Jens Pahnke

  • Group leader

Publications 2024

El Menuawy A, Brüning T, Eiriz I, Hähnel U, Marthe F, Möhle L, Górska AM, Santos-García I, Wangensteen H, Wu J, Pahnke J (2024)
Apolar Extracts of St. John's Wort Alleviate the Effects of β-Amyloid Toxicity in Early Alzheimer's Disease
Int J Mol Sci, 25 (2)
DOI 10.3390/ijms25021301, PubMed 38279301

Hernández-Lozano I, Leterrier S, Mairinger S, Stanek J, Zacher AS, Breyer L, Hacker M, Zeitlinger M, Pahnke J, Tournier N, Wanek T, Langer O (2024)
Performance and Sensitivity of [99mTc]Tc-sestamibi Compared with Positron Emission Tomography Radiotracers to Measure P-glycoprotein Function in the Kidneys and Liver
Mol Pharm, 21 (2), 932-943
DOI 10.1021/acs.molpharmaceut.3c01036, PubMed 38225758

Lauritzen T, Munkhaugen J, Bergan S, Peersen K, Svarstad AC, Andersen AM, Pahnke J, Husebye E, Vethe NT (2024)
The atorvastatin metabolite pattern in muscle tissue and blood plasma is associated with statin muscle side effects in patients with coronary heart disease; An exploratory case-control study
Atheroscler Plus, 55, 31-38
DOI 10.1016/j.athplu.2024.01.001, PubMed 38293288

Mairinger S, Jackwerth M, Soukup O, Blaickner M, Decristoforo C, Nics L, Pahnke J, Hacker M, Zeitlinger M, Langer O (2024)
Advancing 6-bromo-7-[11C]methylpurine to clinical use: improved regioselective radiosynthesis, non-clinical toxicity data and human dosimetry estimates
EJNMMI Radiopharm Chem, 9 (1), 34
DOI 10.1186/s41181-024-00265-z, PubMed 38683266

Misiachna A, Svobodova B, Netolicky J, Chvojkova M, Kleteckova L, Prchal L, Novak M, Hrabinova M, Kucera T, Muckova L, Moravcova Z, Karasova JZ, Pejchal J, Blazek F, Malinak D, Hakenova K, Krausova BH, Kolcheva M, Ladislav M, Korabecny J, Pahnke J, Vales K, Horak M, Soukup O (2024)
Phenoxytacrine derivatives: Low-toxicity neuroprotectants exerting affinity to ifenprodil-binding site and cholinesterase inhibition
Eur J Med Chem, 266, 116130
DOI 10.1016/j.ejmech.2024.116130, PubMed 38218127

Villa M, Wu J, Hansen S, Pahnke J (2024)
Emerging Role of ABC Transporters in Glia Cells in Health and Diseases of the Central Nervous System
Cells, 13 (9)
DOI 10.3390/cells13090740, PubMed 38727275

Publications 2023

Bascuñana P, Brackhan M, Möhle L, Wu J, Brüning T, Eiriz I, Jansone B, Pahnke J (2023)
Time- and Sex-Dependent Effects of Fingolimod Treatment in a Mouse Model of Alzheimer's Disease
Biomolecules, 13 (2)
DOI 10.3390/biom13020331, PubMed 36830699

Dib S, Loiola RA, Sevin E, Saint-Pol J, Shimizu F, Kanda T, Pahnke J, Gosselet F (2023)
TNFα Activates the Liver X Receptor Signaling Pathway and Promotes Cholesterol Efflux from Human Brain Pericytes Independently of ABCA1
Int J Mol Sci, 24 (6)
DOI 10.3390/ijms24065992, PubMed 36983062

Farfara D, Sooliman M, Avrahami L, Royal TG, Amram S, Rozenstein-Tsalkovich L, Trudler D, Blanga-Kanfi S, Eldar-Finkelman H, Pahnke J, Rosenmann H, Frenkel D (2023)
Physiological expression of mutated TAU impaired astrocyte activity and exacerbates β-amyloid pathology in 5xFAD mice
J Neuroinflammation, 20 (1), 174
DOI 10.1186/s12974-023-02823-9, PubMed 37496076

Kolnes AJ, Øystese KAB, Sjöstedt E, Olarescu NC, Heck A, Pahnke J, Dahlberg D, Berg-Johnsen J, Ringstad G, Casar-Borota O, Bollerslev J, Jørgensen AP (2023)
TGFBR3L is associated with gonadotropin production in non-functioning gonadotroph pituitary neuroendocrine tumours
Pituitary, 26 (2), 227-236
DOI 10.1007/s11102-023-01310-x, PubMed 36952069

Mairinger S, Leterrier S, Filip T, Löbsch M, Pahnke J, Hernández-Lozano I, Stanek J, Tournier N, Zeitlinger M, Hacker M, Langer O, Wanek T (2023)
[11C]metoclopramide is a sensitive radiotracer to measure moderate decreases in P-glycoprotein function at the blood-brain barrier
J Cereb Blood Flow Metab, 44 (1), 142-152
DOI 10.1177/0271678X231202336, PubMed 37728771

Möhle L, Stefan K, Bascuñana P, Brackhan M, Brüning T, Eiriz I, El Menuawy A, van Genderen S, Santos-García I, Górska AM, Villa M, Wu J, Stefan SM, Pahnke J (2023)
ABC Transporter C1 Prevents Dimethyl Fumarate from Targeting Alzheimer's Disease
Biology (Basel), 12 (7)
DOI 10.3390/biology12070932, PubMed 37508364

Stefan SM, Pahnke J, Namasivayam V (2023)
HD_BPMDS: a curated binary pattern multitarget dataset of Huntington's disease-targeting agents
J Cheminform, 15 (1), 109
DOI 10.1186/s13321-023-00775-z, PubMed 37978560

Publications 2022

Borovkova M, Sieryi O, Lopushenko I, Kartashkina N, Pahnke J, Bykov A, Meglinski I (2022)
Screening of Alzheimer's Disease With Multiwavelength Stokes Polarimetry in a Mouse Model
IEEE Trans Med Imaging, 41 (4), 977-982
DOI 10.1109/TMI.2021.3129700, PubMed 34807820

