Theis Tønnessen

  • Group leader; Professor II
  • +47-23 01 52 68

Publications 2024

Ruud M, Frisk M, Melleby AO, Norseng PA, Mohamed BA, Li J, Aronsen JM, Setterberg IE, Jakubiczka J, van Hout I, Coffey S, Shen X, Nygård S, Lunde IG, Tønnessen T, Jones PP, Sjaastad I, Gullestad L, Toischer K, Dahl CP, Christensen G, Louch WE (2024)
Regulation of cardiomyocyte t-tubule structure by preload and afterload: Roles in cardiac compensation and decompensation
J Physiol (in press)
DOI 10.1113/JP284566, PubMed 38686538

Publications 2023

Malm CJ, Alfredsson J, Erlinge D, Gudbjartsson T, Gunn J, James S, Møller CH, Nielsen SJ, Sartipy U, Tønnessen T, Jeppsson A (2023)
Dual or single antiplatelet therapy after coronary surgery for acute coronary syndrome (TACSI trial): Rationale and design of an investigator-initiated, prospective, multinational, registry-based randomized clinical trial
Am Heart J, 259, 1-8
DOI 10.1016/j.ahj.2023.01.011, PubMed 36681173

Opstad TB, Papotti B, Åkra S, Hansen CH, Braathen B, Tønnessen T, Solheim S, Seljeflot I (2023)
Sirtuin1, not NAMPT, possesses anti-inflammatory effects in epicardial, pericardial and subcutaneous adipose tissue in patients with CHD
J Transl Med, 21 (1), 644
DOI 10.1186/s12967-023-04518-4, PubMed 37730614

Papotti B, Opstad TB, Åkra S, Tønnessen T, Braathen B, Hansen CH, Arnesen H, Solheim S, Seljeflot I, Ronda N (2023)
Macrophage polarization markers in subcutaneous, pericardial, and epicardial adipose tissue are altered in patients with coronary heart disease
Front Cardiovasc Med, 10, 1055069
DOI 10.3389/fcvm.2023.1055069, PubMed 36937936

Strand ME, Vanhaverbeke M, Henkens MTHM, Sikking MA, Rypdal KB, Braathen B, Almaas VM, Tønnessen T, Christensen G, Heymans S, Lunde IG (2023)
Inflammation and Syndecan-4 Shedding from Cardiac Cells in Ischemic and Non-Ischemic Heart Disease
Biomedicines, 11 (4)
DOI 10.3390/biomedicines11041066, PubMed 37189684

Vistnes M, Erusappan PM, Sasi A, Nordén ES, Bergo KK, Romaine A, Lunde IG, Zhang L, Olsen MB, Øgaard J, Carlson CR, Wang CH, Riise J, Dahl CP, Fiane AE, Hauge-Iversen IM, Espe E, Melleby AO, Tønnessen T, Aronsen JM, Sjaastad I, Christensen G (2023)
Inhibition of the extracellular enzyme A disintegrin and metalloprotease with thrombospondin motif 4 prevents cardiac fibrosis and dysfunction
Cardiovasc Res, 119 (10), 1915-1927
DOI 10.1093/cvr/cvad078, PubMed 37216909

Publications 2022

Andenæs K, Rypdal KB, Palmero S, Tønnessen T, Lunde IG (2022)
The small leucine-rich proteoglycan fibromodulin exerts anti-fibrotic effects in cultured human cardiac fibroblasts
Genet Mol Res, 21 (1), 1-15
DOI 10.4238/gmr19007, PublikaID 434

Kluge KE, Langseth MS, Andersen GØ, Halvorsen S, Opstad TB, Arnesen H, Tønnessen T, Seljeflot I, Helseth R (2022)
Complement activation in association with clinical outcomes in ST-elevation myocardial infarction
Am Heart J Plus, 24, 100228
DOI 10.1016/j.ahjo.2022.100228, PubMed 38560636

Lunde IG, Skrbic B, Sjaastad I, Christensen G, Carlson CR, Tønnessen T (2022)
Calcineurin-NFAT dynamics correspond to cardiac remodeling during aortic banding and debanding, mimicking aortic valve replacement
Front Mol Med, 2, 1-14
DOI 10.3389/fmmed.2022.980717, PublikaID 435

Neerland BE, Busund R, Haaverstad R, Helbostad JL, Landsverk SA, Martinaityte I, Norum HM, Ræder J, Selbaek G, Simpson MR, Skaar E, Skjærvold NK, Skovlund E, Slooter AJ, Svendsen ØS, Tønnessen T, Wahba A, Zetterberg H, Wyller TB (2022)
Alpha-2-adrenergic receptor agonists for the prevention of delirium and cognitive decline after open heart surgery (ALPHA2PREVENT): protocol for a multicentre randomised controlled trial
BMJ Open, 12 (6), e057460
DOI 10.1136/bmjopen-2021-057460, PubMed 35725264

Rixon C, Andreassen K, Shen X, Erusappan PM, Almaas VM, Palmero S, Dahl CP, Ueland T, Sjaastad I, Louch WE, Stokke MK, Tønnessen T, Christensen G, Lunde IG (2022)
Lumican accumulates with fibrillar collagen in fibrosis in hypertrophic cardiomyopathy
ESC Heart Fail, 10 (2), 858-871
DOI 10.1002/ehf2.14234, PubMed 36444917

Rypdal KB, Olav Melleby A, Robinson EL, Li J, Palmero S, Seifert DE, Martin D, Clark C, López B, Andreassen K, Dahl CP, Sjaastad I, Tønnessen T, Stokke MK, Louch WE, González A, Heymans S, Christensen G, Apte SS, Lunde IG (2022)
ADAMTSL3 knock-out mice develop cardiac dysfunction and dilatation with increased TGFβ signalling after pressure overload
Commun Biol, 5 (1), 1392
DOI 10.1038/s42003-022-04361-1, PubMed 36539599

