Publications 2023

Sarkar S, Mayer Bridwell AE, Good JAD, Wang ER, McKee SR, Valenta J, Harrison GA, Flentie KN, Henry FL, Wixe T, Demirel P, Vagolu SK, Chatagnon J, Machelart A, Brodin P, Tønjum T, Stallings CL, Almqvist F (2023)
Design, Synthesis, and Evaluation of Novel Δ²-Thiazolino 2-Pyridone Derivatives That Potentiate Isoniazid Activity in an Isoniazid-Resistant Mycobacterium tuberculosis Mutant
J Med Chem, 66 (16), 11056-11077
DOI 10.1021/acs.jmedchem.3c00358, PubMed 37485869

Özcan E, Vagolu SK, Gündüz MG, Stevanovic M, Kökbudak Z, Tønjum T, Nikodinovic-Runic J, Çetinkaya Y, Doğan ŞD (2023)
Novel Quinoline-Based Thiosemicarbazide Derivatives: Synthesis, DFT Calculations, and Investigation of Antitubercular, Antibacterial, and Antifungal Activities
ACS Omega, 8 (43), 40140-40152
DOI 10.1021/acsomega.3c03018, PubMed 37929089

Publications 2022

Birhanu AG, Gómez-Muñoz M, Kalayou S, Riaz T, Lutter T, Yimer SA, Abebe M, Tønjum T (2022)
Proteome Profiling of Mycobacterium tuberculosis Cells Exposed to Nitrosative Stress
ACS Omega, 7 (4), 3470-3482
DOI 10.1021/acsomega.1c05923, PubMed 35128256

Keleş Atıcı R, Doğan ŞD, Gündüz MG, Krishna VS, Chebaiki M, Homberset H, Lherbet C, Mourey L, Tønjum T (2022)
Urea derivatives carrying a thiophenylthiazole moiety: Design, synthesis, and evaluation of antitubercular and InhA inhibitory activities
Drug Dev Res, 83 (6), 1292-1304
DOI 10.1002/ddr.21958, PubMed 35769019

Koçak Aslan E, Han Mİ, Krishna VS, Tamhaev R, Dengiz C, Doğan ŞD, Lherbet C, Mourey L, Tønjum T, Gündüz MG (2022)
Isoniazid Linked to Sulfonate Esters via Hydrazone Functionality: Design, Synthesis, and Evaluation of Antitubercular Activity
Pharmaceuticals (Basel), 15 (10)
DOI 10.3390/ph15101301, PubMed 36297413

Koçak Aslan E, Vagolu SK, Armakovic SJ, Armakovic S, Sahin O, Tønjum T, Gündüz MG (2022)
Linking azoles to isoniazid via hydrazone bridge: Synthesis, crystal structure determination, antitubercular evaluation and computational studies
Journal of Molecular Liquids, 354, 118873
DOI 10.1016/j.molliq.2022.118873, PublikaID 422

Tapera M, Kekeçmuhammed H, Sahin K, Vagolu SK, Lherbet C, Homberset H, Chebaiki M, Tønjum T, Mourey L, Zorlu Y, Durdagi S, Sarıpınar E (2022)
Synthesis, characterization, anti-tuberculosis activity and molecular modeling studies of thiourea derivatives bearing aminoguanidine moiety
Journal of Molecular Structure, 1270, 133899
DOI 10.1016/j.molstruc.2022.133899, PublikaID 421

Publications 2021

Arenas J, Szabo Z, van der Wal J, Maas C, Riaz T, Tønjum T, Tommassen J (2021)
Serum proteases prevent bacterial biofilm formation: role of kallikrein and plasmin
Virulence, 12 (1), 2902-2917
DOI 10.1080/21505594.2021.2003115, PubMed 34903146

Johansen TEB, Cai T, Naber K, Nicolle LE, Tandogdu Z, Tonjum T, Wagenlehner F, Zahl PH, Koves B (2021)
Pregnant women should be screened for asymptomatic bacteriuria
Tidsskr. Nor. Laegeforen., 141 (11), 1046-1048

Johansen TEB, Cai T, Naber K, Nicolle LE, Tandogdu Z, Tønjum T, Wagenlehner F, Zahl PH, Koves B (2021)
[Pregnant women should be screened for asymptomatic bacteriuria]
Tidsskr Nor Laegeforen, 141 (11)
DOI 10.4045/tidsskr.21.0379, PubMed 34423934

Mekonnen D, Derbie A, Mihret A, Yimer SA, Tønjum T, Gelaw B, Nibret E, Munshae A, Waddell SJ, Aseffa A (2021)
Lipid droplets and the transcriptome of Mycobacterium tuberculosis from direct sputa: a literature review
Lipids Health Dis, 20 (1), 129
DOI 10.1186/s12944-021-01550-5, PubMed 34602073

Welekidan LN, Skjerve E, Dejene TA, Gebremichael MW, Brynildsrud O, Agdestein A, Tessema GT, Tønjum T, Yimer SA (2021)
Correction: Characteristics of pulmonary multidrug-resistant tuberculosis patients in Tigray Region, Ethiopia: A cross-sectional study
PLoS One, 16 (10), e0258457
DOI 10.1371/journal.pone.0258457, PubMed 34614019

Welekidan LN, Yimer SA, Skjerve E, Dejene TA, Homberset H, Tønjum T, Brynildsrud O (2021)
Whole Genome Sequencing of Drug Resistant and Drug Susceptible Mycobacterium tuberculosis Isolates From Tigray Region, Ethiopia
Front Microbiol, 12, 743198
DOI 10.3389/fmicb.2021.743198, PubMed 34938276

Publications 2020

Andersson DI, Balaban NQ, Baquero F, Courvalin P, Glaser P, Gophna U, Kishony R, Molin S, Tønjum T (2020)
Antibiotic resistance: turning evolutionary principles into clinical reality
FEMS Microbiol Rev, 44 (2), 171-188
DOI 10.1093/femsre/fuaa001, PubMed 31981358