Brackhan M, Calza G, Lundgren K, Bascuñana P, Brüning T, Soliymani R, Kumar R, Abelein A, Baumann M, Lalowski M, Pahnke J (2022)
Isotope-labeled amyloid-β does not transmit to the brain in a prion-like manner after peripheral administration
EMBO Rep, 23 (7), e54405
DOI 10.15252/embr.202154405, PubMed 35620875

Namasivayam V, Stefan K, Gorecki L, Korabecny J, Soukup O, Jansson PJ, Pahnke J, Stefan SM (2022)
Physicochemistry shapes bioactivity landscape of pan-ABC transporter modulators: Anchor point for innovative Alzheimer's disease therapeutics
Int J Biol Macromol, 217, 775-791
DOI 10.1016/j.ijbiomac.2022.07.062, PubMed 35839956

Namasivayam V, Stefan K, Silbermann K, Pahnke J, Wiese M, Stefan SM (2022)
Structural feature-driven pattern analysis for multitarget modulator landscapes
Bioinformatics, 38 (5), 1385-1392
DOI 10.1093/bioinformatics/btab832, PubMed 34888617

Puri S, Stefan K, Khan SL, Pahnke J, Stefan SM, Juvale K (2022)
Indole Derivatives as New Structural Class of Potent and Antiproliferative Inhibitors of Monocarboxylate Transporter 1 (MCT1; SLC16A1)
J Med Chem, 66 (1), 657-676
DOI 10.1021/acs.jmedchem.2c01612, PubMed 36584238

Stefan SM, Jansson PJ, Pahnke J, Namasivayam V (2022)
A curated binary pattern multitarget dataset of focused ATP-binding cassette transporter inhibitors
Sci Data, 9 (1), 446
DOI 10.1038/s41597-022-01506-z, PubMed 35882865

Wu J, Möhle L, Brüning T, Eiriz I, Rafehi M, Stefan K, Stefan SM, Pahnke J (2022)
A Novel Huntington's Disease Assessment Platform to Support Future Drug Discovery and Development
Int J Mol Sci, 23 (23)
DOI 10.3390/ijms232314763, PubMed 36499090

Wölfl-Duchek M, Mairinger S, Hernández-Lozano I, Filip T, Zoufal V, Löbsch M, Stanek J, Kuntner C, Wanek T, Bauer M, Pahnke J, Langer O (2022)
Use of PET Imaging to Assess the Efficacy of Thiethylperazine to Stimulate Cerebral MRP1 Transport Activity in Wild-Type and APP/PS1-21 Mice
Int J Mol Sci, 23 (12)
DOI 10.3390/ijms23126514, PubMed 35742960

Publications 2021

Bascuñana P, Brackhan M, Pahnke J (2021)
Machine Learning-Supported Analyses Improve Quantitative Histological Assessments of Amyloid-β Deposits and Activated Microglia
J Alzheimers Dis, 79 (2), 597-605
DOI 10.3233/JAD-201120, PubMed 33337377

Casar-Borota O, Boldt HB, Engström BE, Andersen MS, Baussart B, Bengtsson D, Berinder K, Ekman B, Feldt-Rasmussen U, Höybye C, Jørgensen JOL, Kolnes AJ, Korbonits M, Rasmussen ÅK, Lindsay JR, Loughrey PB, Maiter D, Manojlovic-Gacic E, Pahnke J, Poliani PL, Popovic V, Ragnarsson O, Schalin-Jäntti C, Scheie D, Tóth M et al. (2021)
Corticotroph Aggressive Pituitary Tumors and Carcinomas Frequently Harbor ATRX Mutations
J Clin Endocrinol Metab, 106 (4), 1183-1194
DOI 10.1210/clinem/dgaa749, PubMed 33106857

Dib S, Pahnke J, Gosselet F (2021)
Role of ABCA7 in Human Health and in Alzheimer's Disease
Int J Mol Sci, 22 (9)
DOI 10.3390/ijms22094603, PubMed 33925691

Djirackor L, Halldorsson S, Niehusmann P, Leske H, Capper D, Kuschel LP, Pahnke J, Due-Tønnessen BJ, Langmoen IA, Sandberg CJ, Euskirchen P, Vik-Mo EO (2021)
Intraoperative DNA methylation classification of brain tumors impacts neurosurgical strategy
Neurooncol Adv, 3 (1), vdab149
DOI 10.1093/noajnl/vdab149, PubMed 34729487

Hegrand M, Pahnke J (2021)
[Approval first, research afterwards?]
Tidsskr Nor Laegeforen, 141
DOI 10.4045/tidsskr.21.0590, PubMed 34597005

Hegrand M, Pahnke J (2021)
Approval first, research afterwards?
Tidsskr. Nor. Laegeforen., 141 (13), 1251-1252

Hermansen JU, Wojcik DM, Robinson N, Pahnke J, Haugland HK, Jamtøy AH, Flaegstad T, Halvorsen H, Lund B, Baumbusch LO, Munthe-Kaas MC (2021)
The Norwegian childhood cancer biobank
Cancer Rep (Hoboken), 5 (8), e1555
DOI 10.1002/cnr2.1555, PubMed 34541832

Möhle L, Bascuñana P, Brackhan M, Pahnke J (2021)
Development of deep learning models for microglia analyses in brain tissue using DeePathology™ STUDIO
J Neurosci Methods, 364, 109371
DOI 10.1016/j.jneumeth.2021.109371, PubMed 34592173

Möhle L, Brackhan M, Bascuñana P, Pahnke J (2021)
Dimethyl fumarate does not mitigate cognitive decline and β-amyloidosis in female APPPS1 mice
Brain Res, 1768, 147579
DOI 10.1016/j.brainres.2021.147579, PubMed 34233173

Namasivayam V, Silbermann K, Pahnke J, Wiese M, Stefan SM (2021)
Scaffold fragmentation and substructure hopping reveal potential, robustness, and limits of computer-aided pattern analysis (C@PA)
Comput Struct Biotechnol J, 19, 3269-3283
DOI 10.1016/j.csbj.2021.05.018, PubMed 34141145

Namasivayam V, Silbermann K, Wiese M, Pahnke J, Stefan SM (2021)
C@PA: Computer-Aided Pattern Analysis to Predict Multitarget ABC Transporter Inhibitors
J Med Chem, 64 (6), 3350-3366
DOI 10.1021/acs.jmedchem.0c02199, PubMed 33724808