Åkra S, Seljeflot I, Braathen B, Bratseth V, Hansen CH, Arnesen H, Tønnessen T, Solheim S (2022)
The NLRP3 inflammasome activation in subcutaneous, epicardial and pericardial adipose tissue in patients with coronary heart disease undergoing coronary by-pass surgery
Atheroscler Plus, 48, 47-54
DOI 10.1016/j.athplu.2022.03.005, PubMed 36644557

Publications 2021

Frisk M, Le C, Shen X, Røe ÅT, Hou Y, Manfra O, Silva GJJ, van Hout I, Norden ES, Aronsen JM, Laasmaa M, Espe EKS, Zouein FA, Lambert RR, Dahl CP, Sjaastad I, Lunde IG, Coffey S, Cataliotti A, Gullestad L, Tønnessen T, Jones PP, Altara R, Louch WE (2021)
Etiology-Dependent Impairment of Diastolic Cardiomyocyte Calcium Homeostasis in Heart Failure With Preserved Ejection Fraction
J Am Coll Cardiol, 77 (4), 405-419
DOI 10.1016/j.jacc.2020.11.044, PubMed 33509397

Martinsson A, Nielsen SJ, Milojevic M, Redfors B, Omerovic E, Tønnessen T, Gudbjartsson T, Dellgren G, Jeppsson A (2021)
Life Expectancy After Surgical Aortic Valve Replacement
J Am Coll Cardiol, 78 (22), 2147-2157
DOI 10.1016/j.jacc.2021.09.861, PubMed 34823657

Rypdal KB, Erusappan PM, Melleby AO, Seifert DE, Palmero S, Strand ME, Tønnessen T, Dahl CP, Almaas V, Hubmacher D, Apte SS, Christensen G, Lunde IG (2021)
The extracellular matrix glycoprotein ADAMTSL2 is increased in heart failure and inhibits TGFβ signalling in cardiac fibroblasts
Sci Rep, 11 (1), 19757
DOI 10.1038/s41598-021-99032-2, PubMed 34611183

Publications 2020

Danielsen SO, Moons P, Leegaard M, Solheim S, Tønnessen T, Lie I (2020)
Facilitators of and barriers to reducing thirty-day readmissions and improving patient-reported outcomes after surgical aortic valve replacement: a process evaluation of the AVRre trial
BMC Health Serv Res, 20 (1), 256
DOI 10.1186/s12913-020-05125-5, PubMed 32220252

Herum KM, Romaine A, Wang A, Melleby AO, Strand ME, Pacheco J, Braathen B, Dunér P, Tønnessen T, Lunde IG, Sjaastad I, Brakebusch C, McCulloch AD, Gomez MF, Carlson CR, Christensen G (2020)
Syndecan-4 Protects the Heart From the Profibrotic Effects of Thrombin-Cleaved Osteopontin
J Am Heart Assoc, 9 (3), e013518
DOI 10.1161/JAHA.119.013518, PubMed 32000579

Kluge KE, Langseth MS, Bratseth V, Pettersen AÅ, Arnesen H, Tønnessen T, Seljeflot I, Helseth R (2020)
Circulating levels of the terminal complement complex are associated with hypercoagulability in patients with stable coronary artery disease
Thromb Res, 196, 106-108
DOI 10.1016/j.thromres.2020.08.023, PubMed 32853976

Kluge KE, Langseth MS, Opstad TB, Pettersen AÅ, Arnesen H, Tønnessen T, Seljeflot I, Helseth R (2020)
Complement Activation in Association with Markers of Neutrophil Extracellular Traps and Acute Myocardial Infarction in Stable Coronary Artery Disease
Mediators Inflamm, 2020, 5080743
DOI 10.1155/2020/5080743, PubMed 32308555

Mohammadzadeh N, Melleby AO, Palmero S, Sjaastad I, Chakravarti S, Engebretsen KVT, Christensen G, Lunde IG, Tønnessen T (2020)
Moderate Loss of the Extracellular Matrix Proteoglycan Lumican Attenuates Cardiac Fibrosis in Mice Subjected to Pressure Overload
Cardiology, 145 (3), 187-198
DOI 10.1159/000505318, PubMed 31968347

Publications 2019

Bjørnnes AK, Moons P, Parry M, Halvorsen S, Tønnessen T, Lie I (2019)
Experiences of informal caregivers after cardiac surgery: a systematic integrated review of qualitative and quantitative studies
BMJ Open, 9 (11), e032751
DOI 10.1136/bmjopen-2019-032751, PubMed 31719093

Danielsen SO, Moons P, Sandvik L, Leegaard M, Solheim S, Tønnessen T, Lie I (2019)
Impact of telephone follow-up and 24/7 hotline on 30-day readmission rates following aortic valve replacement -A randomized controlled trial
Int J Cardiol, 300, 66-72
DOI 10.1016/j.ijcard.2019.07.087, PubMed 31387822

Mennander A, Gudbjartsson T, Jeppsson A, Hjortdal V, Tønnessen T (2019)
Specialist training for cardiothoracic surgery in the Nordic countries
J Thorac Cardiovasc Surg, 159 (3), 1002-1008
DOI 10.1016/j.jtcvs.2019.07.110, PubMed 31590947

Mohammadzadeh N, Lunde IG, Andenæs K, Strand ME, Aronsen JM, Skrbic B, Marstein HS, Bandlien C, Nygård S, Gorham J, Sjaastad I, Chakravarti S, Christensen G, Engebretsen KVT, Tønnessen T (2019)
The extracellular matrix proteoglycan lumican improves survival and counteracts cardiac dilatation and failure in mice subjected to pressure overload
Sci Rep, 9 (1), 9206
DOI 10.1038/s41598-019-45651-9, PubMed 31235849

