Publications 2024

Fugmann C, Reid S, Pucholt P, Kvarnström M, Björk A, Mofors J, Sjöwall C, Eriksson P, Olsson P, Mandl T, Forsblad-d'Elia H, Magnusson Bucher S, Johnsen SJ, Norheim KB, Appel S, Hammenfors D, Jensen JL, Palm Ø, Omdal R, Jonsson R, Baecklund E, Wahren-Herlenius M, Leonard D, Imgenberg-Kreuz J, Nordmark G (2024)
A high polygenic risk score is associated with SSA/SSB antibody positivity and early onset in primary Sjögren's disease
Rheumatology (Oxford) (in press)
DOI 10.1093/rheumatology/keae693, PubMed 39693120

Lundtoft C, Knight A, Meadows JRS, Karlsson Å, Rantapää-Dahlqvist S, Berglin E, Palm Ø, Haukeland H, Gunnarsson I, Bruchfeld A, Segelmark M, Ohlsson S, Mohammad AJ, Eriksson P, Söderkvist P, Ronnblom L, Omdal R, Jonsson R, Lindblad-Toh K, Dahlqvist J (2024)
The HLA region in ANCA-associated vasculitis: characterisation of genetic associations in a Scandinavian patient population
RMD Open, 10 (2)
DOI 10.1136/rmdopen-2023-004039, PubMed 38580345

Publications 2023

Ekman D, Sennblad B, Knight A, Karlsson Å, Rantapää-Dahlqvist S, Berglin E, Stegmayr B, Baslund B, Palm Ø, Haukeland H, Gunnarsson I, Bruchfeld A, Segelmark M, Ohlsson S, Mohammad AJ, Svärd A, Pullerits R, Herlitz H, Söderbergh A, Omdal R, Jonsson R, Rönnblom L, Eriksson P, Lindblad-Toh K, Dahlqvist J (2023)
Stratified genetic analysis reveals sex differences in MPO-ANCA-associated vasculitis
Rheumatology (Oxford), 62 (9), 3213-3218
DOI 10.1093/rheumatology/kead152, PubMed 37004177

Khatri B, Tessneer KL, Rasmussen A, Aghakhanian F, Reksten TR, Adler A, Alevizos I, Anaya JM, Aqrawi LA, Baecklund E, Brun JG, Bucher SM, Eloranta ML, Engelke F, Forsblad-d'Elia H, Glenn SB, Hammenfors D, Imgenberg-Kreuz J, Jensen JL, Johnsen SJA, Jonsson MV, Kvarnström M, Kelly JA, Li H, Mandl T et al. (2023)
Author Correction: Genome-wide association study identifies Sjögren's risk loci with functional implications in immune and glandular cells
Nat Commun, 14 (1), 598
DOI 10.1038/s41467-023-36369-4, PubMed 36737443

Vikse J, Midtvedt Ø, Fevang BS, Garen T, Palm Ø, Wallenius M, Bakland G, Norheim KB, Molberg Ø, Hoffmann-Vold AM (2023)
Differential sensitivity of the 2020 revised comprehensive diagnostic criteria and the 2019 ACR/EULAR classification criteria across IgG4-related disease phenotypes: results from a Norwegian cohort
Arthritis Res Ther, 25 (1), 163
DOI 10.1186/s13075-023-03155-y, PubMed 37670401

Wiley MM, Khatri B, Joachims ML, Tessneer KL, Stolarczyk AM, Rasmussen A, Anaya JM, Aqrawi LA, Bae SC, Baecklund E, Björk A, Brun JG, Bucher SM, Dand N, Eloranta ML, Engelke F, Forsblad-d'Elia H, Fugmann C, Glenn SB, Gong C, Gottenberg JE, Hammenfors D, Imgenberg-Kreuz J, Jensen JL, Johnsen SJA et al. (2023)
Variants in the DDX6-CXCR5 autoimmune disease risk locus influence the regulatory network in immune cells and salivary gland
bioRxiv
DOI 10.1101/2023.10.05.561076, PubMed 39071447