Namasivayam V, Stefan K, Pahnke J, Stefan SM (2021)
Binding mode analysis of ABCA7 for the prediction of novel Alzheimer's disease therapeutics
Comput Struct Biotechnol J, 19, 6490-6504
DOI 10.1016/j.csbj.2021.11.035, PubMed 34976306

Pahnke J, Bascuñana P, Brackhan M, Stefan K, Namasivayam V, Koldamova R, Wu J, Möhle L, Stefan SM (2021)
Strategies to gain novel Alzheimer's disease diagnostics and therapeutics using modulators of ABCA transporters
Free Neuropathol, 2
DOI 10.17879/freeneuropathology-2021-3528, PubMed 34977908

Svendsen HA, Meling TR, Nygaard V, Waagene S, Russnes H, Juell S, Rogne SG, Pahnke J, Helseth E, Fodstad Ø, Maelandsmo GM (2021)
Novel human melanoma brain metastasis models in athymic nude fox1nu mice: Site-specific metastasis patterns reflecting their clinical origin
Cancer Med, 10 (23), 8604-8613
DOI 10.1002/cam4.4334, PubMed 34612023

Upīte J, Brüning T, Möhle L, Brackhan M, Bascuñana P, Jansone B, Pahnke J (2021)
A New Tool for the Analysis of the Effect of Intracerebrally Injected Anti-Amyloid-β Compounds
J Alzheimers Dis, 84 (4), 1677-1690
DOI 10.3233/JAD-215180, PubMed 34719500

Publications 2020

Abelein A, Chen G, Kitoka K, Aleksis R, Oleskovs F, Sarr M, Landreh M, Pahnke J, Nordling K, Kronqvist N, Jaudzems K, Rising A, Johansson J, Biverstål H (2020)
High-yield Production of Amyloid-β Peptide Enabled by a Customized Spider Silk Domain
Sci Rep, 10 (1), 235
DOI 10.1038/s41598-019-57143-x, PubMed 31937841

Bascuñana P, Möhle L, Brackhan M, Pahnke J (2020)
Fingolimod as a Treatment in Neurologic Disorders Beyond Multiple Sclerosis
Drugs R D, 20 (3), 197-207
DOI 10.1007/s40268-020-00316-1, PubMed 32696271

Borovkova M, Bykov A, Popov A, Pierangelo A, Novikova T, Pahnke J, Meglinski I (2020)
Evaluating β-amyloidosis progression in Alzheimer's disease with Mueller polarimetry
Biomed Opt Express, 11 (8), 4509-4519
DOI 10.1364/BOE.396294, PubMed 32923060

Borovkova M, Bykov A, Popov A, Pierangelo A, Novikova T, Pahnke J, Meglinski I (2020)
The use of Stokes-Mueller polarimetry for assessment of amyloid-beta progression in a mouse model of Alzheimer's disease
PROC SPIE, 11234, 112340M
DOI 10.1117/12.2550795

Kolnes AJ, Øystese KA, Dahlberg D, Berg-Johnsen J, Niehusmann P, Pahnke J, Bollerslev J, Jørgensen AP (2020)
Cut-off values for sufficient cortisol response to low dose Short Synacthen Test after surgery for non-functioning pituitary adenoma
Acta Neurochir (Wien), 162 (4), 845-852
DOI 10.1007/s00701-019-04068-z, PubMed 31907611

Möhle L, Schwarzová B, Krohn M, Stefan SM, Pahnke J (2020)
Using a qPCR device to screen for modulators of ABC transporter activity: A step-by-step protocol
J Pharmacol Toxicol Methods, 104, 106882
DOI 10.1016/j.vascn.2020.106882, PubMed 32474136

Rai SP, Bascuñana P, Brackhan M, Krohn M, Möhle L, Paarmann K, Pahnke J (2020)
Detection and Prediction of Mild Cognitive Impairment in Alzheimer's Disease Mice
J Alzheimers Dis, 77 (3), 1209-1221
DOI 10.3233/JAD-200675, PubMed 32831204

Rai SP, Krohn M, Pahnke J (2020)
Early Cognitive Training Rescues Remote Spatial Memory but Reduces Cognitive Flexibility in Alzheimer's Disease Mice
J Alzheimers Dis, 75 (4), 1301-1317
DOI 10.3233/JAD-200161, PubMed 32417783

Wanek T, Zoufal V, Brackhan M, Krohn M, Mairinger S, Filip T, Sauberer M, Stanek J, Pekar T, Pahnke J, Langer O (2020)
Brain Distribution of Dual ABCB1/ABCG2 Substrates Is Unaltered in a Beta-Amyloidosis Mouse Model
Int J Mol Sci, 21 (21)
DOI 10.3390/ijms21218245, PubMed 33153231

Publications 2019

Krohn M, Zoufal V, Mairinger S, Wanek T, Paarmann K, Brüning T, Eiriz I, Brackhan M, Langer O, Pahnke J (2019)
Generation and Characterization of an Abcc1 Humanized Mouse Model (hABCC1flx/flx ) with Knockout Capability
Mol Pharmacol, 96 (2), 138-147
DOI 10.1124/mol.119.115824, PubMed 31189668

Latysheva A, Emblem KE, Brandal P, Vik-Mo EO, Pahnke J, Røysland K, Hald JK, Server A (2019)
Dynamic susceptibility contrast and diffusion MR imaging identify oligodendroglioma as defined by the 2016 WHO classification for brain tumors: histogram analysis approach
Neuroradiology, 61 (5), 545-555
DOI 10.1007/s00234-019-02173-5, PubMed 30712139

Zoufal V, Mairinger S, Brackhan M, Krohn M, Filip T, Sauberer M, Stanek J, Wanek T, Tournier N, Bauer M, Pahnke J, Langer O (2019)
Imaging P-Glycoprotein Induction at the Blood-Brain Barrier of a β-Amyloidosis Mouse Model with 11C-Metoclopramide PET
J Nucl Med, 61 (7), 1050-1057
DOI 10.2967/jnumed.119.237198, PubMed 31806767

Zoufal V, Mairinger S, Krohn M, Wanek T, Filip T, Sauberer M, Stanek J, Kuntner C, Pahnke J, Langer O (2019)
Measurement of cerebral ABCC1 transport activity in wild-type and APP/PS1-21 mice with positron emission tomography
J Cereb Blood Flow Metab, 40 (5), 954-965
DOI 10.1177/0271678X19854541, PubMed 31195936

