Mohammed Shakil Ahmed

  • Senior scientist, PhD
  • +47 23071407

Muhammad Shakil Ahmed received his MSc in Biotechnology and PhD in Molecular Cardiology from University of Oslo. His work focuses on molecular mechanisms of cardiopulmonary fibrosis.

 

Publications 2024

Olsen MB, Louwe MC, Yang K, Øgaard J, Dahl TB, Gregersen I, Alfsnes K, Lauritzen KH, Murphy SL, Ahmed MS, Aukrust P, Vinge LE, Yndestad A, Holven KB, Halvorsen B, Fosshaug LE (2024)
Continuous infusion of resolvin D2 in combination with Angiotensin-II show contrary effects on blood pressure and intracardiac artery remodeling
Biochem Biophys Res Commun, 733, 150706
DOI 10.1016/j.bbrc.2024.150706, PubMed 39305571

Publications 2023

Tønnessen TC, Ueland T, Ahmed MS, Attramadal H, Sjaastad I, Vinge LE (2023)
Inflammatory augmentation of the delayed type hypersensitivity arthritis mouse model
Basic Clin Pharmacol Toxicol, 132 (6), 551-555
DOI 10.1111/bcpt.13864, PubMed 36946742

Publications 2022

Lunde IG, Aronsen JM, Melleby AO, Strand ME, Skogestad J, Bendiksen BA, Ahmed MS, Sjaastad I, Attramadal H, Carlson CR, Christensen G (2022)
Cardiomyocyte-specific overexpression of syndecan-4 in mice results in activation of calcineurin-NFAT signalling and exacerbated cardiac hypertrophy
Mol Biol Rep, 49 (12), 11795-11809
DOI 10.1007/s11033-022-07985-y, PubMed 36205855

Tønnessen TC, Melleby AO, Hauge-Iversen IM, Espe EKS, Ahmed MS, Ueland T, Haavardsholm EA, Atkinson SM, Melum E, Attramadal H, Sjaastad I, Vinge LE (2022)
Impact of delayed type hypersensitivity arthritis on development of heart failure by aortic constriction in mice
PLoS One, 17 (1), e0262821
DOI 10.1371/journal.pone.0262821, PubMed 35077491

Publications 2021

Lauritzen KH, Olsen MB, Ahmed MS, Yang K, Rinholm JE, Bergersen LH, Esbensen QY, Sverkeli LJ, Ziegler M, Attramadal H, Halvorsen B, Aukrust P, Yndestad A (2021)
Instability in NAD+ metabolism leads to impaired cardiac mitochondrial function and communication
Elife, 10
DOI 10.7554/eLife.59828, PubMed 34343089

Yang DJ, Shi JH, Xia ZP, Guo WZ, Ahmed MS, Zhang SJ (2021)
Hepatic connective tissue growth factor expression and regulation differ between non-steatotic and non-alcoholic steatotic livers from brain-dead donor
Sci Rep, 11 (1), 3857
DOI 10.1038/s41598-021-83516-2, PubMed 33594198

Zolfaghari S, Kaasbøll OJ, Ahmed MS, Line FA, Hagelin EMV, Monsen VT, Attramadal H (2021)
Tissue distribution and transcriptional regulation of CCN5 in the heart after myocardial infarction
J Cell Commun Signal, 16 (3), 377-395
DOI 10.1007/s12079-021-00659-7, PubMed 34854055

Publications 2020

Louwe MC, Olsen MB, Kaasbøll OJ, Yang K, Fosshaug LE, Alfsnes K, Øgaard JDS, Rashidi A, Skulberg VM, Yang M, de Miranda Fonseca D, Sharma A, Aronsen JM, Schrumpf E, Ahmed MS, Dahl CP, Nyman TA, Ueland T, Melum E, Halvorsen BE, Bjørås M, Attramadal H, Sjaastad I, Aukrust P, Yndestad A (2020)
Absence of NLRP3 Inflammasome in Hematopoietic Cells Reduces Adverse Remodeling After Experimental Myocardial Infarction
JACC Basic Transl Sci, 5 (12), 1210-1224
DOI 10.1016/j.jacbts.2020.09.013, PubMed 33426377

