Qian Peng
- Senior scientist; Dr. med.
- +47 22 78 23 53
Publications 2024
Application of Photodynamic Therapy with 5-Aminolevulinic Acid to Extracorporeal Photopheresis in the Treatment of Cutaneous T-Cell Lymphoma: A First-in-Human Phase I/II Study
Pharmaceutics, 16 (6)
DOI 10.3390/pharmaceutics16060815, PubMed 38931936
Highways and Detours in the Realm of Photodynamic Therapy
Int J Mol Sci, 25 (6)
DOI 10.3390/ijms25063119, PubMed 38542092
Publications 2023
Macrophages as a photosensitizer delivery system for photodynamic therapy: Potential for the local treatment of resected glioblastoma
Photodiagnosis Photodyn Ther, 45, 103897
DOI 10.1016/j.pdpdt.2023.103897, PubMed 37984525
Photodynamic Effects with 5-Aminolevulinic Acid on Cytokines and Exosomes in Human Peripheral Blood Mononuclear Cells from Patients with Crohn's Disease
Int J Mol Sci, 24 (5)
DOI 10.3390/ijms24054554, PubMed 36901982
Publications 2022
Amphiphilic Protoporphyrin IX Derivatives as New Photosensitizing Agents for the Improvement of Photodynamic Therapy
Biomedicines, 10 (2)
DOI 10.3390/biomedicines10020423, PubMed 35203632
Photodynamic Effects with 5-Aminolevulinic Acid on Cytokines and Exosomes in Human Peripheral Blood Mononuclear Cells
Biomedicines, 10 (2)
DOI 10.3390/biomedicines10020232, PubMed 35203441
Inhibition of glioma development by doxorubicin-photochemical internalization generated macrophage vaccine: A survival study in rats
Photodiagnosis Photodyn Ther, 38, 102879
DOI 10.1016/j.pdpdt.2022.102879, PubMed 35489691
Publications 2021
Application of Photodynamic Therapy with 5-Aminolevulinic Acid to Extracorporeal Photopheresis in the Treatment of Patients with Chronic Graft-versus-Host Disease: A First-in-Human Study
Pharmaceutics, 13 (10)
DOI 10.3390/pharmaceutics13101558, PubMed 34683851
Evaluation of In Vitro Phototoxicity of a Minibody-IR700 Conjugate Using Cell Monolayer and Multicellular Tumor Spheroid Models
Cancers (Basel), 13 (13)
DOI 10.3390/cancers13133356, PubMed 34283089
Correction: Sioud et al. Evaluation of In Vitro Phototoxicity of a Minibody-IR700 Conjugate Using Monolayer and Multicellular Tumor Spheroid Models. Cancers 2021, 13, 3356
Cancers (Basel), 13 (21)
DOI 10.3390/cancers13215513, PubMed 34771754
Evaluation of the PSMA-Binding Ligand 212Pb-NG001 in Multicellular Tumour Spheroid and Mouse Models of Prostate Cancer
Int J Mol Sci, 22 (9)
DOI 10.3390/ijms22094815, PubMed 34062920
Publications 2020
Selective Killing of Activated T Cells by 5-Aminolevulinic Acid Mediated Photodynamic Effect: Potential Improvement of Extracorporeal Photopheresis
Cancers (Basel), 12 (2)
DOI 10.3390/cancers12020377, PubMed 32041351
Corrigendum to "Induction of hypoxia-inducible factor-1alpha overexpression by cobalt chloride enhances cellular resistance to photodynamic therapy" [Canc. Lett 244 (2006) 182-189]
Cancer Lett, 498, 244
DOI 10.1016/j.canlet.2020.10.026, PubMed 33109413
Predictive biomarkers for 5-ALA-PDT can lead to personalized treatments and overcome tumor-specific resistances
Cancer Rep (Hoboken), 5 (12), e1278
DOI 10.1002/cnr2.1278, PubMed 32737955
Photosensitizer delivery by fibrin glue: potential for bypassing the blood-brain barrier
Lasers Med Sci, 36 (5), 1031-1038
DOI 10.1007/s10103-020-03140-w, PubMed 33123852
Photochemically-Induced Release of Lysosomal Sequestered Sunitinib: Obstacles for Therapeutic Efficacy
Cancers (Basel), 12 (2)
DOI 10.3390/cancers12020417, PubMed 32053965
Publications 2019
Simultaneous defeat of MCF7 and MDA-MB-231 resistances by a hypericin PDT-tamoxifen hybrid therapy