Zoufal V, Mairinger S, Krohn M, Wanek T, Filip T, Sauberer M, Stanek J, Traxl A, Schuetz JD, Kuntner C, Pahnke J, Langer O (2019)
Influence of Multidrug Resistance-Associated Proteins on the Excretion of the ABCC1 Imaging Probe 6-Bromo-7-[11C]Methylpurine in Mice
Mol Imaging Biol, 21 (2), 306-316
DOI 10.1007/s11307-018-1230-y, PubMed 29942989

Publications 2018

Ceafalan LC, Fertig TE, Gheorghe TC, Hinescu ME, Popescu BO, Pahnke J, Gherghiceanu M (2018)
Age-related ultrastructural changes of the basement membrane in the mouse blood-brain barrier
J Cell Mol Med, 23 (2), 819-827
DOI 10.1111/jcmm.13980, PubMed 30450815

Chee YC, Pahnke J, Bunte R, Adsool VA, Madan B, Virshup DM (2018)
Intrinsic Xenobiotic Resistance of the Intestinal Stem Cell Niche
Dev Cell, 46 (6), 681-695.e5
DOI 10.1016/j.devcel.2018.07.023, PubMed 30146480

Krohn M, Wanek T, Menet MC, Noack A, Declèves X, Langer O, Löscher W, Pahnke J (2018)
Humanization of the Blood-Brain Barrier Transporter ABCB1 in Mice Disrupts Genomic Locus - Lessons from Three Unsuccessful Approaches
Eur J Microbiol Immunol (Bp), 8 (3), 78-86
DOI 10.1556/1886.2018.00008, PubMed 30345087

Lamartinière Y, Boucau MC, Dehouck L, Krohn M, Pahnke J, Candela P, Gosselet F, Fenart L (2018)
ABCA7 Downregulation Modifies Cellular Cholesterol Homeostasis and Decreases Amyloid-β Peptide Efflux in an in vitro Model of the Blood-Brain Barrier
J Alzheimers Dis, 64 (4), 1195-1211
DOI 10.3233/JAD-170883, PubMed 30010117

Latysheva A, Emblem KE, Server A, Brandal P, Meling TR, Pahnke J, Hald JK (2018)
Survival Associations Using Perfusion and Diffusion Magnetic Resonance Imaging in Patients With Histologic and Genetic Defined Diffuse Glioma World Health Organization Grades II and III
J Comput Assist Tomogr, 42 (5), 807-815
DOI 10.1097/RCT.0000000000000742, PubMed 29901512

Leske H, Rushing E, Budka H, Niehusmann P, Pahnke J, Panagopoulos I (2018)
K27/G34 versus K28/G35 in histone H3-mutant gliomas: A note of caution
Acta Neuropathol, 136 (1), 175-176
DOI 10.1007/s00401-018-1867-2, PubMed 29766298

Mairinger S, Zoufal V, Wanek T, Traxl A, Filip T, Sauberer M, Stanek J, Kuntner C, Pahnke J, Müller M, Langer O (2018)
Influence of breast cancer resistance protein and P-glycoprotein on tissue distribution and excretion of Ko143 assessed with PET imaging in mice
Eur J Pharm Sci, 115, 212-222
DOI 10.1016/j.ejps.2018.01.034, PubMed 29360507

Steffen J, Stenzel J, Ibrahim S, Pahnke J (2018)
Short-Term Effects of Microglia-Specific Mitochondrial Dysfunction on Amyloidosis in Transgenic Models of Alzheimer's Disease
J Alzheimers Dis, 65 (2), 465-474
DOI 10.3233/JAD-180395, PubMed 30040730

Storck SE, Hartz AMS, Bernard J, Wolf A, Kachlmeier A, Mahringer A, Weggen S, Pahnke J, Pietrzik CU (2018)
The concerted amyloid-beta clearance of LRP1 and ABCB1/P-gp across the blood-brain barrier is linked by PICALM
Brain Behav Immun, 73, 21-33
DOI 10.1016/j.bbi.2018.07.017, PubMed 30041013

Zoufal V, Wanek T, Krohn M, Mairinger S, Filip T, Sauberer M, Stanek J, Pekar T, Bauer M, Pahnke J, Langer O (2018)
Age dependency of cerebral P-glycoprotein function in wild-type and APPPS1 mice measured with PET
J Cereb Blood Flow Metab, 40 (1), 150-162
DOI 10.1177/0271678X18806640, PubMed 30354871

Publications 2017

Aleksis R, Oleskovs F, Jaudzems K, Pahnke J, Biverstål H (2017)
Structural studies of amyloid-β peptides: Unlocking the mechanism of aggregation and the associated toxicity
Biochimie, 140, 176-192
DOI 10.1016/j.biochi.2017.07.011, PubMed 28751216

Sike Á, Wengenroth J, Upīte J, Brüning T, Eiriz I, Sántha P, Biverstål H, Jansone B, Haugen HJ, Krohn M, Pahnke J (2017)
Improved method for cannula fixation for long-term intracerebral brain infusion
J Neurosci Methods, 290, 145-150
DOI 10.1016/j.jneumeth.2017.07.026, PubMed 28754434

Steffen J, Krohn M, Schwitlick C, Brüning T, Paarmann K, Pietrzik CU, Biverstål H, Jansone B, Langer O, Pahnke J (2017)
Expression of endogenous mouse APP modulates β-amyloid deposition in hAPP-transgenic mice
Acta Neuropathol Commun, 5 (1), 49
DOI 10.1186/s40478-017-0448-2, PubMed 28637503

Publications 2016

Bernstein HG, Hildebrandt J, Dobrowolny H, Steiner J, Bogerts B, Pahnke J (2016)
Morphometric analysis of the cerebral expression of ATP-binding cassette transporter protein ABCB1 in chronic schizophrenia: Circumscribed deficits in the habenula
Schizophr Res, 177 (1-3), 52-58
DOI 10.1016/j.schres.2016.02.036, PubMed 26948503

Hofrichter J, Krohn M, Schumacher T, Lange C, Feistel B, Walbroel B, Pahnke J (2016)
Sideritis spp. Extracts Enhance Memory and Learning in Alzheimer's β-Amyloidosis Mouse Models and Aged C57Bl/6 Mice
J Alzheimers Dis, 53 (3), 967-80
DOI 10.3233/JAD-160301, PubMed 27258424