Shahini N, Schjalm C, Nilsson PH, Holt MF, Øgaard JDS, Lien E, Ahmed MS, Attramadal H, Aukrust P, Yndestad A, Mollnes TE, Louwe MC (2020)
Complement component C3 and the TLR co-receptor CD14 are not involved in angiotensin II induced cardiac remodelling
Biochem Biophys Res Commun, 523 (4), 867-873
DOI 10.1016/j.bbrc.2020.01.018, PubMed 31955888

Stølen TO, Høydal MA, Ahmed MS, Jørgensen K, Garten K, Hortigon-Vinagre MP, Zamora V, Scrimgeour NR, Berre AMO, Nes BM, Skogvoll E, Johnsen AB, Moreira JBN, McMullen JR, Attramadal H, Smith GL, Ellingsen Ø, Wisløff U (2020)
Exercise training reveals micro-RNAs associated with improved cardiac function and electrophysiology in rats with heart failure after myocardial infarction
J Mol Cell Cardiol, 148, 106-119
DOI 10.1016/j.yjmcc.2020.08.015, PubMed 32918915

Publications 2019

Yang K, Lauritzen KH, Olsen MB, Dahl TB, Ranheim T, Ahmed MS, Attramadal H, Aukrust P, Halvorsen B, Nyman TA, Sandanger Ø, Yndestad A (2019)
Low Cellular NAD+ Compromises Lipopolysaccharide-Induced Inflammatory Responses via Inhibiting TLR4 Signal Transduction in Human Monocytes
J Immunol, 203 (6), 1598-1608
DOI 10.4049/jimmunol.1801382, PubMed 31427442

Publications 2017

Dhondup Y, Sjaastad I, Sandanger Ø, Aronsen JM, Ahmed MS, Attramadal H, Finsen AV, Zhang L, Ranheim T, Alfsnes K, Aukrust P, Christensen G, Yndestad A, Vinge LE (2017)
Toll-Like Receptor 9 Promotes Survival in SERCA2a KO Heart Failure Mice
Mediators Inflamm, 2017, 9450439
DOI 10.1155/2017/9450439, PubMed 28490840

Publications 2016

Benterud T, Ystgaard MB, Manueldas S, Pankratov L, Alfaro-Cervello C, Florholmen G, Ahmed MS, Sandvik L, Norgren S, Bjørås M, Baumbusch LO, Solberg R, Saugstad OD (2016)
N-Acetylcysteine Amide Exerts Possible Neuroprotective Effects in Newborn Pigs after Perinatal Asphyxia
Neonatology, 111 (1), 12-21
DOI 10.1159/000447255, PubMed 27497671

Kaasbøll OJ, Moe IT, Ahmed MS, Stang E, Hagelin EM, Attramadal H (2016)
CTGF/CCN2 Postconditioning Increases Tolerance of Murine Hearts towards Ischemia-Reperfusion Injury
PLoS One, 11 (2), e0149000
DOI 10.1371/journal.pone.0149000, PubMed 26872261

Publications 2015

Dhondup Y, Sjaastad I, Scott H, Sandanger Ø, Zhang L, Haugstad SB, Aronsen JM, Ranheim T, Holmen SD, Alfsnes K, Ahmed MS, Attramadal H, Gullestad L, Aukrust P, Christensen G, Yndestad A, Vinge LE (2015)
Sustained Toll-Like Receptor 9 Activation Promotes Systemic and Cardiac Inflammation, and Aggravates Diastolic Heart Failure in SERCA2a KO Mice
PLoS One, 10 (10), e0139715
DOI 10.1371/journal.pone.0139715, PubMed 26461521

Mughal AA, Grieg Z, Skjellegrind H, Fayzullin A, Lamkhannat M, Joel M, Ahmed MS, Murrell W, Vik-Mo EO, Langmoen IA, Stangeland B (2015)
Knockdown of NAT12/NAA30 reduces tumorigenic features of glioblastoma-initiating cells
Mol Cancer, 14, 160
DOI 10.1186/s12943-015-0432-z, PubMed 26292663

Publications 2014

Das MK, Basak S, Ahmed MS, Attramadal H, Duttaroy AK (2014)
Connective tissue growth factor induces tube formation and IL-8 production in first trimester human placental trophoblast cells
Eur J Obstet Gynecol Reprod Biol, 181, 183-8
DOI 10.1016/j.ejogrb.2014.07.045, PubMed 25150958

