Shuo-Wang Qiao
- Group leader
- +47 977 25 876
Publications 2024
High-throughput sequencing of insect specimens with sub-optimal DNA preservation using a practical, plate-based Illumina-compatible Tn5 transposase library preparation method
PLoS One, 19 (3), e0300865
DOI 10.1371/journal.pone.0300865, PubMed 38517905
Systematic characterization of immunoglobulin loci and deep sequencing of the expressed repertoire in the Atlantic cod (Gadus morhua)
BMC Genomics, 25 (1), 663
DOI 10.1186/s12864-024-10571-0, PubMed 38961347
Gluten-Free Diet Induces Rapid Changes in Phenotype and Survival Properties of Gluten-Specific T Cells in Celiac Disease
Gastroenterology, 167 (2), 250-263
DOI 10.1053/j.gastro.2024.03.027, PubMed 38552723
New Monomer Capable of Dual Chemical Binding with Dentin to Improve Bonding Durability
J Dent Res, 103 (8), 820-829
DOI 10.1177/00220345241253526, PubMed 38867655
Publications 2023
Identification of a pharyngeal mucosal lymphoid organ in zebrafish and other teleosts: Tonsils in fish?
Sci Adv, 9 (44), eadj0101
DOI 10.1126/sciadv.adj0101, PubMed 37910624
Publications 2022
TCRpower: quantifying the detection power of T-cell receptor sequencing with a novel computational pipeline calibrated by spike-in sequences
Brief Bioinform, 23 (2)
DOI 10.1093/bib/bbab566, PubMed 35062022
Lymphocyte subsets in Atlantic cod (Gadus morhua) interrogated by single-cell sequencing
Commun Biol, 5 (1), 689
DOI 10.1038/s42003-022-03645-w, PubMed 35821077
Stereotyped B-cell responses are linked to IgG constant region polymorphisms in multiple sclerosis
Eur J Immunol, 52 (4), 550-565
DOI 10.1002/eji.202149576, PubMed 35094395
Innate lymphoid cell characterization in the rat and their correlation to gut commensal microbes
Eur J Immunol, 52 (5), 717-729
DOI 10.1002/eji.202149639, PubMed 35099074
Publications 2021
Potential impact of celiac disease genetic risk factors on T cell receptor signaling in gluten-specific CD4+ T cells
Sci Rep, 11 (1), 9252
DOI 10.1038/s41598-021-86612-5, PubMed 33927210
Comprehensive Analysis of CDR3 Sequences in Gluten-Specific T-Cell Receptors Reveals a Dominant R-Motif and Several New Minor Motifs
Front Immunol, 12, 639672
DOI 10.3389/fimmu.2021.639672, PubMed 33927715
Longevity, clonal relationship, and transcriptional program of celiac disease-specific plasma cells
J Exp Med, 218 (2)
DOI 10.1084/jem.20200852, PubMed 33095260
Frequency of Gluten-Reactive T Cells in Active Celiac Lesions Estimated by Direct Cell Cloning
Front Immunol, 12, 646163
DOI 10.3389/fimmu.2021.646163, PubMed 33796112
Lung CD4+ T-cells in patients with lung fibrosis produce pro-fibrotic interleukin-13 together with interferon-γ
Eur Respir J, 57 (3)
DOI 10.1183/13993003.00983-2020, PubMed 33154027
Systematic Prioritization of Candidate Genes in Disease Loci Identifies TRAFD1 as a Master Regulator of IFNγ Signaling in Celiac Disease
Front Genet, 11, 562434
DOI 10.3389/fgene.2020.562434, PubMed 33569077
Immunobiology and conflicting roles of the human CD161 receptor in T cells
Scand J Immunol, 94 (3), e13090
DOI 10.1111/sji.13090, PubMed 35611672
C-type lectin-like CD161 is not a co-signalling receptor in gluten-reactive CD4 + T cells
Scand J Immunol, 93 (6), e13016
DOI 10.1111/sji.13016, PubMed 33368526
Differential expression profile of gluten-specific T cells identified by single-cell RNA-seq
PLoS One, 16 (10), e0258029
