 2334-42
DOI 10.1210/jc.2009-2197, PubMed 20335450
Publications 2009
The glucocorticoid-induced leucine zipper gene (GILZ) expression decreases after successful treatment of patients with endogenous Cushing's syndrome and may play a role in glucocorticoid-induced osteoporosis
J Clin Endocrinol Metab, 95 (1), 246-55
DOI 10.1210/jc.2009-0595, PubMed 19875485
The Glucocorticoid-Induced Leucine Zipper Gene (GILZ) Expression Decreases after Successful Treatment of Patients with Endogenous Cushing's Syndrome and May Play a Role in Glucocorticoid-Induced Osteoporosis
Endocr Rev, 30 (7), 932
DOI 10.1210/edrv.30.7.9985, PubMed 28199557
Associations between body composition, circulating interleukin-1 receptor antagonist, osteocalcin, and insulin metabolism in active acromegaly
J Clin Endocrinol Metab, 95 (1), 361-8
DOI 10.1210/jc.2009-0422, PubMed 19880791
Associations between Body Composition, Circulating Interleukin-1 Receptor Antagonist, Osteocalcin, and Insulin Metabolism in Active Acromegaly
Endocr Rev, 30 (7), 927
DOI 10.1210/edrv.30.7.9997, PubMed 28199500
Dickkopf-1 enhances inflammatory interaction between platelets and endothelial cells and shows increased expression in atherosclerosis
Arterioscler Thromb Vasc Biol, 29 (8), 1228-34
DOI 10.1161/ATVBAHA.109.189761, PubMed 19498175
Publications 2008
Calmodulin-dependent kinase 1beta is expressed in the epiphyseal growth plate and regulates proliferation of mouse calvarial osteoblasts in vitro
Bone, 43 (4), 700-7
DOI 10.1016/j.bone.2008.06.006, PubMed 18620088
Publications 2007
Levetiracetam, phenytoin, and valproate act differently on rat bone mass, structure, and metabolism
Epilepsia, 48 (10), 1850-60
DOI 10.1111/j.1528-1167.2007.01176.x, PubMed 17634065