Publications 2022

Dahlqvist J, Ekman D, Sennblad B, Kozyrev SV, Nordin J, Karlsson Å, Meadows JRS, Hellbacher E, Rantapää-Dahlqvist S, Berglin E, Stegmayr B, Baslund B, Palm Ø, Haukeland H, Gunnarsson I, Bruchfeld A, Segelmark M, Ohlsson S, Mohammad AJ, Svärd A, Pullerits R, Herlitz H, Söderbergh A, Rosengren Pielberg G, Hultin Rosenberg L et al. (2022)
Identification and functional characterization of a novel susceptibility locus for small vessel vasculitis with MPO-ANCA
Rheumatology (Oxford), 61 (8), 3461-3470
DOI 10.1093/rheumatology/keab912, PubMed 34888651

Hynne H, Aqrawi LA, Jensen JL, Thiede B, Palm Ø, Amdal CD, Westgaard KL, Herlofson BB, Utheim TP, Galtung HK (2022)
Proteomic Profiling of Saliva and Tears in Radiated Head and Neck Cancer Patients as Compared to Primary Sjögren's Syndrome Patients
Int J Mol Sci, 23 (7)
DOI 10.3390/ijms23073714, PubMed 35409074

Khatri B, Tessneer KL, Rasmussen A, Aghakhanian F, Reksten TR, Adler A, Alevizos I, Anaya JM, Aqrawi LA, Baecklund E, Brun JG, Bucher SM, Eloranta ML, Engelke F, Forsblad-d'Elia H, Glenn SB, Hammenfors D, Imgenberg-Kreuz J, Jensen JL, Johnsen SJA, Jonsson MV, Kvarnström M, Kelly JA, Li H, Mandl T et al. (2022)
Genome-wide association study identifies Sjögren's risk loci with functional implications in immune and glandular cells
Nat Commun, 13 (1), 4287
DOI 10.1038/s41467-022-30773-y, PubMed 35896530

Khatri B, Tessneer KL, Rasmussen A, Aghakhanian F, Reksten TR, Adler A, Alevizos I, Anaya JM, Aqrawi LA, Baecklund E, Brun JG, Bucher SM, Eloranta ML, Engelke F, Forsblad-d'Elia H, Glenn SB, Hammenfors D, Imgenberg-Kreuz J, Jensen JL, Johnsen SJA, Jonsson MV, Kvarnström M, Kelly JA, Li H, Mandl T et al. (2022)
Author Correction: Genome-wide association study identifies Sjögren's risk loci with functional implications in immune and glandular cells
Nat Commun, 13 (1), 6519
DOI 10.1038/s41467-022-34311-8, PubMed 36316359

Publications 2021

Skorpen CG, Salvesen KÅB, Palm Ø, Radtke M, Wallenius M (2021)
[Pregnancy complications in women with systemic lupus erythematosus]
Tidsskr Nor Laegeforen, 141 (8)
DOI 10.4045/tidsskr.20.0596, PubMed 34047174

Thorlacius GE, Hultin-Rosenberg L, Sandling JK, Bianchi M, Imgenberg-Kreuz J, Pucholt P, Theander E, Kvarnström M, Forsblad-d'Elia H, Bucher SM, Norheim KB, Johnsen SJA, Hammenfors D, Skarstein K, Jonsson MV, Baecklund E, Aqrawi LA, Jensen JL, Palm Ø, Morris AP, DISSECT consortium, the ImmunoArray consortium, Meadows JRS, Rantapää-Dahlqvist S, Mandl T et al. (2021)
Genetic and clinical basis for two distinct subtypes of primary Sjögren's syndrome
Rheumatology (Oxford), 60 (2), 837-848
DOI 10.1093/rheumatology/keaa367, PubMed 32889544

Publications 2020

Ossum AM, Palm Ø, Cvancarova M, Bernklev T, Jahnsen J, Moum B, Høivik ML, IBSEN Study Group (2020)
The Impact of Spondyloarthritis and Joint Symptoms on Health-Related Quality of Life and Fatigue in IBD Patients. Results From a Population-Based Inception Cohort (20-Year Follow-up in the Ibsen Study)
Inflamm Bowel Dis, 26 (1), 114-124
DOI 10.1093/ibd/izz105, PubMed 31127829

Publications 2019

Aqrawi LA, Galtung HK, Guerreiro EM, Øvstebø R, Thiede B, Utheim TP, Chen X, Utheim ØA, Palm Ø, Skarstein K, Jensen JL (2019)
Proteomic and histopathological characterisation of sicca subjects and primary Sjögren's syndrome patients reveals promising tear, saliva and extracellular vesicle disease biomarkers
Arthritis Res Ther, 21 (1), 181
DOI 10.1186/s13075-019-1961-4, PubMed 31366407

