Kaspar Broch
- Consultant Cardiologist, MD, PhD
- +47 230 73555
Kaspar Broch successfully defended his thesis "Dilated cardiomyopathy: diagnostic work-up, pathogenesis, prognosis and treatment" in February 2016.
The studies in his thesis demonstrate an increased survival rate for patients diagnosed with dilated cardiomyopathy. This is a heart muscle disease that causes impaired heart pump function without coronary artery disease, valve disease or high blood pressure. It is thought that many of the cases are due to viral infection or gene defects, but most often the cause remains unclear. Life prospects have previously been reported to be significantly reduced.
Physician and researcher Kaspar Broch followed 102 patients with dilated cardiomyopathy over several years. Despite extensive research into the underlying cause, this was revealed in only a small number of patients. Nevertheless, morbidity was moderate and survival was good with modern heart failure treatment in these patients. The level of a new disease marker called ST2 is elevated in patients with heart failure. In Broch's patient group, ST2 was related to the degree of heart failure, but not to the underlying cause or amount of fibrous tissue in the heart. This suggests that ST2 may not reflect the disease process in the heart, as previously thought. When interperating blood tests, it is important to keep this in mind.
Cholesterol-lowering drugs called statins can have anti-inflammatory properties. One theory has been that the effect of statins is as much due to these properties as the reduction of cholesterol itself. In a study in which 72 patients with dilated cardiomyopathy were randomly assigned to rosuvastatin or narcotic drugs, Broch and co-workers showed that although cholesterol levels dropped significantly in the statin group, neither the degree of heart failure nor the degree of inflammation was attenuated. This result suggests that statins have no intrinsic anti-inflammatory effect and cannot be used to treat heart failure of this type.
Publications 2024
No adverse association between exercise exposure and diffuse myocardial fibrosis in male endurance athletes
Sci Rep, 14 (1), 6581
DOI 10.1038/s41598-024-57233-5, PubMed 38503845
Long-term follow-up of the randomized, prospective Scandinavian heart transplant everolimus de novo study with early calcineurin inhibitors avoidance (SCHEDULE) trial
J Heart Lung Transplant, 43 (12), 1948-1959
DOI 10.1016/j.healun.2024.07.002, PubMed 39038562
Gut dysbiosis and neutrophil extracellular traps in chronic heart failure
Int J Cardiol, 419, 132689 (in press)
DOI 10.1016/j.ijcard.2024.132689, PubMed 39489348
Randomized Trial of Cholesterol Lowering With Evolocumab for Cardiac Allograft Vasculopathy in Heart Transplant Recipients
JACC Heart Fail, 12 (10), 1677-1688
DOI 10.1016/j.jchf.2024.04.026, PubMed 38934968
Diagnostics, treatment and outcomes of cardiac sarcoidosis in a Norwegian cohort
Int J Cardiol, 400, 131809
DOI 10.1016/j.ijcard.2024.131809, PubMed 38272129
Circular RNA Profile in Atherosclerotic Disease: Regulation during ST-Elevated Myocardial Infarction
Int J Mol Sci, 25 (16)
DOI 10.3390/ijms25169014, PubMed 39201700
The association between body mass index, exercise capacity, and health-related quality of life in heart transplant recipients
Front Transplant, 3, 1379695
DOI 10.3389/frtra.2024.1379695, PubMed 38993775
Cardiac remodelling in patients with atrial fibrillation and obstructive sleep apnoea
Open Heart, 11 (2)
DOI 10.1136/openhrt-2024-002718, PubMed 39477342
Evaluation of left ventricular filling pressure by echocardiography in patients with atrial fibrillation
Echo Res Pract, 11 (1), 14
DOI 10.1186/s44156-024-00048-x, PubMed 38825684
