Hanne Flinstad Harbo
- Group leader, Professor, deputy group leader, senior consultant; MD, PhD, MHA
- +47 221 18660
Hanne F Harbo has a medical degree from the University of Oslo (UiO) from 1988 and is a specialist in neurology from 1997. Since her PhD in MS genetics in 2003, she has worked as the leader of the MS research group at Oslo University Hospital as well as a consultant with a special focus on MS, and is from 2010 a professor of neurology at the University of Oslo. As of September 2018 she is the Head of Department of Neurology at Oslo University Hospital, as well as deputy head of the MS Research Group. She has been a member of several international committees related to neurogenetic- and MS research and acts currently as member of the governance group the Norwegian Brain Council and of the International MS Genetics Consortium (IMSGC) and is member of the ECTRIMS council.
Project/Research interest:
Hanne F Harbo is project leader and supervisor of projects in the MS Research Group at Oslo University Hospital focusing on translational MS-projects spanning from genetic and molecular studies to gene-environment- , phenotype- and MRI- research. She has also a strong clinical interest in MS and takes actively part in the MS clinic as well in the development of local, national and international data collections and research projects.
Publications 2024
Prognostic value of single-subject grey matter networks in early multiple sclerosis
Brain, 147 (1), 135-146
DOI 10.1093/brain/awad288, PubMed 37642541
Multiscale networks in multiple sclerosis
PLoS Comput Biol, 20 (2), e1010980
DOI 10.1371/journal.pcbi.1010980, PubMed 38329927
Are white matter hyperintensities associated with neuroborreliosis? The answer is twofold
Neuroradiology (in press)
DOI 10.1007/s00234-024-03482-0, PubMed 39422730
Publications 2023
Predicting disease severity in multiple sclerosis using multimodal data and machine learning
J Neurol, 271 (3), 1133-1149
DOI 10.1007/s00415-023-12132-z, PubMed 38133801
Immune cell subpopulations and serum neurofilament light chain are associated with increased risk of disease worsening in multiple sclerosis
J Neuroimmunol, 382, 578175
DOI 10.1016/j.jneuroim.2023.578175, PubMed 37573634
[Gender and health, education and research]
Tidsskr Nor Laegeforen, 143 (11)
DOI 10.4045/tidsskr.23.0408, PubMed 37589360
Dynamic contrast-enhanced MRI shows altered blood-brain barrier function of deep gray matter structures in neuroborreliosis: a case-control study
Eur Radiol Exp, 7 (1), 52
DOI 10.1186/s41747-023-00365-6, PubMed 37710058
Using The Virtual Brain to study the relationship between structural and functional connectivity in patients with multiple sclerosis: a multicenter study
Cereb Cortex, 33 (12), 7322-7334
DOI 10.1093/cercor/bhad041, PubMed 36813475
T cell responses to SARS-CoV-2 vaccination differ by disease-modifying therapy for multiple sclerosis
JCI Insight, 8 (12)
DOI 10.1172/jci.insight.165111, PubMed 37159281
Publications 2022
Assessment of cognitive function, structural brain changes and fatigue 6 months after treatment of neuroborreliosis
J Neurol, 270 (3), 1430-1438
DOI 10.1007/s00415-022-11463-7, PubMed 36380166
Cognitive function in patients with neuroborreliosis: A prospective cohort study from the acute phase to 12 months post treatment
Brain Behav, 12 (6), e2608
DOI 10.1002/brb3.2608, PubMed 35593485
Global DNA methylation changes in treated and untreated MS patients measured over time
J Neuroimmunol, 364, 577808
DOI 10.1016/j.jneuroim.2022.577808, PubMed 35093762
Serum neurofilament light chain concentration predicts disease worsening in multiple sclerosis
Mult Scler, 28 (12), 1859-1870
DOI 10.1177/13524585221097296, PubMed 35658739
