Øyvind Molberg
- Professor
- +47 23 07 33 24
Publications 2024
Unraveling the Genetics of Shared Clinical and Serological Manifestations in Patients With Systemic Inflammatory Autoimmune Diseases
Arthritis Rheumatol (in press)
DOI 10.1002/art.42988, PubMed 39284741
Risk loci involved in giant cell arteritis susceptibility: a genome-wide association study
Lancet Rheumatol, 6 (6), e374-e383
DOI 10.1016/S2665-9913(24)00064-X, PubMed 38734017
Declining Incidence of Systemic Lupus Erythematosus in Norway 1999-2017: Data From a Population Cohort Identified by International Classification of Diseases, 10th Revision Code and Verified by Classification
Arthritis Rheumatol, 76 (5), 715-725
DOI 10.1002/art.42775, PubMed 38108106
Sensitivity of classification criteria from time of diagnosis in an incident systemic lupus erythematosus cohort: a population-based study from Norway
RMD Open, 10 (3)
DOI 10.1136/rmdopen-2024-004395, PubMed 39160088
Tubulin beta 5 is not the target of antineutrophil antibodies in primary sclerosing cholangitis
Clin Exp Immunol, 218 (1), 75-77
DOI 10.1093/cei/uxae053, PubMed 38960384
Vascular ultrasound as a follow-up tool in patients with giant cell arteritis: a prospective observational cohort study
Front Med (Lausanne), 11, 1436707
DOI 10.3389/fmed.2024.1436707, PubMed 39135716
Persisting mortality gap in systemic lupus erythematosus; a population-based study on juvenile- and adult-onset SLE in Norway 1999-2022
Rheumatology (Oxford), 63 (8), 2109-2117
DOI 10.1093/rheumatology/kead519, PubMed 37769251
Reply
Arthritis Rheumatol (in press)
DOI 10.1002/art.43031, PubMed 39415494
Discovery of new myositis genetic associations through leveraging other immune-mediated diseases
HGG Adv, 5 (4), 100336
DOI 10.1016/j.xhgg.2024.100336, PubMed 39044428
Meta-analyses uncover the genetic architecture of Idiopathic Inflammatory Myopathies
Arthritis Rheumatol (in press)
DOI 10.1002/art.43088, PubMed 39679859
Publications 2023
Cardiac dysfunction in mixed connective tissue disease: a nationwide observational study
Rheumatol Int, 43 (6), 1055-1065
DOI 10.1007/s00296-023-05308-3, PubMed 36933069
Extended ultrasound examination identifies more large vessel involvement in patients with giant cell arteritis
Rheumatology (Oxford), 62 (5), 1887-1894
DOI 10.1093/rheumatology/keac478, PubMed 35997556
B cell polygenic risk scores associate with anti-dsDNA antibodies and nephritis in systemic lupus erythematosus
Lupus Sci Med, 10 (2)
DOI 10.1136/lupus-2023-000926, PubMed 37844960
Adipokine profile in long-term juvenile dermatomyositis, and associations with adipose tissue distribution and cardiac function: a cross-sectional study
RMD Open, 9 (1)
DOI 10.1136/rmdopen-2022-002815, PubMed 36828644
Identification of Novel Associations and Localization of Signals in Idiopathic Inflammatory Myopathies Using Genome-Wide Imputation
Arthritis Rheumatol, 75 (6), 1021-1027
DOI 10.1002/art.42434, PubMed 36580032
Effects of faecal microbiota transplantation on the small intestinal mucosa in systemic sclerosis
Rheumatology (Oxford), 62 (8), 2918-2929
DOI 10.1093/rheumatology/kead014, PubMed 36688692
Differential sensitivity of the 2020 revised comprehensive diagnostic criteria and the 2019 ACR/EULAR classification criteria across IgG4-related disease phenotypes: results from a Norwegian cohort
Arthritis Res Ther, 25 (1), 163
DOI 10.1186/s13075-023-03155-y, PubMed 37670401
Publications 2022
Treatment Response to Tumor Necrosis Factor Inhibitors and Methotrexate Monotherapy in Adults With Juvenile Idiopathic Arthritis: Data From NOR-DMARD
J Rheumatol, 50 (4), 538-547
DOI 10.3899/jrheum.220645, PubMed 36379571