Neutrophil Extracellular Traps in ST-Segment Elevation Myocardial Infarction: Reduced by Tocilizumab and Associated With Infarct Size
JACC Adv, 3 (9), 101193
DOI 10.1016/j.jacadv.2024.101193, PubMed 39247678
Microbial-derived imidazole propionate links the heart failure-associated microbiome alterations to disease severity
Genome Med, 16 (1), 27
DOI 10.1186/s13073-024-01296-6, PubMed 38331891
Right ventricular remodelling and long-term survival after pulmonary endarterectomy versus balloon pulmonary angioplasty in chronic thromboembolic pulmonary hypertension
Heart (in press)
DOI 10.1136/heartjnl-2024-324243, PubMed 39467613
Non-invasive myocardial work in aortic stenosis: validation and improvement in left ventricular pressure estimation
Eur Heart J Cardiovasc Imaging, 25 (2), 201-212
DOI 10.1093/ehjci/jead227, PubMed 37672652
Effect of tocilizumab on endothelial and platelet-derived CXC-chemokines and their association with inflammation and myocardial injury in STEMI patients undergoing primary PCI
Int J Cardiol, 418, 132613 (in press)
DOI 10.1016/j.ijcard.2024.132613, PubMed 39374793
Publications 2023
An investigator-sponsored pragmatic randomized controlled trial of AntiCoagulation vs AcetylSalicylic Acid after Transcatheter Aortic Valve Implantation: Rationale and design of ACASA-TAVI
Am Heart J, 265, 225-232
DOI 10.1016/j.ahj.2023.08.010, PubMed 37634655
A man in his seventies with fatigue and renal failure
Tidsskr Nor Laegeforen, 143 (9)
DOI 10.4045/tidsskr.22.0679, PubMed 37341412
Invasive haemodynamics at rest and exercise in cardiac amyloidosis
ESC Heart Fail, 11 (2), 1263-1268
DOI 10.1002/ehf2.14621, PubMed 38158705
Intestinal fatty acid binding protein is associated with cardiac function and gut dysbiosis in chronic heart failure
Front Cardiovasc Med, 10, 1160030
DOI 10.3389/fcvm.2023.1160030, PubMed 37332580
Pulmonary endarterectomy and balloon pulmonary angioplasty in chronic thromboembolic pulmonary hypertension: Comparison of changes in hemodynamics and functional capacity
Pulm Circ, 13 (1), e12199
DOI 10.1002/pul2.12199, PubMed 36788941
Temporal expression and spatial distribution of the proteoglycan versican during cardiac fibrosis development
Matrix Biol Plus, 19-20, 100135
DOI 10.1016/j.mbplus.2023.100135, PubMed 38076279
Cytokine pattern in patients with ST-elevation myocardial infarction treated with the interleukin-6 receptor antagonist tocilizumab
Open Heart, 10 (2)
DOI 10.1136/openhrt-2023-002301, PubMed 37591633
Publications 2022
Intravenous ferric derisomaltose in iron-deficient patients undergoing transcatheter aortic valve implantation due to severe aortic stenosis: study protocol of the randomised controlled IIISAS trial
BMJ Open, 12 (9), e059546
DOI 10.1136/bmjopen-2021-059546, PubMed 36691165
Iron homeostasis in heart transplant recipients randomized to ferric derisomaltose or placebo
Clin Transplant, 36 (7), e14695
DOI 10.1111/ctr.14695, PubMed 35532871
Effect of continuous positive airway pressure therapy on recurrence of atrial fibrillation after pulmonary vein isolation in patients with obstructive sleep apnea: A randomized controlled trial
Heart Rhythm, 19 (9), 1433-1441
DOI 10.1016/j.hrthm.2022.06.016, PubMed 35716856
Interleukin-6 inhibition in ST-elevation myocardial infarction: Immune cell profile in the randomised ASSAIL-MI trial
EBioMedicine, 80, 104013
DOI 10.1016/j.ebiom.2022.104013, PubMed 35504178
Intravenous iron supplement for iron deficiency in patients with severe aortic stenosis scheduled for transcatheter aortic valve implantation: results of the IIISAS randomised trial
Eur J Heart Fail, 24 (7), 1269-1279
DOI 10.1002/ejhf.2557, PubMed 35579454
Diastolic Dysfunction Is Unmasked on Exercise in Patients With Asymptomatic, Severe Aortic Stenosis: An Invasive Hemodynamic Study
