Mohammed Shakil Ahmed

  • Senior scientist, PhD
  • +47 23071407

Muhammad Shakil Ahmed received his MSc in Biotechnology and PhD in Molecular Cardiology from University of Oslo. His work focuses on molecular mechanisms of cardiopulmonary fibrosis.

 

Publications 2021

Lauritzen KH, Olsen MB, Ahmed MS, Yang K, Rinholm JE, Bergersen LH, Esbensen QY, Sverkeli LJ, Ziegler M, Attramadal H, Halvorsen B, Aukrust P, Yndestad A (2021)
Instability in NAD(+) metabolism leads to impaired cardiac mitochondrial function and communication
eLife, 10, e59828
DOI 10.7554/eLife.59828

Yang DJ, Shi JH, Xia ZP, Guo WZ, Ahmed MS, Zhang SJ (2021)
Hepatic connective tissue growth factor expression and regulation differ between non-steatotic and non-alcoholic steatotic livers from brain-dead donor
Sci Rep, 11 (1), 3857
DOI 10.1038/s41598-021-83516-2

Publications 2020

Louwe MC, Olsen MB, Kaasboll OJ, Yang K, Fosshaug LE, Alfsnes K, Ogaard JDS, Rashidi A, Skulberg VM, Yang MY, Fonseca DD, Sharma A, Aronsen JM, Schrumpf E, Ahmed MS, Dahl CP, Nyman TA, Ueland T, Melum E, Halvorsen BE, Bjoras M, Attramadal H, Sjaastad I, Aukrust P, Yndestad A (2020)
Absence of NLRP3 Inflammasome in Hematopoietic Cells Reduces Adverse Remodeling After Experimental Myocardial Infarction
JACC-Basic Transl. Sci., 5 (12), 1210-1224
DOI 10.1016/j.jacbts.2020.09.013

Stolen TO, Hoydal MA, Ahmed MS, Jorgensen K, Garten K, Hortigon-Vinagre MP, Zamora V, Scrimgeour NR, Berre AMO, Nes BM, Skogvoll E, Johnsen AB, Moreira JBN, McMullen JR, Attramadal H, Smith GL, Ellingsen O, Wisloff U (2020)
Exercise training reveals micro-RNAs associated with improved cardiac function and electrophysiology in rats with heart failure after myocardial infarction
J. Mol. Cell. Cardiol., 148, 106-119
DOI 10.1016/j.yjmcc.2020.08.015

Publications 2019

Yang K, Lauritzen KH, Olsen MB, Dahl TB, Ranheim T, Ahmed MS, Attramadal H, Aukrust P, Halvorsen B, Nyman TA, Sandanger O, Yndestad A (2019)
Low Cellular NAD(+) Compromises Lipopolysaccharide-Induced Inflammatory Responses via Inhibiting TLR4 Signal Transduction in Human Monocytes
J. Immunol., 203 (6), 1598-1608
DOI 10.4049/jimmunol.1801382

Publications 2017

Benterud T, Ystgaard MB, Manueldas S, Pankratov L, Alfaro-Cervello C, Florholnnen G, Ahmed MS, Sandvik L, Norgren S, Bjoras M, Baumbusch LO, Solberg R, Saugstad OD (2017)
N-Acetylcysteine Amide Exerts Possible Neuroprotective Effects in Newborn Pigs after Perinatal Asphyxia
Neonatology, 111 (1), 12-21
DOI 10.1159/000447255

Dhondup Y, Sjaastad I, Sandanger O, Aronsen JM, Ahmed MS, Attramadal H, Finsen AV, Zhang LL, Ranheim T, Alfsnes K, Aukrust P, Christensen G, Yndestad A, Vinge LE (2017)
Toll-Like Receptor 9 Promotes Survival in SERCA2a KO Heart Failure Mice
Mediat. Inflamm., 2017, 9450439
DOI 10.1155/2017/9450439

Publications 2016

Kaasboll OJ, Moe IT, Ahmed MS, Stang E, Hagelin EMV, Attramadal H (2016)
CTGF/CCN2 Postconditioning Increases Tolerance of Murine Hearts towards Ischemia-Reperfusion Injury
PLoS One, 11 (2), e0149000
DOI 10.1371/journal.pone.0149000