Target organ expression and biomarker characterization of chemokine CCL21 in systemic sclerosis associated pulmonary arterial hypertension
Front Immunol, 13, 991743
DOI 10.3389/fimmu.2022.991743, PubMed 36211384
Complement C4 Copy Number Variation is Linked to SSA/Ro and SSB/La Autoantibodies in Systemic Inflammatory Autoimmune Diseases
Arthritis Rheumatol, 74 (8), 1440-1450
DOI 10.1002/art.42122, PubMed 35315244
Serum markers of cardiac complications in a systemic sclerosis cohort
Sci Rep, 12 (1), 4661
DOI 10.1038/s41598-022-08815-8, PubMed 35304587
Gastrointestinal symptom severity and progression in systemic sclerosis
Rheumatology (Oxford), 61 (10), 4024-4034
DOI 10.1093/rheumatology/keac118, PubMed 35238377
Body composition in long-standing juvenile dermatomyositis: associations with disease activity, muscle strength and cardiometabolic measures
Rheumatology (Oxford), 61 (7), 2959-2968
DOI 10.1093/rheumatology/keab805, PubMed 34718443
Publications 2021
Contribution of Rare Genetic Variation to Disease Susceptibility in a Large Scandinavian Myositis Cohort
Arthritis Rheumatol, 74 (2), 342-352
DOI 10.1002/art.41929, PubMed 34279065
Variants in BANK1 are associated with lupus nephritis of European ancestry
Genes Immun, 22 (3), 194-202
DOI 10.1038/s41435-021-00142-8, PubMed 34127828
Association of Lymphangiogenic Factors With Pulmonary Arterial Hypertension in Systemic Sclerosis
Arthritis Rheumatol, 73 (7), 1277-1287
DOI 10.1002/art.41665, PubMed 33497027
Safety and efficacy of faecal microbiota transplantation by Anaerobic Cultivated Human Intestinal Microbiome (ACHIM) in patients with systemic sclerosis: study protocol for the randomised controlled phase II ReSScue trial
BMJ Open, 11 (6), e048541
DOI 10.1136/bmjopen-2020-048541, PubMed 34168032
Impact of baseline clinical and radiological features on outcome of chronic rhinosinusitis in granulomatosis with polyangiitis
Arthritis Res Ther, 23 (1), 18
DOI 10.1186/s13075-020-02401-x, PubMed 33430923
Small intestinal biopsy findings consistent with celiac disease in patients with idiopathic inflammatory myopathy: Review of existing literature
Semin Arthritis Rheum, 51 (5), 1033-1044
DOI 10.1016/j.semarthrit.2021.07.012, PubMed 34416625
Interaction between the STAT4 rs11889341(T) risk allele and smoking confers increased risk of myocardial infarction and nephritis in patients with systemic lupus erythematosus
Ann Rheum Dis, 80 (9), 1183-1189
DOI 10.1136/annrheumdis-2020-219727, PubMed 33766895
Long-Term Outcome in Systemic Lupus Erythematosus; Knowledge from Population-Based Cohorts
J Clin Med, 10 (19)
DOI 10.3390/jcm10194306, PubMed 34640322
Lung CD4+ T-cells in patients with lung fibrosis produce pro-fibrotic interleukin-13 together with interferon-γ
Eur Respir J, 57 (3)
DOI 10.1183/13993003.00983-2020, PubMed 33154027
Publications 2020
Fecal microbiota transplantation in systemic sclerosis: A double-blind, placebo-controlled randomized pilot trial
PLoS One, 15 (5), e0232739
DOI 10.1371/journal.pone.0232739, PubMed 32437393
Multidimensional tracking of phenotypes and organ involvement in a complete nationwide systemic sclerosis cohort
Rheumatology (Oxford), 59 (10), 2920-2929
DOI 10.1093/rheumatology/keaa026, PubMed 32097470
The potential of fecal microbiota transplantation in systemic sclerosis
Expert Rev Clin Immunol, 16 (2), 117-118
DOI 10.1080/1744666X.2019.1707665, PubMed 31858856
Detection, screening, and classification of interstitial lung disease in patients with systemic sclerosis
Curr Opin Rheumatol, 32 (6), 497-504
DOI 10.1097/BOR.0000000000000741, PubMed 32890027