Circ Heart Fail, 15 (2), e009253
DOI 10.1161/CIRCHEARTFAILURE.121.009253, PubMed 35137599
Progression of cardiac disease in patients with lamin A/C mutations
Eur Heart J Cardiovasc Imaging, 23 (4), 543-550
DOI 10.1093/ehjci/jeab057, PubMed 33824984
Publications 2021
Rifaximin or Saccharomyces boulardii in heart failure with reduced ejection fraction: Results from the randomized GutHeart trial
EBioMedicine, 70, 103511
DOI 10.1016/j.ebiom.2021.103511, PubMed 34329947
Intravenous iron supplement for iron deficiency in cardiac transplant recipients (IronIC): A randomized clinical trial
J Heart Lung Transplant, 40 (5), 359-367
DOI 10.1016/j.healun.2021.01.1390, PubMed 33612360
Prevalence of iron deficiency in heart transplant recipients
Clin Transplant, 35 (8), e14346
DOI 10.1111/ctr.14346, PubMed 33969559
Reply: Clarification Regarding the Lack of Heart Failure Events in the ASSAIL-MI Trial
J Am Coll Cardiol, 78 (6), 637-638
DOI 10.1016/j.jacc.2021.06.005, PubMed 34353542
Randomized Trial of Interleukin-6 Receptor Inhibition in Patients With Acute ST-Segment Elevation Myocardial Infarction
J Am Coll Cardiol, 77 (15), 1845-1855
DOI 10.1016/j.jacc.2021.02.049, PubMed 33858620
Reply: Safety of intravenous iron in heart transplant patients: Comment to paper by Brautaset Englund et al
J Heart Lung Transplant, 40 (10), 1247-1248
DOI 10.1016/j.healun.2021.07.007, PubMed 34384682
Tocilizumab increases citrullinated histone 3 in non-ST segment elevation myocardial infarction
Open Heart, 8 (1)
DOI 10.1136/openhrt-2020-001492, PubMed 33972404
The Alternative Complement Pathway Is Activated Without a Corresponding Terminal Pathway Activation in Patients With Heart Failure
Front Immunol, 12, 800978
DOI 10.3389/fimmu.2021.800978, PubMed 35003128
Chemotherapy-based approach is the preferred treatment for sporadic late-onset nemaline myopathy with a monoclonal protein
Int J Cancer, 148 (11), 2807-2814
DOI 10.1002/ijc.33483, PubMed 33529362
Reply to: Comments on: Chemotherapy-based approach is the preferred treatment for sporadic late-onset nemaline myopathy with a monoclonal protein
Int J Cancer, 149 (3), 743-744
DOI 10.1002/ijc.33571, PubMed 33742687
Outcomes in asymptomatic, severe aortic stenosis
PLoS One, 16 (4), e0249610
DOI 10.1371/journal.pone.0249610, PubMed 33826652
Targeting the Inflammasome in Cardiovascular Disease
JACC Basic Transl Sci, 7 (1), 84-98
DOI 10.1016/j.jacbts.2021.08.006, PubMed 35128212
Effect of Continuous Positive Airway Pressure on Arrhythmia in Atrial Fibrillation and Sleep Apnea: A Randomized Controlled Trial
Am J Respir Crit Care Med, 204 (5), 573-582
DOI 10.1164/rccm.202011-4133OC, PubMed 33938787
Publications 2020
Cholesterol lowering with EVOLocumab to prevent cardiac allograft Vasculopathy in De-novo heart transplant recipients: Design of the randomized controlled EVOLVD trial
Clin Transplant, 34 (9), e13984
DOI 10.1111/ctr.13984, PubMed 32445429
A Middle-Aged Man Presenting With Progressive Heart Failure, Myopathy, and Monoclonal Gammopathy of Uncertain Significance
JACC Case Rep, 2 (5), 785-789
DOI 10.1016/j.jaccas.2020.02.024, PubMed 34317348
Long-term continuous flow mechanical biventricular support: 9 years and counting
Interact Cardiovasc Thorac Surg, 30 (1), 81-84
DOI 10.1093/icvts/ivz231, PubMed 31580433
Distinct patterns of soluble leukocyte activation markers are associated with etiology and outcomes in precapillary pulmonary hypertension
Sci Rep, 10 (1), 18540
DOI 10.1038/s41598-020-75654-w, PubMed 33122779
Low fibre intake is associated with gut microbiota alterations in chronic heart failure
ESC Heart Fail, 7 (2), 456-466
DOI 10.1002/ehf2.12596, PubMed 31978943
Long-term effects of high-intensity training vs moderate intensity training in heart transplant recipients: A 3-year follow-up study of the randomized-controlled HITTS study
