Morten Pedersen Oksvold

  • Scientist; PhD
  • (+47) 22781424

Mini CV:

Education:

2004 PhD (Dr. Philos), University of Oslo. Thesis: ”Trafficking of and signaling from the epidermal growth factor receptor after ligand and stress exposure”.

1996 Ms, University of Oslo. Title: ” A morphological and kinetic study of large vesicular structures in MDCK cells transfected with invariant chain”

Research interests:

• Trafficking of and signaling from BMP/TGF-beta receptors in B-cell lymphoma
• Intracellular localization of signaling molecules down stream of BMP/TGF-beta
receptors
• Confocal immunofluorescence microscopy combined with flow cytometry

Previous employment:

2004-2007 Post doc, Institute of Pathology, Rikshospitalet University Hospital, University of Oslo.

 

Original articles

Darvekar S, Juzenas P, Oksvold M, Kleinauskas A, Holien T, Christensen E, Stokke T, Sioud M, Peng Q (2020)
Selective Killing of Activated T Cells by 5-Aminolevulinic Acid Mediated Photodynamic Effect: Potential Improvement of Extracorporeal Photopheresis
Cancers (Basel), 12 (2)
DOI 10.3390/cancers12020377, PubMed 32041351

Våtsveen TK, Myhre MR, Steen CB, Wälchli S, Lingjærde OC, Bai B, Dillard P, Theodossiou TA, Holien T, Sundan A, Inderberg EM, Smeland EB, Myklebust JH, Oksvold MP (2018)
Artesunate shows potent anti-tumor activity in B-cell lymphoma
J Hematol Oncol, 11 (1), 23
DOI 10.1186/s13045-018-0561-0, PubMed 29458389

Inderberg EM, Mensali N, Oksvold MP, Fallang LE, Fåne A, Skorstad G, Stenvik GE, Progida C, Bakke O, Kvalheim G, Myklebust JH, Wälchli S (2017)
Human c-SRC kinase (CSK) overexpression makes T cells dummy
Cancer Immunol Immunother, 67 (4), 525-536
DOI 10.1007/s00262-017-2105-9, PubMed 29248956

Bollum LK, Huse K, Oksvold MP, Bai B, Hilden VI, Forfang L, Yoon SO, Wälchli S, Smeland EB, Myklebust JH (2017)
BMP-7 induces apoptosis in human germinal center B cells and is influenced by TGF-β receptor type I ALK5
PLoS One, 12 (5), e0177188
DOI 10.1371/journal.pone.0177188, PubMed 28489883

Oksvold MP (2015)
Incidence of Data Duplications in a Randomly Selected Pool of Life Science Publications
Sci Eng Ethics, 22 (2), 487-96
DOI 10.1007/s11948-015-9668-7, PubMed 26065681

Oksvold MP, Duyvestyn JM, Dagger SA, Taylor SJ, Forfang L, Myklebust JH, Smeland EB, Langdon WY (2015)
The targeting of human and mouse B lymphocytes by dasatinib
Exp Hematol, 43 (5), 352-363.e4
DOI 10.1016/j.exphem.2015.01.008, PubMed 25641047

Oksvold MP, Neurauter A, Pedersen KW (2015)
Magnetic bead-based isolation of exosomes
Methods Mol Biol, 1218, 465-81
DOI 10.1007/978-1-4939-1538-5_27, PubMed 25319668

Oksvold MP, Kullmann A, Forfang L, Kierulf B, Li M, Brech A, Vlassov AV, Smeland EB, Neurauter A, Pedersen KW (2014)
Expression of B-cell surface antigens in subpopulations of exosomes released from B-cell lymphoma cells
Clin Ther, 36 (6), 847-862.e1
DOI 10.1016/j.clinthera.2014.05.010, PubMed 24952935

Oksvold MP, Pedersen NM, Forfang L, Smeland EB (2012)
Effect of cycloheximide on epidermal growth factor receptor trafficking and signaling
FEBS Lett, 586 (20), 3575-81
DOI 10.1016/j.febslet.2012.08.022, PubMed 22971756

Bakkebø M, Huse K, Hilden VI, Forfang L, Myklebust JH, Smeland EB, Oksvold MP (2012)
SARA is dispensable for functional TGF-β signaling
FEBS Lett, 586 (19), 3367-72
DOI 10.1016/j.febslet.2012.07.027, PubMed 22819827

Huse K, Bakkebø M, Wälchli S, Oksvold MP, Hilden VI, Forfang L, Bredahl ML, Liestøl K, Alizadeh AA, Smeland EB, Myklebust JH (2012)
Role of Smad proteins in resistance to BMP-induced growth inhibition in B-cell lymphoma
PLoS One, 7 (10), e46117
DOI 10.1371/journal.pone.0046117, PubMed 23049692

