Benedicte Stavik
- Senior Scientist and group leader; MSc, PhD
- +47 23 07 33 48 / 920 65 958
Education
MSc University of Oslo, 2007
PhD University of Oslo, 2011
Positions
2018-present: Acting group leader, Dept. of Haematology/RIIM, Oslo University Hospital Rikshospitalet
2012-2018: Post. Doc., Dept. of Haematology/RIIM, Oslo University Hospital Rikshospitalet
2007-2011: PhD fellow, Dept. of Medical Genetics, Oslo University Hospital Ullevål
2004-2007: Laboratory technician, Dept. of Basic Sciences and Aquatic Medicine, Norwegian School of Veterinary Science.
Research interests
Blood coagulation system, tissue factor pathway inhibitor, atherosclerosis, inflammation, vascular biology.
Publications 2024
Parenteral nutrition emulsion inhibits CYP3A4 in an iPSC derived liver organoids testing platform
J Pediatr Gastroenterol Nutr, 78 (5), 1047-1058
DOI 10.1002/jpn3.12195, PubMed 38529852
Thrombosis, Translational Medicine, and Biomarker Research: Moving the Needle
J Am Heart Assoc, e038782 (in press)
DOI 10.1161/JAHA.124.038782, PubMed 39719414
Elevated TFPI is a prognostic factor in hepatocellular carcinoma: Putative role of miR-7-5p and miR-1236-3p
Thromb Res, 241, 109073
DOI 10.1016/j.thromres.2024.109073, PubMed 38945092
Publications 2023
Scalable production of tissue-like vascularized liver organoids from human PSCs
Exp Mol Med, 55 (9), 2005-2024
DOI 10.1038/s12276-023-01074-1, PubMed 37653039
"iPSC-derived liver organoids and inherited bleeding disorders: Potential and future perspectives"
Front Physiol, 14, 1094249
DOI 10.3389/fphys.2023.1094249, PubMed 36711019
Publications 2022
FSAP Protects against Histone-Mediated Increase in Endothelial Permeability In Vitro
Int J Mol Sci, 23 (22)
DOI 10.3390/ijms232213706, PubMed 36430180
SARS-CoV-2 vaccines are not associated with hypercoagulability in apparently healthy people
Res Pract Thromb Haemost, 7 (1), 100002
DOI 10.1016/j.rpth.2022.100002, PubMed 36448024
Publications 2021
Molecular Characterization of Two Homozygous Factor VII Variants Associated with Intracranial Bleeding
Thromb Haemost, 121 (12), 1588-1598
DOI 10.1055/a-1450-8568, PubMed 33742435
Coagulation Factor V (F5) is an Estrogen-Responsive Gene in Breast Cancer Cells
Thromb Haemost, 122 (8), 1288-1295
DOI 10.1055/a-1707-2130, PubMed 34826880
Publications 2020
Indirect regulation of TFPI-2 expression by miR-494 in breast cancer cells
Sci Rep, 10 (1), 4036
DOI 10.1038/s41598-020-61018-x, PubMed 32132611
Coagulation factor V is a marker of tumor-infiltrating immune cells in breast cancer
Oncoimmunology, 9 (1), 1824644
DOI 10.1080/2162402X.2020.1824644, PubMed 33457104
Publications 2019
Transcription factor FOXP3: A repressor of the TFPI gene?