Marques F, Sousa JC, Brito MA, Pahnke J, Santos C, Correia-Neves M, Palha JA (2016)
The choroid plexus in health and in disease: dialogues into and out of the brain
Neurobiol Dis, 107, 32-40
DOI 10.1016/j.nbd.2016.08.011, PubMed 27546055

Möhle L, Israel N, Paarmann K, Krohn M, Pietkiewicz S, Müller A, Lavrik IN, Buguliskis JS, Schott BH, Schlüter D, Gundelfinger ED, Montag D, Seifert U, Pahnke J, Dunay IR (2016)
Chronic Toxoplasma gondii infection enhances β-amyloid phagocytosis and clearance by recruited monocytes
Acta Neuropathol Commun, 4, 25
DOI 10.1186/s40478-016-0293-8, PubMed 26984535

Steffen J, Krohn M, Paarmann K, Schwitlick C, Brüning T, Marreiros R, Müller-Schiffmann A, Korth C, Braun K, Pahnke J (2016)
Revisiting rodent models: Octodon degus as Alzheimer's disease model?
Acta Neuropathol Commun, 4 (1), 91
DOI 10.1186/s40478-016-0363-y, PubMed 27566602

Publications 2015

Apostolova I, Niedzielska D, Derlin T, Koziolek EJ, Amthauer H, Salmen B, Pahnke J, Brenner W, Mautner VF, Buchert R (2015)
Perfusion single photon emission computed tomography in a mouse model of neurofibromatosis type 1: towards a biomarker of neurologic deficits
J Cereb Blood Flow Metab, 35 (8), 1304-12
DOI 10.1038/jcbfm.2015.43, PubMed 25785829

Budworth H, Harris FR, Williams P, Lee DY, Holt A, Pahnke J, Szczesny B, Acevedo-Torres K, Ayala-Peña S, McMurray CT (2015)
Suppression of Somatic Expansion Delays the Onset of Pathophysiology in a Mouse Model of Huntington's Disease
PLoS Genet, 11 (8), e1005267
DOI 10.1371/journal.pgen.1005267, PubMed 26247199

Fröhlich C, Zschiebsch K, Gröger V, Paarmann K, Steffen J, Thurm C, Schropp EM, Brüning T, Gellerich F, Radloff M, Schwabe R, Lachmann I, Krohn M, Ibrahim S, Pahnke J (2015)
Activation of Mitochondrial Complex II-Dependent Respiration Is Beneficial for α-Synucleinopathies
Mol Neurobiol, 53 (7), 4728-44
DOI 10.1007/s12035-015-9399-4, PubMed 26319560

Krohn M, Bracke A, Avchalumov Y, Schumacher T, Hofrichter J, Paarmann K, Fröhlich C, Lange C, Brüning T, von Bohlen Und Halbach O, Pahnke J (2015)
Accumulation of murine amyloid-β mimics early Alzheimer's disease
Brain, 138 (Pt 8), 2370-82
DOI 10.1093/brain/awv137, PubMed 25991605

Lill CM, Rengmark A, Pihlstrøm L, Fogh I, Shatunov A, Sleiman PM, Wang LS, Liu T, Lassen CF, Meissner E, Alexopoulos P, Calvo A, Chio A, Dizdar N, Faltraco F, Forsgren L, Kirchheiner J, Kurz A, Larsen JP, Liebsch M, Linder J, Morrison KE, Nissbrandt H, Otto M, Pahnke J et al. (2015)
The role of TREM2 R47H as a risk factor for Alzheimer's disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson's disease
Alzheimers Dement, 11 (12), 1407-1416
DOI 10.1016/j.jalz.2014.12.009, PubMed 25936935

Wanek T, Römermann K, Mairinger S, Stanek J, Sauberer M, Filip T, Traxl A, Kuntner C, Pahnke J, Bauer F, Erker T, Löscher W, Müller M, Langer O (2015)
Factors Governing P-Glycoprotein-Mediated Drug-Drug Interactions at the Blood-Brain Barrier Measured with Positron Emission Tomography
Mol Pharm, 12 (9), 3214-25
DOI 10.1021/acs.molpharmaceut.5b00168, PubMed 26202880

Publications 2014

Bernstein HG, Hölzl G, Dobrowolny H, Hildebrandt J, Trübner K, Krohn M, Bogerts B, Pahnke J (2014)
Vascular and extravascular distribution of the ATP-binding cassette transporters ABCB1 and ABCC1 in aged human brain and pituitary
Mech Ageing Dev, 141-142, 12-21
DOI 10.1016/j.mad.2014.08.003, PubMed 25218792

Lemcke S, Müller S, Möller S, Schillert A, Ziegler A, Cepok-Kauffeld S, Comabella M, Montalban X, Rülicke T, Nandakumar KS, Hemmer B, Holmdahl R, Pahnke J, Ibrahim SM (2014)
Nerve conduction velocity is regulated by the inositol polyphosphate-4-phosphatase II gene
Am J Pathol, 184 (9), 2420-9
DOI 10.1016/j.ajpath.2014.05.021, PubMed 25129256

Pahnke J, Fröhlich C, Paarmann K, Krohn M, Bogdanovic N, Årsland D, Winblad B (2014)
Cerebral ABC transporter-common mechanisms may modulate neurodegenerative diseases and depression in elderly subjects
Arch Med Res, 45 (8), 738-43
DOI 10.1016/j.arcmed.2014.10.010, PubMed 25446622

Pahnke J, Langer O, Krohn M (2014)
Alzheimer's and ABC transporters--new opportunities for diagnostics and treatment
Neurobiol Dis, 72 Pt A, 54-60
DOI 10.1016/j.nbd.2014.04.001, PubMed 24746857

Publications 2013

Fröhlich C, Paarmann K, Steffen J, Stenzel J, Krohn M, Heinze HJ, Pahnke J (2013)
Genomic background-related activation of microglia and reduced β-amyloidosis in a mouse model of Alzheimer's disease
Eur J Microbiol Immunol (Bp), 3 (1), 21-27
DOI 10.1556/EuJMI.3.2013.1.3, PubMed 23814667