Hviid CV, Samulin Erdem J, Drechsler S, Weixelbaumer K, Ahmed MS, Attramadal H, Redl H, Bahrami S, Osuchowski MF, Aasen AO (2014)
The matricellular "cysteine-rich protein 61" is released from activated platelets and increased in the circulation during experimentally induced sepsis
Shock, 41 (3), 233-40
DOI 10.1097/SHK.0000000000000105, PubMed 24430538

Publications 2013

Gravning J, Ahmed MS, Qvigstad E, Krobert K, Edvardsen T, Moe IT, Hagelin EM, Sagave J, Valen G, Levy FO, Osnes JB, Skomedal T, Attramadal H (2013)
Connective tissue growth factor/CCN2 attenuates β-adrenergic receptor responsiveness and cardiotoxicity by induction of G protein-coupled receptor kinase-5 in cardiomyocytes
Mol Pharmacol, 84 (3), 372-83
DOI 10.1124/mol.113.087312, PubMed 23778361

Gravning J, Ahmed MS, von Lueder TG, Edvardsen T, Attramadal H (2013)
CCN2/CTGF attenuates myocardial hypertrophy and cardiac dysfunction upon chronic pressure-overload
Int J Cardiol, 168 (3), 2049-56
DOI 10.1016/j.ijcard.2013.01.165, PubMed 23452880

Publications 2012

Gravning J, Ørn S, Kaasbøll OJ, Martinov VN, Manhenke C, Dickstein K, Edvardsen T, Attramadal H, Ahmed MS (2012)
Myocardial connective tissue growth factor (CCN2/CTGF) attenuates left ventricular remodeling after myocardial infarction
PLoS One, 7 (12), e52120
DOI 10.1371/journal.pone.0052120, PubMed 23284892

Hviid CV, Erdem JS, Kunke D, Ahmed SM, Kjeldsen SF, Wang YY, Attramadal H, Aasen AO (2012)
The matri-cellular proteins 'cysteine-rich, angiogenic-inducer, 61' and 'connective tissue growth factor' are regulated in experimentally-induced sepsis with multiple organ dysfunction
Innate Immun, 18 (5), 717-26
DOI 10.1177/1753425912436764, PubMed 22334618

Moe IT, Pham TA, Hagelin EM, Ahmed MS, Attramadal H (2012)
CCN2 exerts direct cytoprotective actions in adult cardiac myocytes by activation of the PI3-kinase/Akt/GSK-3β signaling pathway
J Cell Commun Signal, 7 (1), 31-47
DOI 10.1007/s12079-012-0183-1, PubMed 23208610

von Lueder TG, Gravning J, How OJ, Vinge LE, Ahmed MS, Krobert KA, Levy FO, Larsen TS, Smiseth OA, Aasum E, Attramadal H (2012)
Cardiomyocyte-restricted inhibition of G protein-coupled receptor kinase-3 attenuates cardiac dysfunction after chronic pressure overload
Am J Physiol Heart Circ Physiol, 303 (1), H66-74
DOI 10.1152/ajpheart.00724.2011, PubMed 22542621

Publications 2011

Waehre A, Halvorsen B, Yndestad A, Husberg C, Sjaastad I, Nygård S, Dahl CP, Ahmed MS, Finsen AV, Reims H, Louch WE, Hilfiker-Kleiner D, Vinge LE, Roald B, Attramadal H, Lipp M, Gullestad L, Aukrust P, Christensen G (2011)
Lack of chemokine signaling through CXCR5 causes increased mortality, ventricular dilatation and deranged matrix during cardiac pressure overload
PLoS One, 6 (4), e18668
DOI 10.1371/journal.pone.0018668, PubMed 21533157

Publications 2010

Ahmed MS, Gravning J, Martinov VN, von Lueder TG, Edvardsen T, Czibik G, Moe IT, Vinge LE, Øie E, Valen G, Attramadal H (2010)
Mechanisms of novel cardioprotective functions of CCN2/CTGF in myocardial ischemia-reperfusion injury
Am J Physiol Heart Circ Physiol, 300 (4), H1291-302
DOI 10.1152/ajpheart.00604.2010, PubMed 21186275

Bjørnstad JL, Sjaastad I, Nygård S, Hasic A, Ahmed MS, Attramadal H, Finsen AV, Christensen G, Tønnessen T (2010)
Collagen isoform shift during the early phase of reverse left ventricular remodelling after relief of pressure overload
Eur Heart J, 32 (2), 236-45
DOI 10.1093/eurheartj/ehq166, PubMed 20525982