DOI 10.1371/journal.pone.0258029, PubMed 34618841
Publications 2020
B cell tolerance and antibody production to the celiac disease autoantigen transglutaminase 2
J Exp Med, 217 (2)
DOI 10.1084/jem.20190860, PubMed 31727780
Single-Cell Transcriptome Profiling of Immune Cell Repertoire of the Atlantic Cod Which Naturally Lacks the Major Histocompatibility Class II System
Front Immunol, 11, 559555
DOI 10.3389/fimmu.2020.559555, PubMed 33154745
Characterization of T-cell receptor transgenic mice recognizing immunodominant HLA-DQ2.5-restricted gluten epitopes
Eur J Immunol, 51 (4), 1002-1005
DOI 10.1002/eji.202048859, PubMed 33368209
A molecular basis for the T cell response in HLA-DQ2.2 mediated celiac disease
Proc Natl Acad Sci U S A, 117 (6), 3063-3073
DOI 10.1073/pnas.1914308117, PubMed 31974305
T cell receptor repertoire as a potential diagnostic marker for celiac disease
Clin Immunol, 222, 108621
DOI 10.1016/j.clim.2020.108621, PubMed 33197618
Publications 2019
Resident memory CD8 T cells persist for years in human small intestine
J Exp Med, 216 (10), 2412-2426
DOI 10.1084/jem.20190414, PubMed 31337737
Cytokine release and gastrointestinal symptoms after gluten challenge in celiac disease
Sci Adv, 5 (8), eaaw7756
DOI 10.1126/sciadv.aaw7756, PubMed 31457091
Epitope Selection for HLA-DQ2 Presentation: Implications for Celiac Disease and Viral Defense
J Immunol, 202 (9), 2558-2569
DOI 10.4049/jimmunol.1801454, PubMed 30926644
Two novel HLA-DQ2.5-restricted gluten T cell epitopes in the DQ2.5-glia-γ4 epitope family
Immunogenetics, 71 (10), 665-667
DOI 10.1007/s00251-019-01138-5, PubMed 31673720
Update 2020: nomenclature and listing of celiac disease-relevant gluten epitopes recognized by CD4+ T cells
Immunogenetics, 72 (1-2), 85-88
DOI 10.1007/s00251-019-01141-w, PubMed 31735991
Publications 2018
Discriminative T-cell receptor recognition of highly homologous HLA-DQ2-bound gluten epitopes
J Biol Chem, 294 (3), 941-952
DOI 10.1074/jbc.RA118.005736, PubMed 30455354
Plasma Cells Are the Most Abundant Gluten Peptide MHC-expressing Cells in Inflamed Intestinal Tissues From Patients With Celiac Disease
Gastroenterology, 156 (5), 1428-1439.e10
DOI 10.1053/j.gastro.2018.12.013, PubMed 30593798
BraCeR: B-cell-receptor reconstruction and clonality inference from single-cell RNA-seq
Nat Methods, 15 (8), 563-565
DOI 10.1038/s41592-018-0082-3, PubMed 30065371
Disease-driving CD4+ T cell clonotypes persist for decades in celiac disease
J Clin Invest, 128 (6), 2642-2650
DOI 10.1172/JCI98819, PubMed 29757191
Exploiting antigen receptor information to quantify index switching in single-cell transcriptome sequencing experiments
PLoS One, 13 (12), e0208484
DOI 10.1371/journal.pone.0208484, PubMed 30517183
Publications 2017
A TCRα framework-centered codon shapes a biased T cell repertoire through direct MHC and CDR3β interactions
JCI Insight, 2 (17)
DOI 10.1172/jci.insight.95193, PubMed 28878121
Similar Responses of Intestinal T Cells From Untreated Children and Adults With Celiac Disease to Deamidated Gluten Epitopes
Gastroenterology, 153 (3), 787-798.e4
DOI 10.1053/j.gastro.2017.05.016, PubMed 28535873
HLA-DQ-Gluten Tetramer Blood Test Accurately Identifies Patients With and Without Celiac Disease in Absence of Gluten Consumption
Gastroenterology, 154 (4), 886-896.e6
DOI 10.1053/j.gastro.2017.11.006, PubMed 29146521
Publications 2016