Chen X, Aqrawi LA, Utheim TP, Tashbayev B, Utheim ØA, Reppe S, Hove LH, Herlofson BB, Singh PB, Palm Ø, Galtung HK, Jensen JCL (2019)
Elevated cytokine levels in tears and saliva of patients with primary Sjögren's syndrome correlate with clinical ocular and oral manifestations
Sci Rep, 9 (1), 7319
DOI 10.1038/s41598-019-43714-5, PubMed 31086200

Garen T, Lerang K, Hoffmann-Vold AM, Andersson H, Midtvedt Ø, Brunborg C, Kilian K, Gudbrandsson B, Gunnarsson R, Norby G, Chaudhary A, Thoen J, Forseth KØ, Fresjar K, Førre Ø, Haugen M, Haga HJ, Gran JT, Gilboe IM, Molberg Ø, Palm Ø (2019)
Mortality and causes of death across the systemic connective tissue diseases and the primary systemic vasculitides
Rheumatology (Oxford), 58 (2), 313-320
DOI 10.1093/rheumatology/key285, PubMed 30281089

Singh PB, Young A, Homayouni A, Hove LH, Petrovski BÉ, Herlofson BB, Palm Ø, Rykke M, Jensen JL (2019)
Distorted Taste and Impaired Oral Health in Patients with Sicca Complaints
Nutrients, 11 (2)
DOI 10.3390/nu11020264, PubMed 30682880

Publications 2018

Aqrawi LA, Chen X, Jensen JL, Morthen MK, Thiede B, Utheim ØA, Palm Ø, Tashbayev B, Utheim TP, Galtung HK (2018)
Severity of clinical dry eye manifestations influences protein expression in tear fluid of patients with primary Sjögren's syndrome
PLoS One, 13 (10), e0205762
DOI 10.1371/journal.pone.0205762, PubMed 30312344

Götestam Skorpen C, Lydersen S, Gilboe IM, Skomsvoll JF, Salvesen KÅ, Palm Ø, Koksvik HSS, Jakobsen B, Wallenius M (2018)
Women with systemic lupus erythematosus get pregnant more easily than women with rheumatoid arthritis
Rheumatology (Oxford), 57 (6), 1072-1079
DOI 10.1093/rheumatology/key049, PubMed 29554346

Nesvold MB, Jensen JL, Hove LH, Singh PB, Young A, Palm Ø, Andersen LF, Carlsen MH, Iversen PO (2018)
Dietary Intake, Body Composition, and Oral Health Parameters among Female Patients with Primary Sjögren's Syndrome
Nutrients, 10 (7)
DOI 10.3390/nu10070866, PubMed 29973575

Ossum AM, Palm Ø, Cvancarova M, Solberg IC, Vatn M, Moum B, Høivik ML, IBSEN study group (2018)
Peripheral arthritis in patients with long-term inflammatory bowel disease. Results from 20 years of follow-up in the IBSEN study
Scand J Gastroenterol, 53 (10-11), 1250-1256
DOI 10.1080/00365521.2018.1518482, PubMed 30353756

Ossum AM, Palm Ø, Lunder AK, Cvancarova M, Banitalebi H, Negård A, Høie O, Henriksen M, Moum BA, Høivik ML, IBSEN Study Group (2018)
Ankylosing Spondylitis and Axial Spondyloarthritis in Patients With Long-term Inflammatory Bowel Disease: Results From 20 Years of Follow-up in the IBSEN Study
J Crohns Colitis, 12 (1), 96-104
DOI 10.1093/ecco-jcc/jjx126, PubMed 28961700

Publications 2017

Aqrawi LA, Galtung HK, Vestad B, Øvstebø R, Thiede B, Rusthen S, Young A, Guerreiro EM, Utheim TP, Chen X, Utheim ØA, Palm Ø, Jensen JL (2017)
Identification of potential saliva and tear biomarkers in primary Sjögren's syndrome, utilising the extraction of extracellular vesicles and proteomics analysis
Arthritis Res Ther, 19 (1), 14
DOI 10.1186/s13075-017-1228-x, PubMed 28122643