Impact of Paranasal Sinus Surgery in Granulomatosis With Polyangiitis: A Longitudinal Computed Tomography Study
Laryngoscope, 130 (8), E460-E468
DOI 10.1002/lary.28639, PubMed 32243590
Molecular pathways in patients with systemic lupus erythematosus revealed by gene-centred DNA sequencing
Ann Rheum Dis, 80 (1), 109-117
DOI 10.1136/annrheumdis-2020-218636, PubMed 33037003
Longitudinal Characterisation of the Gastrointestinal Tract Microbiome in Systemic Sclerosis
Eur Med J (Chelmsf), 7, 110-118
DOI 10.33590/emj/20-00043, PubMed 36711108
Publications 2019
Influence of Antisynthetase Antibodies Specificities on Antisynthetase Syndrome Clinical Spectrum Time Course
J Clin Med, 8 (11)
DOI 10.3390/jcm8112013, PubMed 31752231
Distinct phenotype of CD4+ T cells driving celiac disease identified in multiple autoimmune conditions
Nat Med, 25 (5), 734-737
DOI 10.1038/s41591-019-0403-9, PubMed 30911136
Performance of Candidate Serum Biomarkers for Systemic Sclerosis-Associated Interstitial Lung Disease
Arthritis Rheumatol, 71 (6), 972-982
DOI 10.1002/art.40815, PubMed 30624031
Mortality and causes of death across the systemic connective tissue diseases and the primary systemic vasculitides
Rheumatology (Oxford), 58 (2), 313-320
DOI 10.1093/rheumatology/key285, PubMed 30281089
Reply
Arthritis Rheumatol, 71 (4), 655-656
DOI 10.1002/art.40816, PubMed 30663863
Tracking Impact of Interstitial Lung Disease in Systemic Sclerosis in a Complete Nationwide Cohort
Am J Respir Crit Care Med, 200 (10), 1258-1266
DOI 10.1164/rccm.201903-0486OC, PubMed 31310156
Development of CT-based methods for longitudinal analyses of paranasal sinus osteitis in granulomatosis with polyangiitis
BMC Med Imaging, 19 (1), 13
DOI 10.1186/s12880-019-0315-7, PubMed 30717680
Assessing the relative impact of lupus nephritis on mortality in a population-based systemic lupus erythematosus cohort
Lupus, 28 (7), 818-825
DOI 10.1177/0961203319847275, PubMed 31072277
Physical Fitness in Patients With Oligoarticular and Polyarticular Juvenile Idiopathic Arthritis Diagnosed in the Era of Biologics: A Controlled Cross-Sectional Study
Arthritis Care Res (Hoboken), 71 (12), 1611-1620
DOI 10.1002/acr.23818, PubMed 30474929
Focused HLA analysis in Caucasians with myositis identifies significant associations with autoantibody subgroups
Ann Rheum Dis, 78 (7), 996-1002
DOI 10.1136/annrheumdis-2019-215046, PubMed 31138531
Systolic Dysfunction in Systemic Sclerosis: Prevalence and Prognostic Implications
ACR Open Rheumatol, 1 (4), 258-266
DOI 10.1002/acr2.1037, PubMed 31777802
Publications 2018
Lack of Association among Peptidyl Arginine Deiminase Type 4 Autoantibodies, PADI4 Polymorphisms, and Clinical Characteristics in Rheumatoid Arthritis
J Rheumatol, 45 (9), 1211-1219
DOI 10.3899/jrheum.170769, PubMed 29858238
Frequencies of borderline pulmonary hypertension before and after the DETECT algorithm: results from a prospective systemic sclerosis cohort
Rheumatology (Oxford), 57 (3), 480-487
DOI 10.1093/rheumatology/kex435, PubMed 29237073
CCL21 as a Potential Serum Biomarker for Pulmonary Arterial Hypertension in Systemic Sclerosis
Arthritis Rheumatol, 70 (10), 1644-1653
DOI 10.1002/art.40534, PubMed 29687634
CCL21 as a potential biomarker for pulmonary arterial hypertension in systemic sclerosis
Arthritis Rheumatol (in press)
DOI 10.1002/art.40740, PubMed 30281215
Augmented concentrations of CX3CL1 are associated with interstitial lung disease in systemic sclerosis
PLoS One, 13 (11), e0206545
DOI 10.1371/journal.pone.0206545, PubMed 30457999
Differential expression of vitamin D associated genes in the aorta of coronary artery disease patients with and without rheumatoid arthritis