Quantitative proteomics reveals protein dysregulation during T cell activation in multiple sclerosis patients compared to healthy controls
Clin Proteomics, 19 (1), 23
DOI 10.1186/s12014-022-09361-1, PubMed 35790914
Exploring Retinal Blood Vessel Diameters as Biomarkers in Multiple Sclerosis
J Clin Med, 11 (11)
DOI 10.3390/jcm11113109, PubMed 35683496
Deep neural networks learn general and clinically relevant representations of the ageing brain
Neuroimage, 256, 119210
DOI 10.1016/j.neuroimage.2022.119210, PubMed 35462035
Serum neurofilament as a predictor of 10-year grey matter atrophy and clinical disability in multiple sclerosis: a longitudinal study
J Neurol Neurosurg Psychiatry, 93 (8), 849-57 (in press)
DOI 10.1136/jnnp-2021-328568, PubMed 35649699
The Effect of Smoking on Long-term Gray Matter Atrophy and Clinical Disability in Patients with Relapsing-Remitting Multiple Sclerosis
Neurol Neuroimmunol Neuroinflamm, 9 (5)
DOI 10.1212/NXI.0000000000200008, PubMed 35738901
Enhancement of cranial nerves in Lyme neuroborreliosis: incidence and correlation with clinical symptoms and prognosis
Neuroradiology, 64 (12), 2323-2333
DOI 10.1007/s00234-022-02957-2, PubMed 35608630
Brain disconnectome mapping derived from white matter lesions and serum neurofilament light levels in multiple sclerosis: A longitudinal multicenter study
Neuroimage Clin, 35, 103099
DOI 10.1016/j.nicl.2022.103099, PubMed 35772194
Publications 2021
Cognitive function, fatigue and Fazekas score in patients with acute neuroborreliosis
Ticks Tick Borne Dis, 12 (3), 101678
DOI 10.1016/j.ttbdis.2021.101678, PubMed 33529985
Next-Generation Sequencing Identifies Extended HLA Class I and II Haplotypes Associated With Early-Onset and Late-Onset Myasthenia Gravis in Italian, Norwegian, and Swedish Populations
Front Immunol, 12, 667336
DOI 10.3389/fimmu.2021.667336, PubMed 34163474
Exploring the role of the multiple sclerosis susceptibility gene CLEC16A in T cells
Scand J Immunol, 94 (1), e13050
DOI 10.1111/sji.13050, PubMed 34643957
Functional connectivity in multiple sclerosis modelled as connectome stability: A 5-year follow-up study
Mult Scler, 28 (4), 532-540
DOI 10.1177/13524585211030212, PubMed 34259578
Humoral immunity to SARS-CoV-2 mRNA vaccination in multiple sclerosis: the relevance of time since last rituximab infusion and first experience from sporadic revaccinations
J Neurol Neurosurg Psychiatry, 94 (1), 19-22
DOI 10.1136/jnnp-2021-327612, PubMed 34670844
Low vitamin D, but not tobacco use or high BMI, is associated with long-term disability progression in multiple sclerosis
Mult Scler Relat Disord, 50, 102801
DOI 10.1016/j.msard.2021.102801, PubMed 33636616
Blood neurofilament light concentration at admittance: a potential prognostic marker in COVID-19
J Neurol, 268 (10), 3574-3583
DOI 10.1007/s00415-021-10517-6, PubMed 33743046
Publications 2020
CD8+ T cell gene expression analysis identifies differentially expressed genes between multiple sclerosis patients and healthy controls
Mult Scler J Exp Transl Clin, 6 (4), 2055217320978511
DOI 10.1177/2055217320978511, PubMed 33343920
LesionQuant for Assessment of MRI in Multiple Sclerosis-A Promising Supplement to the Visual Scan Inspection
Front Neurol, 11, 546744
DOI 10.3389/fneur.2020.546744, PubMed 33362682
Impact of treatment on cellular immunophenotype in MS: A cross-sectional study
Neurol Neuroimmunol Neuroinflamm, 7 (3)
DOI 10.1212/NXI.0000000000000693, PubMed 32139439
The genetic architecture of human brainstem structures and their involvement in common brain disorders
Nat Commun, 11 (1), 4016
DOI 10.1038/s41467-020-17376-1, PubMed 32782260
Publisher Correction: Common brain disorders are associated with heritable patterns of apparent aging of the brain
Nat Neurosci, 23 (2), 295
DOI 10.1038/s41593-019-0553-6, PubMed 31848485
