Petras Juzenas
- Scientist; PhD
- +47-22781205
Publications 2024
Application of Photodynamic Therapy with 5-Aminolevulinic Acid to Extracorporeal Photopheresis in the Treatment of Cutaneous T-Cell Lymphoma: A First-in-Human Phase I/II Study
Pharmaceutics, 16 (6)
DOI 10.3390/pharmaceutics16060815, PubMed 38931936
Publications 2023
Photodynamic Effects with 5-Aminolevulinic Acid on Cytokines and Exosomes in Human Peripheral Blood Mononuclear Cells from Patients with Crohn's Disease
Int J Mol Sci, 24 (5)
DOI 10.3390/ijms24054554, PubMed 36901982
Publications 2022
Amphiphilic Protoporphyrin IX Derivatives as New Photosensitizing Agents for the Improvement of Photodynamic Therapy
Biomedicines, 10 (2)
DOI 10.3390/biomedicines10020423, PubMed 35203632
Photodynamic Effects with 5-Aminolevulinic Acid on Cytokines and Exosomes in Human Peripheral Blood Mononuclear Cells
Biomedicines, 10 (2)
DOI 10.3390/biomedicines10020232, PubMed 35203441
Publications 2021
Application of Photodynamic Therapy with 5-Aminolevulinic Acid to Extracorporeal Photopheresis in the Treatment of Patients with Chronic Graft-versus-Host Disease: A First-in-Human Study
Pharmaceutics, 13 (10)
DOI 10.3390/pharmaceutics13101558, PubMed 34683851
Evaluation of In Vitro Phototoxicity of a Minibody-IR700 Conjugate Using Cell Monolayer and Multicellular Tumor Spheroid Models
Cancers (Basel), 13 (13)
DOI 10.3390/cancers13133356, PubMed 34283089
Correction: Sioud et al. Evaluation of In Vitro Phototoxicity of a Minibody-IR700 Conjugate Using Monolayer and Multicellular Tumor Spheroid Models. Cancers 2021, 13, 3356
Cancers (Basel), 13 (21)
DOI 10.3390/cancers13215513, PubMed 34771754
Evaluation of the PSMA-Binding Ligand 212Pb-NG001 in Multicellular Tumour Spheroid and Mouse Models of Prostate Cancer
Int J Mol Sci, 22 (9)
DOI 10.3390/ijms22094815, PubMed 34062920
Publications 2020
Selective Killing of Activated T Cells by 5-Aminolevulinic Acid Mediated Photodynamic Effect: Potential Improvement of Extracorporeal Photopheresis
Cancers (Basel), 12 (2)
DOI 10.3390/cancers12020377, PubMed 32041351
Predictive biomarkers for 5-ALA-PDT can lead to personalized treatments and overcome tumor-specific resistances
Cancer Rep (Hoboken), 5 (12), e1278
DOI 10.1002/cnr2.1278, PubMed 32737955
Publications 2018
The Akt pathway in oncology therapy and beyond (Review)
Int J Oncol, 53 (6), 2319-2331
DOI 10.3892/ijo.2018.4597, PubMed 30334567
Publications 2017
Combined inhibition of Wee1 and Chk1 gives synergistic DNA damage in S-phase due to distinct regulation of CDK activity and CDC45 loading
Oncotarget, 8 (7), 10966-10979
DOI 10.18632/oncotarget.14089, PubMed 28030798
Publications 2015
Supramolecular nanoscale assemblies for cancer diagnosis and therapy
J Control Release, 213, 152-167
DOI 10.1016/j.jconrel.2015.06.034, PubMed 26160308
Radiosensitizing effect of zinc oxide and silica nanocomposites on cancer cells
Colloids Surf B Biointerfaces, 129, 79-86
DOI 10.1016/j.colsurfb.2015.03.026, PubMed 25829130
Akt inhibitors in cancer treatment: The long journey from drug discovery to clinical use (Review)
Int J Oncol, 48 (3), 869-85
DOI 10.3892/ijo.2015.3306, PubMed 26698230
Publications 2014
Enhancing proteasome-lnhibitor effect by functionalized gold nanoparticles
J Biomed Nanotechnol, 10 (4), 717-23
DOI 10.1166/jbn.2014.1743, PubMed 24734524