Navarro JF, Croteau DL, Jurek A, Andrusivova Z, Yang B, Wang Y, Ogedegbe B, Riaz T, Støen M, Desler C, Rasmussen LJ, Tønjum T, Galas MC, Lundeberg J, Bohr VA (2020)
Spatial Transcriptomics Reveals Genes Associated with Dysregulated Mitochondrial Functions and Stress Signaling in Alzheimer Disease
iScience, 23 (10), 101556
DOI 10.1016/j.isci.2020.101556, PubMed 33083725

Welekidan LN, Skjerve E, Dejene TA, Gebremichael MW, Brynildsrud O, Agdestein A, Tessema GT, Tønjum T, Yimer SA (2020)
Characteristics of pulmonary multidrug-resistant tuberculosis patients in Tigray Region, Ethiopia: A cross-sectional study
PLoS One, 15 (8), e0236362
DOI 10.1371/journal.pone.0236362, PubMed 32797053

Welekidan LN, Skjerve E, Dejene TA, Gebremichael MW, Brynildsrud O, Tønjum T, Yimer SA (2020)
Frequency and patterns of first- and second-line drug resistance-conferring mutations in Mycobacterium tuberculosis isolated from pulmonary tuberculosis patients in a cross-sectional study in Tigray Region, Ethiopia
J Glob Antimicrob Resist, 24, 6-13
DOI 10.1016/j.jgar.2020.11.017, PubMed 33279682

Yimer SA, Kalayou S, Homberset H, Birhanu AG, Riaz T, Zegeye ED, Lutter T, Abebe M, Holm-Hansen C, Aseffa A, Tønjum T (2020)
Lineage-Specific Proteomic Signatures in the Mycobacterium tuberculosis Complex Reveal Differential Abundance of Proteins Involved in Virulence, DNA Repair, CRISPR-Cas, Bioenergetics and Lipid Metabolism
Front Microbiol, 11, 550760
DOI 10.3389/fmicb.2020.550760, PubMed 33072011

Publications 2019

Birhanu AG, Yimer SA, Kalayou S, Riaz T, Zegeye ED, Holm-Hansen C, Norheim G, Aseffa A, Abebe M, Tønjum T (2019)
Ample glycosylation in membrane and cell envelope proteins may explain the phenotypic diversity and virulence in the Mycobacterium tuberculosis complex
Sci Rep, 9 (1), 2927
DOI 10.1038/s41598-019-39654-9, PubMed 30814666

Mekonnen D, Derbie A, Chanie A, Shumet A, Biadglegne F, Kassahun Y, Bobosha K, Mihret A, Wassie L, Munshea A, Nibret E, Yimer SA, Tønjum T, Aseffa A (2019)
Molecular epidemiology of M. tuberculosis in Ethiopia: A systematic review and meta-analysis
Tuberculosis (Edinb), 118, 101858
DOI 10.1016/j.tube.2019.101858, PubMed 31430694

Shi W, Cui P, Niu H, Zhang S, Tønjum T, Zhu B, Zhang Y (2019)
Introducing RpsA Point Mutations Δ438A and D123A into the Chromosome of Mycobacterium tuberculosis Confirms Their Role in Causing Resistance to Pyrazinamide
Antimicrob Agents Chemother, 63 (6)
DOI 10.1128/AAC.02681-18, PubMed 30858213

Publications 2018

Alfsnes K, Frye SA, Eriksson J, Eldholm V, Brynildsrud OB, Bohlin J, Harrison OB, Hood DW, Maiden MCJ, Tønjum T, Ambur OH (2018)
A genomic view of experimental intraspecies and interspecies transformation of a rifampicin-resistance allele into Neisseria meningitidis
Microb Genom, 4 (11)
DOI 10.1099/mgen.0.000222, PubMed 30251949

Desler C, Lillenes MS, Tønjum T, Rasmussen LJ (2018)
The Role of Mitochondrial Dysfunction in the Progression of Alzheimer's Disease
Curr Med Chem, 25 (40), 5578-5587
DOI 10.2174/0929867324666170616110111, PubMed 28618998

Jensen HLB, Lillenes MS, Rabano A, Günther CC, Riaz T, Kalayou ST, Ulstein ID, Bøhmer T, Tønjum T (2018)
Expression of nucleotide excision repair in Alzheimer's disease is higher in brain tissue than in blood
Neurosci Lett, 672, 53-58
DOI 10.1016/j.neulet.2018.02.043, PubMed 29474873

Publications 2017

Beyene GT, Kalayou S, Riaz T, Tonjum T (2017)
Comparative proteomic analysis of Neisseria meningitidis wildtype and dprA null mutant strains links DNA processing to pilus biogenesis
BMC Microbiol, 17 (1), 96
DOI 10.1186/s12866-017-1004-8, PubMed 28431522

Birhanu AG, Yimer SA, Holm-Hansen C, Norheim G, Aseffa A, Abebe M, Tønjum T (2017)
N_ε- and O-Acetylation in Mycobacterium tuberculosis Lineage 7 and Lineage 4 Strains: Proteins Involved in Bioenergetics, Virulence, and Antimicrobial Resistance Are Acetylated
J Proteome Res, 16 (11), 4045-4059
DOI 10.1021/acs.jproteome.7b00429, PubMed 28920697

Castañeda-García A, Prieto AI, Rodríguez-Beltrán J, Alonso N, Cantillon D, Costas C, Pérez-Lago L, Zegeye ED, Herranz M, Plociński P, Tonjum T, García de Viedma D, Paget M, Waddell SJ, Rojas AM, Doherty AJ, Blázquez J (2017)
A non-canonical mismatch repair pathway in prokaryotes
Nat Commun, 8, 14246
DOI 10.1038/ncomms14246, PubMed 28128207

Frye SA, Beyene GT, Namouchi A, Gómez-Muñoz M, Homberset H, Kalayou S, Riaz T, Tønjum T, Balasingham SV (2017)
The helicase DinG responds to stress due to DNA double strand breaks
PLoS One, 12 (11), e0187900
DOI 10.1371/journal.pone.0187900, PubMed 29121674