Nuru A, Weltzien JAH, Sandvik L, Tønnessen T, Bjørnstad JL (2019)
Short- and long-term survival after isolated coronary artery bypass grafting, the impact of gender and age
Scand Cardiovasc J, 53 (6), 342-347
DOI 10.1080/14017431.2019.1646430, PubMed 31321989

Tønnessen T (2019)
Cardiac Amyloidosis - A Devil in Disguise
Cardiology, 142 (4), 250-252
DOI 10.1159/000500448, PubMed 31230041

Publications 2018

Andenæs K, Lunde IG, Mohammadzadeh N, Dahl CP, Aronsen JM, Strand ME, Palmero S, Sjaastad I, Christensen G, Engebretsen KVT, Tønnessen T (2018)
The extracellular matrix proteoglycan fibromodulin is upregulated in clinical and experimental heart failure and affects cardiac remodeling
PLoS One, 13 (7), e0201422
DOI 10.1371/journal.pone.0201422, PubMed 30052659

Braathen B, Husebye T, Lunde IG, Tønnessen T (2018)
Trifecta has lower gradient and less prosthesis-patient mismatch than Mosaic Ultra in the aortic position: A prospective randomized study
J Thorac Cardiovasc Surg, 158 (4), 1032-1039
DOI 10.1016/j.jtcvs.2018.11.020, PubMed 30635187

Danielsen SO, Moons P, Sandven I, Leegaard M, Solheim S, Tønnessen T, Lie I (2018)
Thirty-day readmissions in surgical and transcatheter aortic valve replacement: A systematic review and meta-analysis
Int J Cardiol, 268, 85-91
DOI 10.1016/j.ijcard.2018.05.026, PubMed 29779575

Publications 2017

Lie I, Danielsen SO, Tønnessen T, Solheim S, Leegaard M, Sandvik L, Wisløff T, Vangen J, Røsstad TH, Moons P (2017)
Determining the impact of 24/7 phone support on hospital readmissions after aortic valve replacement surgery (the AVRre study): study protocol for a randomised controlled trial
Trials, 18 (1), 246
DOI 10.1186/s13063-017-1971-y, PubMed 28693599

Parikh SS, Blackwell DJ, Gomez-Hurtado N, Frisk M, Wang L, Kim K, Dahl CP, Fiane A, Tønnessen T, Kryshtal DO, Louch WE, Knollmann BC (2017)
Thyroid and Glucocorticoid Hormones Promote Functional T-Tubule Development in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes
Circ Res, 121 (12), 1323-1330
DOI 10.1161/CIRCRESAHA.117.311920, PubMed 28974554

Publications 2015

Herum KM, Lunde IG, Skrbic B, Louch WE, Hasic A, Boye S, Unger A, Brorson SH, Sjaastad I, Tønnessen T, Linke WA, Gomez MF, Christensen G (2015)
Syndecan-4 is a key determinant of collagen cross-linking and passive myocardial stiffness in the pressure-overloaded heart
Cardiovasc Res, 106 (2), 217-26
DOI 10.1093/cvr/cvv002, PubMed 25587045

Kaljusto ML, Skaga NO, Pillgram-Larsen J, Tønnessen T (2015)
Survival predictor for penetrating cardiac injury; a 10-year consecutive cohort from a scandinavian trauma center
Scand J Trauma Resusc Emerg Med, 23, 41
DOI 10.1186/s13049-015-0125-z, PubMed 26032760

Skrbic B, Engebretsen KV, Strand ME, Lunde IG, Herum KM, Marstein HS, Sjaastad I, Lunde PK, Carlson CR, Christensen G, Bjørnstad JL, Tønnessen T (2015)
Lack of collagen VIII reduces fibrosis and promotes early mortality and cardiac dilatation in pressure overload in mice
Cardiovasc Res, 106 (1), 32-42
DOI 10.1093/cvr/cvv041, PubMed 25694587

Strand ME, Aronsen JM, Braathen B, Sjaastad I, Kvaløy H, Tønnessen T, Christensen G, Lunde IG (2015)
Shedding of syndecan-4 promotes immune cell recruitment and mitigates cardiac dysfunction after lipopolysaccharide challenge in mice
J Mol Cell Cardiol, 88, 133-44
DOI 10.1016/j.yjmcc.2015.10.003, PubMed 26449522

Publications 2014

Engebretsen KV, Skårdal K, Bjørnstad S, Marstein HS, Skrbic B, Sjaastad I, Christensen G, Bjørnstad JL, Tønnessen T (2014)
Attenuated development of cardiac fibrosis in left ventricular pressure overload by SM16, an orally active inhibitor of ALK5
J Mol Cell Cardiol, 76, 148-57
DOI 10.1016/j.yjmcc.2014.08.008, PubMed 25169971

Majak P, Lunde IG, Hasic AK, Husebye T, Christensen G, Tønnessen T, Bjørnstad JL (2014)
Reduced visfatin levels in aortic stenosis increase after aortic valve replacement and may contribute to reverse left ventricular remodelling
J Cardiovasc Surg (Torino), 56 (3), 483-92
PubMed 24429804

Nygård S, Reitan T, Clancy T, Nygaard V, Bjørnstad J, Skrbic B, Tønnessen T, Christensen G, Hovig E (2014)
Identifying pathogenic processes by integrating microarray data with prior knowledge
BMC Bioinformatics, 15, 115
DOI 10.1186/1471-2105-15-115, PubMed 24758699