Hofrichter J, Krohn M, Schumacher T, Lange C, Feistel B, Walbroel B, Heinze HJ, Crockett S, Sharbel TF, Pahnke J (2013)
Reduced Alzheimer's disease pathology by St. John's Wort treatment is independent of hyperforin and facilitated by ABCC1 and microglia activation in mice
Curr Alzheimer Res, 10 (10), 1057-69
DOI 10.2174/15672050113106660171, PubMed 24156265

Pahnke J, Fröhlich C, Krohn M, Schumacher T, Paarmann K (2013)
Impaired mitochondrial energy production and ABC transporter function-A crucial interconnection in dementing proteopathies of the brain
Mech Ageing Dev, 134 (10), 506-15
DOI 10.1016/j.mad.2013.08.007, PubMed 24012632

Steder M, Alla V, Meier C, Spitschak A, Pahnke J, Fürst K, Kowtharapu BS, Engelmann D, Petigk J, Egberts F, Schäd-Trcka SG, Gross G, Nettelbeck DM, Niemetz A, Pützer BM (2013)
DNp73 exerts function in metastasis initiation by disconnecting the inhibitory role of EPLIN on IGF1R-AKT/STAT3 signaling
Cancer Cell, 24 (4), 512-27
DOI 10.1016/j.ccr.2013.08.023, PubMed 24135282

Publications 2012

Ehler J, Patejdl R, Junghanss C, Lehmitz R, Pahnke J, Großmann A, Vogelgesang S, Brüggemann M, Benecke R, Zettl UK (2012)
Intrathecal large granular lymphocytes as an unusual presentation of a small cell T cell lymphoma
Clin Neurol Neurosurg, 114 (7), 1102-3
DOI 10.1016/j.clineuro.2012.02.029, PubMed 22421252

Scheffler K, Krohn M, Dunkelmann T, Stenzel J, Miroux B, Ibrahim S, von Bohlen Und Halbach O, Heinze HJ, Walker LC, Gsponer JA, Pahnke J (2012)
Mitochondrial DNA polymorphisms specifically modify cerebral β-amyloid proteostasis
Acta Neuropathol, 124 (2), 199-208
DOI 10.1007/s00401-012-0980-x, PubMed 22526016

Schiffmann L, Schwarz F, Linnebacher M, Prall F, Pahnke J, Krentz H, Vollmar B, Klar E (2012)
A novel sialyl Le(X) expression score as a potential prognostic tool in colorectal cancer
World J Surg Oncol, 10, 95
DOI 10.1186/1477-7819-10-95, PubMed 22621806

Schmidt A, Pahnke J (2012)
Efficient near-infrared in vivo imaging of amyoid-β deposits in Alzheimer's disease mouse models
J Alzheimers Dis, 30 (3), 651-64
DOI 10.3233/JAD-2012-112168, PubMed 22460331

Schumacher T, Krohn M, Hofrichter J, Lange C, Stenzel J, Steffen J, Dunkelmann T, Paarmann K, Fröhlich C, Uecker A, Plath AS, Sommer A, Brüning T, Heinze HJ, Pahnke J (2012)
ABC transporters B1, C1 and G2 differentially regulate neuroregeneration in mice
PLoS One, 7 (4), e35613
DOI 10.1371/journal.pone.0035613, PubMed 22545122

Publications 2011

Kamm C, Uflacker N, Asmus F, Schrader C, Wolters A, Wittstock M, Pahnke J, Gasser T, Volkmann J, Münchau A, Hagenah J, Benecke R, Klein C, Lohmann K (2011)
No evidence for THAP1/DYT6 variants as disease modifiers in DYT1 dystonia
Mov Disord, 26 (11), 2136-7
DOI 10.1002/mds.23777, PubMed 21638323

Krohn M, Lange C, Hofrichter J, Scheffler K, Stenzel J, Steffen J, Schumacher T, Brüning T, Plath AS, Alfen F, Schmidt A, Winter F, Rateitschak K, Wree A, Gsponer J, Walker LC, Pahnke J (2011)
Cerebral amyloid-β proteostasis is regulated by the membrane transport protein ABCC1 in mice
J Clin Invest, 121 (10), 3924-31
DOI 10.1172/JCI57867, PubMed 21881209

Scheffler K, Stenzel J, Krohn M, Lange C, Hofrichter J, Schumacher T, Brüning T, Plath AS, Walker L, Pahnke J (2011)
Determination of spatial and temporal distribution of microglia by 230nm-high-resolution, high-throughput automated analysis reveals different amyloid plaque populations in an APP/PS1 mouse model of Alzheimer's disease
Curr Alzheimer Res, 8 (7), 781-8
DOI 10.2174/156720511797633179, PubMed 21244350

Teipel SJ, Buchert R, Thome J, Hampel H, Pahnke J (2011)
Development of Alzheimer-disease neuroimaging-biomarkers using mouse models with amyloid-precursor protein-transgene expression
Prog Neurobiol, 95 (4), 547-56
DOI 10.1016/j.pneurobio.2011.05.004, PubMed 21601614

Teipel SJ, Kaza E, Hadlich S, Bauer A, Brüning T, Plath AS, Krohn M, Scheffler K, Walker LC, Lotze M, Pahnke J (2011)
Automated detection of amyloid-β-related cortical and subcortical signal changes in a transgenic model of Alzheimer's disease using high-field MRI
J Alzheimers Dis, 23 (2), 221-37
DOI 10.3233/JAD-2010-101035, PubMed 20966552

Publications 2010

Soehn AS, Franck T, Biskup S, Giaime E, Melle C, Rott R, Cebo D, Kalbacher H, Ott E, Pahnke J, Meitinger T, Krüger R, Gasser T, Berg D, von Eggeling F, Engelender S, da Costa CA, Riess O (2010)
Periphilin is a novel interactor of synphilin-1, a protein implicated in Parkinson's disease
Neurogenetics, 11 (2), 203-15
DOI 10.1007/s10048-009-0215-z, PubMed 19730898

Publications 2009

Alla V, Engelmann D, Niemetz A, Pahnke J, Schmidt A, Kunz M, Emmrich S, Steder M, Koczan D, Pützer BM (2009)
E2F1 in melanoma progression and metastasis
J Natl Cancer Inst, 102 (2), 127-33
DOI 10.1093/jnci/djp458, PubMed 20026813

