Publications 2022

Beck D, de Lange AG, Alnæs D, Maximov II, Pedersen ML, Leinhard OD, Linge J, Simon R, Richard G, Ulrichsen KM, Dørum ES, Kolskår KK, Sanders AM, Winterton A, Gurholt TP, Kaufmann T, Steen NE, Nordvik JE, Andreassen OA, Westlye LT (2022)
Adipose tissue distribution from body MRI is associated with cross-sectional and longitudinal brain age in adults
Neuroimage Clin, 33, 102949
DOI 10.1016/j.nicl.2022.102949, PubMed 35114636

Elkjaer Greenwood Ormerod MB, Ueland T, Frogner Werner MC, Hjell G, Rødevand L, Sæther LS, Lunding SH, Johansen IT, Ueland T, Lagerberg TV, Melle I, Djurovic S, Andreassen OA, Steen NE (2022)
Composite immune marker scores associated with severe mental disorders and illness course
Brain Behav Immun Health, 24, 100483
DOI 10.1016/j.bbih.2022.100483, PubMed 35856063

Engh JA, Ueland T, Agartz I, Andreou D, Aukrust P, Boye B, Bøen E, Drange OK, Elvsåshagen T, Hope S, Høegh MC, Joa I, Johnsen E, Kroken RA, Lagerberg TV, Lekva T, Malt UF, Melle I, Morken G, Nærland T, Steen VM, Wedervang-Resell K, Weibell MA, Westlye LT, Djurovic S et al. (2022)
Plasma Levels of the Cytokines B Cell-Activating Factor (BAFF) and A Proliferation-Inducing Ligand (APRIL) in Schizophrenia, Bipolar, and Major Depressive Disorder: A Cross Sectional, Multisite Study
Schizophr Bull, 48 (1), 37-46
DOI 10.1093/schbul/sbab106, PubMed 34499169

Gjerde PB, Steen SW, Vedal TSJ, Steen NE, Reponen EJ, Andreassen OA, Steen VM, Melle I (2022)
Lifetime Cannabis Use Is Not Associated With Negative Beliefs About Medication in Patients With First Treatment Psychosis
Front Psychiatry, 13, 824051
DOI 10.3389/fpsyt.2022.824051, PubMed 35422717

Hjell G, Szabo A, Mørch-Johnsen L, Holst R, Tesli N, Bell C, Fischer-Vieler T, Werner MCF, Lunding SH, Ormerod MBEG, Johansen IT, Dieset I, Djurovic S, Melle I, Ueland T, Andreassen OA, Steen NE, Haukvik UK (2022)
Interleukin-18 signaling system links to agitation in severe mental disorders
Psychoneuroendocrinology, 140, 105721
DOI 10.1016/j.psyneuen.2022.105721, PubMed 35301151

Icick R, Melle I, Etain B, Høegh MC, Gard S, Aminoff SR, Leboyer M, Andreassen OA, Belzeaux R, Henry C, Bjella TD, Kahn JP, Steen NE, Bellivier F, Lagerberg TV (2022)
Preventive Medication Patterns in Bipolar Disorder and Their Relationship With Comorbid Substance Use Disorders in a Cross-National Observational Study
Front Psychiatry, 13, 813256
DOI 10.3389/fpsyt.2022.813256, PubMed 35592382

Johansen IT, Steen NE, Haram M, Rødevand L, Werner MCF, Lunding SH, Hjell G, Agartz I, Melle I, Lagerberg TV, Nerhus M, Andreassen OA (2022)
Sex differences in antipsychotic-related triglyceride levels are associated with metabolic hormone differences in patients with severe mental disorders
Schizophr Res, 243, 55-63
DOI 10.1016/j.schres.2022.02.015, PubMed 35240428

Johansen IT, Steen NE, Rødevand L, Werner MCF, Lunding SH, Hjell G, Ormerod MBEG, Agartz I, Melle I, Lagerberg TV, Nerhus M, Andreassen OA (2022)
Sex-specific associations between metabolic hormones, severe mental disorders and antipsychotic treatment
Psychoneuroendocrinology, 146, 105927 (in press)
DOI 10.1016/j.psyneuen.2022.105927, PubMed 36152455

Rokicki J, Kaufmann T, de Lange AG, van der Meer D, Bahrami S, Sartorius AM, Haukvik UK, Steen NE, Schwarz E, Stein DJ, Nærland T, Andreassen OA, Westlye LT, Quintana DS (2022)
Oxytocin receptor expression patterns in the human brain across development
Neuropsychopharmacology, 47 (8), 1550-1560
DOI 10.1038/s41386-022-01305-5, PubMed 35347267

Sheikh MA, O'Connell KS, Lekva T, Szabo A, Akkouh IA, Osete JR, Agartz I, Engh JA, Andreou D, Boye B, Bøen E, Elvsåshagen T, Hope S, Frogner Werner MC, Joa I, Johnsen E, Kroken RA, Lagerberg TV, Melle I, Drange OK, Morken G, Nærland T, Sørensen K, Vaaler AE, Weibell MA et al. (2022)
Systemic Cell Adhesion Molecules in Severe Mental Illness: Potential Role of Intercellular CAM-1 in Linking Peripheral and Neuroinflammation
Biol Psychiatry, 93 (2), 187-196
DOI 10.1016/j.biopsych.2022.06.029, PubMed 36182530

Sæther LS, Ueland T, Haatveit B, Maglanoc LA, Szabo A, Djurovic S, Aukrust P, Roelfs D, Mohn C, Ormerod MBEG, Lagerberg TV, Steen NE, Melle I, Andreassen OA, Ueland T (2022)
Inflammation and cognition in severe mental illness: patterns of covariation and subgroups
Mol Psychiatry (in press)
DOI 10.1038/s41380-022-01924-w, PubMed 36577840