Hovland E, Beyene GT, Frye SA, Homberset H, Balasingham SV, Gómez-Muñoz M, Derrick JP, Tønjum T, Ambur OH (2017)
DprA from Neisseria meningitidis: properties and role in natural competence for transformation
Microbiology (Reading), 163 (7), 1016-1029
DOI 10.1099/mic.0.000489, PubMed 28696187

Lillenes MS, Støen M, Günther CC, Selnes P, Stenset VT, Espeseth T, Reinvang I, Fladby T, Tønjum T (2017)
Mitochondrial transcription factor A (TFAM) rs1937 and AP endonuclease 1 (APE1) rs1130409 alleles are associated with reduced cognitive performance
Neurosci Lett, 645, 46-52
DOI 10.1016/j.neulet.2017.02.062, PubMed 28242328

Norheim G, Seterelv S, Arnesen TM, Mengshoel AT, Tønjum T, Rønning JO, Eldholm V (2017)
Tuberculosis Outbreak in an Educational Institution in Norway
J Clin Microbiol, 55 (5), 1327-1333
DOI 10.1128/JCM.01152-16, PubMed 28202795

Yimer SA, Birhanu AG, Kalayou S, Riaz T, Zegeye ED, Beyene GT, Holm-Hansen C, Norheim G, Abebe M, Aseffa A, Tønjum T (2017)
Comparative Proteomic Analysis of Mycobacterium tuberculosis Lineage 7 and Lineage 4 Strains Reveals Differentially Abundant Proteins Linked to Slow Growth and Virulence
Front Microbiol, 8, 795
DOI 10.3389/fmicb.2017.00795, PubMed 28536560

Publications 2016

Beyene GT, Balasingham SV, Frye SA, Namouchi A, Homberset H, Kalayou S, Riaz T, Tønjum T (2016)
Characterization of the Neisseria meningitidis Helicase RecG
PLoS One, 11 (10), e0164588
DOI 10.1371/journal.pone.0164588, PubMed 27736945

Lillenes MS, Rabano A, Støen M, Riaz T, Misaghian D, Møllersen L, Esbensen Y, Günther CC, Selnes P, Stenset VT, Fladby T, Tønjum T (2016)
Altered DNA base excision repair profile in brain tissue and blood in Alzheimer's disease
Mol Brain, 9 (1), 61
DOI 10.1186/s13041-016-0237-z, PubMed 27234294

Namouchi A, Gómez-Muñoz M, Frye SA, Moen LV, Rognes T, Tønjum T, Balasingham SV (2016)
The Mycobacterium tuberculosis transcriptional landscape under genotoxic stress
BMC Genomics, 17 (1), 791
DOI 10.1186/s12864-016-3132-1, PubMed 27724857

Yimer SA, Namouchi A, Zegeye ED, Holm-Hansen C, Norheim G, Abebe M, Aseffa A, Tønjum T (2016)
Deciphering the recent phylogenetic expansion of the originally deeply rooted Mycobacterium tuberculosis lineage 7
BMC Evol Biol, 16 (1), 146
DOI 10.1186/s12862-016-0715-z, PubMed 27363525

Zegeye N, Asrat D, Woldeamanuel Y, Habte A, Gedlu E, Tønjum T, Aseffa A (2016)
Throat culture positivity rate and antibiotic susceptibility pattern of beta-hemolytic streptococci in children on secondary prophylaxis for rheumatic heart disease
BMC Infect Dis, 16 (1), 510
DOI 10.1186/s12879-016-1841-3, PubMed 27663649

Publications 2015

Dahlberg D, Mariussen E, Goverud IL, Tønjum T, Mæhlen J, Antal EA, Hassel B (2015)
Staphylococcal α-hemolysin is neurotoxic and causes lysis of brain cells in vivo and in vitro
Neurotoxicology, 48, 61-7
DOI 10.1016/j.neuro.2015.03.001, PubMed 25757835

Frye SA, Lång E, Beyene GT, Balasingham SV, Homberset H, Rowe AD, Ambur OH, Tønjum T (2015)
The Inner Membrane Protein PilG Interacts with DNA and the Secretin PilQ in Transformation
PLoS One, 10 (8), e0134954
DOI 10.1371/journal.pone.0134954, PubMed 26248334

Ricanek P, Lunde LK, Frye SA, Støen M, Nygård S, Morth JP, Rydning A, Vatn MH, Amiry-Moghaddam M, Tønjum T (2015)
Reduced expression of aquaporins in human intestinal mucosa in early stage inflammatory bowel disease
Clin Exp Gastroenterol, 8, 49-67
DOI 10.2147/CEG.S70119, PubMed 25624769

Yimer SA, Norheim G, Namouchi A, Zegeye ED, Kinander W, Tønjum T, Bekele S, Mannsåker T, Bjune G, Aseffa A, Holm-Hansen C (2015)
Mycobacterium tuberculosis lineage 7 strains are associated with prolonged patient delay in seeking treatment for pulmonary tuberculosis in Amhara Region, Ethiopia
J Clin Microbiol, 53 (4), 1301-9
DOI 10.1128/JCM.03566-14, PubMed 25673798

Publications 2014

Alfsnes K, Raynaud X, Tønjum T, Ambur OH (2014)
Mathematical and live meningococcal models for simple sequence repeat dynamics - coherent predictions and observations
PLoS One, 9 (7), e101637
DOI 10.1371/journal.pone.0101637, PubMed 24999629

Hassel B, Dahlberg D, Mariussen E, Goverud IL, Antal EA, Tønjum T, Maehlen J (2014)
Brain infection with Staphylococcus aureus leads to high extracellular levels of glutamate, aspartate, γ-aminobutyric acid, and zinc
J Neurosci Res, 92 (12), 1792-800
DOI 10.1002/jnr.23444, PubMed 25043715

Mantaka P, Tønjum T, Gjersvik P (2014)
[A knot on the aquarium owner's hand]
Tidsskr Nor Laegeforen, 134 (7), 715
DOI 10.4045/tidsskr.13.1425, PubMed 24721859