Publications 2019
Quantitative proteomic analyses of CD4+ and CD8+ T cells reveal differentially expressed proteins in multiple sclerosis patients and healthy controls
Clin Proteomics, 16, 19
DOI 10.1186/s12014-019-9241-5, PubMed 31080378
No differential gene expression for CD4+ T cells of MS patients and healthy controls
Mult Scler J Exp Transl Clin, 5 (2), 2055217319856903
DOI 10.1177/2055217319856903, PubMed 31223483
Neurodegenerative Interplay of Cardiovascular Autonomic Dysregulation and the Retina in Early Multiple Sclerosis
Front Neurol, 10, 507
DOI 10.3389/fneur.2019.00507, PubMed 31156539
Cross-Sectional and Longitudinal MRI Brain Scans Reveal Accelerated Brain Aging in Multiple Sclerosis
Front Neurol, 10, 450
DOI 10.3389/fneur.2019.00450, PubMed 31114541
Symptoms of fatigue and depression is reflected in altered default mode network connectivity in multiple sclerosis
PLoS One, 14 (4), e0210375
DOI 10.1371/journal.pone.0210375, PubMed 30933977
Common brain disorders are associated with heritable patterns of apparent aging of the brain
Nat Neurosci, 22 (10), 1617-1623
DOI 10.1038/s41593-019-0471-7, PubMed 31551603
Hjernehelse
In Nevrologi og Nevrokirurgi: fra barn til voksen. (Harbo HF, Helseth E, Rootwelt T, eds.), Fagbokforlaget
PublikaID 430, ISBN 9788245024739
Publications 2018
SVM-based Tool to Detect Patients with Multiple Sclerosis Using a Commercial EMG Sensor
PR IEEE SEN ARRAY, 376-379
[A man in his 50s with dizziness, double vision and walking difficulties]
Tidsskr Nor Laegeforen, 138 (3)
DOI 10.4045/tidsskr.16.1109, PubMed 29411576
A man in the 50s with dizziness, double vision and walking difficulties
Tidsskr. Nor. Laegeforen., 138 (3), 253-256
DNA methylation as a mediator of HLA-DRB1*15:01 and a protective variant in multiple sclerosis
Nat Commun, 9 (1), 2397
DOI 10.1038/s41467-018-04732-5, PubMed 29921915
Imaging in Lyme neuroborreliosis
Insights Imaging, 9 (5), 833-844
DOI 10.1007/s13244-018-0646-x, PubMed 30187265
Assessing genome-wide significance for the detection of differentially methylated regions
Stat Appl Genet Mol Biol, 17 (5)
DOI 10.1515/sagmb-2017-0050, PubMed 30231014
Increased DNA methylation of SLFN12 in CD4+ and CD8+ T cells from multiple sclerosis patients
PLoS One, 13 (10), e0206511
DOI 10.1371/journal.pone.0206511, PubMed 30379917
Restriction spectrum imaging of white matter and its relation to neurological disability in multiple sclerosis
Mult Scler, 25 (5), 687-698
DOI 10.1177/1352458518765671, PubMed 29542336
Publications 2017
Fatigue and cognition: Pupillary responses to problem-solving in early multiple sclerosis patients
Brain Behav, 7 (7), e00717
DOI 10.1002/brb3.717, PubMed 28729927
The interaction between smoking and HLA genes in multiple sclerosis: replication and refinement
Eur J Epidemiol, 32 (10), 909-919
DOI 10.1007/s10654-017-0250-2, PubMed 28597127
Fourteen sequence variants that associate with multiple sclerosis discovered by meta-analysis informed by genetic correlations
NPJ Genom Med, 2, 24
DOI 10.1038/s41525-017-0027-2, PubMed 29263835
Magnetic resonance imaging perfusion is associated with disease severity and activity in multiple sclerosis
Neuroradiology, 59 (7), 655-664
DOI 10.1007/s00234-017-1849-4, PubMed 28585082
Publications 2016
The multiple sclerosis susceptibility genes TAGAP and IL2RA are regulated by vitamin D in CD4+ T cells
Genes Immun, 17 (2), 118-27
DOI 10.1038/gene.2015.61, PubMed 26765264
From genetic associations to functional studies in multiple sclerosis
Eur J Neurol, 23 (5), 847-53
DOI 10.1111/ene.12981, PubMed 26948534
Multiple sclerosis risk loci and disease severity in 7,125 individuals from 10 studies
Neurol Genet, 2 (4), e87
DOI 10.1212/NXG.0000000000000087, PubMed 27540591