Trubetskoy V, Pardiñas AF, Qi T, Panagiotaropoulou G, Awasthi S, Bigdeli TB, Bryois J, Chen CY, Dennison CA, Hall LS, Lam M, Watanabe K, Frei O, Ge T, Harwood JC, Koopmans F, Magnusson S, Richards AL, Sidorenko J, Wu Y, Zeng J, Grove J, Kim M, Li Z, Voloudakis G et al. (2022)
Mapping genomic loci implicates genes and synaptic biology in schizophrenia
Nature, 604 (7906), 502-508
DOI 10.1038/s41586-022-04434-5, PubMed 35396580

Werner MCF, Wirgenes KV, Shadrin A, Lunding SH, Rødevand L, Hjell G, Ormerod MBEG, Haram M, Agartz I, Djurovic S, Melle I, Aukrust P, Ueland T, Andreassen OA, Steen NE (2022)
Immune marker levels in severe mental disorders: associations with polygenic risk scores of related mental phenotypes and psoriasis
Transl Psychiatry, 12 (1), 38
DOI 10.1038/s41398-022-01811-6, PubMed 35082268

Werner MCF, Wirgenes KV, Shadrin AA, Lunding SH, Rødevand L, Hjell G, Ormerod MBEG, Haram M, Agartz I, Djurovic S, Melle I, Aukrust P, Ueland T, Andreassen OA, Steen NE (2022)
Limited association between infections, autoimmune disease and genetic risk and immune activation in severe mental disorders
Prog Neuropsychopharmacol Biol Psychiatry, 116, 110511
DOI 10.1016/j.pnpbp.2022.110511, PubMed 35063598

Winterton A, Bettella F, Beck D, Gurholt TP, Steen NE, Rødevand L, Westlye LT, Andreassen OA, Quintana DS (2022)
The oxytocin signalling gene pathway contributes to the association between loneliness and cardiometabolic health
Psychoneuroendocrinology, 144, 105875
DOI 10.1016/j.psyneuen.2022.105875, PubMed 35939863

Aas M, Ueland T, Lagerberg TV, Melle I, Aminoff SR, Hoegh MC, Lunding SH, Laskemoen JF, Steen NE, Andreassen OA (2022)
Retrospectively assessed childhood trauma experiences are associated with illness severity in mental disorders adjusted for symptom state
Psychiatry Res, 320, 115045
DOI 10.1016/j.psychres.2022.115045, PubMed 36621206

Publications 2021

Andreou D, Steen NE, Jørgensen KN, Smelror RE, Wedervang-Resell K, Nerland S, Westlye LT, Nærland T, Myhre AM, Joa I, Reitan SMK, Vaaler A, Morken G, Bøen E, Elvsåshagen T, Boye B, Malt UF, Aukrust P, Skrede S, Kroken RA, Johnsen E, Djurovic S, Andreassen OA, Ueland T, Agartz I (2021)
Lower circulating neuron-specific enolase concentrations in adults and adolescents with severe mental illness
Psychol Med, 1-10 (in press)
DOI 10.1017/S0033291721003056, PubMed 35387700

Bahrami S, Shadrin A, Frei O, O'Connell KS, Bettella F, Krull F, Fan CC, Røssberg JI, Hindley G, Ueland T, Dale AM, Djurovic S, Steen NE, Smeland OB, Andreassen OA (2021)
Genetic loci shared between major depression and intelligence with mixed directions of effect
Nat Hum Behav, 5 (6), 795-801
DOI 10.1038/s41562-020-01031-2, PubMed 33462475

Beck D, de Lange AG, Pedersen ML, Alnaes D, Maximov II, Voldsbekk I, Richard G, Sanders AM, Ulrichsen KM, Dørum ES, Kolskår KK, Høgestøl EA, Steen NE, Djurovic S, Andreassen OA, Nordvik JE, Kaufmann T, Westlye LT (2021)
Cardiometabolic risk factors associated with brain age and accelerate brain ageing
Hum Brain Mapp, 43 (2), 700-720
DOI 10.1002/hbm.25680, PubMed 34626047

Bigseth TT, Engh JA, Egeland J, Andersen E, Andreassen OA, Bang-Kittilsen G, Falk RS, Holmen TL, Lindberg M, Mordal J, Nielsen J, Steen NE, Ueland T, Vang T, Fredriksen M (2021)
Exploring low grade inflammation by soluble urokinase plasminogen activator receptor levels in schizophrenia: a sex-dependent association with depressive symptoms
BMC Psychiatry, 21 (1), 527
DOI 10.1186/s12888-021-03522-6, PubMed 34702245

Bigseth TT, Fredriksen M, Egeland J, Andersen E, Andreassen OA, Bang-Kittilsen G, Falk RS, Holmen TL, Martinsen EW, Mordal J, Nielsen J, Steen NE, Ueland T, Vang T, Engh JA (2021)
Elevated levels of soluble urokinase plasminogen activator receptor as a low-grade inflammation marker in schizophrenia: A case-control study
Schizophr Res, 228, 190-192
DOI 10.1016/j.schres.2020.11.051, PubMed 33450603

Birkenaes V, Elvsashagen T, Westlye LT, Hoegh MC, Haram M, Werner MCF, Quintana DS, Lunding SH, Martin-Ruiz C, Agartz I, Djurovic S, Steen NE, Andreassen OA, Aas M (2021)
Telomeres are shorter and associated with number of suicide attempts in affective disorders
J. Affect. Disord., 295, 1032-1039
DOI 10.1016/j.jad.2021.08.135

Birkenæs V, Elvsåshagen T, Westlye LT, Høegh MC, Haram M, Werner MCF, Quintana DS, Lunding SH, Martin-Ruiz C, Agartz I, Djurovic S, Steen NE, Andreassen OA, Aas M (2021)
Telomeres are shorter and associated with number of suicide attempts in affective disorders
J Affect Disord, 295, 1032-1039
DOI 10.1016/j.jad.2021.08.135, PubMed 34706411