Wanichawan P, Hafver TL, Hodne K, Aronsen JM, Lunde IG, Dalhus B, Lunde M, Kvaløy H, Louch WE, Tønnessen T, Sjaastad I, Sejersted OM, Carlson CR (2014)
Molecular basis of calpain cleavage and inactivation of the sodium-calcium exchanger 1 in heart failure
J Biol Chem, 289 (49), 33984-98
DOI 10.1074/jbc.M114.602581, PubMed 25336645

Publications 2013

Engebretsen KV, Lunde IG, Strand ME, Waehre A, Sjaastad I, Marstein HS, Skrbic B, Dahl CP, Askevold ET, Christensen G, Bjørnstad JL, Tønnessen T (2013)
Lumican is increased in experimental and clinical heart failure, and its production by cardiac fibroblasts is induced by mechanical and proinflammatory stimuli
FEBS J, 280 (10), 2382-98
DOI 10.1111/febs.12235, PubMed 23480731

Engebretsen KV, Waehre A, Bjørnstad JL, Skrbic B, Sjaastad I, Behmen D, Marstein HS, Yndestad A, Aukrust P, Christensen G, Tønnessen T (2013)
Decorin, lumican, and their GAG chain-synthesizing enzymes are regulated in myocardial remodeling and reverse remodeling in the mouse
J Appl Physiol (1985), 114 (8), 988-97
DOI 10.1152/japplphysiol.00793.2012, PubMed 23412898

Louch WE, Hake J, Mørk HK, Hougen K, Skrbic B, Ursu D, Tønnessen T, Sjaastad I, Sejersted OM (2013)
Slow Ca²⁺ sparks de-synchronize Ca²⁺ release in failing cardiomyocytes: evidence for altered configuration of Ca²⁺ release units?
J Mol Cell Cardiol, 58, 41-52
DOI 10.1016/j.yjmcc.2013.01.014, PubMed 23376034

Strand ME, Herum KM, Rana ZA, Skrbic B, Askevold ET, Dahl CP, Vistnes M, Hasic A, Kvaløy H, Sjaastad I, Carlson CR, Tønnessen T, Gullestad L, Christensen G, Lunde IG (2013)
Innate immune signaling induces expression and shedding of the heparan sulfate proteoglycan syndecan-4 in cardiac fibroblasts and myocytes, affecting inflammation in the pressure-overloaded heart
FEBS J, 280 (10), 2228-47
DOI 10.1111/febs.12161, PubMed 23374111

Søraas CL, Friis C, Engebretsen KV, Sandvik L, Kjeldsen SE, Tønnessen T (2013)
Authors' reply to the letter from Dr Wang: troponins after coronary artery bypass grafting: continuous or cut-point approach?
Am Heart J, 166 (2), e3
DOI 10.1016/j.ahj.2013.05.001, PubMed 23895825

Publications 2012

Askevold ET, Gullestad L, Aakhus S, Ranheim T, Tønnessen T, Solberg OG, Aukrust P, Ueland T (2012)
Secreted Wnt modulators in symptomatic aortic stenosis
J Am Heart Assoc, 1 (6), e002261
DOI 10.1161/JAHA.112.002261, PubMed 23316316

Kaljusto ML, Tønnessen T (2012)
How to mend a broken heart: a major stab wound of the left ventricle
World J Emerg Surg, 7 (1), 17
DOI 10.1186/1749-7922-7-17, PubMed 22640705

Majak P, Bjørnstad JL, Braathen B, Lunde IG, Husebye T, Christensen G, Tønnessen T (2012)
Endothelin-1 in the human myocardium and circulating plasma: evaluation before, during and after correction of aortic stenosis with aortic valve replacement
Cardiology, 123 (1), 1-10
DOI 10.1159/000339756, PubMed 22907118

Majak P, Braathen B, Bjørnstad JL, Tønnessen T (2012)
GDF-15 is increased during early reperfusion following aortic valve replacement
Scand Cardiovasc J, 46 (2), 99-106
DOI 10.3109/14017431.2011.649489, PubMed 22168128

Seim BE, Tønnessen T, Woldbaek PR (2012)
Triclosan-coated sutures do not reduce leg wound infections after coronary artery bypass grafting
Interact Cardiovasc Thorac Surg, 15 (3), 411-5
DOI 10.1093/icvts/ivs266, PubMed 22691378

Skrbic B, Bjørnstad JL, Marstein HS, Carlson CR, Sjaastad I, Nygård S, Bjørnstad S, Christensen G, Tønnessen T (2012)
Differential regulation of extracellular matrix constituents in myocardial remodeling with and without heart failure following pressure overload
Matrix Biol, 32 (2), 133-42
DOI 10.1016/j.matbio.2012.11.011, PubMed 23220517

Søraas CL, Friis C, Engebretsen KV, Sandvik L, Kjeldsen SE, Tønnessen T (2012)
Troponin T is a better predictor than creatine kinase-MB of long-term mortality after coronary artery bypass graft surgery
Am Heart J, 164 (5), 779-85
DOI 10.1016/j.ahj.2012.05.027, PubMed 23137510

Publications 2011

Bjørnstad JL, Skrbic B, Marstein HS, Hasic A, Sjaastad I, Louch WE, Florholmen G, Christensen G, Tønnessen T (2011)
Inhibition of SMAD2 phosphorylation preserves cardiac function during pressure overload
Cardiovasc Res, 93 (1), 100-10
DOI 10.1093/cvr/cvr294, PubMed 22049534

Bjørnstad JL, Skrbic B, Sjaastad I, Bjørnstad S, Christensen G, Tønnessen T (2011)
A mouse model of reverse cardiac remodelling following banding-debanding of the ascending aorta
Acta Physiol (Oxf), 205 (1), 92-102
DOI 10.1111/j.1748-1716.2011.02369.x, PubMed 21974781

