
Olav Bjerkehagen Smeland
- Researcher; PhD
- +47 230 27350
Publications 2021
Genetic loci shared between major depression and intelligence with mixed directions of effect
Nat Hum Behav (in press)
DOI 10.1093/nar/gks1055, PubMed 33462475
Polygenic overlap and shared genetic loci between loneliness, severe mental disorders, and cardiovascular disease risk factors suggest shared molecular mechanisms
Transl Psychiatry, 11 (1), 3
DOI 10.1038/s41398-020-01142-4, PubMed 33414458
Publications 2020
Shared Genetic Loci Between Body Mass Index and Major Psychiatric Disorders: A Genome-wide Association Study
JAMA Psychiatry, 77 (5), 503-512
DOI 10.1001/jamapsychiatry.2019.4188, PubMed 31913414
Genetic control of variability in subcortical and intracranial volumes
Mol Psychiatry
DOI 10.1038/s41380-020-0664-1, PubMed 32047264
Polygenic scores for schizophrenia and general cognitive ability: associations with six cognitive domains, premorbid intelligence, and cognitive composite score in individuals with a psychotic disorder and in healthy controls
Transl Psychiatry, 10 (1), 416
DOI 10.1038/s41398-020-01094-9, PubMed 33257657
Beyond SNP heritability: Polygenicity and discoverability of phenotypes estimated with a univariate Gaussian mixture model
PLoS Genet, 16 (5), e1008612
DOI 10.1371/journal.pgen.1008612, PubMed 32427991
Publisher Correction: Common brain disorders are associated with heritable patterns of apparent aging of the brain
Nat Neurosci, 23 (2), 295
DOI 10.1038/s41593-019-0553-6, PubMed 31848485
Translating big data to better treatment in bipolar disorder - a manifesto for coordinated action
Eur Neuropsychopharmacol, 36, 121-136
DOI 10.1016/j.euroneuro.2020.05.006, PubMed 32536571
Phenotype-specific differences in polygenicity and effect size distribution across functional annotation categories revealed by AI-MiXeR
Bioinformatics, 36 (18), 4749-4756
DOI 10.1093/bioinformatics/btaa568, PubMed 32539089
Correction: Genome-wide analysis reveals extensive genetic overlap between schizophrenia, bipolar disorder, and intelligence
Mol Psychiatry, 25 (4), 914
DOI 10.1038/s41380-019-0456-7, PubMed 31308466
The polygenic architecture of schizophrenia - rethinking pathogenesis and nosology
Nat Rev Neurol, 16 (7), 366-379
DOI 10.1038/s41582-020-0364-0, PubMed 32528109
Genome-wide Association Analysis of Parkinson's Disease and Schizophrenia Reveals Shared Genetic Architecture and Identifies Novel Risk Loci
Biol Psychiatry, 89 (3), 227-235
DOI 10.1016/j.biopsych.2020.01.026, PubMed 32201043
Author Correction: Understanding the genetic determinants of the brain with MOSTest
Nat Commun, 11 (1), 4700
DOI 10.1038/s41467-020-18628-w, PubMed 32929091
Understanding the genetic determinants of the brain with MOSTest
Nat Commun, 11 (1), 3512
DOI 10.1038/s41467-020-17368-1, PubMed 32665545
Publications 2019
Brain Heterogeneity in Schizophrenia and Its Association With Polygenic Risk
JAMA Psychiatry, 76 (7), 739-748
DOI 10.1001/jamapsychiatry.2019.0257, PubMed 30969333
Genetic Overlap Between Alzheimer's Disease and Bipolar Disorder Implicates the MARK2 and VAC14 Genes
Front Neurosci, 13, 220
DOI 10.3389/fnins.2019.00220, PubMed 30930738
Bivariate causal mixture model quantifies polygenic overlap between complex traits beyond genetic correlation
Nat Commun, 10 (1), 2417
DOI 10.1038/s41467-019-10310-0, PubMed 31160569
Common brain disorders are associated with heritable patterns of apparent aging of the brain
Nat Neurosci, 22 (10), 1617-1623
DOI 10.1038/s41593-019-0471-7, PubMed 31551603
GWAS of Suicide Attempt in Psychiatric Disorders and Association With Major Depression Polygenic Risk Scores
Am J Psychiatry, 176 (8), 651-660
DOI 10.1176/appi.ajp.2019.18080957, PubMed 31164008
Identification of genetic overlap and novel risk loci for attention-deficit/hyperactivity disorder and bipolar disorder
Mol Psychiatry (in press)
DOI 10.1038/s41380-019-0613-z, PubMed 31792363
Identification of Genetic Loci Shared Between Attention-Deficit/Hyperactivity Disorder, Intelligence, and Educational Attainment
Biol Psychiatry, 87 (12), 1052-1062
DOI 10.1016/j.biopsych.2019.11.015, PubMed 32061372
Genome-wide analysis reveals extensive genetic overlap between schizophrenia, bipolar disorder, and intelligence
Mol Psychiatry, 25 (4), 844-853
DOI 10.1038/s41380-018-0332-x, PubMed 30610197
The emerging pattern of shared polygenic architecture of psychiatric disorders, conceptual and methodological challenges
Psychiatr Genet, 29 (5), 152-159
DOI 10.1097/YPG.0000000000000234, PubMed 31464996
Discovery of shared genomic loci using the conditional false discovery rate approach
Hum Genet, 139 (1), 85-94
DOI 10.1007/s00439-019-02060-2, PubMed 31520123
Genome-wide association study identifies 30 loci associated with bipolar disorder
Nat Genet, 51 (5), 793-803
DOI 10.1038/s41588-019-0397-8, PubMed 31043756
Metabolic dysfunctions in the kynurenine pathway, noradrenergic and purine metabolism in schizophrenia and bipolar disorders
Psychol Med, 50 (4), 595-606
DOI 10.1017/S0033291719000400, PubMed 30867076
Publications 2018
Cross-tissue eQTL enrichment of associations in schizophrenia
PLoS One, 13 (9), e0202812
DOI 10.1371/journal.pone.0202812, PubMed 30188921
Beyond heritability: improving discoverability in imaging genetics
Hum Mol Genet, 27 (R1), R22-R28
DOI 10.1093/hmg/ddy082, PubMed 29522091
Selective Genetic Overlap Between Amyotrophic Lateral Sclerosis and Diseases of the Frontotemporal Dementia Spectrum
JAMA Neurol, 75 (7), 860-875
DOI 10.1001/jamaneurol.2018.0372, PubMed 29630712
Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence
Nat Genet, 50 (7), 912-919
DOI 10.1038/s41588-018-0152-6, PubMed 29942086
How can genetics help understand the relationship between cognitive dysfunction and schizophrenia?