NPJ Breast Cancer, 5, 13
DOI 10.1038/s41523-019-0108-8, PubMed 30993194
Publications 2018
Photodynamic therapy mediated immune therapy of brain tumors
Neuroimmunol Neuroinflamm, 5
DOI 10.20517/2347-8659.2018.31, PubMed 30221185
Comparison between 8-methoxypsoralen and 5-aminolevulinic acid in killing T cells of photopheresis patients ex vivo
Lasers Surg Med, 50 (5), 469-475
DOI 10.1002/lsm.22806, PubMed 29460964
Limiting glioma development by photodynamic therapy-generated macrophage vaccine and allo-stimulation: an in vivo histological study in rats
J Biomed Opt, 23 (2), 1-7
DOI 10.1117/1.JBO.23.2.028001, PubMed 29417766
On-chip photodynamic therapy - monitoring cell metabolism using electrochemical microsensors
Lab Chip, 18 (22), 3353-3360
DOI 10.1039/c8lc00799c, PubMed 30310892
Enhancing the effects of chemotherapy by combined macrophage-mediated photothermal therapy (PTT) and photochemical internalization (PCI)
Lasers Med Sci, 33 (8), 1747-1755
DOI 10.1007/s10103-018-2534-5, PubMed 29802587
The Akt pathway in oncology therapy and beyond (Review)
Int J Oncol, 53 (6), 2319-2331
DOI 10.3892/ijo.2018.4597, PubMed 30334567
Development of a new high-affinity human antibody with antitumor activity against solid and blood malignancies
FASEB J, 32 (9), 5063-5077
DOI 10.1096/fj.201701544R, PubMed 29913558
Light-enhanced VEGF121/rGel: A tumor targeted modality with vascular and immune-mediated efficacy
J Control Release, 288, 161-172
DOI 10.1016/j.jconrel.2018.09.005, PubMed 30217739
Publications 2017
Photothermal Therapy Employing Gold Nanoparticle- Loaded Macrophages as Delivery Vehicles: Comparing the Efficiency of Nanoshells Versus Nanorods
J Environ Pathol Toxicol Oncol, 36 (3), 229-235
DOI 10.1615/JEnvironPatholToxicolOncol.2017021545, PubMed 29283336
Protein 4.1R is Involved in the Transport of 5-Aminolevulinic Acid by Interaction with GATs in MEF Cells
Photochem Photobiol, 94 (1), 173-178
DOI 10.1111/php.12842, PubMed 28881432
Photochemical internalization (PCI) of bleomycin is equally effective in two dissimilar leiomyosarcoma xenografts in athymic mice
Photodiagnosis Photodyn Ther, 20, 95-106
DOI 10.1016/j.pdpdt.2017.08.015, PubMed 28865875
Publications 2016
Increasing the efficacy of antitumor glioma vaccines by photodynamic therapy and local injection of allogeneic glioma cells
PROC SPIE, 9690, 96900D
DOI 10.1117/12.2213569
MtDNA depleted PC3 cells exhibit Warburg effect and cancer stem cell features
Oncotarget, 7 (26), 40297-40313
DOI 10.18632/oncotarget.9610, PubMed 27248169
Photothermal enhancement of chemotherapy mediated by gold-silica nanoshell-loaded macrophages: in vitro squamous cell carcinoma study
J Biomed Opt, 21 (1), 18004
DOI 10.1117/1.JBO.21.1.018004, PubMed 26811077
Electrochemical microsensor system for cancer research on photodynamic therapy in vitro
J PHYS CONF SER, 757, 012002
DOI 10.1088/1742-6596/757/1/012002
Cancer cell-binding peptide fused Fc domain activates immune effector cells and blocks tumor growth
Oncotarget, 7 (46), 75940-75953
DOI 10.18632/oncotarget.12445, PubMed 27713158
Publications 2015
Studies of the photosensitizer disulfonated meso-tetraphenyl chlorin in an orthotopic rat bladder tumor model
Photodiagnosis Photodyn Ther, 12 (1), 58-66
DOI 10.1016/j.pdpdt.2014.12.005, PubMed 25575731
Design of an EGFR-targeting toxin for photochemical delivery: in vitro and in vivo selectivity and efficacy
Oncogene, 34 (44), 5582-92
DOI 10.1038/onc.2015.15, PubMed 25684137
Light-controlled endosomal escape of the novel CD133-targeting immunotoxin AC133-saporin by photochemical internalization - A minimally invasive cancer stem cell-targeting strategy