Multiple sclerosis risk loci and disease severity in 7,125 individuals from 10 studies
Neurol.-Genet., 2 (4), eB7
DOI 10.1212/NXG.00000000000000B7
Migraine and frequent tension-type headache are not associated with multiple sclerosis in a Norwegian case-control study
Mult Scler J Exp Transl Clin, 2, 2055217316682976
DOI 10.1177/2055217316682976, PubMed 28607748
Allelic imbalance of multiple sclerosis susceptibility genes IKZF3 and IQGAP1 in human peripheral blood
BMC Genet, 17, 59
DOI 10.1186/s12863-016-0367-4, PubMed 27080863
Power estimation for non-standardized multisite studies
Neuroimage, 134, 281-294
DOI 10.1016/j.neuroimage.2016.03.051, PubMed 27039700
[Not Available]
Tidsskr Nor Laegeforen, 136 (19), 1608
DOI 10.4045/tidsskr.16.0826, PubMed 27790879
[Not Available]
Tidsskr Nor Laegeforen, 136 (20), 1702
DOI 10.4045/tidsskr.16.0865, PubMed 27830899
[MRI in multiple sclerosis]
Tidsskr Nor Laegeforen, 136 (16), 1373-6
DOI 10.4045/tidsskr.15.1361, PubMed 27637059
MRI- investigations in multiple sclerosis
Tidsskr. Nor. Laegeforen., 136 (16), 1373-1376
Genetic overlap between multiple sclerosis and several cardiovascular disease risk factors
Mult Scler, 22 (14), 1783-1793
DOI 10.1177/1352458516635873, PubMed 26920376
Publications 2015
Comments on the review article 'Time trends in the incidence and prevalence of multiple sclerosis in Norway during eight decades'
Acta Neurol Scand, 132 (5), 364-7
DOI 10.1111/ane.12489, PubMed 26423981
Genome-wide DNA methylation profiles indicate CD8+ T cell hypermethylation in multiple sclerosis
PLoS One, 10 (3), e0117403
DOI 10.1371/journal.pone.0117403, PubMed 25734800
Genetic variants are major determinants of CSF antibody levels in multiple sclerosis
Brain, 138 (Pt 3), 632-43
DOI 10.1093/brain/awu405, PubMed 25616667
Multiple Sclerosis Risk Allele in CLEC16A Acts as an Expression Quantitative Trait Locus for CLEC16A and SOCS1 in CD4+ T Cells
PLoS One, 10 (7), e0132957
DOI 10.1371/journal.pone.0132957, PubMed 26203907
Class II HLA interactions modulate genetic risk for multiple sclerosis
Nat Genet, 47 (10), 1107-1113
DOI 10.1038/ng.3395, PubMed 26343388
A Longitudinal Study of Disability, Cognition and Gray Matter Atrophy in Early Multiple Sclerosis Patients According to Evidence of Disease Activity
PLoS One, 10 (8), e0135974
DOI 10.1371/journal.pone.0135974, PubMed 26280173
Eye and hand motor interactions with the Symbol Digit Modalities Test in early multiple sclerosis
Mult Scler Relat Disord, 4 (6), 585-9
DOI 10.1016/j.msard.2015.08.003, PubMed 26590666
Assessing the Power of Exome Chips
PLoS One, 10 (10), e0139642
DOI 10.1371/journal.pone.0139642, PubMed 26437075
Genome-Wide Association Study of Late-Onset Myasthenia Gravis: Confirmation of TNFRSF11A and Identification of ZBTB10 and Three Distinct HLA Associations
Mol Med, 21 (1), 769-781
DOI 10.2119/molmed.2015.00232, PubMed 26562150
Reduced perfusion in white matter lesions in multiple sclerosis
Eur J Radiol, 84 (12), 2605-12
DOI 10.1016/j.ejrad.2015.09.007, PubMed 26391230
Publications 2014
Genetic pleiotropy between multiple sclerosis and schizophrenia but not bipolar disorder: differential involvement of immune-related gene loci
Mol Psychiatry, 20 (2), 207-14
DOI 10.1038/mp.2013.195, PubMed 24468824
VAV1 and BAFF, via NFκB pathway, are genetic risk factors for myasthenia gravis
Ann Clin Transl Neurol, 1 (5), 329-39
DOI 10.1002/acn3.51, PubMed 25356403
High prevalence and no latitude gradient of multiple sclerosis in Norway
Mult Scler, 20 (13), 1780-2
DOI 10.1177/1352458514525871, PubMed 24603884
Prevalence of multiple sclerosis among immigrants in Norway
Mult Scler, 21 (6), 695-702
DOI 10.1177/1352458514554055, PubMed 25344371
Retinoic acid enhances the levels of IL-10 in TLR-stimulated B cells from patients with relapsing-remitting multiple sclerosis