Publications 2013

Frye SA, Nilsen M, Tønjum T, Ambur OH (2013)
Dialects of the DNA uptake sequence in Neisseriaceae
PLoS Genet, 9 (4), e1003458
DOI 10.1371/journal.pgen.1003458, PubMed 23637627

Klenk HD, Ron E, Sansonetti P, Tønjum T (2013)
The synergies of microorganisms enlightened - convergent approaches to delineating coinfections
Pathog Dis, 69 (2), 71
DOI 10.1111/2049-632X.12101, PubMed 24151184

Lillenes MS, Støen M, Gómez-Muñoz M, Torp R, Günther CC, Nilsson LN, Tønjum T (2013)
Transient OGG1, APE1, PARP1 and Polβ expression in an Alzheimer's disease mouse model
Mech Ageing Dev, 134 (10), 467-77
DOI 10.1016/j.mad.2013.09.002, PubMed 24121118

Nagelhus EA, Amiry-Moghaddam M, Bergersen LH, Bjaalie JG, Eriksson J, Gundersen V, Leergaard TB, Morth JP, Storm-Mathisen J, Torp R, Walhovd KB, Tønjum T (2013)
The glia doctrine: addressing the role of glial cells in healthy brain ageing
Mech Ageing Dev, 134 (10), 449-59
DOI 10.1016/j.mad.2013.10.001, PubMed 24141107

Rasmussen LJ, Shiloh Y, Bergersen LH, Sander M, Bohr VA, Tønjum T (2013)
DNA damage response, bioenergetics, and neurological disease: the challenge of maintaining brain health in an aging human population
Mech Ageing Dev, 134 (10), 427-33
DOI 10.1016/j.mad.2013.05.001, PubMed 23665461

Warner DF, Tønjum T, Mizrahi V (2013)
DNA metabolism in mycobacterial pathogenesis
Curr Top Microbiol Immunol, 374, 27-51
DOI 10.1007/82_2013_328, PubMed 23633106

Zegeye ED, Balasingham SV, Laerdahl JK, Homberset H, Kristiansen PE, Tønjum T (2013)
Effects of conserved residues and naturally occurring mutations on Mycobacterium tuberculosis RecG helicase activity
Microbiology (Reading), 160 (Pt 1), 217-227
DOI 10.1099/mic.0.072140-0, PubMed 24169816

Publications 2012

Ambur OH, Frye SA, Nilsen M, Hovland E, Tønjum T (2012)
Restriction and sequence alterations affect DNA uptake sequence-dependent transformation in Neisseria meningitidis
PLoS One, 7 (7), e39742
DOI 10.1371/journal.pone.0039742, PubMed 22768309

Balasingham SV, Zegeye ED, Homberset H, Rossi ML, Laerdahl JK, Bohr VA, Tønjum T (2012)
Enzymatic activities and DNA substrate specificity of Mycobacterium tuberculosis DNA helicase XPB
PLoS One, 7 (5), e36960
DOI 10.1371/journal.pone.0036960, PubMed 22615856

Berry JL, Phelan MM, Collins RF, Adomavicius T, Tønjum T, Frye SA, Bird L, Owens R, Ford RC, Lian LY, Derrick JP (2012)
Structure and assembly of a trans-periplasmic channel for type IV pili in Neisseria meningitidis
PLoS Pathog, 8 (9), e1002923
DOI 10.1371/journal.ppat.1002923, PubMed 23028322

Karch H, Denamur E, Dobrindt U, Finlay BB, Hengge R, Johannes L, Ron EZ, Tønjum T, Sansonetti PJ, Vicente M (2012)
The enemy within us: lessons from the 2011 European Escherichia coli O104:H4 outbreak
EMBO Mol Med, 4 (9), 841-8
DOI 10.1002/emmm.201201662, PubMed 22927122

Ricanek P, Lothe SM, Frye SA, Rydning A, Vatn MH, Tønjum T (2012)
Gut bacterial profile in patients newly diagnosed with treatment-naïve Crohn's disease
Clin Exp Gastroenterol, 5, 173-86
DOI 10.2147/CEG.S33858, PubMed 23049264

Zegeye ED, Balasingham SV, Laerdahl JK, Homberset H, Tønjum T (2012)
Mycobacterium tuberculosis RecG binds and unwinds model DNA substrates with a preference for Holliday junctions
Microbiology (Reading), 158 (Pt 8), 1982-1993
DOI 10.1099/mic.0.058693-0, PubMed 22628485

Publications 2011

Benam AV, Lång E, Alfsnes K, Fleckenstein B, Rowe AD, Hovland E, Ambur OH, Frye SA, Tønjum T (2011)
Structure-function relationships of the competence lipoprotein ComL and SSB in meningococcal transformation
Microbiology (Reading), 157 (Pt 5), 1329-1342
DOI 10.1099/mic.0.046896-0, PubMed 21330432

Lillenes MS, Espeseth T, Støen M, Lundervold AJ, Frye SA, Rootwelt H, Reinvang I, Tønjum T (2011)
DNA base excision repair gene polymorphisms modulate human cognitive performance and decline during normal life span
Mech Ageing Dev, 132 (8-9), 449-58
DOI 10.1016/j.mad.2011.08.002, PubMed 21884718

Ricanek P, Rydning A, Vatn MH, Tonjum T (2011)
Considered "negative" for MAP, these results would be very "positive" for tuberculoid leprosy Reply
J. Crohns Colitis, 5 (4), 374
DOI 10.1016/j.crohns.2011.04.007

Tønjum T, Koomey M (2011)
Kiss and run - phosphoglycerol modifications of N. Meningitidis pili mediate detachment
Front Microbiol, 2, 82
DOI 10.3389/fmicb.2011.00082, PubMed 21747798

Yang M, Aamodt RM, Dalhus B, Balasingham S, Helle I, Andersen P, Tønjum T, Alseth I, Rognes T, Bjørås M (2011)
The ada operon of Mycobacterium tuberculosis encodes two DNA methyltransferases for inducible repair of DNA alkylation damage
DNA Repair (Amst), 10 (6), 595-602
DOI 10.1016/j.dnarep.2011.03.007, PubMed 21570366

