Dr. Anita Sveen and co-workers recently published a review article about alternative splicing in cancer in the journal Oncogene (journal impact factor 8.56). In this article, an overview of known aberrant splicing events in cancer-critical genes and their potential as cancer biomarkers is given. The article also discusses cancer-associated patterns of splicing on a genome-wide scale. Furthermore, the genes encoding splicing factors are found to be enriched for cancer-critical somatic mutations and to have dysregulated expression patterns. Several novel cancer-critical splicing factors are proposed.
Sveen has previously investigated the biomarker potential of aberrant splicing events in cancer (Sveen et al., Int J Cancer 2012;131:1479-85) and identified transcriptome instability, TIN, in colorectal cancer as a splicing-related molecular feature that is associated with splicing factor gene expression levels and poor patient survival (Sveen et al., Genome Med 2011;3:32 and BMC Genomics 2014;15:672). Sveen is currently a post doc in the Lothe group, working with genomics of colorectal cancer in a translational research perspective.
Link to article:
Aberrant RNA splicing in cancer; expression changes and driver mutations of splicing factor genes.
Sveen A, Kilpinen S, Ruusulehto A, Lothe RA, Skotheim RI.
Oncogene. 2015 Aug 24. doi: 10.1038/onc.2015.318.