Fjukstad KK, Athanasiu L, Bahrami S, O'Connell KS, van der Meer D, Bettella F, Dieset I, Steen NE, Djurovic S, Spigset O, Andreassen OA (2021)
Genetic variants associated with cardiometabolic abnormalities during treatment with selective serotonin reuptake inhibitors: a genome-wide association study
Pharmacogenomics J, 21 (5), 574-585
DOI 10.1038/s41397-021-00234-8, PubMed 33824429

Gjerde PB, Simonsen CE, Lagerberg TV, Steen NE, Andreassen OA, Steen VM, Melle I (2021)
Sex-Specific Effect of Serum Lipids and Body Mass Index on Psychotic Symptoms, a Cross-Sectional Study of First-Episode Psychosis Patients
Front Psychiatry, 12, 723158
DOI 10.3389/fpsyt.2021.723158, PubMed 34744818

Gurholt TP, Kaufmann T, Frei O, Alnæs D, Haukvik UK, van der Meer D, Moberget T, O'Connell KS, Leinhard OD, Linge J, Simon R, Smeland OB, Sønderby IE, Winterton A, Steen NE, Westlye LT, Andreassen OA (2021)
Population-based body-brain mapping links brain morphology with anthropometrics and body composition
Transl Psychiatry, 11 (1), 295
DOI 10.1038/s41398-021-01414-7, PubMed 34006848

Hindley G, Bahrami S, Steen NE, O'Connell KS, Frei O, Shadrin A, Bettella F, Rødevand L, Fan CC, Dale AM, Djurovic S, Smeland OB, Andreassen OA (2021)
Characterising the shared genetic determinants of bipolar disorder, schizophrenia and risk-taking
Transl Psychiatry, 11 (1), 466
DOI 10.1038/s41398-021-01576-4, PubMed 34497263

Krull F, Akkouh I, Hughes T, Bettella F, Athanasiu L, Smeland OB, O'Connell KS, Brattbakk HR, Steen VM, Steen NE, Djurovic S, Andreassen OA (2021)
Dose-dependent transcriptional effects of lithium and adverse effect burden in a psychiatric cohort
Prog Neuropsychopharmacol Biol Psychiatry, 112, 110408
DOI 10.1016/j.pnpbp.2021.110408, PubMed 34320404

Lunding SH, Simonsen C, Aas M, Rødevand L, Werner MCF, Laskemoen JF, Hjell G, Ringen PA, Lagerberg TV, Melle I, Andreassen OA, Ueland T, Steen NE (2021)
Childhood trauma and cardiometabolic risk in severe mental disorders: The mediating role of cognitive control
Eur Psychiatry, 64 (1), e24
DOI 10.1192/j.eurpsy.2021.14, PubMed 33775258

O'Connell KS, Frei O, Bahrami S, Smeland OB, Bettella F, Cheng W, Chu Y, Hindley G, Lin A, Shadrin A, Barrett EA, Lagerberg TV, Steen NE, Dale AM, Djurovic S, Andreassen OA (2021)
Characterizing the Genetic Overlap Between Psychiatric Disorders and Sleep-Related Phenotypes
Biol Psychiatry, 90 (9), 621-631
DOI 10.1016/j.biopsych.2021.07.007, PubMed 34482950

Osete JR, Akkouh IA, de Assis DR, Szabo A, Frei E, Hughes T, Smeland OB, Steen NE, Andreassen OA, Djurovic S (2021)
Lithium increases mitochondrial respiration in iPSC-derived neural precursor cells from lithium responders
Mol Psychiatry, 26 (11), 6789-6805
DOI 10.1038/s41380-021-01164-4, PubMed 34075196

Reponen EJ, Tesli M, Dieset I, Steen NE, Vedal TSJ, Szabo A, Werner MCF, Lunding SH, Johansen IT, Rødevand LN, Andreassen OA, Ueland T (2021)
Adiponectin Is Related to Cardiovascular Risk in Severe Mental Illness Independent of Antipsychotic Treatment
Front Psychiatry, 12, 623192
DOI 10.3389/fpsyt.2021.623192, PubMed 34122163

Rødevand L, Bahrami S, Frei O, Chu Y, Shadrin A, O'Connell KS, Smeland OB, Elvsåshagen T, Hindley GFL, Djurovic S, Dale AM, Lagerberg TV, Steen NE, Andreassen OA (2021)
Extensive bidirectional genetic overlap between bipolar disorder and cardiovascular disease phenotypes
Transl Psychiatry, 11 (1), 407
DOI 10.1038/s41398-021-01527-z, PubMed 34301917

Rødevand L, Bahrami S, Frei O, Lin A, Gani O, Shadrin A, Smeland OB, Connell KSO, Elvsåshagen T, Winterton A, Quintana DS, Hindley GFL, Werner MCF, Djurovic S, Dale AM, Lagerberg TV, Steen NE, Andreassen OA (2021)
Polygenic overlap and shared genetic loci between loneliness, severe mental disorders, and cardiovascular disease risk factors suggest shared molecular mechanisms
Transl Psychiatry, 11 (1), 3
DOI 10.1038/s41398-020-01142-4, PubMed 33414458

Szabo A, O'Connell KS, Ueland T, Sheikh MA, Agartz I, Andreou D, Aukrust P, Boye B, Bøen E, Drange OK, Elvsåshagen T, Engh JA, Hope S, Collier Høegh M, Joa I, Johnsen E, Kroken RA, Vik Lagerberg T, Lekva T, Malt UF, Melle I, Morken G, Nærland T, Steen VM, Sørensen K et al. (2021)
Increased circulating IL-18 levels in severe mental disorders indicate systemic inflammasome activation
Brain Behav Immun, 99, 299-306
DOI 10.1016/j.bbi.2021.10.017, PubMed 34758379