J Control Release, 206, 37-48
DOI 10.1016/j.jconrel.2015.03.008, PubMed 25758331
Photochemical activation of MH3-B1/rGel: a HER2-targeted treatment approach for ovarian cancer
Oncotarget, 6 (14), 12436-51
DOI 10.18632/oncotarget.3814, PubMed 26002552
Macrophages as nanoparticle delivery vectors for photothermal therapy of brain tumors
Ther Deliv, 6 (3), 371-84
DOI 10.4155/tde.14.121, PubMed 25853311
Vulvovaginal photodynamic therapy vs. topical corticosteroids in genital erosive lichen planus: a randomized controlled trial
Br J Dermatol, 173 (5), 1156-62
DOI 10.1111/bjd.14033, PubMed 26189484
Combined concurrent nanoshell loaded macrophage-mediated photothermal and photodynamic therapies
PROC SPIE, 9303, 930322
DOI 10.1117/12.2082850
Nanoparticle-loaded macrophage-mediated photothermal therapy: potential for glioma treatment
Lasers Med Sci, 30 (4), 1357-65
DOI 10.1007/s10103-015-1742-5, PubMed 25794592
Photodynamic Therapy - In Vitro Investigation Using an Electrochemical Microsensor System
PROCEDIA ENGINEER, 120, 468-471
DOI 10.1016/j.proeng.2015.08.671
Recombinant Lactobacillus plantarum induces immune responses to cancer testis antigen NY-ESO-1 and maturation of dendritic cells
Hum Vaccin Immunother, 11 (11), 2664-73
DOI 10.1080/21645515.2015.1056952, PubMed 26185907
Akt inhibitors in cancer treatment: The long journey from drug discovery to clinical use (Review)
Int J Oncol, 48 (3), 869-85
DOI 10.3892/ijo.2015.3306, PubMed 26698230
Publications 2014
Modification of extracorporeal photopheresis technology with porphyrin precursors. Comparison between 8-methoxypsoralen and hexaminolevulinate in killing human T-cell lymphoma cell lines in vitro
Biochim Biophys Acta, 1840 (9), 2702-8
DOI 10.1016/j.bbagen.2014.05.020, PubMed 24915603
Biodistribution of protoporphyrin IX in female genital erosive lichen planus after topical application of hexaminolevulinate
Photodiagnosis Photodyn Ther, 11 (2), 113-7
DOI 10.1016/j.pdpdt.2014.01.005, PubMed 24530993
Combined concurrent photodynamic and gold nanoshell loaded macrophage-mediated photothermal therapies: an in vitro study on squamous cell head and neck carcinoma
Lasers Surg Med, 46 (4), 310-8
DOI 10.1002/lsm.22235, PubMed 24648368
Photochemical internalization augments tumor vascular cytotoxicity and specificity of VEGF(121)/rGel fusion toxin
J Control Release, 180, 1-9
DOI 10.1016/j.jconrel.2014.02.003, PubMed 24531010
Publications 2013
Factors implicated in the assessment of aminolevulinic acid-induced protoporphyrin IX fluorescence
Biochim Biophys Acta, 1830 (3), 2750-62
DOI 10.1016/j.bbagen.2012.10.023, PubMed 23142760
Increased nanoparticle-loaded exogenous macrophage migration into the brain following PDT-induced blood-brain barrier disruption
Lasers Surg Med, 45 (8), 524-32
DOI 10.1002/lsm.22172, PubMed 24037939
Lamin A/C cleavage by caspase-6 activation is crucial for apoptotic induction by photodynamic therapy with hexaminolevulinate in human B-cell lymphoma cells
Cancer Lett, 339 (1), 25-32
DOI 10.1016/j.canlet.2013.07.026, PubMed 23916608
The use of femto-second lasers to trigger powerful explosions of gold nanorods to destroy cancer cells
Biomaterials, 34 (26), 6157-62
DOI 10.1016/j.biomaterials.2013.04.048, PubMed 23706782
Publications 2011
Simultaneously targeting mitochondria and endoplasmic reticulum by photodynamic therapy induces apoptosis in human lymphoma cells
Photochem Photobiol Sci, 10 (11), 1773-82
DOI 10.1039/c1pp05169e, PubMed 21881674