Publications 2015

Dhondup Y, Sjaastad I, Scott H, Sandanger O, Zhang LL, Haugstad SB, Aronsen JM, Ranheim T, Holmen SD, Alfsnes K, Ahmed MS, Attramadal H, Gullestad L, Aukrust P, Christensen G, Yndestad A, Vinge LE (2015)
Sustained Toll-Like Receptor 9 Activation Promotes Systemic and Cardiac Inflammation, and Aggravates Diastolic Heart Failure in SERCA2a KO Mice
PLoS One, 10 (10), e0139715
DOI 10.1371/journal.pone.0139715

Publications 2013

Gravning J, Ahmed MS, von Lueder TG, Edvardsen T, Attramadal H (2013)
CCN2/CTGF attenuates myocardial hypertrophy and cardiac dysfunction upon chronic pressure-overload
Int. J. Cardiol., 168 (3), 2049-2056
DOI 10.1016/j.ijcard.2013.01.165

Moe IT, Pham TA, Hagelin EMV, Ahmed MS, Attramadal H (2013)
CCN2 exerts direct cytoprotective actions in adult cardiac myocytes by activation of the PI3-kinase/Akt/GSK-3 beta signaling pathway
J. Cell Commun. Signal, 7 (1), 31-47
DOI 10.1007/s12079-012-0183-1

Publications 2012

Gravning J, Orn S, Kaasboll OJ, Martinov VN, Manhenke C, Dickstein K, Edvardsen T, Attramadal H, Ahmed MS (2012)
Myocardial Connective Tissue Growth Factor (CCN2/CTGF) Attenuates Left Ventricular Remodeling after Myocardial Infarction
PLoS One, 7 (12), e52120
DOI 10.1371/journal.pone.0052120

von Lueder TG, Gravning J, How OJ, Vinge LE, Ahmed MS, Krobert KA, Levy FO, Larsen TS, Smiseth OA, Aasum E, Attramadal H (2012)
Cardiomyocyte-restricted inhibition of G protein-coupled receptor kinase-3 attenuates cardiac dysfunction after chronic pressure overload
Am. J. Physiol.-Heart Circul. Physiol., 303 (1), H66-H74
DOI 10.1152/ajpheart.00724.2011

Publications 2011

Bjornstad JL, Sjaastad I, Nygard S, Hasic A, Ahmed MS, Attramadal H, Finsen AV, Christensen G, Tonnessen T (2011)
Collagen isoform shift during the early phase of reverse left ventricular remodelling after relief of pressure overload
Eur. Heart J., 32 (2), 236-245
DOI 10.1093/eurheartj/ehq166

Publications 2010

Oie E, Ahmed MS, Ueland T, Sikkeland LIB, Dahl CP, Hagelin EMV, von Lueder T, Edvardsen T, Andreassen AK, Gullestad L, Aukrust P, Yndestad A, Vinge LE, Attramadal H (2010)
Adrenomedullin is increased in alveolar macrophages and released from the lungs into the circulation in severe heart failure
Basic Res. Cardiol., 105 (1), 89-98
DOI 10.1007/s00395-009-0070-y

Oie E, Sandberg WJ, Ahmed MS, Yndestad A, Laerum OD, Attramadal H, Aukrust P, Eiken HG (2010)
Activation of Notch signaling in cardiomyocytes during post-infarction remodeling
Scand. Cardiovasc. J., 44 (6), 359-366
DOI 10.3109/14017431.2010.511256

Publications 2007

Ahmed MS, Oie E, Vinge LE, von Lueder TG, Attramadal T, Attramadal H (2007)
Induction of pulmonary connective tissue growth factor in heart failure is associated with pulmonary parenchymal and vascular remodeling
Cardiovasc. Res., 74 (2), 323-333
DOI 10.1016/j.cardiores.2006.12.010

Vinge LE, Andressen KW, Attramadal T, Andersen GO, Ahmed MS, Peppel K, Koch WJ, Freedman NJ, Levy FO, Skomedal T, Osnes JB, Attramadal H (2007)
Substrate specificities of G protein-coupled receptor kinase-2 and -3 at cardiac myocyte receptors provide basis for distinct roles in regulation of myocardial function
Mol. Pharmacol., 72 (3), 582-591
DOI 10.1124/mol.107.035766