Valstad M, Roelfs D, Slapø NB, Timpe CMF, Rai A, Matziorinis AM, Beck D, Richard G, Sæther LS, Haatveit B, Nordvik JE, Hatlestad-Hall C, Einevoll GT, Mäki-Marttunen T, Haram M, Ueland T, Lagerberg TV, Steen NE, Melle I, Westlye LT, Jönsson EG, Andreassen OA, Moberget T, Elvsåshagen T (2021)
Evidence for Reduced Long-Term Potentiation-Like Visual Cortical Plasticity in Schizophrenia and Bipolar Disorder
Schizophr Bull, 47 (6), 1751-1760
DOI 10.1093/schbul/sbab049, PubMed 33963856

Winterton A, Bettella F, de Lange AG, Haram M, Steen NE, Westlye LT, Andreassen OA, Quintana DS (2021)
Oxytocin-pathway polygenic scores for severe mental disorders and metabolic phenotypes in the UK Biobank
Transl Psychiatry, 11 (1), 599
DOI 10.1038/s41398-021-01725-9, PubMed 34824196

Wiström ED, O'Connell KS, Karadag N, Bahrami S, Hindley GFL, Lin A, Cheng W, Steen NE, Shadrin A, Frei O, Djurovic S, Dale AM, Andreassen OA, Smeland OB (2021)
Genome-wide analysis reveals genetic overlap between alcohol use behaviours, schizophrenia and bipolar disorder and identifies novel shared risk loci
Addiction, 117 (3), 600-610
DOI 10.1111/add.15680, PubMed 34472679

Aas M, Ueland T, Mørch RH, Laskemoen JF, Lunding SH, Reponen EJ, Cattaneo A, Agartz I, Melle I, Steen NE, Andreassen OA (2021)
Physical activity and childhood trauma experiences in patients with schizophrenia or bipolar disorders
World J Biol Psychiatry, 22 (8), 637-645
DOI 10.1080/15622975.2021.1907707, PubMed 33779484

Publications 2020

Akkouh IA, Ueland T, Hansson L, Inderhaug E, Hughes T, Steen NE, Aukrust P, Andreassen OA, Szabo A, Djurovic S (2020)
Decreased IL-1β-induced CCL20 response in human iPSC-astrocytes in schizophrenia: Potential attenuating effects on recruitment of regulatory T cells
Brain Behav Immun, 87, 634-644
DOI 10.1016/j.bbi.2020.02.008, PubMed 32109548

Bahrami S, Steen NE, Shadrin A, O'Connell K, Frei O, Bettella F, Wirgenes KV, Krull F, Fan CC, Dale AM, Smeland OB, Djurovic S, Andreassen OA (2020)
Shared Genetic Loci Between Body Mass Index and Major Psychiatric Disorders: A Genome-wide Association Study
JAMA Psychiatry, 77 (5), 503-512
DOI 10.1001/jamapsychiatry.2019.4188, PubMed 31913414

Benjamin BR, Valstad M, Elvsåshagen T, Jönsson EG, Moberget T, Winterton A, Haram M, Høegh MC, Lagerberg TV, Steen NE, Larsen L, Andreassen OA, Westlye LT, Quintana DS (2020)
Heart rate variability is associated with disease severity in psychosis spectrum disorders
Prog Neuropsychopharmacol Biol Psychiatry, 111, 110108
DOI 10.1016/j.pnpbp.2020.110108, PubMed 32946948

Hjell G, Mørch-Johnsen L, Holst R, Tesli N, Bell C, Lunding SH, Rødevand L, Werner MCF, Melle I, Andreassen OA, Lagerberg TV, Steen NE, Haukvik UK (2020)
Disentangling the relationship between cholesterol, aggression, and impulsivity in severe mental disorders
Brain Behav, 10 (9), e01751
DOI 10.1002/brb3.1751, PubMed 32681586

Hjelseng IV, Vaskinn A, Ueland T, Lunding SH, Reponen EJ, Steen NE, Andreassen OA, Aas M (2020)
Childhood trauma is associated with poorer social functioning in severe mental disorders both during an active illness phase and in remission
Schizophr Res, 243, 241-246
DOI 10.1016/j.schres.2020.03.015, PubMed 32222348

Hope S, Naerland T, Høiland AL, Torske T, Malt E, Abrahamsen T, Nerhus M, Wedervang-Resell K, Lonning V, Johannessen J, Steen NE, Agartz I, Stenberg N, Hundhausen T, Mørkrid L, Andreassen OA (2020)
Higher vitamin B12 levels in neurodevelopmental disorders than in healthy controls and schizophrenia: A comparison among participants between 2 and 53 years
FASEB J, 34 (6), 8114-8124
DOI 10.1096/fj.201900855RRR, PubMed 32323402

Reponen EJ, Dieset I, Tesli M, Mørch RH, Aas M, Vedal TSJ, Haug E, Drange OK, Steen NE, Hope S, Szabo A, Gohar SM, Wedervang-Resell K, Djurovic S, Melle I, Aukrust P, Andreassen OA, Ueland T (2020)
Atherogenic Lipid Ratios Related to Myeloperoxidase and C-Reactive Protein Levels in Psychotic Disorders
Front Psychiatry, 11, 672
DOI 10.3389/fpsyt.2020.00672, PubMed 32754070

Smeland OB, Bahrami S, Frei O, Shadrin A, O'Connell K, Savage J, Watanabe K, Krull F, Bettella F, Steen NE, Ueland T, Posthuma D, Djurovic S, Dale AM, Andreassen OA (2020)
Correction: Genome-wide analysis reveals extensive genetic overlap between schizophrenia, bipolar disorder, and intelligence
Mol Psychiatry, 25 (4), 914
DOI 10.1038/s41380-019-0456-7, PubMed 31308466