Finsen AV, Lunde IG, Sjaastad I, Østli EK, Lyngra M, Jarstadmarken HO, Hasic A, Nygård S, Wilcox-Adelman SA, Goetinck PF, Lyberg T, Skrbic B, Florholmen G, Tønnessen T, Louch WE, Djurovic S, Carlson CR, Christensen G (2011)
Syndecan-4 is essential for development of concentric myocardial hypertrophy via stretch-induced activation of the calcineurin-NFAT pathway
PLoS One, 6 (12), e28302
DOI 10.1371/journal.pone.0028302, PubMed 22164265

Lunde IG, Aronsen JM, Kvaløy H, Qvigstad E, Sjaastad I, Tønnessen T, Christensen G, Grønning-Wang LM, Carlson CR (2011)
Cardiac O-GlcNAc signaling is increased in hypertrophy and heart failure
Physiol Genomics, 44 (2), 162-72
DOI 10.1152/physiolgenomics.00016.2011, PubMed 22128088

Sadi L, Tønnessen T, Pillgram-Larsen J (2011)
Short and long-term survival in type A aortic dissection justifies the operative risk and effort
Scand Cardiovasc J, 46 (1), 45-50
DOI 10.3109/14017431.2011.626439, PubMed 22029877

Søraas CL, Larstorp AC, Mangschau A, Tønnessen T, Kjeldsen SE, Bjørnerheim R (2011)
Echocardiographic demonstration of improved myocardial function early after coronary artery bypass graft surgery
Interact Cardiovasc Thorac Surg, 12 (6), 946-51
DOI 10.1510/icvts.2010.260414, PubMed 21422155

Ueland T, Aukrust P, Dahl CP, Husebye T, Solberg OG, Tønnessen T, Aakhus S, Gullestad L (2011)
Osteoprotegerin levels predict mortality in patients with symptomatic aortic stenosis
J Intern Med, 270 (5), 452-60
DOI 10.1111/j.1365-2796.2011.02393.x, PubMed 21623962

Publications 2010

Bjørnstad JL, Sjaastad I, Nygård S, Hasic A, Ahmed MS, Attramadal H, Finsen AV, Christensen G, Tønnessen T (2010)
Collagen isoform shift during the early phase of reverse left ventricular remodelling after relief of pressure overload
Eur Heart J, 32 (2), 236-45
DOI 10.1093/eurheartj/ehq166, PubMed 20525982

Braathen B, Jeppsson A, Scherstén H, Hagen OM, Vengen Ø, Rexius H, Lepore V, Tønnessen T (2010)
One single dose of histidine-tryptophan-ketoglutarate solution gives equally good myocardial protection in elective mitral valve surgery as repetitive cold blood cardioplegia: a prospective randomized study
J Thorac Cardiovasc Surg, 141 (4), 995-1001
DOI 10.1016/j.jtcvs.2010.07.011, PubMed 20800244

Majak P, Bjørnstad J, Vengen OA, Neverdal NO, Husebye T, Woldbaek P, Pepper J, Lie M, Christensen G, Tønnessen T (2010)
Plasma IL-18 and IL-18BP are altered differently in reverse remodeling following aortic valve replacement
Scand Cardiovasc J, 44 (2), 113-8
DOI 10.3109/14017430903426902, PubMed 19961286

Søraas CL, Wachtell K, Okin PM, Dahlöf B, Devereux RB, Tønnessen T, Kjeldsen SE, Olsen MH (2010)
Lack of regression of left ventricular hypertrophy is associated with higher incidence of revascularization in hypertension: The LIFE Study
Blood Press, 19 (3), 145-51
DOI 10.3109/08037051.2010.481812, PubMed 20429689

Publications 2009

Bjørnstad JL, Pillgram-Larsen J, Tønnessen T (2009)
Coronary artery dissection and acute myocardial infarction following blunt chest trauma
World J Emerg Surg, 4, 14
DOI 10.1186/1749-7922-4-14, PubMed 19366447

Braathen B, Bøen A, Thorsen T, Tønnessen T (2009)
Gunshot through the left ventricle
Resuscitation, 80 (6), 615-6
DOI 10.1016/j.resuscitation.2009.02.022, PubMed 19406553

Braathen B, Tønnessen T (2009)
Cold blood cardioplegia reduces the increase in cardiac enzyme levels compared with cold crystalloid cardioplegia in patients undergoing aortic valve replacement for isolated aortic stenosis
J Thorac Cardiovasc Surg, 139 (4), 874-80
DOI 10.1016/j.jtcvs.2009.05.036, PubMed 19660338

Engebretsen KV, Friis C, Sandvik L, Tønnessen T (2009)
Survival after CABG--better than predicted by EuroSCORE and equal to the general population
Scand Cardiovasc J, 43 (2), 123-8
DOI 10.1080/14017430802354085, PubMed 18781451

Kaljusto ML, Vengen OA, Tønnessen T (2009)
Traumatic aortic valve rupture after a high-speed motor-vehicle accident: case report
J Heart Valve Dis, 18 (3), 345-6
PubMed 19557995

Publications 2008

Bjørnstad JL, Neverdal NO, Vengen OA, Knudsen CW, Husebye T, Pepper J, Lie M, Christensen G, Tønnessen T (2008)
Alterations in circulating activin A, GDF-15, TGF-beta3 and MMP-2, -3, and -9 during one year of left ventricular reverse remodelling in patients operated for severe aortic stenosis
Eur J Heart Fail, 10 (12), 1201-7
DOI 10.1016/j.ejheart.2008.09.010, PubMed 18996047

Kaljusto ML, Vengen OA, Tønnessen T (2008)
Traumatic aortic valve rupture after a high-speed motor vehicle accident
J Heart Valve Dis, 17 (5), 586-8
PubMed 18980095