X-ray-induced nanoparticle-based photodynamic therapy of cancer
Nanomedicine (Lond), 9 (15), 2339-51
DOI 10.2217/nnm.13.198, PubMed 24471504
Publications 2013
Gold nanoparticle delivery-enhanced proteasome inhibitor effect in adenocarcinoma cells
Expert Opin Drug Deliv, 10 (10), 1345-52
DOI 10.1517/17425247.2013.827659, PubMed 23937147
Photoactivatable carbon nanodots for cancer therapy
Appl. Phys. Lett., 103 (6), 063701
DOI 10.1063/1.4817787
Carbon-core silver-shell nanodots as sensitizers for phototherapy and radiotherapy
Nanotechnology, 24 (32), 325103
DOI 10.1088/0957-4484/24/32/325103, PubMed 23868054
Publications 2012
Blebbistatin, a myosin inhibitor, is phototoxic to human cancer cells under exposure to blue light
Biochim Biophys Acta, 1820 (7), 870-7
DOI 10.1016/j.bbagen.2012.04.003, PubMed 22507270
Publications 2011
Carbon dots as antioxidants and prooxidants
J Biomed Nanotechnol, 7 (5), 667-76
DOI 10.1166/jbn.2011.1334, PubMed 22195484
Entrapment in phospholipid vesicles quenches photoactivity of quantum dots
Int J Nanomedicine, 6, 1875-88
DOI 10.2147/IJN.S22953, PubMed 21931483
Epigallocatechin gallate-loaded polysaccharide nanoparticles for prostate cancer chemoprevention
Nanomedicine (Lond), 6 (1), 79-87
DOI 10.2217/nnm.10.101, PubMed 21182420
Quantum dots affect expression of CD133 surface antigen in melanoma cells
Int J Nanomedicine, 6, 2437-44
DOI 10.2147/IJN.S24477, PubMed 22072879
Publications 2010
Cytotoxicity and Phototoxicity of Red Fluorescent Nontargeted Quantum Dots
IEEE J. Sel. Top. Quantum Electron., 16 (4), 997-1003
DOI 10.1109/JSTQE.2009.2034387
Reduction of cutaneous photosensitivity by application of ointment containing ferrous or cobaltous ions concomitant with the use of topical protoporphyrin IX precursors
Photodiagnosis Photodyn Ther, 7 (3), 152-7
DOI 10.1016/j.pdpdt.2010.06.003, PubMed 20728838
Reflectance spectroscopy and fluorescein angiography applied to assess photodynamic response in healthy mouse skin treated with topical hexylaminolevulinate
Photodiagnosis Photodyn Ther, 7 (4), 239-45
DOI 10.1016/j.pdpdt.2010.07.001, PubMed 21112546
Application of 5-aminolevulinic acid and its derivatives for photodynamic therapy in vitro and in vivo
Methods Mol Biol, 635, 97-106
DOI 10.1007/978-1-60761-697-9_7, PubMed 20552342
Hexyl aminolaevulinate is a more effective topical photosensitiser precursor than methyl aminolaevulinate and 5-aminolaevulinic acids when applied in equimolar doses
J Pharm Sci, 99 (8), 3486-98
DOI 10.1002/jps.22116, PubMed 20222026
Novel patch-based systems for the localised delivery of ALA-esters
J Photochem Photobiol B, 101 (1), 59-69
DOI 10.1016/j.jphotobiol.2010.06.012, PubMed 20634088
Influence of penetration enhancers on topical delivery of 5-aminolevulinic acid from bioadhesive patches
J Pharm Pharmacol, 62 (6), 685-95
DOI 10.1211/jpp.62.06.0004, PubMed 20636855
CHARACTERIZATION OF CANCER STEM CELLS AND THEIR RESPONSE TO CdTe QUANTUM DOTS
MED PHYS BALTIC STAT (2), 71-+
Characterization of cancer stem cells and their response to CdTe quantum dots
Med Phys Balt Stat, 8, 71-76
PublikaID 41
Publications 2009
Influence of formulation factors on PpIX production and photodynamic action of novel ALA-loaded microparticles
Biopharm Drug Dispos, 30 (2), 55-70
DOI 10.1002/bdd.645, PubMed 19226650
Generation of singlet oxygen and other radical species by quantum dot and carbon dot nanosensitizers