PLoS One, 13 (8), e0202346
DOI 10.1371/journal.pone.0202346, PubMed 30138371
Progression and mortality of interstitial lung disease in mixed connective tissue disease: a long-term observational nationwide cohort study
Rheumatology (Oxford), 57 (2), 255-262
DOI 10.1093/rheumatology/kex077, PubMed 28379478
Physical activity in patients with oligo- and polyarticular juvenile idiopathic arthritis diagnosed in the era of biologics: a controlled cross-sectional study
Pediatr Rheumatol Online J, 16 (1), 64
DOI 10.1186/s12969-018-0281-6, PubMed 30333025
Left Ventricular Diastolic Dysfunction Predicts Mortality in Patients With Systemic Sclerosis
J Am Coll Cardiol, 72 (15), 1804-1813
DOI 10.1016/j.jacc.2018.07.068, PubMed 30286924
Publications 2017
Comparative analyses of muscle MRI and muscular function in anti-synthetase syndrome patients and matched controls: a cross-sectional study
Arthritis Res Ther, 19 (1), 17
DOI 10.1186/s13075-017-1219-y, PubMed 28122635
Role of Stromelysin 2 (Matrix Metalloproteinase 10) as a Novel Mediator of Vascular Remodeling Underlying Pulmonary Hypertension Associated With Systemic Sclerosis
Arthritis Rheumatol, 69 (11), 2209-2221
DOI 10.1002/art.40229, PubMed 28805015
TNF inhibitors appear to inhibit disease progression and improve outcome in Takayasu arteritis; an observational, population-based time trend study
Arthritis Res Ther, 19 (1), 99
DOI 10.1186/s13075-017-1316-y, PubMed 28521841
Takayasu Arteritis and Pregnancy: A Population-Based Study on Outcomes and Mother/Child-Related Concerns
Arthritis Care Res (Hoboken), 69 (9), 1384-1390
DOI 10.1002/acr.23146, PubMed 27813289
Cardiopulmonary Disease Development in Anti-RNA Polymerase III-positive Systemic Sclerosis: Comparative Analyses from an Unselected, Prospective Patient Cohort
J Rheumatol, 44 (4), 459-465
DOI 10.3899/jrheum.160867, PubMed 28089974
Disease evolution in mixed connective tissue disease: results from a long-term nationwide prospective cohort study
Arthritis Res Ther, 19 (1), 284
DOI 10.1186/s13075-017-1494-7, PubMed 29268795
Immune-Array Analysis in Sporadic Inclusion Body Myositis Reveals HLA-DRB1 Amino Acid Heterogeneity Across the Myositis Spectrum
Arthritis Rheumatol, 69 (5), 1090-1099
DOI 10.1002/art.40045, PubMed 28086002
Systemic sclerosis is associated with specific alterations in gastrointestinal microbiota in two independent cohorts
BMJ Open Gastroenterol, 4 (1), e000134
DOI 10.1136/bmjgast-2017-000134, PubMed 28761687
Publications 2016
Pulmonary Involvement in the Antisynthetase Syndrome: A Comparative Cross-sectional Study
J Rheumatol, 43 (6), 1107-13
DOI 10.3899/jrheum.151067, PubMed 27036381
A Genome-wide Association Study Identifies Risk Alleles in Plasminogen and P4HA2 Associated with Giant Cell Arteritis
Am J Hum Genet, 100 (1), 64-74
DOI 10.1016/j.ajhg.2016.11.013, PubMed 28041642
OX40L blockade protects against inflammation-driven fibrosis
Proc Natl Acad Sci U S A, 113 (27), E3901-10
DOI 10.1073/pnas.1523512113, PubMed 27298374
Prevalence, Incidence, and Disease Characteristics of Takayasu Arteritis by Ethnic Background: Data From a Large, Population-Based Cohort Resident in Southern Norway
Arthritis Care Res (Hoboken), 69 (2), 278-285
DOI 10.1002/acr.22931, PubMed 27159262
Mixed connective tissue disease
Best Pract Res Clin Rheumatol, 30 (1), 95-111
DOI 10.1016/j.berh.2016.03.002, PubMed 27421219
High Level of Chemokine CCL18 Is Associated With Pulmonary Function Deterioration, Lung Fibrosis Progression, and Reduced Survival in Systemic Sclerosis
Chest, 150 (2), 299-306
DOI 10.1016/j.chest.2016.03.004, PubMed 26997242