Gudbrandsson B, Molberg Ø, Palm Ø (2017)
TNF inhibitors appear to inhibit disease progression and improve outcome in Takayasu arteritis; an observational, population-based time trend study
Arthritis Res Ther, 19 (1), 99
DOI 10.1186/s13075-017-1316-y, PubMed 28521841

Gudbrandsson B, Wallenius M, Garen T, Henriksen T, Molberg Ø, Palm Ø (2017)
Takayasu Arteritis and Pregnancy: A Population-Based Study on Outcomes and Mother/Child-Related Concerns
Arthritis Care Res (Hoboken), 69 (9), 1384-1390
DOI 10.1002/acr.23146, PubMed 27813289

Götestam Skorpen C, Lydersen S, Gilboe IM, Skomsvoll JF, Salvesen KÅ, Palm Ø, Koksvik HSS, Jakobsen B, Wallenius M (2017)
Disease Activity During Pregnancy and the First Year Postpartum in Women With Systemic Lupus Erythematosus
Arthritis Care Res (Hoboken), 69 (8), 1201-1208
DOI 10.1002/acr.23102, PubMed 27696790

Rusthen S, Young A, Herlofson BB, Aqrawi LA, Rykke M, Hove LH, Palm Ø, Jensen JL, Singh PB (2017)
Oral disorders, saliva secretion, and oral health-related quality of life in patients with primary Sjögren's syndrome
Eur J Oral Sci, 125 (4), 265-271
DOI 10.1111/eos.12358, PubMed 28643390

Skorpen CG, Lydersen S, Gilboe IM, Skomsvoll JF, Salvesen KÅ, Palm Ø, Svean Koksvik HS, Jakobsen B, Wallenius M (2017)
Influence of disease activity and medications on offspring birth weight, pre-eclampsia and preterm birth in systemic lupus erythematosus: a population-based study
Ann Rheum Dis, 77 (2), 264-269
DOI 10.1136/annrheumdis-2017-211641, PubMed 29092851

Tashbayev B, Rusthen S, Young A, Herlofson BB, Hove LH, Singh PB, Rykke M, Aqrawi LA, Chen X, Utheim ØA, Utheim TP, Palm Ø, Jensen JL (2017)
Interdisciplinary, Comprehensive Oral and Ocular Evaluation of Patients with Primary Sjögren's Syndrome
Sci Rep, 7 (1), 10761
DOI 10.1038/s41598-017-10809-w, PubMed 28883442

Publications 2016

Gudbrandsson B, Molberg Ø, Garen T, Palm Ø (2016)
Prevalence, Incidence, and Disease Characteristics of Takayasu Arteritis by Ethnic Background: Data From a Large, Population-Based Cohort Resident in Southern Norway
Arthritis Care Res (Hoboken), 69 (2), 278-285
DOI 10.1002/acr.22931, PubMed 27159262

Palm Ø, Ueland T, Garen T, Michelsen AE, Reiseter S, Aukrust P, Aaløkken TM, Molberg Ø (2016)
Endostatin is higher and associated with pulmonary involvement in primary Sjögren's syndrome
Clin Exp Rheumatol, 34 (4), 690-3
PubMed 27214260

Uhlig T, Bjørneboe O, Krøll F, Palm Ø, Olsen IC, Grotle M (2016)
Involvement of the multidisciplinary team and outcomes in inpatient rehabilitation among patients with inflammatory rheumatic disease
BMC Musculoskelet Disord, 17, 18
DOI 10.1186/s12891-016-0870-9, PubMed 26762160

Publications 2015

Carmona FD, Mackie SL, Martín JE, Taylor JC, Vaglio A, Eyre S, Bossini-Castillo L, Castañeda S, Cid MC, Hernández-Rodríguez J, Prieto-González S, Solans R, Ramentol-Sintas M, González-Escribano MF, Ortiz-Fernández L, Morado IC, Narváez J, Miranda-Filloy JA, Spanish GCA Group, Beretta L, Lunardi C, Cimmino MA, Gianfreda D, Santilli D, Ramirez GA et al. (2015)
A large-scale genetic analysis reveals a strong contribution of the HLA class II region to giant cell arteritis susceptibility
Am J Hum Genet, 96 (4), 565-80
DOI 10.1016/j.ajhg.2015.02.009, PubMed 25817017