Publications 2010

Aspholm M, Aas FE, Harrison OB, Quinn D, Vik A, Viburiene R, Tønjum T, Moir J, Maiden MC, Koomey M (2010)
Structural alterations in a component of cytochrome c oxidase and molecular evolution of pathogenic Neisseria in humans
PLoS Pathog, 6 (8), e1001055
DOI 10.1371/journal.ppat.1001055, PubMed 20808844

Ricanek P, Lothe SM, Szpinda I, Jorde AT, Brackmann S, Perminow G, Jørgensen KK, Rydning A, Vatn MH, Tønjum T, IBSEN II study group (2010)
Paucity of mycobacteria in mucosal bowel biopsies from adults and children with early inflammatory bowel disease
J Crohns Colitis, 4 (5), 561-6
DOI 10.1016/j.crohns.2010.05.003, PubMed 21122560

Publications 2009

Ambur OH, Davidsen T, Frye SA, Balasingham SV, Lagesen K, Rognes T, Tønjum T (2009)
Genome dynamics in major bacterial pathogens
FEMS Microbiol Rev, 33 (3), 453-70
DOI 10.1111/j.1574-6976.2009.00173.x, PubMed 19396949

Balasingham SV, Davidsen T, Szpinda I, Frye SA, Tønjum T (2009)
Molecular diagnostics in tuberculosis: basis and implications for therapy
Mol Diagn Ther, 13 (3), 137-51
DOI 10.1007/BF03256322, PubMed 19650669

Bayliss CD, Casadesus J, Rocha E, Tønjum T (2009)
Microbial DNA metabolism, genome dynamics and human disease
FEMS Microbiol Rev, 33 (3), 451-2
DOI 10.1111/j.1574-6976.2009.00174.x, PubMed 19396948

Dos Vultos T, Mestre O, Tonjum T, Gicquel B (2009)
DNA repair in Mycobacterium tuberculosis revisited
FEMS Microbiol Rev, 33 (3), 471-87
DOI 10.1111/j.1574-6976.2009.00170.x, PubMed 19385996

Lång E, Haugen K, Fleckenstein B, Homberset H, Frye SA, Ambur OH, Tønjum T (2009)
Identification of neisserial DNA binding components
Microbiology (Reading), 155 (Pt 3), 852-862
DOI 10.1099/mic.0.022640-0, PubMed 19246756

Olsen I, Balasingham SV, Davidsen T, Debebe E, Rødland EA, van Soolingen D, Kremer K, Alseth I, Tønjum T (2009)
Characterization of the major formamidopyrimidine-DNA glycosylase homolog in Mycobacterium tuberculosis and its linkage to variable tandem repeats
FEMS Immunol Med Microbiol, 56 (2), 151-61
DOI 10.1111/j.1574-695X.2009.00562.x, PubMed 19496823

Tibballs KL, Ambur OH, Alfsnes K, Homberset H, Frye SA, Davidsen T, Tønjum T (2009)
Characterization of the meningococcal DNA glycosylase Fpg involved in base excision repair
BMC Microbiol, 9, 7
DOI 10.1186/1471-2180-9-7, PubMed 19134198

Publications 2008

Dos Vultos T, Mestre O, Rauzier J, Golec M, Rastogi N, Rasolofo V, Tonjum T, Sola C, Matic I, Gicquel B (2008)
Evolution and diversity of clonal bacteria: the paradigm of Mycobacterium tuberculosis
PLoS One, 3 (2), e1538
DOI 10.1371/journal.pone.0001538, PubMed 18253486

Glosli H, Stray-Pedersen A, Brun AC, Holtmon LW, Tønjum T, Chapgier A, Casanova JL, Abrahamsen TG (2008)
Infections due to various atypical mycobacteria in a Norwegian multiplex family with dominant interferon-gamma receptor deficiency
Clin Infect Dis, 46 (3), e23-7
DOI 10.1086/525855, PubMed 18171304

Sinha S, Ambur OH, Langford PR, Tønjum T, Kroll JS (2008)
Reduced DNA binding and uptake in the absence of DsbA1 and DsbA2 of Neisseria meningitidis due to inefficient folding of the outer-membrane secretin PilQ
Microbiology (Reading), 154 (Pt 1), 217-225
DOI 10.1099/mic.0.2007/010496-0, PubMed 18174140

Treangen TJ, Ambur OH, Tonjum T, Rocha EP (2008)
The impact of the neisserial DNA uptake sequences on genome evolution and stability
Genome Biol, 9 (3), R60
DOI 10.1186/gb-2008-9-3-r60, PubMed 18366792

Tønjum T (2008)
Neisseriaceae, Moraxellaceae, Chlamydia, Mycoplasma and Ureaplasma, Rickettsiaceae, Gardnerella, Calymmatobacterium, Cardiobacterium, Streptobacillus and Capnocytophaga
In Medisinsk mikrobiologi, 3. utgave (Degré M, Hovig B, Rollag H, eds.), Gyldendal, Oslo, 111-128, 202-217, 218-222, 240-250, 251-260, 264-269, 270-272
PublikaID 53, ISBN 978-82-05-31590-7

Publications 2007

Assalkhou R, Balasingham S, Collins RF, Frye SA, Davidsen T, Benam AV, Bjørås M, Derrick JP, Tønjum T (2007)
The outer membrane secretin PilQ from Neisseria meningitidis binds DNA
Microbiology (Reading), 153 (Pt 5), 1593-1603
DOI 10.1099/mic.0.2006/004200-0, PubMed 17464074

Balasingham SV, Collins RF, Assalkhou R, Homberset H, Frye SA, Derrick JP, Tønjum T (2007)
Interactions between the lipoprotein PilP and the secretin PilQ in Neisseria meningitidis
J Bacteriol, 189 (15), 5716-27
DOI 10.1128/JB.00060-07, PubMed 17526700

Bohr VA, Ottersen OP, Tønjum T (2007)
Genome instability and DNA repair in brain, ageing and neurological disease
Neuroscience, 145 (4), 1183-6
DOI 10.1016/j.neuroscience.2007.03.015, PubMed 17400394