Am J Transplant, 20 (12), 3538-3549
DOI 10.1111/ajt.16087, PubMed 32484261
High-intensity interval training and health-related quality of life in de novo heart transplant recipients - results from a randomized controlled trial
Health Qual Life Outcomes, 18 (1), 283
DOI 10.1186/s12955-020-01536-4, PubMed 32807179
The gut microbiome in coronary artery disease and heart failure: Current knowledge and future directions
EBioMedicine, 52, 102649
DOI 10.1016/j.ebiom.2020.102649, PubMed 32062353
Publications 2019
Blood Pressure in De Novo Heart Transplant Recipients Treated With Everolimus Compared With a Cyclosporine-based Regimen: Results From the Randomized SCHEDULE Trial
Transplantation, 103 (4), 781-788
DOI 10.1097/TP.0000000000002445, PubMed 30211826
Rationale for the ASSAIL-MI-trial: a randomised controlled trial designed to assess the effect of tocilizumab on myocardial salvage in patients with acute ST-elevation myocardial infarction (STEMI)
Open Heart, 6 (2), e001108
DOI 10.1136/openhrt-2019-001108, PubMed 31673391
Legumain is upregulated in acute cardiovascular events and associated with improved outcome - potentially related to anti-inflammatory effects on macrophages
Atherosclerosis, 296, 74-82
DOI 10.1016/j.atherosclerosis.2019.12.008, PubMed 31870625
Reply: Potential risk associated with direct modulation of the gut flora in patients with heart failure
ESC Heart Fail, 6 (3), 557-558
DOI 10.1002/ehf2.12437, PubMed 31034162
The carnitine-butyrobetaine-TMAO pathway after cardiac transplant: Impact on cardiac allograft vasculopathy and acute rejection
J Heart Lung Transplant, 38 (10), 1097-1103
DOI 10.1016/j.healun.2019.06.003, PubMed 31301965
Publications 2018
sST2 Predicts Outcome in Chronic Heart Failure Beyond NT-proBNP and High-Sensitivity Troponin T
J Am Coll Cardiol, 72 (19), 2309-2320
DOI 10.1016/j.jacc.2018.08.2165, PubMed 30384887
Interleukin-6 receptor inhibition with tocilizumab induces a selective and substantial increase in plasma IP-10 and MIP-1β in non-ST-elevation myocardial infarction
Int J Cardiol, 271, 1-7
DOI 10.1016/j.ijcard.2018.04.136, PubMed 29961572
Gut Microbiota Signature in Heart Failure Defined From Profiling of 2 Independent Cohorts
J Am Coll Cardiol, 71 (10), 1184-1186
DOI 10.1016/j.jacc.2017.12.057, PubMed 29519360
Prevalence and prognostic implication of iron deficiency and anaemia in patients with severe aortic stenosis
Open Heart, 5 (2), e000901
DOI 10.1136/openhrt-2018-000901, PubMed 30613413
Design of the GutHeart-targeting gut microbiota to treat heart failure-trial: a Phase II, randomized clinical trial
ESC Heart Fail, 5 (5), 977-984
DOI 10.1002/ehf2.12332, PubMed 30088346
Publications 2017
Wnt5a is associated with right ventricular dysfunction and adverse outcome in dilated cardiomyopathy
Sci Rep, 7 (1), 3490
DOI 10.1038/s41598-017-03625-9, PubMed 28615692
Left Ventricular Contraction Pattern in Chronic Aortic Regurgitation and Preserved Ejection Fraction: Simultaneous Stress-Strain Analysis by Three-Dimensional Echocardiography
J Am Soc Echocardiogr, 30 (4), 422-430.e2
DOI 10.1016/j.echo.2016.11.012, PubMed 28065583
Soluble ST2 is associated with disease severity in arrhythmogenic right ventricular cardiomyopathy
Biomarkers, 22 (3-4), 367-371
DOI 10.1080/1354750X.2016.1278266, PubMed 28067540
Effect of interleukin-6 inhibition on coronary microvascular and endothelial function in myocardial infarction
Heart, 103 (19), 1521-1527
DOI 10.1136/heartjnl-2016-310875, PubMed 28432157
Increased Secondary/Primary Bile Acid Ratio in Chronic Heart Failure
J Card Fail, 23 (9), 666-671
DOI 10.1016/j.cardfail.2017.06.007, PubMed 28688889
The Notch Ligands DLL1 and Periostin Are Associated with Symptom Severity and Diastolic Function in Dilated Cardiomyopathy