Publications 2014

Isene R, Bernklev T, Høie O, Munkholm P, Tsianos E, Stockbrügger R, Odes S, Palm Ø, Småstuen M, Moum B, EC-IBD Study Group (2014)
Extraintestinal manifestations in Crohn's disease and ulcerative colitis: results from a prospective, population-based European inception cohort
Scand J Gastroenterol, 50 (3), 300-5
DOI 10.3109/00365521.2014.991752, PubMed 25535653

Márquez A, Solans R, Hernández-Rodríguez J, Cid MC, Castañeda S, Ramentol M, Rodriguez-Rodriguez L, Narváez J, Blanco R, Ortego-Centeno N, Spanish GCA Consortium, Palm O, Diamantopoulos AP, Braun N, Moosig F, Witte T, Beretta L, Lunardi C, Cimmino MA, Vaglio A, Salvarani C, González-Gay MA, Martín J (2014)
A candidate gene approach identifies an IL33 genetic variant as a novel genetic risk factor for GCA
PLoS One, 9 (11), e113476
DOI 10.1371/journal.pone.0113476, PubMed 25409453

Publications 2013

Gunnarsson R, Andreassen AK, Molberg Ø, Lexberg ÅS, Time K, Dhainaut AS, Bertelsen LT, Palm Ø, Irgens K, Becker-Merok A, Nordeide JL, Johnsen V, Pedersen S, Prøven A, Garabet LS, Garen T, Aaløkken TM, Gilboe IM, Gran JT (2013)
Prevalence of pulmonary hypertension in an unselected, mixed connective tissue disease cohort: results of a nationwide, Norwegian cross-sectional multicentre study and review of current literature
Rheumatology (Oxford), 52 (7), 1208-13
DOI 10.1093/rheumatology/kes430, PubMed 23407386

Publications 2012

Cénit MC, Simeón CP, Vonk MC, Callejas-Rubio JL, Espinosa G, Carreira P, Blanco FJ, Narvaez J, Tolosa C, Román-Ivorra JA, Gómez-García I, García-Hernández FJ, Gallego M, García-Portales R, Egurbide MV, Fonollosa V, García de la Peña P, López-Longo FJ, González-Gay MA, Spanish Scleroderma Group, Hesselstrand R, Riemekasten G, Witte T, Voskuyl AE, Schuerwegh AJ et al. (2012)
Influence of the IL6 gene in susceptibility to systemic sclerosis
J Rheumatol, 39 (12), 2294-302
DOI 10.3899/jrheum.120506, PubMed 23027890

Gunnarsson R, Aaløkken TM, Molberg Ø, Lund MB, Mynarek GK, Lexberg AS, Time K, Dhainaut AS, Bertelsen LT, Palm O, Irgens K, Becker-Merok A, Nordeide JL, Johnsen V, Pedersen S, Prøven A, Garabet LS, Gran JT (2012)
Prevalence and severity of interstitial lung disease in mixed connective tissue disease: a nationwide, cross-sectional study
Ann Rheum Dis, 71 (12), 1966-72
DOI 10.1136/annrheumdis-2011-201253, PubMed 22550317

Lilleby V, Palm Ø, Andersson H, Gran JT, Aaløkken TM (2012)
[A man in his sixties with hoarseness, difficulty breathing and chest pain]
Tidsskr Nor Laegeforen, 132 (3), 308-11
DOI 10.4045/tidsskr.11.0765, PubMed 22314743

Palm O, Garen T, Berge Enger T, Jensen JL, Lund MB, Aaløkken TM, Gran JT (2012)
Clinical pulmonary involvement in primary Sjogren's syndrome: prevalence, quality of life and mortality--a retrospective study based on registry data
Rheumatology (Oxford), 52 (1), 173-9
DOI 10.1093/rheumatology/kes311, PubMed 23192906

Publications 2011

Bossini-Castillo L, Martin JE, Broen J, Gorlova O, Simeón CP, Beretta L, Vonk MC, Callejas JL, Castellví I, Carreira P, García-Hernández FJ, Fernández Castro M, Spanish Scleroderma Group, Coenen MJ, Riemekasten G, Witte T, Hunzelmann N, Kreuter A, Distler JH, Koeleman BP, Voskuyl AE, Schuerwegh AJ, Palm Ø, Hesselstrand R, Nordin A et al. (2011)
A GWAS follow-up study reveals the association of the IL12RB2 gene with systemic sclerosis in Caucasian populations
Hum Mol Genet, 21 (4), 926-33
DOI 10.1093/hmg/ddr522, PubMed 22076442