Smeland OB, Shadrin A, Bahrami S, Broce I, Tesli M, Frei O, Wirgenes KV, O'Connell KS, Krull F, Bettella F, Steen NE, Sugrue L, Wang Y, Svenningsson P, Sharma M, Pihlstrøm L, Toft M, O'Donovan M, Djurovic S, Desikan R, Dale AM, Andreassen OA (2020)
Genome-wide Association Analysis of Parkinson's Disease and Schizophrenia Reveals Shared Genetic Architecture and Identifies Novel Risk Loci
Biol Psychiatry, 89 (3), 227-235
DOI 10.1016/j.biopsych.2020.01.026, PubMed 32201043

Werner MCF, Wirgenes KV, Haram M, Bettella F, Lunding SH, Rødevand L, Hjell G, Agartz I, Djurovic S, Melle I, Andreassen OA, Steen NE (2020)
Indicated association between polygenic risk score and treatment-resistance in a naturalistic sample of patients with schizophrenia spectrum disorders
Schizophr Res, 218, 55-62
DOI 10.1016/j.schres.2020.03.006, PubMed 32171635

Winterton A, Rødevand L, Westlye LT, Steen NE, Andreassen OA, Quintana DS (2020)
Associations of loneliness and social isolation with cardiovascular and metabolic health: a systematic review and meta-analysis protocol
Syst Rev, 9 (1), 102
DOI 10.1186/s13643-020-01369-8, PubMed 32366295

Winterton A, Westlye LT, Steen NE, Andreassen OA, Quintana DS (2020)
Improving the precision of intranasal oxytocin research
Nat Hum Behav, 5 (1), 9-18
DOI 10.1038/s41562-020-00996-4, PubMed 33257880

Aas M, Ueland T, Inova A, Melle I, Andreassen OA, Steen NE (2020)
Childhood Trauma Is Nominally Associated With Elevated Cortisol Metabolism in Severe Mental Disorder
Front Psychiatry, 11, 391
DOI 10.3389/fpsyt.2020.00391, PubMed 32528319

Publications 2019

Gjerde PB, Simonsen CE, Lagerberg TV, Steen NE, Ueland T, Andreassen OA, Steen VM, Melle I (2019)
Improvement in verbal learning over the first year of antipsychotic treatment is associated with serum HDL levels in a cohort of first episode psychosis patients
Eur Arch Psychiatry Clin Neurosci, 270 (1), 49-58
DOI 10.1007/s00406-019-01017-w, PubMed 31028479

Gohar SM, Dieset I, Steen NE, Mørch RH, Vedal TSJ, Reponen EJ, Steen VM, Andreassen OA, Melle I (2019)
Association between leptin levels and severity of suicidal behaviour in schizophrenia spectrum disorders
Acta Psychiatr Scand, 139 (5), 464-471
DOI 10.1111/acps.13019, PubMed 30848483

O'Connell KS, Shadrin A, Bahrami S, Smeland OB, Bettella F, Frei O, Krull F, Askeland RB, Walters GB, Davíðsdóttir K, Haraldsdóttir GS, Guðmundsson ÓÓ, Stefánsson H, Fan CC, Steen NE, Reichborn-Kjennerud T, Dale AM, Stefánsson K, Djurovic S, Andreassen OA (2019)
Identification of genetic overlap and novel risk loci for attention-deficit/hyperactivity disorder and bipolar disorder
Mol Psychiatry, 26 (8), 4055-4065
DOI 10.1038/s41380-019-0613-z, PubMed 31792363

O'Connell KS, Shadrin A, Smeland OB, Bahrami S, Frei O, Bettella F, Krull F, Fan CC, Askeland RB, Knudsen GPS, Halmøy A, Steen NE, Ueland T, Walters GB, Davíðsdóttir K, Haraldsdóttir GS, Guðmundsson ÓÓ, Stefánsson H, Reichborn-Kjennerud T, Haavik J, Dale AM, Stefánsson K, Djurovic S, Andreassen OA (2019)
Identification of Genetic Loci Shared Between Attention-Deficit/Hyperactivity Disorder, Intelligence, and Educational Attainment
Biol Psychiatry, 87 (12), 1052-1062
DOI 10.1016/j.biopsych.2019.11.015, PubMed 32061372

Ringen PA, Reponen EJ, Vedal TSJ, Andreassen OA, Steen NE, Melle I (2019)
Predictors for Antipsychotic Dosage Change in the First Year of Treatment in Schizophrenia Spectrum and Bipolar Disorders
Front Psychiatry, 10, 649
DOI 10.3389/fpsyt.2019.00649, PubMed 31551838

Rødevand L, Steen NE, Elvsåshagen T, Quintana DS, Reponen EJ, Mørch RH, Lunding SH, Vedal TSJ, Dieset I, Melle I, Lagerberg TV, Andreassen OA (2019)
Cardiovascular risk remains high in schizophrenia with modest improvements in bipolar disorder during past decade
Acta Psychiatr Scand, 139 (4), 348-360
DOI 10.1111/acps.13008, PubMed 30697685

Scott J, Hidalgo-Mazzei D, Strawbridge R, Young A, Resche-Rigon M, Etain B, Andreassen OA, Bauer M, Bennabi D, Blamire AM, Boumezbeur F, Brambilla P, Cattane N, Cattaneo A, Chupin M, Coello K, Cointepas Y, Colom F, Cousins DA, Dubertret C, Duchesnay E, Ferro A, Garcia-Estela A, Goikolea J, Grigis A et al. (2019)
Prospective cohort study of early biosignatures of response to lithium in bipolar-I-disorders: overview of the H2020-funded R-LiNK initiative
Int J Bipolar Disord, 7 (1), 20
DOI 10.1186/s40345-019-0156-x, PubMed 31552554