Antineutrophil antibodies define clinical and genetic subgroups in primary sclerosing cholangitis
Liver Int, 37 (3), 458-465
DOI 10.1111/liv.13238, PubMed 27558072
Brief Report: IRF4 Newly Identified as a Common Susceptibility Locus for Systemic Sclerosis and Rheumatoid Arthritis in a Cross-Disease Meta-Analysis of Genome-Wide Association Studies
Arthritis Rheumatol, 68 (9), 2338-44
DOI 10.1002/art.39730, PubMed 27111665
Epidemiology of sporadic inclusion body myositis
Curr Opin Rheumatol, 28 (6), 657-60
DOI 10.1097/BOR.0000000000000327, PubMed 27541181
Interstitial lung disease in systemic sclerosis: progress in screening and early diagnosis
Curr Opin Rheumatol, 28 (6), 613-8
DOI 10.1097/BOR.0000000000000323, PubMed 27387267
Plasma vitamin D levels and inflammation in the aortic wall of patients with coronary artery disease with and without inflammatory rheumatic disease
Scand J Rheumatol, 46 (3), 198-205
DOI 10.3109/03009742.2016.1172664, PubMed 27379927
Endostatin is higher and associated with pulmonary involvement in primary Sjögren's syndrome
Clin Exp Rheumatol, 34 (4), 690-3
PubMed 27214260
T-helper signals restore B-cell receptor signaling in autoreactive anergic B cells by upregulating CD45 phosphatase activity
J Allergy Clin Immunol, 138 (3), 839-851.e8
DOI 10.1016/j.jaci.2016.01.035, PubMed 27056269
Publications 2015
Long-term experience with rituximab in anti-synthetase syndrome-related interstitial lung disease
Rheumatology (Oxford), 54 (8), 1420-8
DOI 10.1093/rheumatology/kev004, PubMed 25740830
A large-scale genetic analysis reveals a strong contribution of the HLA class II region to giant cell arteritis susceptibility
Am J Hum Genet, 96 (4), 565-80
DOI 10.1016/j.ajhg.2015.02.009, PubMed 25817017
Survival and cancer risk in an unselected and complete Norwegian idiopathic inflammatory myopathy cohort
Semin Arthritis Rheum, 45 (3), 301-8
DOI 10.1016/j.semarthrit.2015.06.005, PubMed 26190563
Associations between anti-Ro52 antibodies and lung fibrosis in mixed connective tissue disease
Rheumatology (Oxford), 55 (1), 103-8
DOI 10.1093/rheumatology/kev300, PubMed 26320136
Predictive value of serial high-resolution computed tomography analyses and concurrent lung function tests in systemic sclerosis
Arthritis Rheumatol, 67 (8), 2205-12
DOI 10.1002/art.39166, PubMed 25916462
Associations between circulating endostatin levels and vascular organ damage in systemic sclerosis and mixed connective tissue disease: an observational study
Arthritis Res Ther, 17 (1), 231
DOI 10.1186/s13075-015-0756-5, PubMed 26315510
Dense genotyping of immune-related loci in idiopathic inflammatory myopathies confirms HLA alleles as the strongest genetic risk factor and suggests different genetic background for major clinical subgroups
Ann Rheum Dis, 75 (8), 1558-66
DOI 10.1136/annrheumdis-2015-208119, PubMed 26362759
Publications 2014
Arterial haemodynamics and coronary artery calcification in adult patients with juvenile idiopathic arthritis
Ann Rheum Dis, 74 (8), 1515-21
DOI 10.1136/annrheumdis-2013-204804, PubMed 24695010
Prevalence and clinical characteristics of adult polymyositis and dermatomyositis; data from a large and unselected Norwegian cohort
Ann Rheum Dis, 74 (8), 1551-6
DOI 10.1136/annrheumdis-2013-205127, PubMed 24695011
High prevalence of inclusion body myositis in Norway; a population-based clinical epidemiology study
Eur J Neurol, 22 (4), 672-e41
DOI 10.1111/ene.12627, PubMed 25530508
The HLA profiles of mixed connective tissue disease differ distinctly from the profiles of clinically related connective tissue diseases
Rheumatology (Oxford), 54 (3), 528-35
DOI 10.1093/rheumatology/keu310, PubMed 25187641