Davidsen T, Amundsen EK, Rødland EA, Tønjum T (2007)
DNA repair profiles of disease-associated isolates of Neisseria meningitidis
FEMS Immunol Med Microbiol, 49 (2), 243-51
DOI 10.1111/j.1574-695X.2006.00195.x, PubMed 17284282

Davidsen T, Koomey M, Tønjum T (2007)
Microbial genome dynamics in CNS pathogenesis
Neuroscience, 145 (4), 1375-87
DOI 10.1016/j.neuroscience.2007.01.059, PubMed 17367950

Davidsen T, Tuven HK, Bjørås M, Rødland EA, Tønjum T (2007)
Genetic interactions of DNA repair pathways in the pathogen Neisseria meningitidis
J Bacteriol, 189 (15), 5728-37
DOI 10.1128/JB.00161-07, PubMed 17513474

Publications 2006

Ambur OH, Frye SA, Tønjum T (2006)
New functional identity for the DNA uptake sequence in transformation and its presence in transcriptional terminators
J Bacteriol, 189 (5), 2077-85
DOI 10.1128/JB.01408-06, PubMed 17194793

Davidsen T, Ambur OH, Tønjum T (2006)
Transformation and DNA repair
In Handbook of Meningococcal Disease: Infection Biology, Vaccination, Clinical Management (Frosch M, Maiden MCJ, eds.), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG, 119-144
DOI 10.1002/3527608508.ch7, PublikaID 51, ISBN 978-3-527-31260-3

Davidsen T, Tønjum T (2006)
Meningococcal genome dynamics
Nat Rev Microbiol, 4 (1), 11-22
DOI 10.1038/nrmicro1324, PubMed 16357857

Frye SA, Assalkhou R, Collins RF, Ford RC, Petersson C, Derrick JP, Tønjum T (2006)
Topology of the outer-membrane secretin PilQ from Neisseria meningitidis
Microbiology (Reading), 152 (Pt 12), 3751-3764
DOI 10.1099/mic.0.2006/000315-0, PubMed 17159226

Golovanov AP, Balasingham S, Tzitzilonis C, Goult BT, Lian LY, Homberset H, Tønjum T, Derrick JP (2006)
Assignment of 1H, 13C, and 15N resonances for the PilP pilot protein from Neisseria meningitidis
J Biomol NMR, 36 Suppl 1, 68
DOI 10.1007/s10858-006-9054-5, PubMed 16933020

Golovanov AP, Balasingham S, Tzitzilonis C, Goult BT, Lian LY, Homberset H, Tønjum T, Derrick JP (2006)
The solution structure of a domain from the Neisseria meningitidis lipoprotein PilP reveals a new beta-sandwich fold
J Mol Biol, 364 (2), 186-95
DOI 10.1016/j.jmb.2006.08.078, PubMed 17007878

Vicente M, Hodgson J, Massidda O, Tonjum T, Henriques-Normark B, Ron EZ (2006)
The fallacies of hope: will we discover new antibiotics to combat pathogenic bacteria in time?
FEMS Microbiol Rev, 30 (6), 841-52
DOI 10.1111/j.1574-6976.2006.00038.x, PubMed 17064283

Publications 2005

Collins RF, Frye SA, Balasingham S, Ford RC, Tønjum T, Derrick JP (2005)
Interaction with type IV pili induces structural changes in the bacterial outer membrane secretin PilQ
J Biol Chem, 280 (19), 18923-30
DOI 10.1074/jbc.M411603200, PubMed 15753075

Davidsen T, Bjørås M, Seeberg EC, Tønjum T (2005)
Antimutator role of DNA glycosylase MutY in pathogenic Neisseria species
J Bacteriol, 187 (8), 2801-9
DOI 10.1128/JB.187.8.2801-2809.2005, PubMed 15805527

Hedlund BP, Tønjum T (2005)
Genus Simonsiella
In Bergey's Manual of Systematic Bacteriology. Volume 2: The Proteobacteria. Part C: The Alpha-, Beta-, Delta-, and Epsilonproteobacteria. 2nd ed. (Garrity GM, ed.), Springer Verlag New York Inc., New York, 844-851
DOI 10.1007/0-387-29298-5_195, PublikaID 46, ISBN 978-0-387-24145-6

Tønjum T (2005)
Order Neisseriales
In Bergey's Manual of Systematic Bacteriology. Volume 2: The Proteobacteria. Part C: The Alpha-, Beta-, Delta-, and Epsilonproteobacteria. 2nd ed. (Garrity GM, ed.), Springer Verlag New York Inc., New York, 774
PublikaID 47, ISBN 978-0-387-24145-6

Tønjum T (2005)
Family Neisseriaceae
In Bergey's Manual of Systematic Bacteriology. Volume 2: The Proteobacteria. Part C: The Alpha-, Beta-, Delta-, and Epsilonproteobacteria. 2nd ed. (Garrity GM, ed.), Springer Verlag New York Inc., New York, 775-776
PublikaID 48, ISBN 978-0-387-24145-6

Tønjum T (2005)
Genus Neisseria
In Bergey's Manual of Systematic Bacteriology. Volume 2: The Proteobacteria. Part C: The Alpha-, Beta-, Delta-, and Epsilonproteobacteria. 2nd ed. (Garrity GM, ed.), Springer Verlag New York Inc., New York, 777-798
DOI 10.1007/0-387-29298-5_185, PublikaID 49, ISBN 978-0-387-24145-6

Tønjum T (2005)
Genus Alysiella
In Bergey's Manual of Systematic Bacteriology. Volume 2: The Proteobacteria. Part C: The Alpha-, Beta-, Delta-, and Epsilonproteobacteria. 2nd ed. (Garrity GM, ed.), Springer Verlag New York Inc., New York, 798-801
DOI 10.1007/0-387-29298-5_186, PublikaID 50, ISBN 978-0-387-24145-6