Smeland OB, Bahrami S, Frei O, Shadrin A, O'Connell K, Savage J, Watanabe K, Krull F, Bettella F, Steen NE, Ueland T, Posthuma D, Djurovic S, Dale AM, Andreassen OA (2019)
Genome-wide analysis reveals extensive genetic overlap between schizophrenia, bipolar disorder, and intelligence
Mol Psychiatry, 25 (4), 844-853
DOI 10.1038/s41380-018-0332-x, PubMed 30610197

Steen NE, Dieset I, Hope S, Vedal TSJ, Smeland OB, Matson W, Kaddurah-Daouk R, Agartz I, Melle I, Djurovic S, Jönsson EG, Bogdanov M, Andreassen OA (2019)
Metabolic dysfunctions in the kynurenine pathway, noradrenergic and purine metabolism in schizophrenia and bipolar disorders
Psychol Med, 50 (4), 595-606
DOI 10.1017/S0033291719000400, PubMed 30867076

Vedal TSJ, Steen NE, Birkeland KI, Dieset I, Reponen EJ, Laskemoen JF, Rødevand L, Melle I, Andreassen OA, Molden E, Jönsson EG (2019)
Adipokine levels are associated with insulin resistance in antipsychotics users independently of BMI
Psychoneuroendocrinology, 103, 87-95
DOI 10.1016/j.psyneuen.2019.01.001, PubMed 30659986

Aas M, Elvsåshagen T, Westlye LT, Kaufmann T, Athanasiu L, Djurovic S, Melle I, van der Meer D, Martin-Ruiz C, Steen NE, Agartz I, Andreassen OA (2019)
Telomere length is associated with childhood trauma in patients with severe mental disorders
Transl Psychiatry, 9 (1), 97
DOI 10.1038/s41398-019-0432-7, PubMed 30898995

Aas M, Pizzagalli DA, Laskemoen JF, Reponen EJ, Ueland T, Melle I, Agartz I, Steen NE, Andreassen OA (2019)
Elevated hair cortisol is associated with childhood maltreatment and cognitive impairment in schizophrenia and in bipolar disorders
Schizophr Res, 213, 65-71
DOI 10.1016/j.schres.2019.01.011, PubMed 30660575

Publications 2018

Gjerde PB, Jørgensen KN, Steen NE, Melle I, Andreassen OA, Steen VM, Agartz I (2018)
Association between olanzapine treatment and brain cortical thickness and gray/white matter contrast is moderated by cholesterol in psychotic disorders
Psychiatry Res Neuroimaging, 282, 55-63
DOI 10.1016/j.pscychresns.2018.10.001, PubMed 30415175

Gohar SM, Dieset I, Steen NE, Mørch RH, Iversen TS, Steen VM, Andreassen OA, Melle I (2018)
Association between serum lipid levels, osteoprotegerin and depressive symptomatology in psychotic disorders
Eur Arch Psychiatry Clin Neurosci, 269 (7), 795-802
DOI 10.1007/s00406-018-0897-z, PubMed 29721726

Hoseth EZ, Krull F, Dieset I, Mørch RH, Hope S, Gardsjord ES, Steen NE, Melle I, Brattbakk HR, Steen VM, Aukrust P, Djurovic S, Andreassen OA, Ueland T (2018)
Exploring the Wnt signaling pathway in schizophrenia and bipolar disorder
Transl Psychiatry, 8 (1), 55
DOI 10.1038/s41398-018-0102-1, PubMed 29507296

Hoseth EZ, Krull F, Dieset I, Mørch RH, Hope S, Gardsjord ES, Steen NE, Melle I, Brattbakk HR, Steen VM, Aukrust P, Djurovic S, Andreassen OA, Ueland T (2018)
Attenuated Notch signaling in schizophrenia and bipolar disorder
Sci Rep, 8 (1), 5349
DOI 10.1038/s41598-018-23703-w, PubMed 29593239

Quintana DS, Steen NE, Andreassen OA (2018)
The Promise of Intranasal Esketamine as a Novel and Effective Antidepressant
JAMA Psychiatry, 75 (2), 123-124
DOI 10.1001/jamapsychiatry.2017.3738, PubMed 29282452

Vedal TSJ, Steen NE, Birkeland KI, Dieset I, Reponen EJ, Laskemoen JF, Rødevand L, Melle I, Andreassen OA, Molden E, Jönsson EG (2018)
Free thyroxine and thyroid-stimulating hormone in severe mental disorders: A naturalistic study with focus on antipsychotic medication
J Psychiatr Res, 106, 74-81
DOI 10.1016/j.jpsychires.2018.09.014, PubMed 30292780

Vedal TSJ, Steen NE, Birkeland KI, Dieset I, Reponen EJ, Laskemoen JF, Rødevand L, Melle I, Andreassen OA, Molden E, Jönsson EG (2018)
Response: Are thyroid abnormalities only related to antipsychotic treatment in patients with severe mental disorders?
J Psychiatr Res, 117, 150
DOI 10.1016/j.jpsychires.2018.11.012, PubMed 30454945

Aas M, Dieset I, Mørch R, Steen NE, Hope S, Reponen EJ, Laskemoen JF, Ueland T, Aukrust P, Melle I, Agartz I, Andreassen OA (2018)
Reduced brain-derived neurotrophic factor is associated with childhood trauma experiences and number of depressive episodes in severe mental disorders
Schizophr Res, 205, 45-50
DOI 10.1016/j.schres.2018.08.007, PubMed 30126813

Publications 2017

Fjukstad KK, Engum A, Lydersen S, Dieset I, Steen NE, Andreassen OA, Spigset O (2017)
Metabolic risk factors in schizophrenia and bipolar disorder: The effect of comedication with selective serotonin reuptake inhibitors and antipsychotics
Eur Psychiatry, 48, 71-78
DOI 10.1016/j.eurpsy.2017.04.001, PubMed 29331603