Performance of the 2013 American College of Rheumatology/European League Against Rheumatism Classification Criteria for Systemic Sclerosis (SSc) in large, well-defined cohorts of SSc and mixed connective tissue disease
J Rheumatol, 42 (1), 60-3
DOI 10.3899/jrheum.140047, PubMed 25274890
Influence of the IL17A locus in giant cell arteritis susceptibility
Ann Rheum Dis, 73 (9), 1742-5
DOI 10.1136/annrheumdis-2014-205261, PubMed 24919468
Publications 2013
Prevalence of pulmonary hypertension in an unselected, mixed connective tissue disease cohort: results of a nationwide, Norwegian cross-sectional multicentre study and review of current literature
Rheumatology (Oxford), 52 (7), 1208-13
DOI 10.1093/rheumatology/kes430, PubMed 23407386
Survival and causes of death in an unselected and complete cohort of Norwegian patients with systemic sclerosis
J Rheumatol, 40 (7), 1127-33
DOI 10.3899/jrheum.121390, PubMed 23637316
Identification of the PTPN22 functional variant R620W as susceptibility genetic factor for giant cell arteritis
Ann Rheum Dis, 72 (11), 1882-1886
DOI 10.1136/annrheumdis-2013-203641, PubMed 23946333
Publications 2012
Long-term follow-up of sporadic inclusion body myositis treated with intravenous immunoglobulin: a retrospective study of 16 patients
Clin Exp Rheumatol, 30 (6), 838-42
PubMed 22935197
Prevalence and severity of interstitial lung disease in mixed connective tissue disease: a nationwide, cross-sectional study
Ann Rheum Dis, 71 (12), 1966-72
DOI 10.1136/annrheumdis-2011-201253, PubMed 22550317
Prevalence of systemic sclerosis in south-east Norway
Rheumatology (Oxford), 51 (9), 1600-5
DOI 10.1093/rheumatology/kes076, PubMed 22539477
Publications 2011
The prevalence and incidence of mixed connective tissue disease: a national multicentre survey of Norwegian patients
Ann Rheum Dis, 70 (6), 1047-51
DOI 10.1136/ard.2010.143792, PubMed 21398332
Interleukin-15 induces interleukin-17 production by synovial T cell lines from patients with rheumatoid arthritis
Scand J Immunol, 73 (3), 243-9
DOI 10.1111/j.1365-3083.2010.02498.x, PubMed 21204897
Anti-PAD4 autoantibodies in rheumatoid arthritis: levels in serum over time and impact on PAD4 activity as measured with a small synthetic substrate
Rheumatol Int, 32 (5), 1271-6
DOI 10.1007/s00296-010-1765-y, PubMed 21267570
Long-term outcome of lung transplantation in a patient with the anti-synthetase syndrome
Scand J Rheumatol, 40 (4), 327-8
DOI 10.3109/03009742.2011.566280, PubMed 21623666
Publications 2009
[Myositis-specific autoantibodies]
Tidsskr Nor Laegeforen, 129 (16), 1631-4
DOI 10.4045/tidsskr.09.35501, PubMed 19721478
Rituximab treatment of the anti-synthetase syndrome: a retrospective case series
Rheumatology (Oxford), 48 (8), 968-71
DOI 10.1093/rheumatology/kep157, PubMed 19531628
Primary sequence, together with other factors, influence peptide deimination by peptidylarginine deiminase-4
Biol Chem, 390 (2), 99-107
DOI 10.1515/BC.2009.019, PubMed 19040354
Publications 2008
Serum IgG antibodies to peptidylarginine deiminase 4 predict radiographic progression in patients with rheumatoid arthritis treated with tumour necrosis factor-alpha blocking agents
Ann Rheum Dis, 68 (2), 249-52
DOI 10.1136/ard.2008.094490, PubMed 18723564
Publications 2007
Serum IgG antibodies to peptidylarginine deiminase 4 in rheumatoid arthritis and associations with disease severity
Ann Rheum Dis, 67 (3), 414-7
DOI 10.1136/ard.2007.080267, PubMed 18006540
Expression of SH2D2A in T-cells is regulated both at the transcriptional and translational level
Mol Immunol, 45 (8), 2380-90
DOI 10.1016/j.molimm.2007.11.005, PubMed 18160104
[Can it be celiac disease?]
