Matthias Kolberg
- Special adviser; PhD
- +47 23 02 60 64
Academic degree:
2001: Ph.D. (Dr.rer.nat.) Biophysical Chemistry, Technical University Berlin, Germany.
Theses:
Kolberg M (2001)
Generation and Characterization of Free and Metal Associated Amino Acid Radicals in Ribonucleotide Reductase Using EPR Techniques.
Doctoral dissertation, Fakultät II - Technische Universität Berlin.
Kolberg M (1997)
Fraksjonering og karakterisering av proteinkomponenter i alkenmonooksygenase fra Mycobacterium E3.
Cand. scient. thesis, University of Oslo
Publications 2023
Transcriptomic subtyping of malignant peripheral nerve sheath tumours highlights immune signatures, genomic profiles, patient survival and therapeutic targets
EBioMedicine, 97, 104829
DOI 10.1016/j.ebiom.2023.104829, PubMed 37837931
Publications 2020
Prediction of relapse-free survival according to adjuvant chemotherapy and regulator of chromosome condensation 2 (RCC2) expression in colorectal cancer
ESMO Open, 5 (6), e001040
DOI 10.1136/esmoopen-2020-001040, PubMed 33219056
Publications 2018
Prognostic, predictive, and pharmacogenomic assessments of CDX2 refine stratification of colorectal cancer
Mol Oncol, 12 (9), 1639-1655
DOI 10.1002/1878-0261.12347, PubMed 29900672
Inferior survival for patients with malignant peripheral nerve sheath tumors defined by aberrant TP53
Mod Pathol, 31 (11), 1694-1707
DOI 10.1038/s41379-018-0074-y, PubMed 29946184
Publications 2017
Drug sensitivity and resistance testing identifies PLK1 inhibitors and gemcitabine as potent drugs for malignant peripheral nerve sheath tumors
Mol Oncol, 11 (9), 1156-1171
DOI 10.1002/1878-0261.12086, PubMed 28556483
Publications 2015
Regulator of Chromosome Condensation 2 Identifies High-Risk Patients within Both Major Phenotypes of Colorectal Cancer
Clin Cancer Res, 21 (16), 3759-70
DOI 10.1158/1078-0432.CCR-14-3294, PubMed 25910952
Protein expression of BIRC5, TK1, and TOP2A in malignant peripheral nerve sheath tumours--A prognostic test after surgical resection
Mol Oncol, 9 (6), 1129-39
DOI 10.1016/j.molonc.2015.02.005, PubMed 25769404
Publications 2014
Prognostic Significance of β-Catenin, E-Cadherin, and SOX9 in Colorectal Cancer: Results from a Large Population-Representative Series
Front Oncol, 4, 118
DOI 10.3389/fonc.2014.00118, PubMed 24904831
Methylated RASSF1A in malignant peripheral nerve sheath tumors identifies neurofibromatosis type 1 patients with inferior prognosis
Neuro Oncol, 17 (1), 63-9
DOI 10.1093/neuonc/nou140, PubMed 25038505
Connexins in colorectal cancer pathogenesis
Int J Cancer, 137 (1), 1-11
DOI 10.1002/ijc.28911, PubMed 24752574
Publications 2012
The gap junction channel protein connexin 43 is covalently modified and regulated by SUMOylation
J Biol Chem, 287 (19), 15851-61
DOI 10.1074/jbc.M111.281832, PubMed 22411987
Survival meta-analyses for >1800 malignant peripheral nerve sheath tumor patients with and without neurofibromatosis type 1
Neuro Oncol, 15 (2), 135-47
DOI 10.1093/neuonc/nos287, PubMed 23161774
Antibody crossreactivity between the tumour suppressor PHLPP1 and the proto-oncogene β-catenin
EMBO Rep, 14 (1), 10-1
DOI 10.1038/embor.2012.188, PubMed 23229585
Studies of ribonucleotide reductase in crucian carp-an oxygen dependent enzyme in an anoxia tolerant vertebrate
PLoS One, 7 (8), e42784
DOI 10.1371/journal.pone.0042784, PubMed 22916159
Publications 2011
Connexin43 acts as a colorectal cancer tumor suppressor and predicts disease outcome
Int J Cancer, 131 (3), 570-81
DOI 10.1002/ijc.26392, PubMed 21866551