Enhancement of intracellular delivery of anti-cancer drugs by the Tat peptide
Ultrastruct Pathol, 35 (3), 119-23
DOI 10.3109/01913123.2011.557522, PubMed 21405950
Effects of cell cycle on the uptake of water soluble quantum dots by cells
J. Appl. Phys., 110 (12), 124701
DOI 10.1063/1.3669364
Publications 2010
Hexaminolevulinate-mediated photodynamic purging of marrow grafts with murine breast carcinoma
Bone Marrow Transplant, 46 (8), 1118-27
DOI 10.1038/bmt.2010.277, PubMed 21057550
Hexaminolevulinate-mediated photodynamic purging of leukemia cells from BM
Bone Marrow Transplant, 45 (10), 1553-61
DOI 10.1038/bmt.2009.382, PubMed 20118993
Plasmonic gold nanorods can carry sulfonated aluminum phthalocyanine to improve photodynamic detection and therapy of cancers
J Phys Chem B, 114 (51), 17194-200
DOI 10.1021/jp109363n, PubMed 21138283
Publications 2009
Apoptotic induction by photodynamic therapy using Hexaminolevulinate with a literature review
PROC SPIE, 7380, 73800X
DOI 10.1117/12.823956
Targeted opening of the blood brain barrier by ALA mediated photodynamic therapy
PROC SPIE, 7380, 73801C
DOI 10.1117/12.822693
Targeted delivery of bleomycin to the brain using photo-chemical internalization of Clostridium perfringens epsilon prototoxin
J Neurooncol, 95 (3), 317-329
DOI 10.1007/s11060-009-9930-4, PubMed 19506813
Photodynamic therapy targets the mTOR signaling network in vitro and in vivo
Mol Pharm, 6 (1), 255-64
DOI 10.1021/mp800156e, PubMed 19125612
Intracellular re-localisation by photochemical internalisation enhances the cytotoxic effect of gelonin--quantitative studies in normal rat liver
J Control Release, 142 (3), 347-53
DOI 10.1016/j.jconrel.2009.11.017, PubMed 19932724
Subcellular Localization of Thiol-Capped CdTe Quantum Dots in Living Cells
Nanoscale Res Lett, 4 (7), 606-12
DOI 10.1007/s11671-009-9307-9, PubMed 20596411
Publications 2008
Thermosetting gel for the delivery of 5-aminolevulinic acid esters to the cervix
J Pharm Sci, 97 (7), 2680-90
DOI 10.1002/jps.21181, PubMed 17828758
Disruption of the blood-brain barrier following ALA-mediated photodynamic therapy
Lasers Surg Med, 40 (8), 535-42
DOI 10.1002/lsm.20670, PubMed 18798293
Fluorescence detection of protoporphyrin IX in living cells: a comparative study on single- and two-photon excitation
J Biomed Opt, 13 (2), 024014
DOI 10.1117/1.2907316, PubMed 18465977
Photochemical internalization of bleomycin is superior to photodynamic therapy due to the therapeutic effect in the tumor periphery
Photochem Photobiol, 85 (3), 740-9
DOI 10.1111/j.1751-1097.2008.00477.x, PubMed 19076314
Lasers in medicine
Rep. Prog. Phys., 71 (5), 056701
DOI 10.1088/0034-4885/71/5/056701
Thiol-capped CdTe quantum dots with two-photon excitation for imaging high autofluorescence background living cells
J Fluoresc, 19 (4), 615-21
DOI 10.1007/s10895-008-0452-9, PubMed 19104920
Publications 2004
Effects of photodynamic therapy on tumor stroma
Ultrastruct Pathol, 28 (5-6), 333-40
DOI 10.1080/01913120490515586, PubMed 15764581
Publications 2001
Selective distribution of porphyrins in skin thick basal cell carcinoma after topical application of methyl 5-aminolevulinate
J Photochem Photobiol B, 62 (3), 140-5
DOI 10.1016/s1011-1344(01)00173-7, PubMed 11566277
Antitumor effect of 5-aminolevulinic acid-mediated photodynamic therapy can be enhanced by the use of a low dose of photofrin in human tumor xenografts
Cancer Res, 61 (15), 5824-32
PubMed 11479222
Publications 1997
5-Aminolevulinic acid-based photodynamic therapy: principles and experimental research