Tidsskr Nor Laegeforen, 127 (15), 1952-3
PubMed 17708061
Surface expression of transglutaminase 2 by dendritic cells and its potential role for uptake and presentation of gluten peptides to T cells
Scand J Immunol, 65 (3), 213-20
DOI 10.1111/j.1365-3083.2006.01881.x, PubMed 17309775
Publications 2006
A gut feeling for joint inflammation - using coeliac disease to understand rheumatoid arthritis
Trends Immunol, 27 (4), 188-94
DOI 10.1016/j.it.2006.02.006, PubMed 16530013
A unique dendritic cell subset accumulates in the celiac lesion and efficiently activates gluten-reactive T cells
Gastroenterology, 131 (2), 428-38
DOI 10.1053/j.gastro.2006.06.002, PubMed 16890596
HLA-DQ2 and -DQ8 signatures of gluten T cell epitopes in celiac disease
J Clin Invest, 116 (8), 2226-36
DOI 10.1172/JCI27620, PubMed 16878175
Publications 2005
[Pathophysiologic aspects of systemic sclerosis]
Tidsskr Nor Laegeforen, 125 (19), 2622-3
PubMed 16215604
Mapping of gluten T-cell epitopes in the bread wheat ancestors: implications for celiac disease
Gastroenterology, 128 (2), 393-401
DOI 10.1053/j.gastro.2004.11.003, PubMed 15685550
Refining the rules of gliadin T cell epitope binding to the disease-associated DQ2 molecule in celiac disease: importance of proline spacing and glutamine deamidation
J Immunol, 175 (1), 254-61
DOI 10.4049/jimmunol.175.1.254, PubMed 15972656
Tissue transglutaminase-mediated formation and cleavage of histamine-gliadin complexes: biological effects and implications for celiac disease
J Immunol, 174 (3), 1657-63
DOI 10.4049/jimmunol.174.3.1657, PubMed 15661929
The effects of atorvastatin on gluten-induced intestinal T cell responses in coeliac disease
Clin Exp Immunol, 142 (2), 333-40
DOI 10.1111/j.1365-2249.2005.02915.x, PubMed 16232221
Identification and analysis of multivalent proteolytically resistant peptides from gluten: implications for celiac sprue
J Proteome Res, 4 (5), 1732-41
DOI 10.1021/pr050173t, PubMed 16212427
Publications 2004
The molecular basis for oat intolerance in patients with celiac disease
PLoS Med, 1 (1), e1
DOI 10.1371/journal.pmed.0010001, PubMed 15526039
Prolyl endopeptidase-mediated destruction of T cell epitopes in whole gluten: chemical and immunological characterization
J Pharmacol Exp Ther, 312 (1), 19-26
DOI 10.1124/jpet.104.073312, PubMed 15358813
Antigen presentation to celiac lesion-derived T cells of a 33-mer gliadin peptide naturally formed by gastrointestinal digestion
J Immunol, 173 (3), 1757-62
DOI 10.4049/jimmunol.173.3.1757, PubMed 15265905
Publications 2003
Intestinal T-cell responses to high-molecular-weight glutenins in celiac disease
Gastroenterology, 125 (2), 337-44
DOI 10.1016/s0016-5085(03)00890-4, PubMed 12891534
Gluten peptides and celiac disease - Response
Science, 299 (5606), 513-514
The T cell response to gluten and control of coeliac disease development
COELIAC DISEASE, 71-76
Publications 2002
Celiac lesion T cells recognize epitopes that cluster in regions of gliadins rich in proline residues
Gastroenterology, 123 (3), 803-9
DOI 10.1053/gast.2002.35381, PubMed 12198706
Gliadin T cell epitope selection by tissue transglutaminase in celiac disease. Role of enzyme specificity and pH influence on the transamidation versus deamidation process
J Biol Chem, 277 (37), 34109-16
DOI 10.1074/jbc.M204521200, PubMed 12093810
Structural basis for gluten intolerance in celiac sprue
Science, 297 (5590), 2275-9
DOI 10.1126/science.1074129, PubMed 12351792
Publications 2001
T cells from celiac disease lesions recognize gliadin epitopes deamidated in situ by endogenous tissue transglutaminase
Eur J Immunol, 31 (5), 1317-23
DOI 10.1002/1521-4141(200105)31:5<1317::AID-IMMU1317>3.0.CO;2-I, PubMed 11465088
Genes and environment in celiac disease
Acta Odontol Scand, 59 (3), 183-6