Publications 2007

Kaljusto ML, Tønnessen T (2007)
Aortic perforation with cardiac tamponade two weeks after pacemaker implantation
J Thorac Cardiovasc Surg, 134 (2), 502-3
DOI 10.1016/j.jtcvs.2007.03.037, PubMed 17662797

Publications 2006

Andersson KB, Florholmen G, Winer LH, Tønnessen T, Christensen G (2006)
Regulation of neuronal type genes in congestive heart failure rats
Acta Physiol (Oxf), 186 (1), 17-27
DOI 10.1111/j.1748-1716.2005.01503.x, PubMed 16497176

Braathen B, Vengen OA, Tønnessen T (2006)
Myocardial cooling with ice-slush provides no cardioprotective effects in aortic valve replacement
Scand Cardiovasc J, 40 (6), 368-73
DOI 10.1080/14017430600987912, PubMed 17118828

Diplas S, Jorgensen S, Tafto J, Tonnessen T, Knutsen T, Lehrmann J, Valand T, Abel ML, Watts JF (2006)
Probing the electronic structure of Ni-X, (X = B, S, P) catalysts with XPS
Surf. Interface Anal., 38 (4), 238-242
DOI 10.1002/sia.2322

Kaljusto ML, Koldsland S, Vengen OA, Woldbaek PR, Tønnessen T (2006)
Cardiac tamponade caused by acute spontaneous coronary artery rupture
J Card Surg, 21 (3), 301-3
DOI 10.1111/j.1540-8191.2006.00239.x, PubMed 16684069

Larstorp AC, Lund Søraas C, Tønnessen T, Müller C, Kjeldsen SE, Mangschau A (2006)
Scintigraphic demonstration of myocardial perfusion and ischaemia associated with coronary artery bypass grafting
Scand Cardiovasc J, 40 (6), 354-62
DOI 10.1080/14017430601004063, PubMed 17118826

Lunde PK, Sejersted OM, Thorud HM, Tønnessen T, Henriksen UL, Christensen G, Westerblad H, Bruton J (2006)
Effects of congestive heart failure on Ca2+ handling in skeletal muscle during fatigue
Circ Res, 98 (12), 1514-9
DOI 10.1161/01.RES.0000226529.66545.e5, PubMed 16690878

Neverdal NO, Knudsen CW, Husebye T, Vengen OA, Pepper J, Lie M, Tønnessen T (2006)
The effect of aortic valve replacement on plasma B-type natriuretic peptide in patients with severe aortic stenosis--one year follow-up
Eur J Heart Fail, 8 (3), 257-62
DOI 10.1016/j.ejheart.2005.08.004, PubMed 16466963

Rzyman W, Tønnessen T (2006)
Fulminant thoracic sarcoma masked by hemothorax
J Thorac Oncol, 1 (8), 856
PubMed 17409970

Publications 2005

Tønnessen T, Knudsen CW (2005)
Surgical left ventricular remodeling in heart failure
Eur J Heart Fail, 7 (5), 704-9
DOI 10.1016/j.ejheart.2005.07.005, PubMed 16087128

Woldbaek PR, Sande JB, Strømme TA, Lunde PK, Djurovic S, Lyberg T, Christensen G, Tønnessen T (2005)
Daily administration of interleukin-18 causes myocardial dysfunction in healthy mice
Am J Physiol Heart Circ Physiol, 289 (2), H708-14
DOI 10.1152/ajpheart.01179.2004, PubMed 15821032

Publications 2004

Finsen AV, Woldbaek PR, Li J, Wu J, Lyberg T, Tønnessen T, Christensen G (2004)
Increased syndecan expression following myocardial infarction indicates a role in cardiac remodeling
Physiol Genomics, 16 (3), 301-8
DOI 10.1152/physiolgenomics.00144.2002, PubMed 14625378

Publications 2003

Tønnessen T, Florholmen G, Henriksen UL, Christensen G (2003)
Cardiopulmonary alterations in mRNA expression for interleukin-1beta, the interleukin-6 superfamily and CXC-chemokines during development of postischaemic heart failure in the rat
Clin Physiol Funct Imaging, 23 (5), 263-8
DOI 10.1046/j.1475-097x.2003.00503.x, PubMed 12950323

Woldbaek PR, Stromme TA, Sande JB, Christensen G, Tønnessen T, Ilebekk A (2003)
Evaluation of a new fiber-optic pressure recording system for cardiovascular measurements in mice
Am J Physiol Heart Circ Physiol, 285 (5), H2233-9
DOI 10.1152/ajpheart.01123.2002, PubMed 12829434

Woldbaek PR, Tønnessen T, Henriksen UL, Florholmen G, Lunde PK, Lyberg T, Christensen G (2003)
Increased cardiac IL-18 mRNA, pro-IL-18 and plasma IL-18 after myocardial infarction in the mouse; a potential role in cardiac dysfunction
Cardiovasc Res, 59 (1), 122-31
DOI 10.1016/s0008-6363(03)00339-0, PubMed 12829183

Publications 2002

Iversen PO, Woldbaek PR, Tønnessen T, Christensen G (2002)
Decreased hematopoiesis in bone marrow of mice with congestive heart failure
Am J Physiol Regul Integr Comp Physiol, 282 (1), R166-72
DOI 10.1152/ajpregu.2002.282.1.R166, PubMed 11742835

Sande JB, Sjaastad I, Hoen IB, Bøkenes J, Tønnessen T, Holt E, Lunde PK, Christensen G (2002)
Reduced level of serine(16) phosphorylated phospholamban in the failing rat myocardium: a major contributor to reduced SERCA2 activity
Cardiovasc Res, 53 (2), 382-91
DOI 10.1016/s0008-6363(01)00489-8, PubMed 11827689