Iversen TSJ, Steen NE, Dieset I, Hope S, Mørch R, Gardsjord ES, Jørgensen KN, Melle I, Andreassen OA, Molden E, Jönsson EG (2017)
Side effect burden of antipsychotic drugs in real life - Impact of gender and polypharmacy
Prog Neuropsychopharmacol Biol Psychiatry, 82, 263-271
DOI 10.1016/j.pnpbp.2017.11.004, PubMed 29122637

Aas M, Dieset I, Hope S, Hoseth E, Mørch R, Reponen E, Steen NE, Laskemoen JF, Ueland T, Aukrust P, Agartz I, Andreassen OA, Melle I (2017)
Childhood maltreatment severity is associated with elevated C-reactive protein and body mass index in adults with schizophrenia and bipolar diagnoses
Brain Behav Immun, 65, 342-349
DOI 10.1016/j.bbi.2017.06.005, PubMed 28619247

Publications 2016

Fjukstad KK, Engum A, Lydersen S, Dieset I, Steen NE, Andreassen OA, Spigset O (2016)
Metabolic Abnormalities Related to Treatment With Selective Serotonin Reuptake Inhibitors in Patients With Schizophrenia or Bipolar Disorder
J Clin Psychopharmacol, 36 (6), 615-620
DOI 10.1097/JCP.0000000000000582, PubMed 27749681

Steen NE, Aas M, Simonsen C, Dieset I, Tesli M, Nerhus M, Gardsjord E, Mørch R, Agartz I, Melle I, Ueland T, Spigset O, Andreassen OA (2016)
Serum levels of second-generation antipsychotics are associated with cognitive function in psychotic disorders
World J Biol Psychiatry, 18 (6), 471-482
DOI 10.1080/15622975.2016.1245441, PubMed 27712130

Steen NE, Aas M, Simonsen C, Dieset I, Tesli M, Nerhus M, Gardsjord E, Mørch R, Agartz I, Melle I, Vaskinn A, Spigset O, Andreassen OA (2016)
Serum concentrations of mood stabilizers are associated with memory, but not other cognitive domains in psychosis spectrum disorders; explorative analyses in a naturalistic setting
Int J Bipolar Disord, 4 (1), 24
DOI 10.1186/s40345-016-0067-z, PubMed 27858347

Tesli M, Wirgenes KV, Hughes T, Bettella F, Athanasiu L, Hoseth ES, Nerhus M, Lagerberg TV, Steen NE, Agartz I, Melle I, Dieset I, Djurovic S, Andreassen OA (2016)
VRK2 gene expression in schizophrenia, bipolar disorder and healthy controls
Br J Psychiatry, 209 (2), 114-20
DOI 10.1192/bjp.bp.115.161950, PubMed 26941264

Aas M, Kauppi K, Brandt CL, Tesli M, Kaufmann T, Steen NE, Agartz I, Westlye LT, Andreassen OA, Melle I (2016)
Childhood trauma is associated with increased brain responses to emotionally negative as compared with positive faces in patients with psychotic disorders
Psychol Med, 47 (4), 669-679
DOI 10.1017/S0033291716002762, PubMed 27834153

Publications 2015

Quintana DS, Westlye LT, Kaufmann T, Rustan ØG, Brandt CL, Haatveit B, Steen NE, Andreassen OA (2015)
Reduced heart rate variability in schizophrenia and bipolar disorder compared to healthy controls
Acta Psychiatr Scand, 133 (1), 44-52
DOI 10.1111/acps.12498, PubMed 26371411

Steen NE, Aas M, Simonsen C, Dieset I, Tesli M, Nerhus M, Gardsjord E, Mørch R, Agartz I, Melle I, Vaskinn A, Spigset O, Andreassen OA (2015)
Serum level of venlafaxine is associated with better memory in psychotic disorders
Schizophr Res, 169 (1-3), 386-392
DOI 10.1016/j.schres.2015.10.021, PubMed 26516101

Publications 2014

Haram M, Tesli M, Dieset I, Steen NE, Røssberg JI, Djurovic S, Andreassen OA, Melle I (2014)
An attempt to identify single nucleotide polymorphisms contributing to possible relationships between personality traits and oxytocin-related genes
Neuropsychobiology, 69 (1), 25-30
DOI 10.1159/000356965, PubMed 24458227

Steen NE, Methlie P, Lorentzen S, Dieset I, Aas M, Nerhus M, Haram M, Agartz I, Melle I, Berg JP, Andreassen OA (2014)
Altered systemic cortisol metabolism in bipolar disorder and schizophrenia spectrum disorders
J Psychiatr Res, 52, 57-62
DOI 10.1016/j.jpsychires.2014.01.017, PubMed 24534618

Publications 2013

Hope S, Ueland T, Steen NE, Dieset I, Lorentzen S, Berg AO, Agartz I, Aukrust P, Andreassen OA (2013)
Interleukin 1 receptor antagonist and soluble tumor necrosis factor receptor 1 are associated with general severity and psychotic symptoms in schizophrenia and bipolar disorder
Schizophr Res, 145 (1-3), 36-42
DOI 10.1016/j.schres.2012.12.023, PubMed 23403415

Larsson S, Aas M, Klungsøyr O, Agartz I, Mork E, Steen NE, Barrett EA, Lagerberg TV, Røssberg JI, Melle I, Andreassen OA, Lorentzen S (2013)
Patterns of childhood adverse events are associated with clinical characteristics of bipolar disorder
BMC Psychiatry, 13, 97
DOI 10.1186/1471-244X-13-97, PubMed 23522391

Mork E, Walby FA, Harkavy-Friedman JM, Barrett EA, Steen NE, Lorentzen S, Andreassen OA, Melle I, Mehlum L (2013)
Clinical characteristics in schizophrenia patients with or without suicide attempts and non-suicidal self-harm--a cross-sectional study
BMC Psychiatry, 13, 255
DOI 10.1186/1471-244X-13-255, PubMed 24106884