J Neuroimmunol, 278, 11-8
DOI 10.1016/j.jneuroim.2014.11.019, PubMed 25595247
No association between multiple sclerosis and periodontitis after adjusting for smoking habits
Eur J Neurol, 22 (3), 588-90
DOI 10.1111/ene.12520, PubMed 25041906
Environmental exposures and the risk of multiple sclerosis investigated in a Norwegian case-control study
BMC Neurol, 14, 196
DOI 10.1186/s12883-014-0196-x, PubMed 25274070
Oligoclonal band phenotypes in MS differ in their HLA class II association, while specific KIR ligands at HLA class I show association to MS in general
J Neuroimmunol, 274 (1-2), 174-9
DOI 10.1016/j.jneuroim.2014.06.024, PubMed 25037176
Cortical thickness and surface area relate to specific symptoms in early relapsing-remitting multiple sclerosis
Mult Scler, 21 (4), 402-14
DOI 10.1177/1352458514543811, PubMed 25139946
Hereditary diffuse leukoencephalopathy with spheroids with phenotype of primary progressive multiple sclerosis
Eur J Neurol, 22 (2), 328-333
DOI 10.1111/ene.12572, PubMed 25311247
Identity-by-descent mapping in a Scandinavian multiple sclerosis cohort
Eur J Hum Genet, 23 (5), 688-92
DOI 10.1038/ejhg.2014.155, PubMed 25159868
Publications 2013
No evidence of association between mutant alleles of the CYP27B1 gene and multiple sclerosis
Ann Neurol, 73 (3), 430-2
DOI 10.1002/ana.23833, PubMed 23444327
Increased disease severity in non-Western immigrants with multiple sclerosis in Oslo, Norway
Eur J Neurol, 20 (12), 1546-52
DOI 10.1111/ene.12227, PubMed 23834430
From Identification to Characterization of the Multiple Sclerosis Susceptibility Gene CLEC16A
Int J Mol Sci, 14 (3), 4476-97
DOI 10.3390/ijms14034476, PubMed 23439554
Sex and gender issues in multiple sclerosis
Ther Adv Neurol Disord, 6 (4), 237-48
DOI 10.1177/1756285613488434, PubMed 23858327
Oligoclonal bands and age at onset correlate with genetic risk score in multiple sclerosis
Mult Scler, 20 (6), 660-8
DOI 10.1177/1352458513506503, PubMed 24099750
A one year follow-up study of natural killer and dendritic cells activities in multiple sclerosis patients receiving glatiramer acetate (GA)
PLoS One, 8 (4), e62237
DOI 10.1371/journal.pone.0062237, PubMed 23614042
Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis
Nat Genet, 45 (11), 1353-60
DOI 10.1038/ng.2770, PubMed 24076602
Genetic risk variants in African Americans with multiple sclerosis
Neurology, 81 (3), 219-27
DOI 10.1212/WNL.0b013e31829bfe2f, PubMed 23771490
Association of genetic markers with CSF oligoclonal bands in multiple sclerosis patients
PLoS One, 8 (6), e64408
DOI 10.1371/journal.pone.0064408, PubMed 23785401
Oligoclonal band status in Scandinavian multiple sclerosis patients is associated with specific genetic risk alleles
PLoS One, 8 (3), e58352
DOI 10.1371/journal.pone.0058352, PubMed 23472185
Publications 2012
Association between DPP6 polymorphism and the risk of progressive multiple sclerosis in Northern and Southern Europeans
Neurosci Lett, 530 (2), 155-60
DOI 10.1016/j.neulet.2012.10.008, PubMed 23069673
The genetics of multiple sclerosis: an up-to-date review
Immunol Rev, 248 (1), 87-103
DOI 10.1111/j.1600-065X.2012.01134.x, PubMed 22725956
Risk for myasthenia gravis maps to a (151) Pro→Ala change in TNIP1 and to human leukocyte antigen-B*08
Ann Neurol, 72 (6), 927-35
DOI 10.1002/ana.23691, PubMed 23055271
From genes to characteristics of multiple sclerosis
Acta Neurol Scand Suppl (195), 76-83
DOI 10.1111/ane.12027, PubMed 23278661
Multiple sclerosis-associated single-nucleotide polymorphisms in CLEC16A correlate with reduced SOCS1 and DEXI expression in the thymus
Genes Immun, 14 (1), 62-6
DOI 10.1038/gene.2012.52, PubMed 23151489
Importance of human leukocyte antigen (HLA) class I and II alleles on the risk of multiple sclerosis