PROC SPIE, 7380, 738072
DOI 10.1117/12.830353
Publications 2008
Microneedle arrays permit enhanced intradermal delivery of a preformed photosensitizer
Photochem Photobiol, 85 (1), 195-204
DOI 10.1111/j.1751-1097.2008.00417.x, PubMed 18764907
Microneedle-mediated intradermal delivery of 5-aminolevulinic acid: potential for enhanced topical photodynamic therapy
J Control Release, 129 (3), 154-62
DOI 10.1016/j.jconrel.2008.05.002, PubMed 18556084
Quantum dots and nanoparticles for photodynamic and radiation therapies of cancer
Adv Drug Deliv Rev, 60 (15), 1600-14
DOI 10.1016/j.addr.2008.08.004, PubMed 18840487
Generation of Nitrogen Oxide and Oxygen Radicals by Quantum Dots
J. Biomed. Nanotechnol., 4 (4), 450-456
DOI 10.1166/jbn.2008.008
Depth profile of protoporphyrin IX fluorescence in an amelanotic mouse melanoma model
Photochem Photobiol, 85 (3), 760-4
DOI 10.1111/j.1751-1097.2008.00496.x, PubMed 19140894
Publications 2007
Photodynamic therapy with di-l-arginine protoporphyrinate on WiDr human colon adenocarcinoma xenografts in athymic nude mice
Photodiagnosis Photodyn Ther, 4 (4), 237-41
DOI 10.1016/j.pdpdt.2007.08.001, PubMed 25047558
Topical applications of iron chelators in photosensitization
Photochem Photobiol Sci, 6 (12), 1268-74
DOI 10.1039/b703861e, PubMed 18046481
Biological activity of 5-aminolevulinic acid and its methyl ester after storage under different conditions
J Photochem Photobiol B, 87 (2), 67-72
DOI 10.1016/j.jphotobiol.2007.01.003, PubMed 17350278
Publications 2006
The effect of dimethylsulfoxide, 1-[2-(decylthio)ethyl]azacyclopentan-2-one and Labrafac(®)CC on porphyrin formation in normal mouse skin during topical application of methyl 5-aminolevulinate: A fluorescence and extraction study
Photodiagnosis Photodyn Ther, 3 (1), 27-33
DOI 10.1016/S1572-1000(05)00109-2, PubMed 25049025
The effect of skin permeation enhancers on the formation of porphyrins in mouse skin during topical application of the methyl ester of 5-aminolevulinic acid
J Photochem Photobiol B, 83 (2), 94-7
DOI 10.1016/j.jphotobiol.2005.12.003, PubMed 16442808
Influence of formulation factors on methyl-ALA-induced protoporphyrin IX accumulation in vivo
Photodiagnosis Photodyn Ther, 3 (3), 190-201
DOI 10.1016/j.pdpdt.2006.03.007, PubMed 25049154
Topical bioadhesive patch systems enhance selectivity of protoporphyrin IX accumulation
Photochem Photobiol, 82 (3), 670-5
DOI 10.1562/2005-08-08-RA-641, PubMed 16475870
The influence of light and darkness on cutaneous fluorescence in mice
Luminescence, 21 (3), 159-63
DOI 10.1002/bio.900, PubMed 16502394
The influence of temperature on photodynamic cell killing in vitro with 5-aminolevulinic acid
J Photochem Photobiol B, 84 (2), 161-6
DOI 10.1016/j.jphotobiol.2006.02.009, PubMed 16624569
Topical application of 5-aminolaevulinic acid, methyl 5-aminolaevulinate and hexyl 5-aminolaevulinate on normal human skin
Br J Dermatol, 155 (4), 791-9
DOI 10.1111/j.1365-2133.2006.07484.x, PubMed 16965430
Facilitated delivery of ALA to inaccessible regions via bioadhesive patch systems
J Environ Pathol Toxicol Oncol, 25 (1-2), 389-402
DOI 10.1615/jenvironpatholtoxicoloncol.v25.i1-2.240, PubMed 16566730
Singlet oxygen in photosensitization
J Environ Pathol Toxicol Oncol, 25 (1-2), 29-50
DOI 10.1615/jenvironpatholtoxicoloncol.v25.i1-2.30, PubMed 16566709