Carmona FD, Simeon CP, Beretta L, Carreira P, Vonk MC, Ríos-Fernández R, Espinosa G, Navarrete N, Vicente-Rabaneda E, Rodríguez-Rodríguez L, Tolosa C, García-Hernández FJ, Castellví I, Egurbide MV, Fonollosa V, González-Gay MA, Rodríguez-Carballeira M, Díaz-Gónzalez F, Sáez-Comet L, Hesselstrand R, Riemekasten G, Witte T, Voskuyl AE, Schuerwegh AJ, Madhok R et al. (2011)
Association of a non-synonymous functional variant of the ITGAM gene with systemic sclerosis
Ann Rheum Dis, 70 (11), 2050-2
DOI 10.1136/ard.2010.148874, PubMed 21571730

Enger TB, Palm Ø, Garen T, Sandvik L, Jensen JL (2011)
Oral distress in primary Sjögren's syndrome: implications for health-related quality of life
Eur J Oral Sci, 119 (6), 474-80
DOI 10.1111/j.1600-0722.2011.00891.x, PubMed 22112034

Gorlova O, Martin JE, Rueda B, Koeleman BP, Ying J, Teruel M, Diaz-Gallo LM, Broen JC, Vonk MC, Simeon CP, Alizadeh BZ, Coenen MJ, Voskuyl AE, Schuerwegh AJ, van Riel PL, Vanthuyne M, van 't Slot R, Italiaander A, Ophoff RA, Hunzelmann N, Fonollosa V, Ortego-Centeno N, González-Gay MA, García-Hernández FJ, González-Escribano MF et al. (2011)
Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy
PLoS Genet, 7 (7), e1002178
DOI 10.1371/journal.pgen.1002178, PubMed 21779181

Haga HJ, Palm O, Peen E (2011)
Prevalence of IgA class antibodies to cyclic citrullinated peptide in patients with inflammatory bowel disease (IBD)
Clin Rheumatol, 30 (7), 955-7
DOI 10.1007/s10067-011-1696-3, PubMed 21337132

Publications 2010

Bossini-Castillo L, Broen JC, Simeon CP, Beretta L, Vonk MC, Ortego-Centeno N, Espinosa G, Carreira P, Camps MT, Navarrete N, González-Escribano MF, Vicente-Rabaneda E, Rodríguez L, Tolosa C, Román-Ivorra JA, Gómez-Gracia I, García-Hernández FJ, Castellví I, Gallego M, Fernández-Nebro A, García-Portales R, Egurbide MV, Fonollosa V, de la Peña PG, Pros A et al. (2010)
A replication study confirms the association of TNFSF4 (OX40L) polymorphisms with systemic sclerosis in a large European cohort
Ann Rheum Dis, 70 (4), 638-41
DOI 10.1136/ard.2010.141838, PubMed 21187296

Publications 2005

Palm Ø, Bernklev T, Moum B, Gran JT (2005)
Non-inflammatory joint pain in patients with inflammatory bowel disease is prevalent and has a significant impact on health related quality of life
J Rheumatol, 32 (9), 1755-9
PubMed 16142874

Publications 2002

Palm O, Moum B, Ongre A, Gran JT (2002)
Prevalence of ankylosing spondylitis and other spondyloarthropathies among patients with inflammatory bowel disease: a population study (the IBSEN study)
J Rheumatol, 29 (3), 511-5
PubMed 11908564

Palm Ø (2002)
Rheumatic manifestations in chronic inflammatory bowel disease: a population based epidemiological study
Department of Rheumatology, Institute of Clinical Medicine, University of Tromsø, Tromsø, 1 b. (flere pag.)
BIBSYS 030007852, ISBN 82-497-0117-8

Palm Ø, Moum B, Gran JT (2002)
Estimation of Sjögren's syndrome among IBD patients. A six year post-diagnostic prevalence study
Scand J Rheumatol, 31 (3), 140-5
PubMed 12195627