PLoS One, 7 (5), e36779
DOI 10.1371/journal.pone.0036779, PubMed 22586495
Smoking and socio-economic status may affect myasthenia gravis
Eur J Neurol, 20 (3), 453-460
DOI 10.1111/j.1468-1331.2012.03843.x, PubMed 22934661
Late onset myasthenia gravis is associated with HLA DRB1*15:01 in the Norwegian population
PLoS One, 7 (5), e36603
DOI 10.1371/journal.pone.0036603, PubMed 22590574
A genome-wide association study in progressive multiple sclerosis
Mult Scler, 18 (10), 1384-94
DOI 10.1177/1352458512439118, PubMed 22457343
Polymorphisms of the BDNF gene show neither association with multiple sclerosis susceptibility nor clinical course
J Neuroimmunol, 244 (1-2), 107-10
DOI 10.1016/j.jneuroim.2012.01.011, PubMed 22341604
Publications 2011
EFNS guidelines for the molecular diagnosis of neurogenetic disorders: motoneuron, peripheral nerve and muscle disorders
Eur J Neurol, 18 (2), 207-217
DOI 10.1111/j.1468-1331.2010.03069.x, PubMed 20500522
Genetic association of multiple sclerosis with the marker rs391745 near the endogenous retroviral locus HERV-Fc1: analysis of disease subtypes
PLoS One, 6 (10), e26438
DOI 10.1371/journal.pone.0026438, PubMed 22039488
[New gene map for multiple sclerosis]
Tidsskr Nor Laegeforen, 131 (21), 2126-30
DOI 10.4045/tidsskr.10.0823, PubMed 22048209
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis
Nature, 476 (7359), 214-9
DOI 10.1038/nature10251, PubMed 21833088
No influence on disease progression of non-HLA susceptibility genes in MS
J Neuroimmunol, 237 (1-2), 98-100
DOI 10.1016/j.jneuroim.2011.05.003, PubMed 21742385
Identification of human NK17/NK1 cells
PLoS One, 6 (10), e26780
DOI 10.1371/journal.pone.0026780, PubMed 22039549
Alterations in KLRB1 gene expression and a Scandinavian multiple sclerosis association study of the KLRB1 SNP rs4763655
Eur J Hum Genet, 19 (10), 1100-3
DOI 10.1038/ejhg.2011.88, PubMed 21610746
Publications 2010
IL-22RA2 associates with multiple sclerosis and macrophage effector mechanisms in experimental neuroinflammation
J Immunol, 185 (11), 6883-90
DOI 10.4049/jimmunol.1001392, PubMed 21041731
EFNS guidelines on the molecular diagnosis of channelopathies, epilepsies, migraine, stroke, and dementias
Eur J Neurol, 17 (5), 641-8
DOI 10.1111/j.1468-1331.2010.02985.x, PubMed 20298421
[Treatment of multiple sclerosis]
Tidsskr Nor Laegeforen, 130 (9), 923; author reply 923
DOI 10.4045/tidsskr.10.0346, PubMed 20453948
Lack of support for association between the KIF1B rs10492972[C] variant and multiple sclerosis
Nat Genet, 42 (6), 469-70; author reply 470-1
DOI 10.1038/ng0610-469, PubMed 20502484
Genome-wide association study in a high-risk isolate for multiple sclerosis reveals associated variants in STAT3 gene
Am J Hum Genet, 86 (2), 285-91
DOI 10.1016/j.ajhg.2010.01.017, PubMed 20159113
Two HLA class I genes independently associated with multiple sclerosis
J Neuroimmunol, 226 (1-2), 172-6
DOI 10.1016/j.jneuroim.2010.07.006, PubMed 20678810
Association to the Glypican-5 gene in multiple sclerosis
J Neuroimmunol, 226 (1-2), 194-7
DOI 10.1016/j.jneuroim.2010.07.003, PubMed 20692050
Exploring the CLEC16A gene reveals a MS-associated variant with correlation to the relative expression of CLEC16A isoforms in thymus
Genes Immun, 12 (3), 191-8
DOI 10.1038/gene.2010.59, PubMed 21179112
RGMA and IL21R show association with experimental inflammation and multiple sclerosis
Genes Immun, 11 (4), 279-93
DOI 10.1038/gene.2009.111, PubMed 20072140
Publications 2009
Replication analysis identifies TYK2 as a multiple sclerosis susceptibility factor
Eur J Hum Genet, 17 (10), 1309-13
DOI 10.1038/ejhg.2009.41, PubMed 19293837
EFNS guidelines on the molecular diagnosis of mitochondrial disorders
Eur J Neurol, 16 (12), 1255-64
