Håvard Homberset

  • Principal engineer; M.Sc
  • +47 23079035

I am a research technician working with a variety of the projects in the Genome Dynamics group, in addition to trying to keep the lab running as smoothly as possible. My main methodological focus is cloning, purification and characterization of recombinant proteins. The characterization involves sometimes structural studies as well as protein interactions and enzyme activities. I’m currently involved in projects on DNA repair in Mycobacterium tuberculosis and Neisseria meningitidis and in projects studying the mechanisms for horizontal gene transfer in Neisseria meningitidis.


Publications 2022

Keleş Atıcı R, Doğan ŞD, Gündüz MG, Krishna VS, Chebaiki M, Homberset H, Lherbet C, Mourey L, Tønjum T (2022)
Urea derivatives carrying a thiophenylthiazole moiety: Design, synthesis, and evaluation of antitubercular and InhA inhibitory activities
Drug Dev Res, 83 (6), 1292-1304
DOI 10.1002/ddr.21958, PubMed 35769019

Tapera M, Kekeçmuhammed H, Sahin K, Vagolu SK, Lherbet C, Homberset H, Chebaiki M, Tønjum T, Mourey L, Zorlu Y, Durdagi S, Sarıpınar E (2022)
Synthesis, characterization, anti-tuberculosis activity and molecular modeling studies of thiourea derivatives bearing aminoguanidine moiety
Journal of Molecular Structure, 1270, 133899
DOI 10.1016/j.molstruc.2022.133899, PublikaID 421

Publications 2021

Welekidan LN, Yimer SA, Skjerve E, Dejene TA, Homberset H, Tønjum T, Brynildsrud O (2021)
Whole Genome Sequencing of Drug Resistant and Drug Susceptible Mycobacterium tuberculosis Isolates From Tigray Region, Ethiopia
Front Microbiol, 12, 743198
DOI 10.3389/fmicb.2021.743198, PubMed 34938276

Publications 2020

Yimer SA, Kalayou S, Homberset H, Birhanu AG, Riaz T, Zegeye ED, Lutter T, Abebe M, Holm-Hansen C, Aseffa A, Tønjum T (2020)
Lineage-Specific Proteomic Signatures in the Mycobacterium tuberculosis Complex Reveal Differential Abundance of Proteins Involved in Virulence, DNA Repair, CRISPR-Cas, Bioenergetics and Lipid Metabolism
Front Microbiol, 11, 550760
DOI 10.3389/fmicb.2020.550760, PubMed 33072011

Publications 2017

Frye SA, Beyene GT, Namouchi A, Gómez-Muñoz M, Homberset H, Kalayou S, Riaz T, Tønjum T, Balasingham SV (2017)
The helicase DinG responds to stress due to DNA double strand breaks
PLoS One, 12 (11), e0187900
DOI 10.1371/journal.pone.0187900, PubMed 29121674

Hovland E, Beyene GT, Frye SA, Homberset H, Balasingham SV, Gómez-Muñoz M, Derrick JP, Tønjum T, Ambur OH (2017)
DprA from Neisseria meningitidis: properties and role in natural competence for transformation
Microbiology (Reading), 163 (7), 1016-1029
DOI 10.1099/mic.0.000489, PubMed 28696187

Publications 2016

Beyene GT, Balasingham SV, Frye SA, Namouchi A, Homberset H, Kalayou S, Riaz T, Tønjum T (2016)
Characterization of the Neisseria meningitidis Helicase RecG
PLoS One, 11 (10), e0164588
DOI 10.1371/journal.pone.0164588, PubMed 27736945

Publications 2015

Frye SA, Lång E, Beyene GT, Balasingham SV, Homberset H, Rowe AD, Ambur OH, Tønjum T (2015)
The Inner Membrane Protein PilG Interacts with DNA and the Secretin PilQ in Transformation
PLoS One, 10 (8), e0134954
DOI 10.1371/journal.pone.0134954, PubMed 26248334

Publications 2013

Zegeye ED, Balasingham SV, Laerdahl JK, Homberset H, Kristiansen PE, Tønjum T (2013)
Effects of conserved residues and naturally occurring mutations on Mycobacterium tuberculosis RecG helicase activity
Microbiology (Reading), 160 (Pt 1), 217-227
DOI 10.1099/mic.0.072140-0, PubMed 24169816

Publications 2012

Balasingham SV, Zegeye ED, Homberset H, Rossi ML, Laerdahl JK, Bohr VA, Tønjum T (2012)
Enzymatic activities and DNA substrate specificity of Mycobacterium tuberculosis DNA helicase XPB
PLoS One, 7 (5), e36960
DOI 10.1371/journal.pone.0036960, PubMed 22615856

Zegeye ED, Balasingham SV, Laerdahl JK, Homberset H, Tønjum T (2012)
Mycobacterium tuberculosis RecG binds and unwinds model DNA substrates with a preference for Holliday junctions
Microbiology (Reading), 158 (Pt 8), 1982-1993
DOI 10.1099/mic.0.058693-0, PubMed 22628485

Publications 2009

Lång E, Haugen K, Fleckenstein B, Homberset H, Frye SA, Ambur OH, Tønjum T (2009)
Identification of neisserial DNA binding components
Microbiology (Reading), 155 (Pt 3), 852-862
DOI 10.1099/mic.0.022640-0, PubMed 19246756

Tibballs KL, Ambur OH, Alfsnes K, Homberset H, Frye SA, Davidsen T, Tønjum T (2009)
Characterization of the meningococcal DNA glycosylase Fpg involved in base excision repair
BMC Microbiol, 9, 7
DOI 10.1186/1471-2180-9-7, PubMed 19134198

Publications 2007

Balasingham SV, Collins RF, Assalkhou R, Homberset H, Frye SA, Derrick JP, Tønjum T (2007)
Interactions between the lipoprotein PilP and the secretin PilQ in Neisseria meningitidis
J Bacteriol, 189 (15), 5716-27
DOI 10.1128/JB.00060-07, PubMed 17526700

Publications 2006

Golovanov AP, Balasingham S, Tzitzilonis C, Goult BT, Lian LY, Homberset H, Tønjum T, Derrick JP (2006)
Assignment of 1H, 13C, and 15N resonances for the PilP pilot protein from Neisseria meningitidis
J Biomol NMR, 36 Suppl 1, 68
DOI 10.1007/s10858-006-9054-5, PubMed 16933020

Golovanov AP, Balasingham S, Tzitzilonis C, Goult BT, Lian LY, Homberset H, Tønjum T, Derrick JP (2006)
The solution structure of a domain from the Neisseria meningitidis lipoprotein PilP reveals a new beta-sandwich fold
J Mol Biol, 364 (2), 186-95
DOI 10.1016/j.jmb.2006.08.078, PubMed 17007878

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