Aas M, Haukvik UK, Djurovic S, Bergmann Ø, Athanasiu L, Tesli MS, Hellvin T, Steen NE, Agartz I, Lorentzen S, Sundet K, Andreassen OA, Melle I (2013)
BDNF val66met modulates the association between childhood trauma, cognitive and brain abnormalities in psychoses
Prog Neuropsychopharmacol Biol Psychiatry, 46, 181-8
DOI 10.1016/j.pnpbp.2013.07.008, PubMed 23876786

Publications 2012

Larsson S, Andreassen OA, Aas M, Røssberg JI, Mork E, Steen NE, Barrett EA, Lagerberg TV, Peleikis D, Agartz I, Melle I, Lorentzen S (2012)
High prevalence of childhood trauma in patients with schizophrenia spectrum and affective disorder
Compr Psychiatry, 54 (2), 123-7
DOI 10.1016/j.comppsych.2012.06.009, PubMed 22901835

Aas M, Steen NE, Agartz I, Aminoff SR, Lorentzen S, Sundet K, Andreassen OA, Melle I (2012)
Is cognitive impairment following early life stress in severe mental disorders based on specific or general cognitive functioning?
Psychiatry Res, 198 (3), 495-500
DOI 10.1016/j.psychres.2011.12.045, PubMed 22472845

Publications 2011

Hope S, Dieset I, Agartz I, Steen NE, Ueland T, Melle I, Aukrust P, Andreassen OA (2011)
Affective symptoms are associated with markers of inflammation and immune activation in bipolar disorders but not in schizophrenia
J Psychiatr Res, 45 (12), 1608-16
DOI 10.1016/j.jpsychires.2011.08.003, PubMed 21889167

Steen NE (2011)
Cortisol metabolism and release in bipolar disorder and schizophrenia spectrum disorders
In Series of dissertations submitted to the Faculty of Medicine, University of Oslo, Unipub, Oslo, no. 1193, 1 b. (flere pag.)
BIBSYS 114686122, ISBN 978-82-8264-044-2

Steen NE, Lorentzen S, Barrett EA, Lagerberg TV, Hope S, Larsson S, Berg AO, Agartz I, Melle I, Berg JP, Andreassen OA (2011)
Sex-specific cortisol levels in bipolar disorder and schizophrenia during mental challenge--relationship to clinical characteristics and medication
Prog Neuropsychopharmacol Biol Psychiatry, 35 (4), 1100-7
DOI 10.1016/j.pnpbp.2011.03.008, PubMed 21420462

Steen NE, Methlie P, Lorentzen S, Hope S, Barrett EA, Larsson S, Mork E, Almås B, Løvås K, Agartz I, Melle I, Berg JP, Andreassen OA (2011)
Increased systemic cortisol metabolism in patients with schizophrenia and bipolar disorder: a mechanism for increased stress vulnerability?
J Clin Psychiatry, 72 (11), 1515-21
DOI 10.4088/JCP.10m06068yel, PubMed 21367348

Aas M, Djurovic S, Athanasiu L, Steen NE, Agartz I, Lorentzen S, Sundet K, Andreassen OA, Melle I (2011)
Serotonin transporter gene polymorphism, childhood trauma, and cognition in patients with psychotic disorders
Schizophr Bull, 38 (1), 15-22
DOI 10.1093/schbul/sbr113, PubMed 21908796

Publications 2010

Barrett EA, Sundet K, Faerden A, Agartz I, Bratlien U, Romm KL, Mork E, Rossberg JI, Steen NE, Andreassen OA, Melle I (2010)
Suicidality in first episode psychosis is associated with insight and negative beliefs about psychosis
Schizophr Res, 123 (2-3), 257-62
DOI 10.1016/j.schres.2010.07.018, PubMed 20685083

Barrett EA, Sundet K, Faerden A, Nesvåg R, Agartz I, Fosse R, Mork E, Steen NE, Andreassen OA, Melle I (2010)
Suicidality before and in the early phases of first episode psychosis
Schizophr Res, 119 (1-3), 11-7
DOI 10.1016/j.schres.2010.03.022, PubMed 20399077

Hope S, Melle I, Aukrust P, Agartz I, Lorentzen S, Steen NE, Djurovic S, Ueland T, Andreassen OA (2010)
Osteoprotegerin levels in patients with severe mental disorders
J Psychiatry Neurosci, 35 (5), 304-10
DOI 10.1503/jpn.090088, PubMed 20569643

Steen NE, Tesli M, Kähler AK, Methlie P, Hope S, Barrett EA, Larsson S, Mork E, Løvås K, Røssberg JI, Agartz I, Melle I, Djurovic S, Lorentzen S, Berg JP, Andreassen OA (2010)
SRD5A2 is associated with increased cortisol metabolism in schizophrenia spectrum disorders
Prog Neuropsychopharmacol Biol Psychiatry, 34 (8), 1500-6
DOI 10.1016/j.pnpbp.2010.08.013, PubMed 20800085

Publications 2009

Hope S, Melle I, Aukrust P, Steen NE, Birkenaes AB, Lorentzen S, Agartz I, Ueland T, Andreassen OA (2009)
Similar immune profile in bipolar disorder and schizophrenia: selective increase in soluble tumor necrosis factor receptor I and von Willebrand factor
Bipolar Disord, 11 (7), 726-34
DOI 10.1111/j.1399-5618.2009.00757.x, PubMed 19839997

Larsson S, Lorentzen S, Mork E, Barrett EA, Steen NE, Lagerberg TV, Berg AO, Aminoff SR, Agartz I, Melle I, Andreassen OA (2009)
Age at onset of bipolar disorder in a Norwegian catchment area sample
J Affect Disord, 124 (1-2), 174-7
DOI 10.1016/j.jad.2009.10.031, PubMed 19931918