Scand J Psychol, 59 (1), 26-31
DOI 10.1111/sjop.12407, PubMed 29356008
Genetic Overlap Between Schizophrenia and Volumes of Hippocampus, Putamen, and Intracranial Volume Indicates Shared Molecular Genetic Mechanisms
Schizophr Bull, 44 (4), 854-864
DOI 10.1093/schbul/sbx148, PubMed 29136250
Enrichment of genetic markers of recent human evolution in educational and cognitive traits
Sci Rep, 8 (1), 12585
DOI 10.1038/s41598-018-30387-9, PubMed 30135563
Brain scans from 21,297 individuals reveal the genetic architecture of hippocampal subfield volumes
Mol Psychiatry, 25 (11), 3053-3065
DOI 10.1038/s41380-018-0262-7, PubMed 30279459
Identification of shared genetic variants between schizophrenia and lung cancer
Sci Rep, 8 (1), 674
DOI 10.1038/s41598-017-16481-4, PubMed 29330379
Publications 2017
Psychotic patients who used cannabis frequently before illness onset have higher genetic predisposition to schizophrenia than those who did not
Psychol Med, 48 (1), 43-49
DOI 10.1017/S0033291717001209, PubMed 28967348
Leveraging genome characteristics to improve gene discovery for putamen subcortical brain structure
Sci Rep, 7 (1), 15736
DOI 10.1038/s41598-017-15705-x, PubMed 29147026
Genetic evidence for role of integration of fast and slow neurotransmission in schizophrenia
Mol Psychiatry, 22 (6), 792-801
DOI 10.1038/mp.2017.33, PubMed 28348379
Modeling prior information of common genetic variants improves gene discovery for neuroticism
Hum Mol Genet, 26 (22), 4530-4539
DOI 10.1093/hmg/ddx340, PubMed 28973307
Novel Loci Associated With Attention-Deficit/Hyperactivity Disorder Are Revealed by Leveraging Polygenic Overlap With Educational Attainment
J Am Acad Child Adolesc Psychiatry, 57 (2), 86-95
DOI 10.1016/j.jaac.2017.11.013, PubMed 29413154
Identification of Genetic Loci Jointly Influencing Schizophrenia Risk and the Cognitive Traits of Verbal-Numerical Reasoning, Reaction Time, and General Cognitive Function
JAMA Psychiatry, 74 (10), 1065-1075
DOI 10.1001/jamapsychiatry.2017.1986, PubMed 28746715
Identification of genetic loci shared between schizophrenia and the Big Five personality traits
Sci Rep, 7 (1), 2222
DOI 10.1038/s41598-017-02346-3, PubMed 28533504
Publications 2016
Genome-wide analyses for personality traits identify six genomic loci and show correlations with psychiatric disorders
Nat Genet, 49 (1), 152-156
DOI 10.1038/ng.3736, PubMed 27918536
Publications 2015
Modification of Astrocyte Metabolism as an Approach to the Treatment of Epilepsy: Triheptanoin and Acetyl-L-Carnitine
Neurochem Res, 41 (1-2), 86-95
DOI 10.1007/s11064-015-1728-5, PubMed 26433381
Publications 2013
Triheptanoin partially restores levels of tricarboxylic acid cycle intermediates in the mouse pilocarpine model of epilepsy
J Neurochem, 129 (1), 107-19
DOI 10.1111/jnc.12610, PubMed 24236946
Brain mitochondrial metabolic dysfunction and glutamate level reduction in the pilocarpine model of temporal lobe epilepsy in mice
J Cereb Blood Flow Metab, 33 (7), 1090-7
DOI 10.1038/jcbfm.2013.54, PubMed 23611869
Publications 2012
Chronic acetyl-L-carnitine alters brain energy metabolism and increases noradrenaline and serotonin content in healthy mice
Neurochem Int, 61 (1), 100-7
DOI 10.1016/j.neuint.2012.04.008, PubMed 22549035
Dietary supplementation with acetyl-l-carnitine in seizure treatment of pentylenetetrazole kindled mice
Neurochem Int, 61 (4), 444-54
DOI 10.1016/j.neuint.2012.06.008, PubMed 22709675
Publications 2010
Knockout of GAD65 has major impact on synaptic GABA synthesized from astrocyte-derived glutamine
J Cereb Blood Flow Metab, 31 (2), 494-503
DOI 10.1038/jcbfm.2010.115, PubMed 20664610