Huse K, Bakkebø M, Oksvold MP, Forfang L, Hilden VI, Stokke T, Smeland EB, Myklebust JH (2011)
Bone morphogenetic proteins inhibit CD40L/IL-21-induced Ig production in human B cells: differential effects of BMP-6 and BMP-7
Eur J Immunol, 41 (11), 3135-45
DOI 10.1002/eji.201141558, PubMed 21898381

Bakkebø M, Huse K, Hilden VI, Smeland EB, Oksvold MP (2010)
TGF-β-induced growth inhibition in B-cell lymphoma correlates with Smad1/5 signalling and constitutively active p38 MAPK
BMC Immunol, 11, 57
DOI 10.1186/1471-2172-11-57, PubMed 21092277

Rosseland CM, Wierød L, Flinder LI, Oksvold MP, Skarpen E, Huitfeldt HS (2008)
Distinct functions of H-Ras and K-Ras in proliferation and survival of primary hepatocytes due to selective activation of ERK and PI3K
J Cell Physiol, 215 (3), 818-26
DOI 10.1002/jcp.21367, PubMed 18163378

Oksvold MP, Funderud A, Kvissel AK, Skarpen E, Henanger H, Huitfeldt HS, Skålhegg BS, Ørstavik S (2008)
Epidermal growth factor receptor levels are reduced in mice with targeted disruption of the protein kinase A catalytic subunit
BMC Cell Biol, 9, 16
DOI 10.1186/1471-2121-9-16, PubMed 18380891

Wierød L, Rosseland CM, Lindeman B, Oksvold MP, Grøsvik H, Skarpen E, Huitfeldt HS (2007)
Activation of the p53-p21(Cip1) pathway is required for CDK2 activation and S-phase entry in primary rat hepatocytes
Oncogene, 27 (19), 2763-71
DOI 10.1038/sj.onc.1210937, PubMed 18026139

Skarpen E, Flinder LI, Rosseland CM, Orstavik S, Wierød L, Oksvold MP, Skålhegg BS, Huitfeldt HS (2007)
MEK1 and MEK2 regulate distinct functions by sorting ERK2 to different intracellular compartments
FASEB J, 22 (2), 466-76
DOI 10.1096/fj.07-8650com, PubMed 17928366

Oksvold MP, Dagger SA, Thien CB, Langdon WY (2007)
The Cbl-b RING finger domain has a limited role in regulating inflammatory cytokine production by IgE-activated mast cells
Mol Immunol, 45 (4), 925-36
DOI 10.1016/j.molimm.2007.08.002, PubMed 17868870

Wierød L, Rosseland CM, Lindeman B, Oksvold MP, Grøsvik H, Skarpen E, Huitfeldt HS (2007)
CDK2 regulation through PI3K and CDK4 is necessary for cell cycle progression of primary rat hepatocytes
Cell Prolif, 40 (4), 475-87
DOI 10.1111/j.1365-2184.2007.00451.x, PubMed 17635516

Rosseland CM, Wierød L, Oksvold MP, Werner H, Ostvold AC, Thoresen GH, Paulsen RE, Huitfeldt HS, Skarpen E (2005)
Cytoplasmic retention of peroxide-activated ERK provides survival in primary cultures of rat hepatocytes
Hepatology, 42 (1), 200-7
DOI 10.1002/hep.20762, PubMed 15962331

Skarpen E, Oksvold MP, Grøsvik H, Widnes C, Huitfeldt HS (2005)
Altered regulation of EGF receptor signaling following a partial hepatectomy
J Cell Physiol, 202 (3), 707-16
DOI 10.1002/jcp.20171, PubMed 15389569

Paasche JD, Attramadal T, Kristiansen K, Oksvold MP, Johansen HK, Huitfeldt HS, Dahl SG, Attramadal H (2005)
Subtype-specific sorting of the ETA endothelin receptor by a novel endocytic recycling signal for G protein-coupled receptors
Mol Pharmacol, 67 (5), 1581-90
DOI 10.1124/mol.104.007013, PubMed 15713850

Oksvold MP, Huitfeldt HS, Langdon WY (2004)
Identification of 14-3-3zeta as an EGF receptor interacting protein
FEBS Lett, 569 (1-3), 207-10
DOI 10.1016/j.febslet.2004.05.068, PubMed 15225635