Publications 2004

Collins RF, Frye SA, Kitmitto A, Ford RC, Tønjum T, Derrick JP (2004)
Structure of the Neisseria meningitidis outer membrane PilQ secretin complex at 12 A resolution
J Biol Chem, 279 (38), 39750-6
DOI 10.1074/jbc.M405971200, PubMed 15254043

Davidsen T, Rødland EA, Lagesen K, Seeberg E, Rognes T, Tønjum T (2004)
Biased distribution of DNA uptake sequences towards genome maintenance genes
Nucleic Acids Res, 32 (3), 1050-8
DOI 10.1093/nar/gkh255, PubMed 14960717

Tønjum T, Håvarstein LS, Koomey M, Seeberg E (2004)
Transformation and DNA repair: linkage by DNA recombination
Trends Microbiol, 12 (1), 1-4
DOI 10.1016/j.tim.2003.11.008, PubMed 14700543

Publications 2003

Collins RF, Ford RC, Kitmitto A, Olsen RO, Tønjum T, Derrick JP (2003)
Three-dimensional structure of the Neisseria meningitidis secretin PilQ determined from negative-stain transmission electron microscopy
J Bacteriol, 185 (8), 2611-7
DOI 10.1128/JB.185.8.2611-2617.2003, PubMed 12670986

Publications 2001

Collins RF, Davidsen L, Derrick JP, Ford RC, Tønjum T (2001)
Analysis of the PilQ secretin from Neisseria meningitidis by transmission electron microscopy reveals a dodecameric quaternary structure
J Bacteriol, 183 (13), 3825-32
DOI 10.1128/JB.183.13.3825-3832.2001, PubMed 11395444

Harmsen D, Singer C, Rothgänger J, Tønjum T, de Hoog GS, Shah H, Albert J, Frosch M (2001)
Diagnostics of neisseriaceae and moraxellaceae by ribosomal DNA sequencing: ribosomal differentiation of medical microorganisms
J Clin Microbiol, 39 (3), 936-42
DOI 10.1128/JCM.39.3.936-942.2001, PubMed 11230407

Tønjum T, Seeberg E (2001)
Microbial fitness and genome dynamics
Trends Microbiol, 9 (8), 356-8
DOI 10.1016/s0966-842x(01)02099-6, PubMed 11519528

Publications 2000

Hartmann A, Halvorsen CE, Jenssen T, Bjørneklett A, Brekke IB, Bakke SJ, Hirschberg H, Tønjum T, Gaustad P (2000)
Intracerebral abscess caused by Nocardia otitidiscaviarum in a renal transplant patient--cured by evacuation plus antibiotic therapy
Nephron, 86 (1), 79-83
DOI 10.1159/000045716, PubMed 10971157

Publications 1998

Bergan T, Gaustad P, Høiby EA, Berdal BP, Furuberg G, Baann J, Tønjum T (1998)
Antibiotic resistance of pneumococci in Norway
Int J Antimicrob Agents, 10 (1), 77-81
DOI 10.1016/s0924-8579(98)00018-1, PubMed 9624547

Pettersson B, Kodjo A, Ronaghi M, Uhlén M, Tønjum T (1998)
Phylogeny of the family Moraxellaceae by 16S rDNA sequence analysis, with special emphasis on differentiation of Moraxella species
Int J Syst Bacteriol, 48 Pt 1, 75-89
DOI 10.1099/00207713-48-1-75, PubMed 9542079

Tønjum T, Caugant DA, Dunham SA, Koomey M (1998)
Structure and function of repetitive sequence elements associated with a highly polymorphic domain of the Neisseria meningitidis PilQ protein
Mol Microbiol, 29 (1), 111-24
DOI 10.1046/j.1365-2958.1998.00910.x, PubMed 9701807

Tønjum T, Welty DB, Jantzen E, Small PL (1998)
Differentiation of Mycobacterium ulcerans, M. marinum, and M. haemophilum: mapping of their relationships to M. tuberculosis by fatty acid profile analysis, DNA-DNA hybridization, and 16S rRNA gene sequence analysis
J Clin Microbiol, 36 (4), 918-25
DOI 10.1128/JCM.36.4.918-925.1998, PubMed 9542909

Publications 1997

Kodjo A, Richard Y, Tønjum T (1997)
Moraxella boevrei sp. nov., a new Moraxella species found in goats
Int J Syst Bacteriol, 47 (1), 115-21
DOI 10.1099/00207713-47-1-115, PubMed 8995812

Lindbråthen A, Gaustad P, Hovig B, Tønjum T (1997)
Direct detection of Mycobacterium tuberculosis complex in clinical samples from patients in Norway by ligase chain reaction
J Clin Microbiol, 35 (12), 3248-53
DOI 10.1128/jcm.35.12.3248-3253.1997, PubMed 9399528

Petrini B, Bauer J, Hoffner S, Miörner H, Tønjum T (1997)
[Molecular mycobacterium-diagnostics. Weapon against increased global spread of tuberculosis]
Lakartidningen, 94 (41), 3612-4, 3616
PubMed 9411108

Tønjum T, Koomey M (1997)
The pilus colonization factor of pathogenic neisserial species: organelle biogenesis and structure/function relationships--a review
Gene, 192 (1), 155-63
DOI 10.1016/s0378-1119(97)00018-8, PubMed 9224886

Publications 1996

Kodjo A, Tonjum T, Richard Y, Bovre K (1996)
Moraxella caprae sp nov, a new member of the classical Moraxellae with very close affinity to Moraxella bovis (vol 45, pg 467, 1995)
Int. J. Syst. Bacteriol., 46 (1), 366
DOI 10.1099/00207713-46-1-366a

Tønjum T, Klintz L, Bergan T, Baann J, Furuberg G, Cristea M, Petrini B, Hoffner S (1996)
Direct detection of Mycobacterium tuberculosis in respiratory samples from patients in Scandinavia by polymerase chain reaction
Clin Microbiol Infect, 2 (2), 127-131
DOI 10.1111/j.1469-0691.1996.tb00218.x, PubMed 11866830