Tønnessen T, Sejersted OM (2002)
Molecular medicine for the cardiac surgeon
Scand Cardiovasc J, 36 (4), 201-8
DOI 10.1080/14017430260180346, PubMed 12201966

Woldbaek PR, Hoen IB, Christensen G, Tønnessen T (2002)
Gene expression of colony-stimulating factors and stem cell factor after myocardial infarction in the mouse
Acta Physiol Scand, 175 (3), 173-81
DOI 10.1046/j.1365-201X.2002.00989.x, PubMed 12100356

Publications 2001

Eiken HG, Øie E, Damås JK, Yndestad A, Bjerkeli V, Aass H, Simonsen S, Geiran OR, Tønnessen T, Christensen G, Frøland SS, Gullestad L, Attramadal H, Aukrust P (2001)
Myocardial gene expression of leukaemia inhibitory factor, interleukin-6 and glycoprotein 130 in end-stage human heart failure
Eur J Clin Invest, 31 (5), 389-97
DOI 10.1046/j.1365-2362.2001.00795.x, PubMed 11380590

Tønnessen T, Carlsen E (2001)
[Perforated ulcer]
Tidsskr Nor Laegeforen, 121 (7), 790-2
PubMed 11301699

Publications 2000

Damås JK, Eiken HG, Oie E, Bjerkeli V, Yndestad A, Ueland T, Tonnessen T, Geiran OR, Aass H, Simonsen S, Christensen G, Froland SS, Attramadal H, Gullestad L, Aukrust P (2000)
Myocardial expression of CC- and CXC-chemokines and their receptors in human end-stage heart failure
Cardiovasc Res, 47 (4), 778-87
DOI 10.1016/s0008-6363(00)00142-5, PubMed 10974226

Mjåland O, Clausen T, Tønnessen T (2000)
[Traditional surgery of inguinal hernia]
Tidsskr Nor Laegeforen, 120 (1), 18-21
PubMed 10815473

Tonnessen T (2000)
Process improvement and the human factor
Total Qual. Manage., 11 (4-6), S773-S778

Tønnessen T, Lyberg T, Geiran O, Christensen G (2000)
Cardiac endothelin-like immunoreactivity and preproendothelin-1 mRNA expression in human heart failure
Scand Cardiovasc J, 34 (1), 21-7
DOI 10.1080/14017430050142350, PubMed 10816056

Ujhelyi MR, Miller AW, Raibon S, Corley J, Robinson VJ, Sims JJ, Tonnessen T, Burke G, Ilebekk A, Rutlen DL (2000)
Endotoxemia alters splanchnic capacitance
Shock, 14 (1), 68-72
DOI 10.1097/00024382-200014010-00012, PubMed 10909896

Publications 1999

Tonnessen T, Gjefsen T (1999)
The enterprise development: direct employee participation in strategic planning
Total Qual. Manage., 10 (4-5), S739-S744

Publications 1998

Bender J, Anspach J, Tonnessen T (1998)
Manufacturing advances in large grazing-incidence optics
J Synchrotron Radiat, 5 (Pt 3), 832-5
DOI 10.1107/S0909049598000673, PubMed 15263668

Hassel B, Ilebekk A, Tønnessen T (1998)
Cardiac accumulation of citrate during brief myocardial ischaemia and reperfusion in the pig in vivo
Acta Physiol Scand, 164 (1), 53-9
DOI 10.1046/j.1365-201X.1998.0400e.x, PubMed 9777025

Holt E, Tønnessen T, Lunde PK, Semb SO, Wasserstrom JA, Sejersted OM, Christensen G (1998)
Mechanisms of cardiomyocyte dysfunction in heart failure following myocardial infarction in rats
J Mol Cell Cardiol, 30 (8), 1581-93
DOI 10.1006/jmcc.1998.0724, PubMed 9737944

Seljeflot I, Moan A, Aspelin T, Tønnessen T, Kjeldsen SE, Arnesen H (1998)
Circulating levels of endothelin-1 during acute hyperinsulinemia in patients with essential hypertension treated with type 1 angiotensin receptor antagonist or placebo
Metabolism, 47 (3), 292-6
DOI 10.1016/s0026-0495(98)90259-1, PubMed 9500565

Semb SO, Lunde PK, Holt E, Tønnessen T, Christensen G, Sejersted OM (1998)
Reduced myocardial Na+, K(+)-pump capacity in congestive heart failure following myocardial infarction in rats
J Mol Cell Cardiol, 30 (7), 1311-28
DOI 10.1006/jmcc.1998.0696, PubMed 9710800

Tølløfsrud S, Tønnessen T, Skraastad O, Noddeland H (1998)
Hypertonic saline and dextran in normovolaemic and hypovolaemic healthy volunteers increases interstitial and intravascular fluid volumes
Acta Anaesthesiol Scand, 42 (2), 145-53
DOI 10.1111/j.1399-6576.1998.tb05100.x, PubMed 9509194

Tønnessen T, Lunde PK, Giaid A, Sejersted OM, Christensen G (1998)
Pulmonary and cardiac expression of preproendothelin-1 mRNA are increased in heart failure after myocardial infarction in rats. Localization of preproendothelin-1 mRNA and endothelin peptide
Cardiovasc Res, 39 (3), 633-43
DOI 10.1016/s0008-6363(98)00156-4, PubMed 9861306

Publications 1997

Finsnes F, Skjønsberg OH, Tønnessen T, Naess O, Lyberg T, Christensen G (1997)
Endothelin production and effects of endothelin antagonism during experimental airway inflammation
Am J Respir Crit Care Med, 155 (4), 1404-12
DOI 10.1164/ajrccm.155.4.9105086, PubMed 9105086