Healthy HLA-DQ2.5+ Subjects Lack Regulatory and Memory T Cells Specific for Immunodominant Gluten Epitopes of Celiac Disease
J Immunol, 196 (6), 2819-26
DOI 10.4049/jimmunol.1501152, PubMed 26895834
TCR sequencing of single cells reactive to DQ2.5-glia-α2 and DQ2.5-glia-ω2 reveals clonal expansion and epitope-specific V-gene usage
Mucosal Immunol, 9 (3), 587-96
DOI 10.1038/mi.2015.147, PubMed 26838051
Publications 2015
Coeliac disease - from genetic and immunological studies to clinical applications
Scand J Gastroenterol, 50 (6), 708-17
DOI 10.3109/00365521.2015.1030766, PubMed 25846940
Small bowel, celiac disease and adaptive immunity
Dig Dis, 33 (2), 115-121
DOI 10.1159/000369512, PubMed 25925911
Publications 2014
Tetramer-visualized gluten-specific CD4+ T cells in blood as a potential diagnostic marker for coeliac disease without oral gluten challenge
United European Gastroenterol J, 2 (4), 268-78
DOI 10.1177/2050640614540154, PubMed 25083284
HLA-DQ molecules as affinity matrix for identification of gluten T cell epitopes
J Immunol, 193 (9), 4497-506
DOI 10.4049/jimmunol.1301466, PubMed 25261484
Publications 2013
Biased usage and preferred pairing of α- and β-chains of TCRs specific for an immunodominant gluten epitope in coeliac disease
Int Immunol, 26 (1), 13-9
DOI 10.1093/intimm/dxt037, PubMed 24038601
Fc-fusion proteins and FcRn: structural insights for longer-lasting and more effective therapeutics
Crit Rev Biotechnol, 35 (2), 235-54
DOI 10.3109/07388551.2013.834293, PubMed 24156398
Publications 2012
High abundance of plasma cells secreting transglutaminase 2-specific IgA autoantibodies with limited somatic hypermutation in celiac disease intestinal lesions
Nat Med, 18 (3), 441-5
DOI 10.1038/nm.2656, PubMed 22366952
The adaptive immune response in celiac disease
Semin Immunopathol, 34 (4), 523-40
DOI 10.1007/s00281-012-0314-z, PubMed 22535446
The immunologic functions of the neonatal Fc receptor for IgG
J Clin Immunol, 33 Suppl 1 (Suppl 1), S9-17
DOI 10.1007/s10875-012-9768-y, PubMed 22948741
Nomenclature and listing of celiac disease relevant gluten T-cell epitopes restricted by HLA-DQ molecules
Immunogenetics, 64 (6), 455-60
DOI 10.1007/s00251-012-0599-z, PubMed 22322673
Publications 2011
Neonatal Fc receptor for IgG (FcRn) regulates cross-presentation of IgG immune complexes by CD8-CD11b+ dendritic cells
Proc Natl Acad Sci U S A, 108 (24), 9927-32
DOI 10.1073/pnas.1019037108, PubMed 21628593
Posttranslational modification of gluten shapes TCR usage in celiac disease
J Immunol, 187 (6), 3064-71
DOI 10.4049/jimmunol.1101526, PubMed 21849672
Epithelial transport and deamidation of gliadin peptides: a role for coeliac disease patient immunoglobulin A
Clin Exp Immunol, 164 (1), 127-36
DOI 10.1111/j.1365-2249.2010.04317.x, PubMed 21235541
Publications 2010
The preferred substrates for transglutaminase 2 in a complex wheat gluten digest are Peptide fragments harboring celiac disease T-cell epitopes
PLoS One, 5 (11), e14056
DOI 10.1371/journal.pone.0014056, PubMed 21124911
Neonatal Fc receptor: from immunity to therapeutics
J Clin Immunol, 30 (6), 777-89
DOI 10.1007/s10875-010-9468-4, PubMed 20886282
Publications 2009
Immune and non-immune functions of the (not so) neonatal Fc receptor, FcRn
Semin Immunopathol, 31 (2), 223-36
DOI 10.1007/s00281-009-0160-9, PubMed 19495758