DOI 10.1080/000163501750266792, PubMed 11501889
Publications 2000
Production of a panel of recombinant gliadins for the characterisation of T cell reactivity in coeliac disease
Gut, 46 (1), 46-51
DOI 10.1136/gut.46.1.46, PubMed 10601054
The intestinal T cell response to alpha-gliadin in adult celiac disease is focused on a single deamidated glutamine targeted by tissue transglutaminase
J Exp Med, 191 (4), 603-12
DOI 10.1084/jem.191.4.603, PubMed 10684852
Studies of gliadin-specific T-cells in celiac disease
Methods Mol Med, 41, 105-24
DOI 10.1385/1-59259-082-9:105, PubMed 21374436
Role of tissue transglutaminase in celiac disease
J Pediatr Gastroenterol Nutr, 30 (3), 232-40
DOI 10.1097/00005176-200003000-00005, PubMed 10749404
Publications 1999
HLA binding and T cell recognition of a tissue transglutaminase-modified gliadin epitope
Eur J Immunol, 29 (8), 2506-14
DOI 10.1002/(SICI)1521-4141(199908)29:08<2506::AID-IMMU2506>3.0.CO;2-9, PubMed 10458765
Publications 1998
HLA restriction patterns of gliadin- and astrovirus-specific CD4+ T cells isolated in parallel from the small intestine of celiac disease patients
Tissue Antigens, 52 (5), 407-15
DOI 10.1111/j.1399-0039.1998.tb03066.x, PubMed 9864029
Tissue transglutaminase selectively modifies gliadin peptides that are recognized by gut-derived T cells in celiac disease
Nat Med, 4 (6), 713-7
DOI 10.1038/nm0698-713, PubMed 9623982
CD4+ T cells with specific reactivity against astrovirus isolated from normal human small intestine
Gastroenterology, 114 (1), 115-22
DOI 10.1016/s0016-5085(98)70639-0, PubMed 9428225
T cells of the human small intestinal mucosa: studies of HLA restriction and antigen-specificity with particular reference to coeliac disease
Institute of Transplantation Immunology, Department Groupof Laboratory Medicine, Rikshospitalet, University of Oslo, Oslo, 1 b. (flere pag.)
BIBSYS 98239117x, ISBN 82-7633-110-6
Identification of a gliadin T-cell epitope in coeliac disease: general importance of gliadin deamidation for intestinal T-cell recognition
Scand J Immunol, 48 (2), 111-5
DOI 10.1046/j.1365-3083.1998.00397.x, PubMed 9716100
Small intestinal T cells of celiac disease patients recognize a natural pepsin fragment of gliadin
Proc Natl Acad Sci U S A, 95 (17), 10050-4
DOI 10.1073/pnas.95.17.10050, PubMed 9707598
Publications 1997
Heterogeneous reactivity patterns of HLA-DQ-restricted, small intestinal T-cell clones from patients with celiac disease
Gastroenterology, 112 (3), 752-9
DOI 10.1053/gast.1997.v112.pm9041236, PubMed 9041236
Gliadin specific, HLA DQ2-restricted T cells are commonly found in small intestinal biopsies from coeliac disease patients, but not from controls
Scand J Immunol, 46 (1), 103-8
PubMed 9246215
Gliadin specific, HLA DQ2-restricted T cells are commonly found in small intestinal biopsies from coeliac disease patients, but not from controls
Scand J Immunol, 46 (3), 103-9
DOI 10.1046/j.1365-3083.1997.d01-93.x, PubMed 9315123
Gliadin specific, HLA DQ2-restricted T cells are commonly found in small intestinal biopsies from coeliac disease patients, but not from controls (vol 46, pg 103, 1997)
Scand. J. Immunol., 46 (3), 317-+
Immunopathology of gluten-sensitive enteropathy
Springer Semin Immunopathol, 18 (4), 535-53
DOI 10.1007/BF00824057, PubMed 9144869
The molecular basis of the HLA association in celiac disease: A model for other HLA-associated diseases
ALFRED BENZON SYMP S, 40, 362-377
The molecular basis of the HLA association in celiac disease - A model disease for type 1 diabetes and other HLA associated diseases
NATO ASI 3 HIGH TECH, 35, 61-69
HLA-DQ molecules, peptides and T cells in coeliac disease
COELIAC DISEASE, 265-274
Autoantibodies in coeliac disease: tissue transglutaminase--guilt by association?
Gut, 41 (6), 851-2
DOI 10.1136/gut.41.6.851, PubMed 9462222