Baumann F, Pahnke J, Radovanovic I, Rülicke T, Bremer J, Tolnay M, Aguzzi A (2009)
Functionally relevant domains of the prion protein identified in vivo
PLoS One, 4 (9), e6707
DOI 10.1371/journal.pone.0006707, PubMed 19738901

Pahnke J, Walker LC, Scheffler K, Krohn M (2009)
Alzheimer's disease and blood-brain barrier function-Why have anti-beta-amyloid therapies failed to prevent dementia progression?
Neurosci Biobehav Rev, 33 (7), 1099-108
DOI 10.1016/j.neubiorev.2009.05.006, PubMed 19481107

Westman E, Spenger C, Oberg J, Reyer H, Pahnke J, Wahlund LO (2009)
In vivo 1H-magnetic resonance spectroscopy can detect metabolic changes in APP/PS1 mice after donepezil treatment
BMC Neurosci, 10, 33
DOI 10.1186/1471-2202-10-33, PubMed 19351388

Publications 2008

Miksch RM, Armbrust S, Pahnke J, Fusch C (2008)
Outcome of very low birthweight infants after introducing a new standard regime with the early use of nasal CPAP
Eur J Pediatr, 167 (8), 909-16
DOI 10.1007/s00431-007-0646-1, PubMed 18172681

Pahnke J, Wolkenhauer O, Krohn M, Walker LC (2008)
Clinico-pathologic function of cerebral ABC transporters - implications for the pathogenesis of Alzheimer's disease
Curr Alzheimer Res, 5 (4), 396-405
DOI 10.2174/156720508785132262, PubMed 18690837

Publications 2007

Baumann F, Tolnay M, Brabeck C, Pahnke J, Kloz U, Niemann HH, Heikenwalder M, Rülicke T, Bürkle A, Aguzzi A (2007)
Lethal recessive myelin toxicity of prion protein lacking its central domain
EMBO J, 26 (2), 538-47
DOI 10.1038/sj.emboj.7601510, PubMed 17245436

Bramkamp M, Dedes KJ, Strobel K, Pahnke J, Breitenstein S, Clavien PA (2007)
Cholestasis from malignant melanoma
J Clin Oncol, 25 (6), 725-6
DOI 10.1200/JCO.2006.09.6230, PubMed 17308277

Henning J, Koczan D, Glass A, Karopka T, Pahnke J, Rolfs A, Benecke R, Gimsa U (2007)
Deep brain stimulation in a rat model modulates TH, CaMKIIa and Homer1 gene expression
Eur J Neurosci, 25 (1), 239-50
DOI 10.1111/j.1460-9568.2006.05264.x, PubMed 17241285

Hoffrogge R, Beyer S, Hübner R, Mikkat S, Mix E, Scharf C, Schmitz U, Pauleweit S, Berth M, Zubrzycki IZ, Christoph H, Pahnke J, Wolkenhauer O, Uhrmacher A, Völker U, Rolfs A (2007)
2-DE profiling of GDNF overexpression-related proteome changes in differentiating ST14A rat progenitor cells
Proteomics, 7 (1), 33-46
DOI 10.1002/pmic.200600614, PubMed 17146836

Marx FP, Soehn AS, Berg D, Melle C, Schiesling C, Lang M, Kautzmann S, Strauss KM, Franck T, Engelender S, Pahnke J, Dawson S, von Eggeling F, Schulz JB, Riess O, Krüger R (2007)
The proteasomal subunit S6 ATPase is a novel synphilin-1 interacting protein--implications for Parkinson's disease
FASEB J, 21 (8), 1759-67
DOI 10.1096/fj.06-6734com, PubMed 17327361

Wyss MT, Spaeth N, Biollaz G, Pahnke J, Alessi P, Trachsel E, Treyer V, Weber B, Neri D, Buck A (2007)
Uptake of 18F-Fluorocholine, 18F-FET, and 18F-FDG in C6 gliomas and correlation with 131I-SIP(L19), a marker of angiogenesis
J Nucl Med, 48 (4), 608-14
DOI 10.2967/jnumed.106.036251, PubMed 17401099

Publications 2006

Hoffrogge R, Mikkat S, Scharf C, Beyer S, Christoph H, Pahnke J, Mix E, Berth M, Uhrmacher A, Zubrzycki IZ, Miljan E, Völker U, Rolfs A (2006)
2-DE proteome analysis of a proliferating and differentiating human neuronal stem cell line (ReNcell VM)
Proteomics, 6 (6), 1833-47
DOI 10.1002/pmic.200500556, PubMed 16475233

Mix E, Ibrahim SM, Pahnke J, Glass A, Mazón-Peláez I, Lemcke S, Koczan D, Gimsa U, Bansemer S, Scheel T, Karopka T, Böttcher T, Müller J, Dazert E, Antipova V, Hoffrogge R, Wree A, Zschiesche M, Strauss U, Kundt G, Warzok R, Gierl L, Rolfs A (2006)
3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitor Atorvastatin mediated effects depend on the activation status of target cells in PLP-EAE
J Autoimmun, 27 (4), 251-65
DOI 10.1016/j.jaut.2006.09.006, PubMed 17085013

Spaeth N, Wyss MT, Pahnke J, Biollaz G, Lutz A, Goepfert K, Westera G, Treyer V, Weber B, Buck A (2006)
Uptake of 18F-fluorocholine, 18F-fluoro-ethyl-L: -tyrosine and 18F-fluoro-2-deoxyglucose in F98 gliomas in the rat
Eur J Nucl Med Mol Imaging, 33 (6), 673-82
DOI 10.1007/s00259-005-0045-7, PubMed 16538503

Spaeth N, Wyss MT, Pahnke J, Biollaz G, Trachsel E, Drandarov K, Treyer V, Weber B, Neri D, Buck A (2006)
Radioimmunotherapy targeting the extra domain B of fibronectin in C6 rat gliomas: a preliminary study about the therapeutic efficacy of iodine-131-labeled SIP(L19)
Nucl Med Biol, 33 (5), 661-6
DOI 10.1016/j.nucmedbio.2006.05.001, PubMed 16843841

Vogler S, Pahnke J, Rousset S, Ricquier D, Moch H, Miroux B, Ibrahim SM (2006)
Uncoupling protein 2 has protective function during experimental autoimmune encephalomyelitis
Am J Pathol, 168 (5), 1570-5
DOI 10.2353/ajpath.2006.051069, PubMed 16651623