Measurement of lipid oxidation and porphyrins in high oxygen modified atmosphere and vacuum-packed minced turkey and pork meat by fluorescence spectra and images
Meat Sci, 73 (3), 511-20
DOI 10.1016/j.meatsci.2006.02.001, PubMed 22062491
Spectroscopic measurements of photoinduced processes in human skin after topical application of the hexyl ester of 5-aminolevulinic acid
J Environ Pathol Toxicol Oncol, 25 (1-2), 307-20
DOI 10.1615/jenvironpatholtoxicoloncol.v25.i1-2.200, PubMed 16566726
Publications 2005
Pharmaceutical analysis of 5-aminolevulinic acid in solution and in tissues
J Photochem Photobiol B, 82 (1), 59-71
DOI 10.1016/j.jphotobiol.2005.08.007, PubMed 16242952
Deferoxamine photosensitizes cancer cells in vitro
Biochem Biophys Res Commun, 332 (2), 388-91
DOI 10.1016/j.bbrc.2005.04.138, PubMed 15910749
Formation of protoporphyrin IX from carboxylic- and amino-derivatives of 5-aminolevulinic acid
Photodiagnosis Photodyn Ther, 2 (2), 129-34
DOI 10.1016/S1572-1000(05)00012-8, PubMed 25048672
Kinetics of protoporphyrin IX formation in rat oral mucosa and skin after application of 5-aminolevulinic acid and its methylester
Photochem Photobiol, 81 (2), 394-7
DOI 10.1562/2004-04-02-RA-132, PubMed 15535733
Radiosensitization of tumours by porphyrins
Cancer Lett, 235 (1), 40-7
DOI 10.1016/j.canlet.2005.03.041, PubMed 15946797
Choice of optimal wavelength for PDT: the significance of oxygen depletion
Photochem Photobiol, 81 (5), 1190-4
DOI 10.1562/2005-04-06-RA-478, PubMed 15934793
The role of naturally occurring chlorophyll and porphyrins in light-induced oxidation of dairy products. A study based on fluorescence spectroscopy and sensory analysis
Int. Dairy J., 15 (4), 343-353
DOI 10.1016/j.idairyj.2004.08.009
Publications 2004
Spectroscopic evidence of monomeric aluminium phthalocyanine tetrasulphonate in aqueous solutions
J Photochem Photobiol B, 75 (1-2), 107-10
DOI 10.1016/j.jphotobiol.2004.05.011, PubMed 15246357
Effectiveness of different light sources for 5-aminolevulinic acid photodynamic therapy
Lasers Med Sci, 19 (3), 139-49
DOI 10.1007/s10103-004-0314-x, PubMed 15503248
Reflectance spectra of pigmented and nonpigmented skin in the UV spectral region
Photochem Photobiol, 80 (3), 450-5
DOI 10.1562/0031-8655(2004)080<0450:RSOPAN>2.0.CO;2, PubMed 15623329
The effect of sub-lethal ALA-PDT on the cytoskeleton and adhesion of cultured human cancer cells
Biochim Biophys Acta, 1722 (1), 43-50
DOI 10.1016/j.bbagen.2004.11.011, PubMed 15716135
Photosensitization with protoporphyrin IX inhibits attachment of cancer cells to a substratum
Biochem Biophys Res Commun, 322 (2), 452-7
DOI 10.1016/j.bbrc.2004.07.132, PubMed 15325251
Publications 2003
Pharmacology of protoporphyrin IX in nude mice after application of ALA and ALA esters
Int J Cancer, 103 (1), 132-5
DOI 10.1002/ijc.10802, PubMed 12455066
Publications 2002
Systemic photodynamic therapy with aminolevulinic acid induces apoptosis in lesional T lymphocytes of psoriatic plaques
J Invest Dermatol, 119 (1), 77-83
DOI 10.1046/j.1523-1747.2002.01827.x, PubMed 12164928
Investigations of endogenous photosensitizer protoporphyrin IX in hairless mouse skin by means of fluorescence spectroscopy
In Series of dissertations submitted to the Faculty of Mathematics and Natural Sciences, University of Oslo, The Faculty, Oslo, no. 237, 1 b. (flere pag.)