Øie E, Ahmed MS, Ueland T, Sikkeland LI, Dahl CP, Hagelin EM, von Lueder T, Edvardsen T, Andreassen AK, Gullestad L, Aukrust P, Yndestad A, Vinge LE, Attramadal H (2010)
Adrenomedullin is increased in alveolar macrophages and released from the lungs into the circulation in severe heart failure
Basic Res Cardiol, 105 (1), 89-98
DOI 10.1007/s00395-009-0070-y, PubMed 19823891

Øie E, Sandberg WJ, Ahmed MS, Yndestad A, Lærum OD, Attramadal H, Aukrust P, Eiken HG (2010)
Activation of Notch signaling in cardiomyocytes during post-infarction remodeling
Scand Cardiovasc J, 44 (6), 359-66
DOI 10.3109/14017431.2010.511256, PubMed 20799913

Publications 2007

Vinge LE, Andressen KW, Attramadal T, Andersen GØ, Ahmed MS, Peppel K, Koch WJ, Freedman NJ, Levy FO, Skomedal T, Osnes JB, Attramadal H (2007)
Substrate specificities of g protein-coupled receptor kinase-2 and -3 at cardiac myocyte receptors provide basis for distinct roles in regulation of myocardial function
Mol Pharmacol, 72 (3), 582-91
DOI 10.1124/mol.107.035766, PubMed 17573483

Vinge LE, von Lueder TG, Aasum E, Qvigstad E, Gravning JA, How OJ, Edvardsen T, Bjørnerheim R, Ahmed MS, Mikkelsen BW, Oie E, Attramadal T, Skomedal T, Smiseth OA, Koch WJ, Larsen TS, Attramadal H (2007)
Cardiac-restricted expression of the carboxyl-terminal fragment of GRK3 Uncovers Distinct Functions of GRK3 in regulation of cardiac contractility and growth: GRK3 controls cardiac alpha1-adrenergic receptor responsiveness
J Biol Chem, 283 (16), 10601-10
DOI 10.1074/jbc.M708912200, PubMed 18165681

Publications 2006

Ahmed MS, Øie E, Vinge LE, von Lueder TG, Attramadal T, Attramadal H (2006)
Induction of pulmonary connective tissue growth factor in heart failure is associated with pulmonary parenchymal and vascular remodeling
Cardiovasc Res, 74 (2), 323-33
DOI 10.1016/j.cardiores.2006.12.010, PubMed 17254558

Publications 2004

Ahmed MS, Øie E, Vinge LE, Yndestad A, Øystein Andersen G, Andersson Y, Attramadal T, Attramadal H (2004)
Connective tissue growth factor--a novel mediator of angiotensin II-stimulated cardiac fibroblast activation in heart failure in rats
J Mol Cell Cardiol, 36 (3), 393-404
DOI 10.1016/j.yjmcc.2003.12.004, PubMed 15010278

Sattar SP, Ahmed MS, Madison J, Olsen DR, Bhatia SC, Ellahi S, Majeed F, Ramaswamy S, Petty F, Wilson DR (2004)
Patient and physician attitudes to using medications with religiously forbidden ingredients
Ann Pharmacother, 38 (11), 1830-5
DOI 10.1345/aph.1E001, PubMed 15479773

Øie E, Vinge LE, Andersen GØ, Yndestad A, Krobert KA, Sandberg C, Ahmed MS, Haug T, Levy FO, Skomedal T, Attramadal H (2004)
RAMP2 and RAMP3 mRNA levels are increased in failing rat cardiomyocytes and associated with increased responsiveness to adrenomedullin
J Mol Cell Cardiol, 38 (1), 145-51
DOI 10.1016/j.yjmcc.2004.10.009, PubMed 15623431

Publications 2003

Ahmed MS, Øie E, Vinge LE, Yndestad A, Andersen G GØ, Andersson Y, Attramadal T, Attramadal H (2003)
Induction of myocardial biglycan in heart failure in rats--an extracellular matrix component targeted by AT(1) receptor antagonism
Cardiovasc Res, 60 (3), 557-68
DOI 10.1016/j.cardiores.2003.08.017, PubMed 14659801