A quantitative analysis of transglutaminase 2-mediated deamidation of gluten peptides: implications for the T-cell response in celiac disease
J Proteome Res, 8 (4), 1748-55
DOI 10.1021/pr800960n, PubMed 19239248
An FcRn-dependent role for anti-flagellin immunoglobulin G in pathogenesis of colitis in mice
Gastroenterology, 137 (5), 1746-56.e1
DOI 10.1053/j.gastro.2009.07.059, PubMed 19664634
Antigen presentation in celiac disease
Curr Opin Immunol, 21 (1), 111-7
DOI 10.1016/j.coi.2009.03.004, PubMed 19342211
Enzymatic detoxification of gluten by germinating wheat proteases: implications for new treatment of celiac disease
Ann Med, 41 (5), 390-400
DOI 10.1080/07853890902878138, PubMed 19353359
Publications 2008
Carcinoembryonic antigen-related cell adhesion molecule 1 inhibits proximal TCR signaling by targeting ZAP-70
J Immunol, 180 (9), 6085-93
DOI 10.4049/jimmunol.180.9.6085, PubMed 18424730
Dependence of antibody-mediated presentation of antigen on FcRn
Proc Natl Acad Sci U S A, 105 (27), 9337-42
DOI 10.1073/pnas.0801717105, PubMed 18599440
Publications 2006
SHP1 phosphatase-dependent T cell inhibition by CEACAM1 adhesion molecule isoforms
Immunity, 25 (5), 769-81
DOI 10.1016/j.immuni.2006.08.026, PubMed 17081782
How the controller is controlled - neonatal Fc receptor expression and immunoglobulin G homeostasis
Immunology, 120 (2), 145-7
DOI 10.1111/j.1365-2567.2006.02507.x, PubMed 17140402
Publications 2005
Molecular characterization of covalent transglutaminase (TG2)-gliadin peptide complexes involved in coeliac disease
Peptides 2004, Proceedings: BRIDGES BETWEEN DISCIPLINES, 73-74
On the immune response to gluten in coeliac disease
In Series of dissertations submitted to the Faculty of Medicine, University of Oslo, Unipub, Oslo, no. 306, 1 b. (flere pag.)
BIBSYS 051151219, ISBN 82-8072-640-3
Refining the rules of gliadin T cell epitope binding to the disease-associated DQ2 molecule in celiac disease: importance of proline spacing and glutamine deamidation
J Immunol, 175 (1), 254-61
DOI 10.4049/jimmunol.175.1.254, PubMed 15972656
Tissue transglutaminase-mediated formation and cleavage of histamine-gliadin complexes: biological effects and implications for celiac disease
J Immunol, 174 (3), 1657-63
DOI 10.4049/jimmunol.174.3.1657, PubMed 15661929
Identification and analysis of multivalent proteolytically resistant peptides from gluten: implications for celiac sprue
J Proteome Res, 4 (5), 1732-41
DOI 10.1021/pr050173t, PubMed 16212427
Publications 2004
Molecular characterization of covalent complexes between tissue transglutaminase and gliadin peptides
J Biol Chem, 279 (17), 17607-16
DOI 10.1074/jbc.M310198200, PubMed 14747475
Antigen presentation to celiac lesion-derived T cells of a 33-mer gliadin peptide naturally formed by gastrointestinal digestion
J Immunol, 173 (3), 1757-62
DOI 10.4049/jimmunol.173.3.1757, PubMed 15265905
Publications 2002
Gliadin T cell epitope selection by tissue transglutaminase in celiac disease. Role of enzyme specificity and pH influence on the transamidation versus deamidation process
J Biol Chem, 277 (37), 34109-16
DOI 10.1074/jbc.M204521200, PubMed 12093810
Publications 1998
Chronic L-deprenyl treatment alters brain monoamine levels and reduces impulsiveness in an animal model of Attention-Deficit/Hyperactivity Disorder
Behav Brain Res, 94 (1), 153-62
DOI 10.1016/s0166-4328(97)00176-9, PubMed 9708846