DOI 10.1111/j.1468-1331.2009.02811.x, PubMed 19950421
EFNS guidelines on the molecular diagnosis of ataxias and spastic paraplegias
Eur J Neurol, 17 (2), 179-88
DOI 10.1111/j.1468-1331.2009.02873.x, PubMed 20050888
EFNS guidelines on the molecular diagnosis of neurogenetic disorders: general issues, Huntington's disease, Parkinson's disease and dystonias
Eur J Neurol, 16 (7), 777-85
DOI 10.1111/j.1468-1331.2009.02646.x, PubMed 19469830
Norwegian Sami differs significantly from other Norwegians according to their HLA profile
Tissue Antigens, 75 (3), 207-17
DOI 10.1111/j.1399-0039.2009.01425.x, PubMed 20047643
Genetic and molecular approaches to the immunopathogenesis of multiple sclerosis: an update
Curr Mol Med, 9 (5), 591-611
DOI 10.2174/156652409788488793, PubMed 19601809
A role for VAV1 in experimental autoimmune encephalomyelitis and multiple sclerosis
Sci Transl Med, 1 (10), 10ra21
DOI 10.1126/scitranslmed.3000278, PubMed 20368159
Use of a genetic isolate to identify rare disease variants: C7 on 5p associated with MS
Hum Mol Genet, 18 (9), 1670-83
DOI 10.1093/hmg/ddp073, PubMed 19221116
MYO9B polymorphisms in multiple sclerosis
Eur J Hum Genet, 17 (6), 840-3
DOI 10.1038/ejhg.2008.251, PubMed 19142207
Killer immunoglobulin-like receptor ligand HLA-Bw4 protects against multiple sclerosis
Ann Neurol, 65 (6), 658-66
DOI 10.1002/ana.21695, PubMed 19630074
A rare variant of the TYK2 gene is confirmed to be associated with multiple sclerosis
Eur J Hum Genet, 18 (4), 502-4
DOI 10.1038/ejhg.2009.195, PubMed 19888296
HLA-DRB1 and month of birth in multiple sclerosis
Neurology, 73 (24), 2107-11
DOI 10.1212/WNL.0b013e3181c679f3, PubMed 20018638
Publications 2008
The SH2D2A gene and susceptibility to multiple sclerosis
J Neuroimmunol, 197 (2), 152-8
DOI 10.1016/j.jneuroim.2008.04.037, PubMed 18554728
Environmental risk factors in multiple sclerosis
Acta Neurol Scand Suppl, 188, 34-40
DOI 10.1111/j.1600-0404.2008.01029.x, PubMed 18439219
Publications 2007
A follow-up study of Nordic multiple sclerosis candidate gene regions
Mult Scler, 13 (5), 584-9
DOI 10.1177/1352458506071790, PubMed 17548436
[Multiple sclerosis biobank established]
Tidsskr Nor Laegeforen, 127 (17), 2276
PubMed 17828328
Genetics in multiple sclerosis: past and future perspectives
Acta Neurol Scand Suppl, 187, 34-8
DOI 10.1111/j.1600-0404.2007.00843.x, PubMed 17419826
Low frequency of the disease-associated DRB1*15-DQB1*06 haplotype may contribute to the low prevalence of multiple sclerosis in Sami
Tissue Antigens, 69 (4), 299-304
DOI 10.1111/j.1399-0039.2007.00803.x, PubMed 17389012
Familial effects on the clinical course of multiple sclerosis
Neurology, 68 (5), 376-83
DOI 10.1212/01.wnl.0000252822.53506.46, PubMed 17261686
X chromosome inactivation in females with multiple sclerosis
Eur J Neurol, 14 (12), 1392-6
DOI 10.1111/j.1468-1331.2007.01987.x, PubMed 17970735
Variation in interleukin 7 receptor alpha chain (IL7R) influences risk of multiple sclerosis
Nat Genet, 39 (9), 1108-13
DOI 10.1038/ng2106, PubMed 17660816
The impact of HLA-A and -DRB1 on age at onset, disease course and severity in Scandinavian multiple sclerosis patients
Eur J Neurol, 14 (8), 835-40
DOI 10.1111/j.1468-1331.2007.01825.x, PubMed 17662002
Marked differences in prevalence of multiple sclerosis between ethnic groups in Oslo, Norway
J Neurol, 255 (1), 49-55
DOI 10.1007/s00415-007-0659-8, PubMed 18080855
Publications 2006
Linkage disequilibrium screening for multiple sclerosis implicates JAG1 and POU2AF1 as susceptibility genes in Europeans
J Neuroimmunol, 179 (1-2), 108-16
DOI 10.1016/j.jneuroim.2006.06.003, PubMed 16934875
Coding region polymorphisms in T cell signal transduction genes. Prevalence and association to development of multiple sclerosis