Photochem Photobiol, 65 (2), 235-51
DOI 10.1111/j.1751-1097.1997.tb08549.x, PubMed 9066303
5-Aminolevulinic acid-based photodynamic therapy. Clinical research and future challenges
Cancer, 79 (12), 2282-308
DOI 10.1002/(sici)1097-0142(19970615)79:12<2282::aid-cncr2>3.0.co;2-o, PubMed 9191516
Publications 1996
Correlation of subcellular and intratumoral photosensitizer localization with ultrastructural features after photodynamic therapy
Ultrastruct Pathol, 20 (2), 109-129
DOI 10.3109/01913129609016306, PubMed 8882357
Build-up of esterified aminolevulinic-acid-derivative-induced porphyrin fluorescence in normal mouse skin
J Photochem Photobiol B, 34 (1), 95-6
DOI 10.1016/1011-1344(95)07268-3, PubMed 8765664
Publications 1995
Correlation of distribution of sulphonated aluminium phthalocyanines with their photodynamic effect in tumour and skin of mice bearing CaD2 mammary carcinoma
Br J Cancer, 72 (3), 565-74
DOI 10.1038/bjc.1995.375, PubMed 7669563
Uptake, localization, and photodynamic effect of meso-tetra(hydroxyphenyl)porphine and its corresponding chlorin in normal and tumor tissues of mice bearing mammary carcinoma
Cancer Res, 55 (12), 2620-6
PubMed 7780978
Distribution of 5-aminolevulinic acid-induced porphyrins in noduloulcerative basal cell carcinoma
Photochem Photobiol, 62 (5), 906-13
DOI 10.1111/j.1751-1097.1995.tb09154.x, PubMed 8570730
Publications 1993
Biodistribution of a methylene blue derivative in tumor and normal tissues of rats
J Photochem Photobiol B, 20 (1), 63-71
DOI 10.1016/1011-1344(93)80132-s, PubMed 8229471
Publications 1992
Distribution and photosensitizing efficiency of porphyrins induced by application of exogenous 5-aminolevulinic acid in mice bearing mammary carcinoma
Int J Cancer, 52 (3), 433-43
DOI 10.1002/ijc.2910520318, PubMed 1399120
Publications 1991
Subcellular localization, redistribution and photobleaching of sulfonated aluminum phthalocyanines in a human melanoma cell line
Int J Cancer, 49 (2), 290-5
DOI 10.1002/ijc.2910490225, PubMed 1879972
The effect of glucose administration on the uptake of photofrin II in a human tumor xenograft
Cancer Lett, 58 (1-2), 29-35
DOI 10.1016/0304-3835(91)90020-i, PubMed 1828712
Localization of potent photosensitizers in human tumor LOX by means of laser scanning microscopy
Cancer Lett, 58 (1-2), 17-27
DOI 10.1016/0304-3835(91)90019-e, PubMed 1828711
Location of P-II and AlPCS4 in human tumor LOX in vitro and in vivo by means of computer-enhanced video fluorescence microscopy
Cancer Lett, 58 (1-2), 37-47
DOI 10.1016/0304-3835(91)90021-9, PubMed 1828713
Sensitizer for photodynamic therapy of cancer: a comparison of the tissue distribution of Photofrin II and aluminum phthalocyanine tetrasulfonate in nude mice bearing a human malignant tumor
Int J Cancer, 48 (2), 258-64
DOI 10.1002/ijc.2910480218, PubMed 1826901
Publications 1990
Localization of potent photosensitizers in human tumor LOX by means of laser scanning microscopy
Cancer Lett, 53 (2-3), 129-39
DOI 10.1016/0304-3835(90)90205-c, PubMed 2208072
Aluminum phthalocyanines with asymmetrical lower sulfonation and with symmetrical higher sulfonation: a comparison of localizing and photosensitizing mechanism in human tumor LOX xenografts
Int J Cancer, 46 (4), 719-26
DOI 10.1002/ijc.2910460428, PubMed 2210887
Localization of fluorescent Photofrin II and aluminum phthalocyanine tetrasulfonate in transplanted human malignant tumor LOX and normal tissues of nude mice using highly light-sensitive video intensification microscopy
Int J Cancer, 45 (5), 972-9
DOI 10.1002/ijc.2910450533, PubMed 2139867