Peritoneal carcinomatosis of colon cancer origin: highest incidence in women and in patients with right-sided tumors
J Surg Oncol, 104 (7), 792-7
DOI 10.1002/jso.21959, PubMed 21547915
Publications 2010
Genomic changes in chromosomes 10, 16, and X in malignant peripheral nerve sheath tumors identify a high-risk patient group
J Clin Oncol, 28 (9), 1573-82
DOI 10.1200/JCO.2009.24.8989, PubMed 20159821
Publications 2009
Identification of p53 as a strong predictor of survival for patients with malignant peripheral nerve sheath tumors
Neuro Oncol, 11 (5), 514-28
DOI 10.1215/15228517-2008-127, PubMed 19182148
Publications 2008
Recent Studies of Class I RNR
In Ribonucleotide Reductase (Andersson KK, ed.), Nova Science Publishers Inc, Hauppauge, NY, USA
PublikaID 160, ISBN 1604561998
Hypermethylated MAL gene - a silent marker of early colon tumorigenesis
J Transl Med, 6, 13
DOI 10.1186/1479-5876-6-13, PubMed 18346269
Publications 2005
A new tyrosyl radical on Phe208 as ligand to the diiron center in Escherichia coli ribonucleotide reductase, mutant R2-Y122H. Combined x-ray diffraction and EPR/ENDOR studies
J Biol Chem, 280 (12), 11233-46
DOI 10.1074/jbc.M414634200, PubMed 15634667
The active site residue tyrosine 325 influences iron binding and coupling efficiency in human phenylalanine hydroxylase
J Inorg Biochem, 99 (6), 1320-8
DOI 10.1016/j.jinorgbio.2005.03.005, PubMed 15917086
A comparative reactivity study of microperoxidases based on hemin, mesohemin and deuterohemin
J Inorg Biochem, 99 (3), 852-63
DOI 10.1016/j.jinorgbio.2004.12.020, PubMed 15708807
Publications 2004
The use of multi-frequency EPR techniques to identify the radicals produced in irradiated beta-blockers
Free Radic Res, 38 (1), 59-66
DOI 10.1080/1071576310001634672, PubMed 15061654
Structure, function, and mechanism of ribonucleotide reductases
Biochim Biophys Acta, 1699 (1-2), 1-34
DOI 10.1016/j.bbapap.2004.02.007, PubMed 15158709
Crystal structural studies of changes in the native dinuclear iron center of ribonucleotide reductase protein R2 from mouse
J Biol Chem, 279 (45), 46794-801
DOI 10.1074/jbc.M407346200, PubMed 15322079
Publications 2003
Displacement of the tyrosyl radical cofactor in ribonucleotide reductase obtained by single-crystal high-field EPR and 1.4-A x-ray data
Proc Natl Acad Sci U S A, 100 (6), 3209-14
DOI 10.1073/pnas.0536684100, PubMed 12624184
Protein thiyl radicals in disordered systems: A comparative EPR study at low temperature
Phys Chem Chem Phys, 5 (11), 2442-2453
DOI 10.1039/B302601A , PublikaID 258
Publications 2002
Protein thiyl radicals directly observed by EPR spectroscopy
Arch Biochem Biophys, 403 (1), 141-4
DOI 10.1016/S0003-9861(02)00264-3, PubMed 12061811
Generation and electron paramagnetic resonance spin trapping detection of thiyl radicals in model proteins and in the R1 subunit of Escherichia coli ribonucleotide reductase
Arch Biochem Biophys, 397 (1), 57-68
DOI 10.1006/abbi.2001.2658, PubMed 11747310
Publications 2001
Tryptophan and Tyrosine Radicals in Ribonucleotide Reductase: A Comparative High-Field EPR Study at 94 GHz
Biochemistry, 40 (50), 15362-15368
DOI 10.1021/bi010707d, PublikaID 257
Publications 2000
A New Stable High-Valent Diiron Center in R2 Mutant Y122H of E. coli Ribonucleotide Reductase Studied by High-Field EPR and 57Fe-ENDOR
J Am Chem Soc, 122 (40), 9856–9857
DOI 10.1021/ja0005892, PublikaID 256
Publications 1997
Fraksjonering og karakterisering av proteinkomponenter i alkenmonooksygenase fra Mycobacterium E3
M. Kolberg, Oslo, 90 s.
BIBSYS 970790481