J Neuroimmunol, 177 (1-2), 40-5
DOI 10.1016/j.jneuroim.2006.04.021, PubMed 16764945
Association analysis of the LAG3 and CD4 genes in multiple sclerosis in two independent populations
J Neuroimmunol, 180 (1-2), 193-8
DOI 10.1016/j.jneuroim.2006.08.009, PubMed 17020785
No major effect of the CD28/CTLA4/ICOS gene region on susceptibility to primary sclerosing cholangitis
Scand J Gastroenterol, 41 (5), 586-91
DOI 10.1080/00365520500377870, PubMed 16638702
Publications 2005
Lack of association with the CD28/CTLA4/ICOS gene region among Norwegian multiple sclerosis patients
J Neuroimmunol, 166 (1-2), 197-201
DOI 10.1016/j.jneuroim.2005.06.002, PubMed 16005527
A high-density screen for linkage in multiple sclerosis
Am J Hum Genet, 77 (3), 454-67
DOI 10.1086/444547, PubMed 16080120
Systemic lupus erythematosus and the extended major histocompatibility complex--evidence for several predisposing loci
Rheumatology (Oxford), 44 (11), 1368-73
DOI 10.1093/rheumatology/kei015, PubMed 16174649
Ethnic variations of IL-10 polymorphisms in a Sami and Norwegian population
Scand J Immunol, 62 (1), 71-4
DOI 10.1111/j.1365-3083.2005.01635.x, PubMed 16091126
Ethnic variation of Fc gamma receptor polymorphism in Sami and Norwegian populations
Immunology, 115 (3), 416-21
DOI 10.1111/j.1365-2567.2005.02158.x, PubMed 15946259
Publications 2004
Genes in the HLA class I region may contribute to the HLA class II-associated genetic susceptibility to multiple sclerosis
Tissue Antigens, 63 (3), 237-47
DOI 10.1111/j.0001-2815.2004.00173.x, PubMed 14989713
Concordance for disease course and age of onset in Scandinavian multiple sclerosis coaffected sib pairs
Mult Scler, 10 (1), 5-8
DOI 10.1191/1352458504ms975oa, PubMed 14760946
Publications 2003
Refining the linkage analysis on chromosome 10 in 449 sib-pairs with multiple sclerosis
J Neuroimmunol, 143 (1-2), 31-8
DOI 10.1016/j.jneuroim.2003.08.008, PubMed 14575911
Two genome-wide linkage disequilibrium screens in Scandinavian multiple sclerosis patients
J Neuroimmunol, 143 (1-2), 101-6
DOI 10.1016/j.jneuroim.2003.08.021, PubMed 14575924
[Multiple sclerosis--a disease with complex genetics]
Tidsskr Nor Laegeforen, 123 (19), 2723-6
PubMed 14600746
Publications 2002
A genome-wide screen for linkage in Nordic sib-pairs with multiple sclerosis
Genes Immun, 3 (5), 279-85
DOI 10.1038/sj.gene.6363866, PubMed 12140746
Publications 2001
The T cell regulator gene SH2D2A contributes to the genetic susceptibility of multiple sclerosis
Genes Immun, 2 (5), 263-8
DOI 10.1038/sj.gene.6363774, PubMed 11528519
Analysis of an interferon-gamma gene dinucleotide-repeat polymorphism in Nordic multiple sclerosis patients
Mult Scler, 7 (3), 157-63
DOI 10.1177/135245850100700304, PubMed 11475438
Altered ovarian function and cardiovascular risk factors in valproate-treated women
Am J Med, 111 (4), 290-6
DOI 10.1016/s0002-9343(01)00806-3, PubMed 11566460
Publications 2000
Sex and age at diagnosis are correlated with the HLA-DR2, DQ6 haplotype in multiple sclerosis
J Neurol Sci, 178 (2), 132-5
DOI 10.1016/s0022-510x(00)00389-0, PubMed 11018705
Linkage analysis of a candidate region in Scandinavian sib pairs with multiple sclerosis reveals linkage to chromosome 17q
Genes Immun, 1 (7), 456-9
DOI 10.1038/sj.gene.6363705, PubMed 11196677
Publications 1999
CTLA4 promoter and exon 1 dimorphisms in multiple sclerosis
Tissue Antigens, 53 (1), 106-10
DOI 10.1034/j.1399-0039.1999.530112.x, PubMed 10082437
Long-term valproate treatment induces changes in ovarian morphology and serum sex steroid hormone levels in female Wistar rats
Seizure, 8 (8), 490-3
DOI 10.1053/seiz.1999.0342, PubMed 10627413
Publications 1996
[Brain abscess. A difficult diagnosis?]
Tidsskr Nor Laegeforen, 116 (7), 866-8
PubMed 8644101