Publications 1995

Caugant DA, Sandven P, Eng J, Jeque JT, Tønjum T (1995)
Detection of rifampin resistance among isolates of Mycobacterium tuberculosis from Mozambique
Microb Drug Resist, 1 (4), 321-6
DOI 10.1089/mdr.1995.1.321, PubMed 9158803

Kodjo A, Tønjum T, Richard Y, Bøvre K (1995)
Moraxella caprae sp. nov., a new member of the classical Moraxellae with very close affinity to Moraxella bovis
Int J Syst Bacteriol, 45 (3), 467-71
DOI 10.1099/00207713-45-3-467, PubMed 8590674

Tønjum T, Bøvre K, Juni E (1995)
Fastidious gram-negative bacteria: meeting the diagnostic challenge with nucleic acid analysis
APMIS, 103 (9), 609-27
DOI 10.1111/j.1699-0463.1995.tb01414.x, PubMed 7488382

Tønjum T, Freitag NE, Namork E, Koomey M (1995)
Identification and characterization of pilG, a highly conserved pilus-assembly gene in pathogenic Neisseria
Mol Microbiol, 16 (3), 451-64
DOI 10.1111/j.1365-2958.1995.tb02410.x, PubMed 7565106

Publications 1994

Skaar I, Gaustad P, Tønjum T, Holm B, Stenwig H (1994)
Streptococcus phocae sp. nov., a new species isolated from clinical specimens from seals
Int J Syst Bacteriol, 44 (4), 646-50
DOI 10.1099/00207713-44-4-646, PubMed 7981096

Publications 1993

Tønjum T (1993)
DNA probing into fastidious gram-negative bacterial species: a search for diagnostic criteria
Kaptein W. Wilhelmsen og Frues bakteriologiske institutt,Rikshospitalet (National hospital), University of Oslo, Oslo, 1 b. (flere pag.)
BIBSYS 931794889, ISBN 82-7633-031-2

Tønjum T, Haas R (1993)
Identification of Actinobacillus actinomycetemcomitans by leukotoxin gene-specific hybridization and polymerase chain reaction assays
J Clin Microbiol, 31 (7), 1856-9
DOI 10.1128/jcm.31.7.1856-1859.1993, PubMed 8349764

Tønjum T, Weir S, Bøvre K, Progulske-Fox A, Marrs CF (1993)
Sequence divergence in two tandemly located pilin genes of Eikenella corrodens
Infect Immun, 61 (5), 1909-16
DOI 10.1128/iai.61.5.1909-1916.1993, PubMed 8478080

Publications 1992

Tønjum T, Caugant DA, Bøvre K (1992)
Differentiation of Moraxella nonliquefaciens, M. lacunata, and M. bovis by using multilocus enzyme electrophoresis and hybridization with pilin-specific DNA probes
J Clin Microbiol, 30 (12), 3099-107
DOI 10.1128/jcm.30.12.3099-3107.1992, PubMed 1452691

Publications 1991

Borchsenius F, Bruun JN, Tønjum T (1991)
Systemic meningococcal disease: the diagnosis on admission to hospital
NIPH Ann, 14 (1), 11-22
PubMed 1881574

Degré M, Rollag H, Holter E, Tønjum T, Krajci Z, Bukholm G (1991)
[Diagnosis of cytomegalovirus infections in hospitalized patients]
Tidsskr Nor Laegeforen, 111 (28), 3401-4
PubMed 1665258

Tønjum T, Marrs CF, Rozsa F, Bøvre K (1991)
The type 4 pilin of Moraxella nonliquefaciens exhibits unique similarities with the pilins of Neisseria gonorrhoeae and Dichelobacter (Bacteroides) nodosus
J Gen Microbiol, 137 (10), 2483-90
DOI 10.1099/00221287-137-10-2483, PubMed 1770363

Publications 1990

Tønjum T, Bukholm G, Bøvre K (1990)
Identification of Haemophilus aphrophilus and Actinobacillus actinomycetemcomitans by DNA-DNA hybridization and genetic transformation
J Clin Microbiol, 28 (9), 1994-8
DOI 10.1128/jcm.28.9.1994-1998.1990, PubMed 2229383

Publications 1989

Bøvre K, Bukholm G, Tønjum T, Kapperud G (1989)
[Gene technology in medical microbiology--a general review]
Tidsskr Nor Laegeforen, 109 (31), 3216-8
PubMed 2595686

Rostrup M, Tønjum T, Ekeberg O (1989)
[Self-poisoning in Northwest Norway in 1975-1984]
Tidsskr Nor Laegeforen, 109 (2), 173-6
PubMed 2916191

Rostrup M, Tønjum T, Ekeberg O (1989)
[Self-poisoning in Northwest Norway in 1984. A follow-up after 6 months. A prospective study]
Tidsskr Nor Laegeforen, 109 (2), 177-9
PubMed 2916192

Tønjum T, Bukholm G, Bøvre K (1989)
Differentiation of some species of Neisseriaceae and other bacterial groups by DNA-DNA hybridization
APMIS, 97 (5), 395-405
DOI 10.1111/j.1699-0463.1989.tb00806.x, PubMed 2730785

Publications 1986

Melby K, Tønjum T, Skjørten F (1986)
Detection of serum antibody response in patients infected with one strain of Campylobacter jejuni with a DIG-ELISA method
NIPH Ann, 9 (2), 51-60
PubMed 3808455

Publications 1985

Tønjum T, Hagen N, Bøvre K (1985)
Identification of Eikenella corrodens and Cardiobacterium hominis by genetic transformation
Acta Pathol Microbiol Immunol Scand B, 93 (6), 389-94
DOI 10.1111/j.1699-0463.1985.tb02907.x, PubMed 2939687

Publications 1983

Haneberg B, Tønjum T, Rodahl K, Gedde-Dahl TW (1983)
Factors preceding the onset of meningococcal disease, with special emphasis on passive smoking, symptoms of ill health
NIPH Ann, 6 (2), 169-73
PubMed 6676682

Tønjum T, Nilsson F, Bruun JN, Haneberg B (1983)
The early phase of meningococcal disease
NIPH Ann, 6 (2), 175-81
PubMed 6676683