BIBSYS 022449027
Noninvasive fluorescence excitation spectroscopy during application of 5-aminolevulinic acid in vivo
Photochem Photobiol Sci, 1 (10), 745-8
DOI 10.1039/b203459j, PubMed 12656473
Photosensitizing effect of protoporphyrin IX in pigmented melanoma of mice
Biochem Biophys Res Commun, 297 (3), 468-72
DOI 10.1016/s0006-291x(02)02238-6, PubMed 12270116
Protoporphyrin IX fluorescence kinetics in UV-induced tumours and normal skin of hairless mice after topical application of 5-aminolevulinic acid methyl ester
J Photochem Photobiol B, 67 (1), 11-7
DOI 10.1016/s1011-1344(02)00269-5, PubMed 12007462
Topical application of 5-aminolevulinic acid and its methylester, hexylester and octylester derivatives: considerations for dosimetry in mouse skin model
Photochem Photobiol, 76 (3), 329-34
DOI 10.1562/0031-8655(2002)076<0329:taoaaa>2.0.co;2, PubMed 12403455
Temperature effect on accumulation of protoporphyrin IX after topical application of 5-aminolevulinic acid and its methylester and hexylester derivatives in normal mouse skin
Photochem Photobiol, 76 (4), 452-6
DOI 10.1562/0031-8655(2002)076<0452:teoaop>2.0.co;2, PubMed 12405155
Production of protoporphyrin IX from 5-aminolevulinic acid and two of its esters in cells in vitro and tissues in vivo
Cell Mol Biol (Noisy-le-grand), 48 (8), 911-6
PubMed 12699250
Weekly topical application of methyl aminolevulinate followed by light exposure delays the appearance of UV-induced skin tumours in mice
Arch Dermatol Res, 294 (5), 237-42
DOI 10.1007/s00403-002-0320-4, PubMed 12115027
Publications 2001
Fluorescence spectroscopy of normal mouse skin exposed to 5-aminolaevulinic acid and red light
J Photochem Photobiol B, 61 (1-2), 78-86
DOI 10.1016/s1011-1344(01)00149-x, PubMed 11485851
Mechanisms and procedures in PDT
SKIN AND ENVIRONMENT - PERCEPTION AND PROTECTION, VOLS 1 AND 2, 641-647
On the basis for tumor selectivity in the 5-aminolevulinic acid-induced synthesis of protoporphyrin IX
J. Porphyr. Phthalocyanines, 5 (2), 170-176
DOI 10.1002/jpp.329
The influence of UV exposure on 5-aminolevulinic acid-induced protoporphyrin IX production in skin
Photochem Photobiol, 74 (6), 825-8
DOI 10.1562/0031-8655(2001)074<0825:tioueo>2.0.co;2, PubMed 11783939
Publications 2000
Phototransformations of 5-aminolevulinic acid-induced protoporphyrin IX in vitro: a spectroscopic study
Photochem Photobiol, 72 (2), 186-92
DOI 10.1562/0031-8655(2000)072<0186:poaaip>2.0.co;2, PubMed 10946571
Publications 1999
Clearance of protoporphyrin IX from mouse skin after topical application of 5-aminolevulinic acid and its methyl ester
P SOC PHOTO-OPT INS, 3563, 161-166
DOI 10.1117/12.339134
Uptake of topically applied 5-aminolevulinic acid and production of protoporphyrin IX in normal mouse skin: dependence on skin temperature
Photochem Photobiol, 69 (4), 478-81
DOI 10.1111/j.1751-1097.1999.tb03315.x, PubMed 10212580
The temperature dependence of protoporphyrin IX production in cells and tissues
Photochem Photobiol, 70 (4), 669-73
DOI 10.1111/j.1751-1097.1999.tb08268.x, PubMed 10546563
Formation of protoporphyrin IX in mouse skin after topical application of 5-aminolevulinic acid and its methyl ester.
P SOC PHOTO-OPT INS, 3563, 77-81
DOI 10.1117/12.339121