J Cardiovasc Transl Res, 10 (4), 401-410
DOI 10.1007/s12265-017-9748-y, PubMed 28474304
Limited Added Value of Circulating Inflammatory Biomarkers in Chronic Heart Failure
JACC Heart Fail, 5 (4), 256-264
DOI 10.1016/j.jchf.2017.01.008, PubMed 28359413
The alternative complement pathway is dysregulated in patients with chronic heart failure
Sci Rep, 7, 42532
DOI 10.1038/srep42532, PubMed 28195242
Publications 2016
Exercise capacity and peak oxygen consumption in asymptomatic patients with chronic aortic regurgitation
Int J Cardiol, 223, 688-692
DOI 10.1016/j.ijcard.2016.08.237, PubMed 27568990
Effect of a single dose of the interleukin-6 receptor antagonist tocilizumab on inflammation and troponin T release in patients with non-ST-elevation myocardial infarction: a double-blind, randomized, placebo-controlled phase 2 trial
Eur Heart J, 37 (30), 2406-13
DOI 10.1093/eurheartj/ehw171, PubMed 27161611
Impaired Right Ventricular Function in Long-Term Lymphoma Survivors
J Am Soc Echocardiogr, 29 (6), 528-36
DOI 10.1016/j.echo.2016.02.014, PubMed 27038515
Publications 2015
Results of comprehensive diagnostic work-up in 'idiopathic' dilated cardiomyopathy
Open Heart, 2 (1), e000271
DOI 10.1136/openhrt-2015-000271, PubMed 26468400
Echocardiographic evidence of right ventricular functional improvement after balloon pulmonary angioplasty in chronic thromboembolic pulmonary hypertension
J Heart Lung Transplant, 35 (1), 80-86
DOI 10.1016/j.healun.2015.08.007, PubMed 26476768
Contemporary Outcome in Patients With Idiopathic Dilated Cardiomyopathy
Am J Cardiol, 116 (6), 952-9
DOI 10.1016/j.amjcard.2015.06.022, PubMed 26233575
Controlled release metoprolol for aortic regurgitation: a randomised clinical trial
Heart, 102 (3), 191-7
DOI 10.1136/heartjnl-2015-308416, PubMed 26661319
Increased Serum Levels of the Notch Ligand DLL1 are Associated with Diastolic Dysfunction, Reduced Exercise Capacity, and Adverse Outcome in Chronic Heart Failure
J Card Fail, 22 (3), 218-23
DOI 10.1016/j.cardfail.2015.07.012, PubMed 26211721
Publications 2014
Echocardiographic evaluation of left ventricular filling pressure in heart transplant recipients
Scand Cardiovasc J, 48 (6), 349-56
DOI 10.3109/14017431.2014.981579, PubMed 25414078
Soluble ST2 reflects hemodynamic stress in non-ischemic heart failure
Int J Cardiol, 179, 378-84
DOI 10.1016/j.ijcard.2014.11.003, PubMed 25464491
The effect of rosuvastatin on inflammation, matrix turnover and left ventricular remodeling in dilated cardiomyopathy: a randomized, controlled trial
PLoS One, 9 (2), e89732
DOI 10.1371/journal.pone.0089732, PubMed 24586994
Publications 2012
NT-proBNP predicts myocardial recovery after non-ST-elevation acute coronary syndrome
Scand Cardiovasc J, 46 (2), 65-71
DOI 10.3109/14017431.2011.652981, PubMed 22191851
Soluble ST2 is associated with adverse outcome in patients with heart failure of ischaemic aetiology
Eur J Heart Fail, 14 (3), 268-77
DOI 10.1093/eurjhf/hfs006, PubMed 22302661
Publications 2011
Galectin-3 in heart failure: high levels are associated with all-cause mortality
Int J Cardiol, 150 (3), 361-4
DOI 10.1016/j.ijcard.2011.05.081, PubMed 21641051
Circulating levels of non-phosphorylated undercarboxylated matrix Gla protein are associated with disease severity in patients with chronic heart failure
Clin Sci (Lond), 121 (3), 119-27
DOI 10.1042/CS20100589, PubMed 21294711
Publications 2009
Elevated serum uric acid levels following heart transplantation predict all-cause and cardiac mortality
Eur J Heart Fail, 11 (10), 1005-13
DOI 10.1093/eurjhf/hfp115, PubMed 19737803
[A patient with aortic stenosis and reduced left ventricular function]
Tidsskr Nor Laegeforen, 129 (20), 2119-21
DOI 10.4045/tidsskr.08.0622, PubMed 19855451