Young Investigator Prize to Anita Sveen during annual "Onkologisk Forum" meeting Nov 2017

Anita Sveen's research focus is on computational oncology of colorectal cancer, involving multi-level genomic analyses of primary and metastatic cancers in translational research projects. By integration of genomic data at different levels, the aim is to determine the clinical importance of tumor heterogeneity, both with respect to prognostic assessment of the patients and prediction of treatment response. Current research projects include analyses of tumor heterogeneity within and among tumors from individual patients, during metastatic progression, as well as within the biologically distinct subgroups of colorectal cancer. 

Selected papers she focused on during her presentation:

• Sveen A, Ågesen TH, Nesbakken A, Meling GI, Rognum TO, Liestøl K, Skotheim RI, Lothe RA (2012)
  ColoGuidePro: a prognostic 7-gene expression signature for stage III colorectal cancer patients
  Clin Cancer Res, 18 (21), 6001-10
  PubMed 22991413
• Agesen TH, Sveen A, Merok MA, Lind GE, Nesbakken A, Skotheim RI, Lothe RA (2012)
  ColoGuideEx: a robust gene classifier specific for stage II colorectal cancer prognosis
  Gut, 61 (11), 1560-7
  PubMed 22213796
• Sveen A, Løes IM, Alagaratnam S, Nilsen G, Høland M, Lingjærde OC, Sorbye H, Berg KC, Horn A, Angelsen JH, Knappskog S, Lønning PE, Lothe RA (2016)
  Intra-patient Inter-metastatic Genetic Heterogeneity in Colorectal Cancer as a Key Determinant of Survival after Curative Liver Resection
  PLoS Genet, 12 (7), e1006225
  PubMed 27472274
• Sveen A, Løes IM, Alagaratnam S, Nilsen G, Høland M, Lingjærde OC, Sorbye H, Berg KC, Horn A, Angelsen JH, Knappskog S, Lønning PE, Lothe RA (2016)
  Intra-patient Inter-metastatic Genetic Heterogeneity in Colorectal Cancer as a Key Determinant of Survival after Curative Liver Resection
  PLoS Genet, 12 (7), e1006225
  PubMed 27472274
• Sveen, Bruun et al., Clinic Cancer Res, in press accepted last week.
  “Colorectal cancer Consensus Molecular Subtypes translated to preclinical models uncover potentially targetable cancer-cell dependencies”

Links:

Anita Sveen's publication list

Home page of Ragnhild Lothe's "Genetics" research group

Department of Molecular Oncology