J Cell Biochem, 120 (8), 12924-12936
DOI 10.1002/jcb.28563, PubMed 30861202
Publications 2017
Estrogen induced expression of tissue factor pathway inhibitor-2 in MCF7 cells involves lysine-specific demethylase 1
Mol Cell Endocrinol, 443, 80-88
DOI 10.1016/j.mce.2017.01.016, PubMed 28088469
A novel hypoxia response element regulates oxygen-related repression of tissue factor pathway inhibitor in the breast cancer cell line MCF-7
Thromb Res, 157, 111-116
DOI 10.1016/j.thromres.2017.07.013, PubMed 28734156
Tissue factor pathway inhibitor attenuates ER stress-induced inflammation in human M2-polarized macrophages
Biochem Biophys Res Commun, 491 (2), 442-448
DOI 10.1016/j.bbrc.2017.07.070, PubMed 28712870
Increased expression of TFPI in human carotid stenosis
Thromb Res, 155, 31-37
DOI 10.1016/j.thromres.2017.04.024, PubMed 28482260
Publications 2016
The role of microRNA-27a/b and microRNA-494 in estrogen-mediated downregulation of tissue factor pathway inhibitor α
J Thromb Haemost, 14 (6), 1226-37
DOI 10.1111/jth.13321, PubMed 26999003
Oestrogens Downregulate Tissue Factor Pathway Inhibitor through Oestrogen Response Elements in the 5'-Flanking Region
PLoS One, 11 (3), e0152114
DOI 10.1371/journal.pone.0152114, PubMed 26999742
Effect of hypoxia on tissue factor pathway inhibitor expression in breast cancer
J Thromb Haemost, 14 (2), 387-96
DOI 10.1111/jth.13206, PubMed 26598923
LIGHT/TNFSF14 is increased in patients with type 2 diabetes mellitus and promotes islet cell dysfunction and endothelial cell inflammation in vitro
Diabetologia, 59 (10), 2134-44
DOI 10.1007/s00125-016-4036-y, PubMed 27421726
EPAS1/HIF-2 alpha-mediated downregulation of tissue factor pathway inhibitor leads to a pro-thrombotic potential in endothelial cells
Biochim Biophys Acta, 1862 (4), 670-678
DOI 10.1016/j.bbadis.2016.01.017, PubMed 26826018
Publications 2015
Syndecan-3 and TFPI colocalize on the surface of endothelial-, smooth muscle-, and cancer cells
PLoS One, 10 (1), e0117404
DOI 10.1371/journal.pone.0117404, PubMed 25617766
Publications 2014
Oestrogen induced downregulation of TFPI expression is mediated by ERα
Thromb Res, 134 (1), 138-43
DOI 10.1016/j.thromres.2014.04.004, PubMed 24785473
Publications 2013
TFPIα and TFPIβ are expressed at the surface of breast cancer cells and inhibit TF-FVIIa activity
J Hematol Oncol, 6, 5
DOI 10.1186/1756-8722-6-5, PubMed 23320987
Publications 2012
TFPI alpha and beta regulate mRNAs and microRNAs involved in cancer biology and in the immune system in breast cancer cells
PLoS One, 7 (10), e47184
DOI 10.1371/journal.pone.0047184, PubMed 23071754
Publications 2011
Accumulation and effects of natural mixtures of persistent organic pollutants (POP) in Zebrafish after two generations of exposure
J Toxicol Environ Health A, 74 (7-9), 407-23
DOI 10.1080/15287394.2011.550455, PubMed 21391088
Natural mixtures of POPs affected body weight gain and induced transcription of genes involved in weight regulation and insulin signaling
Aquat Toxicol, 102 (3-4), 197-204
DOI 10.1016/j.aquatox.2011.01.017, PubMed 21356182
Downregulation of TFPI in breast cancer cells induces tyrosine phosphorylation signaling and increases metastatic growth by stimulating cell motility
BMC Cancer, 11, 357
DOI 10.1186/1471-2407-11-357, PubMed 21849050
Publications 2010
Natural mixtures of persistent organic pollutants (POP) increase weight gain, advance puberty, and induce changes in gene expression associated with steroid hormones and obesity in female zebrafish
J Toxicol Environ Health A, 73 (15), 1032-57
DOI 10.1080/15287394.2010.481618, PubMed 20526952
Functional characterization of polymorphisms in the human TFPI gene
Biochem Biophys Res Commun, 397 (1), 106-11
DOI 10.1016/j.bbrc.2010.05.078, PubMed 20519147
Overexpression of both TFPIα and TFPIβ induces apoptosis and expression of genes involved in the death receptor pathway in breast cancer cells
Mol Carcinog, 49 (11), 951-63
DOI 10.1002/mc.20679, PubMed 20886581
Publications 2009
Transcriptional regulation in liver and testis associated with developmental and reproductive effects in male zebrafish exposed to natural mixtures of persistent organic pollutants (POP)
J Toxicol Environ Health A, 72 (3-4), 112-30
DOI 10.1080/15287390802537255, PubMed 19184727
Publications 2007
Evaluating the effects of long term exposure to environmental relevant concentrations of real life mixtures of persistent organic pollutants (POPs) in the zebrafish model
B. Stavik, Oslo, 130 s.
BIBSYS 070674957