Grund F, Sommerschild HT, Winecoff A, Ujhelyi MR, Tønnessen T, Kirkebøen KA, Rutlen DL, Ilebekk A (1997)
Importance of nitric oxide in hepatic arterial blood flow and total hepatic blood volume regulation in pigs
Acta Physiol Scand, 161 (3), 303-9
DOI 10.1046/j.1365-201X.1997.00229.x, PubMed 9401582

Oie E, Vinge LE, Tønnessen T, Grøgaard HK, Kjekshus H, Christensen G, Smiseth OA, Attramadal H (1997)
Transient, isopeptide-specific induction of myocardial endothelin-1 mRNA in congestive heart failure in rats
Am J Physiol, 273 (4), H1727-36
DOI 10.1152/ajpheart.1997.273.4.H1727, PubMed 9362237

Tonnessen T (1997)
The international total quality management concept and Scandinavian traditions of industrial democracy: Conflicting or mutually reinforcing development strategies
Total Qual. Manage., 8 (2-3), S286-S290

Tønnessen T, Christensen G, Oie E, Holt E, Kjekshus H, Smiseth OA, Sejersted OM, Attramadal H (1997)
Increased cardiac expression of endothelin-1 mRNA in ischemic heart failure in rats
Cardiovasc Res, 33 (3), 601-10
DOI 10.1016/s0008-6363(96)00266-0, PubMed 9093530

Publications 1996

Tønnessen T, Ilebekk A, Naess PA, Christensen G (1996)
Inhibition of granulocyte-derived proteases reduces the increase in plasma endothelin associated with myocardial ischemia in the pig
Basic Res Cardiol, 91 (4), 289-95
DOI 10.1007/BF00789301, PubMed 8874778

Vestavik OM, Tonnessen T (1996)
Milling with abrasive jet in petroleum wells
BHR GR CONF SER PUBL (21), 497-507

Vaagenes P, Ginsberg M, Ebmeyer U, Ernster L, Fischer M, Gisvold SE, Gurvitch A, Hossmann KA, Nemoto EM, Radovsky A, Severinghaus JW, Safar P, Schlichtig R, Sterz F, Tonnessen T, White RJ, Xiao F, Zhou Y (1996)
Cerebral resuscitation from cardiac arrest: pathophysiologic mechanisms
Crit Care Med, 24 (2 Suppl), S57-68
PubMed 8608707

Publications 1995

Offstad J, Naess PA, Aksnes G, Tønnessen T, Ilebekk A, Kirkebøen KA (1995)
Nitric oxide regulates coronary blood flow at various coronary arterial pressures in intact porcine hearts
Acta Physiol Scand, 154 (2), 93-102
DOI 10.1111/j.1748-1716.1995.tb09891.x, PubMed 7572225

Offstad J, Tønnessen T, Kirkebøen KA, Ilebekk A, Downing SE (1995)
Modulation of systolic and diastolic function by endothelin-1: relation to coronary flow
Acta Physiol Scand, 154 (2), 103-11
DOI 10.1111/j.1748-1716.1995.tb09892.x, PubMed 7572206

Tønnessen T (1995)
Effects of ischemia on endothelin processing
Institute for Experimental Medical Research, University of Oslo and Ullevål Hospital, Oslo, 1 b. (flere pag.)
BIBSYS 960706313, ISBN 82-90246-46-3

Tønnessen T, Giaid A, Saleh D, Naess PA, Yanagisawa M, Christensen G (1995)
Increased in vivo expression and production of endothelin-1 by porcine cardiomyocytes subjected to ischemia
Circ Res, 76 (5), 767-72
DOI 10.1161/01.res.76.5.767, PubMed 7728993

Tønnessen T, Schlichting E, Lyberg T, Christensen G (1995)
Endothelin release associated with splanchnic ischemia is abolished by inhibition of leukocyte-derived proteases
Endothelium, 3, 225-234
DOI 10.3109/10623329509024668, PublikaID 318

Publications 1994

Kirkebøen KA, Ilebekk A, Tønnessen T, Leistad E, Naess PA, Christensen G, Aksnes G (1994)
Cardiac contractile function following repetitive brief ischemia: effects of nucleoside transport inhibition
Am J Physiol, 267 (1 Pt 2), H57-65
DOI 10.1152/ajpheart.1994.267.1.H57, PubMed 8048608

Cardiovasc. Res., 28 (5), 722
DOI 10.1093/cvr/28.5.722a

Publications 1993

Tønnessen T, Naess PA, Kirkebøen KA, Ilebekk A, Christensen G (1993)
Alterations in plasma endothelin during passage through the left heart chambers before and after brief myocardial ischaemia
Cardiovasc Res, 27 (12), 2160-3
DOI 10.1093/cvr/27.12.2160, PubMed 8313423

Tønnessen T, Naess PA, Kirkebøen KA, Offstad J, Ilebekk A, Christensen G (1993)
Endothelin is released from the porcine coronary circulation after short-term ischemia
J Cardiovasc Pharmacol, 22 Suppl 8, S313-6
DOI 10.1097/00005344-199322008-00082, PubMed 7509974

Tønnessen T, Naess PA, Kirkebøen KA, Offstad J, Ilebekk A, Christensen G (1993)
Release of endothelin from the porcine heart after short term coronary artery occlusion
Cardiovasc Res, 27 (8), 1482-5
DOI 10.1093/cvr/27.8.1482, PubMed 8221801

Tønnessen T, Tølløfsrud S, Kongsgaard UE, Noddeland H (1993)
Colloid osmotic pressure of plasma replacement fluids
Acta Anaesthesiol Scand, 37 (4), 424-6
DOI 10.1111/j.1399-6576.1993.tb03741.x, PubMed 7686710

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