Oksvold MP, Thien CB, Widerberg J, Chantry A, Huitfeldt HS, Langdon WY (2004)
UV-radiation-induced internalization of the epidermal growth factor receptor requires distinct serine and tyrosine residues in the cytoplasmic carboxy-terminal domain
Radiat Res, 161 (6), 685-91
DOI 10.1667/rr3185, PubMed 15161351

Oksvold MP, Thien CB, Widerberg J, Chantry A, Huitfeldt HS, Langdon WY (2003)
Serine mutations that abrogate ligand-induced ubiquitination and internalization of the EGF receptor do not affect c-Cbl association with the receptor
Oncogene, 22 (52), 8509-18
DOI 10.1038/sj.onc.1207117, PubMed 14627991

Oksvold MP, Huitfeldt HS, Østvold AC, Skarpen E (2002)
UV induces tyrosine kinase-independent internalisation and endosome arrest of the EGF receptor
J Cell Sci, 115 (Pt 4), 793-803
PubMed 11865035

Oksvold MP, Skarpen E, Wierød L, Paulsen RE, Huitfeldt HS (2001)
Re-localization of activated EGF receptor and its signal transducers to multivesicular compartments downstream of early endosomes in response to EGF
Eur J Cell Biol, 80 (4), 285-94
DOI 10.1078/0171-9335-00160, PubMed 11370743

Skarpen E, Lindeman B, Thoresen GH, Guren TK, Oksvold MP, Christoffersen T, Huitfeldt HS (2000)
Impaired nuclear accumulation and shortened phosphorylation of ERK after growth factor stimulation in cultured hepatocytes from rats exposed to 2-acetylaminofluorene
Mol Carcinog, 28 (2), 84-96
DOI 10.1002/1098-2744(200006)28:2<84::aid-mc4>3.0.co;2-x, PubMed 10900465

Lindeman B, Skarpen E, Oksvold MP, Huitfeldt HS (2000)
The carcinogen 2-acetylaminofluorene inhibits activation and nuclear accumulation of cyclin-dependent kinase 2 in growth-induced rat liver
Mol Carcinog, 27 (3), 190-9
DOI 10.1002/(SICI)1098-2744(200003)27:3<190::AID-MC6>3.0.CO;2-N, PubMed 10708481

Oksvold MP, Skarpen E, Lindeman B, Roos N, Huitfeldt HS (2000)
Immunocytochemical localization of Shc and activated EGF receptor in early endosomes after EGF stimulation of HeLa cells
J Histochem Cytochem, 48 (1), 21-33
DOI 10.1177/002215540004800103, PubMed 10653583

Saebøe-Larssen S, Lyamouri M, Merriam J, Oksvold MP, Lambertsson A (1998)
Ribosomal protein insufficiency and the minute syndrome in Drosophila: a dose-response relationship
Genetics, 148 (3), 1215-24
PubMed 9539436

Review articles

Oksvold MP, Skarpen E, Widerberg J, Huitfeldt HS (2002)
Fluorescent histochemical techniques for analysis of intracellular signaling
J Histochem Cytochem, 50 (3), 289-303
DOI 10.1177/002215540205000301, PubMed 11850432

Huitfeldt HS, Lindeman B, Skarpen E, Oksvold MP, Wierød L (1999)
[Why is dioxin harmful?]
Tidsskr Nor Laegeforen, 119 (29), 4323-8
PubMed 10667131

Other articles

Oksvold M, Huitfeldt H, Stang E, Madshus I (2002)
Localizing the EGF receptor
Nat Cell Biol, 4 (2), E22; author reply E22-3
DOI 10.1038/ncb0202-e22a, PubMed 11835048

Books

Oksvold MP (2010)
Flere gullkorn fra pasientjournalen: morsomme sitater fra pasientjournalen, doktorskolen og pasienter
Gyldendal, [Oslo], 136 s.
BIBSYS 100829643, ISBN 978-82-05-39776-7

Oksvold MP (2008)
Gullkorn fra pasientjournalen
Gyldendal litteratur, [Oslo], 136 s.
BIBSYS 082330158, ISBN 978-82-05-38463-7

Theses

Oksvold MP (2004)
Trafficking of and signaling from the epidermal growth factor receptor after ligand and stress exposure
In Series of dissertations submitted to the Faculty of Medicine, University of Oslo, Unipub, Oslo, no. 155, 1 b. (flere pag.)
BIBSYS 04023956x, ISBN 82-8072-097-9

Oksvold MP (1996)
Et morfologisk og kinetisk studie av store vesikulære strukturer i MDCK II-celler stabilt transfektert med Invariant chain
M.P. Oksvold, Oslo, 73 s.
BIBSYS 961645113

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