Publications 2005

Mazón Peláez I, Vogler S, Strauss U, Wernhoff P, Pahnke J, Brockmann G, Moch H, Thiesen HJ, Rolfs A, Ibrahim SM (2005)
Identification of quantitative trait loci controlling cortical motor evoked potentials in experimental autoimmune encephalomyelitis: correlation with incidence, onset and severity of disease
Hum Mol Genet, 14 (14), 1977-89
DOI 10.1093/hmg/ddi203, PubMed 15917267

Möller S, Mix E, Blüggel M, Serrano-Fernández P, Koczan D, Kotsikoris V, Kunz M, Watson M, Pahnke J, Illges H, Kreutzer M, Mikkat S, Thiesen HJ, Glocker MO, Zettl UK, Ibrahim SM (2005)
Collection of soluble variants of membrane proteins for transcriptomics and proteomics
In Silico Biol, 5 (3), 295-311
PubMed 15984938

Rolfs A, Böttcher T, Zschiesche M, Morris P, Winchester B, Bauer P, Walter U, Mix E, Löhr M, Harzer K, Strauss U, Pahnke J, Grossmann A, Benecke R (2005)
Prevalence of Fabry disease in patients with cryptogenic stroke: a prospective study
Lancet, 366 (9499), 1794-6
DOI 10.1016/S0140-6736(05)67635-0, PubMed 16298216

Publications 2004

Mix E, Ibrahim S, Pahnke J, Koczan D, Sina C, Böttcher T, Thiesen HJ, Rolfs A (2004)
Gene-expression profiling of the early stages of MOG-induced EAE proves EAE-resistance as an active process
J Neuroimmunol, 151 (1-2), 158-70
DOI 10.1016/j.jneuroim.2004.03.007, PubMed 15145614

Pahnke J, Mix E, Knoblich R, Müller J, Zschiesche M, Schubert B, Koczan D, Bauer P, Böttcher T, Thiesen HJ, Lazarov L, Wree A, Rolfs A (2004)
Overexpression of glial cell line-derived neurotrophic factor induces genes regulating migration and differentiation of neuronal progenitor cells
Exp Cell Res, 297 (2), 484-94
DOI 10.1016/j.yexcr.2004.03.037, PubMed 15212950

Peters S, Mix E, Bauer P, Weinelt S, Schubert B, Knoblich R, Böttcher T, Strauss U, Pahnke J, Cattaneo E, Wree A, Rolfs A (2004)
Wnt-5a expression in the rat neuronal progenitor cell line ST14A
Exp Brain Res, 158 (2), 189-95
DOI 10.1007/s00221-004-1887-0, PubMed 15309358

Spaeth N, Wyss MT, Weber B, Scheidegger S, Lutz A, Verwey J, Radovanovic I, Pahnke J, Wild D, Westera G, Weishaupt D, Hermann DM, Kaser-Hotz B, Aguzzi A, Buck A (2004)
Uptake of 18F-fluorocholine, 18F-fluoroethyl-L-tyrosine, and 18F-FDG in acute cerebral radiation injury in the rat: implications for separation of radiation necrosis from tumor recurrence
J Nucl Med, 45 (11), 1931-8
PubMed 15534065

Strauss U, Kole MH, Bräuer AU, Pahnke J, Bajorat R, Rolfs A, Nitsch R, Deisz RA (2004)
An impaired neocortical Ih is associated with enhanced excitability and absence epilepsy
Eur J Neurosci, 19 (11), 3048-58
DOI 10.1111/j.0953-816X.2004.03392.x, PubMed 15182313

Vogelgesang S, Warzok RW, Cascorbi I, Kunert-Keil C, Schroeder E, Kroemer HK, Siegmund W, Walker LC, Pahnke J (2004)
The role of P-glycoprotein in cerebral amyloid angiopathy; implications for the early pathogenesis of Alzheimer's disease
Curr Alzheimer Res, 1 (2), 121-5
DOI 10.2174/1567205043332225, PubMed 15975076

Publications 2003

Böttcher T, Mix E, Koczan D, Bauer P, Pahnke J, Peters S, Weinelt S, Knoblich R, Strauss U, Cattaneo E, Thiesen HJ, Rolfs A (2003)
Gene expression profiling of ciliary neurotrophic factor-overexpressing rat striatal progenitor cells (ST14A) indicates improved stress response during the early stage of differentiation
J Neurosci Res, 73 (1), 42-53
DOI 10.1002/jnr.10624, PubMed 12815707

Fischer G, Ibrahim SM, Brockmann GA, Pahnke J, Bartocci E, Thiesen HJ, Serrano-Fernández P, Möller S (2003)
Expressionview: visualization of quantitative trait loci and gene-expression data in Ensembl
Genome Biol, 4 (11), R77
DOI 10.1186/gb-2003-4-11-r77, PubMed 14611663

Jung HH, Hergersberg M, Vogt M, Pahnke J, Treyer V, Röthlisberger B, Kollias SS, Russo D, Frey BM (2003)
McLeod phenotype associated with a XK missense mutation without hematologic, neuromuscular, or cerebral involvement
Transfusion, 43 (7), 928-38
DOI 10.1046/j.1537-2995.2003.t01-1-00434.x, PubMed 12823753

Publications 2002

Mix E, Pahnke J, Ibrahim SM (2002)
Gene-expression profiling of experimental autoimmune encephalomyelitis
Neurochem Res, 27 (10), 1157-63
DOI 10.1023/a:1020925425780, PubMed 12462414

Vogelgesang S, Cascorbi I, Schroeder E, Pahnke J, Kroemer HK, Siegmund W, Kunert-Keil C, Walker LC, Warzok RW (2002)
Deposition of Alzheimer's beta-amyloid is inversely correlated with P-glycoprotein expression in the brains of elderly non-demented humans
Pharmacogenetics, 12 (7), 535-41
DOI 10.1097/00008571-200210000-00005, PubMed 12360104

Vogelgesang S, Junge MH, Pahnke J, Gaab MR, Warzok RW (2002)
August 2001: Sellar/suprasellar mass in a 59-year-old woman
Brain Pathol, 12 (1), 135-6, 139
PubMed 11770897

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