HÃ¥vard Attramadal
- Professor; MD
- +47 23071396
Publications 2021
Instability in NAD(+) metabolism leads to impaired cardiac mitochondrial function and communication
eLife, 10, e59828
DOI 10.7554/eLife.59828
Tissue distribution and transcriptional regulation of CCN5 in the heart after myocardial infarction
J. Cell Commun. Signal
DOI 10.1007/s12079-021-00659-7
Publications 2020
Absence of NLRP3 Inflammasome in Hematopoietic Cells Reduces Adverse Remodeling After Experimental Myocardial Infarction
JACC-Basic Transl. Sci., 5 (12), 1210-1224
DOI 10.1016/j.jacbts.2020.09.013
Complement component C3 and the TLR co-receptor CD14 are not involved in angiotensin II induced cardiac remodelling
Biochem. Biophys. Res. Commun., 523 (4), 867-873
DOI 10.1016/j.bbrc.2020.01.018
Exercise training reveals micro-RNAs associated with improved cardiac function and electrophysiology in rats with heart failure after myocardial infarction
J. Mol. Cell. Cardiol., 148, 106-119
DOI 10.1016/j.yjmcc.2020.08.015
Publications 2019
Low Cellular NAD(+) Compromises Lipopolysaccharide-Induced Inflammatory Responses via Inhibiting TLR4 Signal Transduction in Human Monocytes
J. Immunol., 203 (6), 1598-1608
DOI 10.4049/jimmunol.1801382
Publications 2018
Connective tissue growth factor (CCN2) is a matricellular preproprotein controlled by proteolytic activation
J. Biol. Chem., 293 (46), 17953-17970
DOI 10.1074/jbc.RA118.004559
Publications 2017
Toll-Like Receptor 9 Promotes Survival in SERCA2a KO Heart Failure Mice
Mediat. Inflamm., 2017, 9450439
DOI 10.1155/2017/9450439
Connective tissue growth factor and bone morphogenetic protein 2 are induced following myocardial ischemia in mice and humans
Scand. J. Clin. Lab. Invest., 77 (5), 321-331
DOI 10.1080/00365513.2017.1318447
Palmitate promotes inflammatory responses and cellular senescence in cardiac fibroblasts
Biochim. Biophys. Acta Mol. Cell Biol. Lipids, 1862 (2), 234-245
DOI 10.1016/j.bbalip.2016.11.003
Publications 2016
CTGF/CCN2 Postconditioning Increases Tolerance of Murine Hearts towards Ischemia-Reperfusion Injury
PLoS One, 11 (2), e0149000
DOI 10.1371/journal.pone.0149000
NLRP3 inflammasome activation during myocardial ischemia reperfusion is cardioprotective
Biochem. Biophys. Res. Commun., 469 (4), 1012-1020
DOI 10.1016/j.bbrc.2015.12.051
Publications 2015
Sustained Toll-Like Receptor 9 Activation Promotes Systemic and Cardiac Inflammation, and Aggravates Diastolic Heart Failure in SERCA2a KO Mice
PLoS One, 10 (10), e0139715
DOI 10.1371/journal.pone.0139715
Impaired dynamics and function of mitochondria caused by mtDNA toxicity leads to heart failure
Am. J. Physiol.-Heart Circul. Physiol., 309 (3), H434-H449
DOI 10.1152/ajpheart.00253.2014
Exercise training promotes cardioprotection through oxygen-sparing action in high fat-fed mice
Am. J. Physiol.-Heart Circul. Physiol., 308 (8), H823-H829
DOI 10.1152/ajpheart.00734.2014
The lactate receptor, G-protein-coupled receptor 81/hydroxycarboxylic acid receptor 1: Expression and action in brain
J. Neurosci. Res., 93 (7), 1045-1055
DOI 10.1002/jnr.23593
Publications 2014
The cardiokine secreted Frizzled-related protein 3, a modulator of Wnt signalling, in clinical and experimental heart failure
J. Intern. Med., 275 (6), 621-630
DOI 10.1111/joim.12175
Connective tissue growth factor induces tube formation and IL-8 production in first trimester human placental trophoblast cells
Eur. J. Obstet. Gynecol. Reprod. Biol., 181, 183-188
DOI 10.1016/j.ejogrb.2014.07.045
THE MATRICELLULAR "CYSTEINE-RICH PROTEIN 61" IS RELEASED FROM ACTIVATED PLATELETS AND INCREASED IN THE CIRCULATION DURING EXPERIMENTALLY INDUCED SEPSIS
Shock, 41 (3), 233-240
DOI 10.1097/SHK.0000000000000105
Lactate Receptor Sites Link Neurotransmission, Neurovascular Coupling, and Brain Energy Metabolism
Cereb. Cortex, 24 (10), 2784-2795
DOI 10.1093/cercor/bht136
Publications 2013
Connective Tissue Growth Factor/CCN2 Attenuates beta-Adrenergic Receptor Responsiveness and Cardiotoxicity by Induction of G Protein-Coupled Receptor Kinase-5 in Cardiomyocytes
Mol. Pharmacol., 84 (3), 372-383
DOI 10.1124/mol.113.087312
CCN2/CTGF attenuates myocardial hypertrophy and cardiac dysfunction upon chronic pressure-overload
Int. J. Cardiol., 168 (3), 2049-2056
DOI 10.1016/j.ijcard.2013.01.165
CCN2 exerts direct cytoprotective actions in adult cardiac myocytes by activation of the PI3-kinase/Akt/GSK-3 beta signaling pathway
J. Cell Commun. Signal, 7 (1), 31-47
DOI 10.1007/s12079-012-0183-1
Publications 2012
Protecting the heart through delivering DNA encoding for heme oxygenase-1 into skeletal muscle
Life Sci., 91 (17-18), 828-836
DOI 10.1016/j.lfs.2012.08.014
Myocardial Connective Tissue Growth Factor (CCN2/CTGF) Attenuates Left Ventricular Remodeling after Myocardial Infarction
PLoS One, 7 (12), e52120
DOI 10.1371/journal.pone.0052120
The matri-cellular proteins 'cysteine-rich, angiogenic-inducer, 61' and 'connective tissue growth factor' are regulated in experimentally-induced sepsis with multiple organ dysfunction
Innate Immun., 18 (5), 717-726
DOI 10.1177/1753425912436764
Cardiomyocyte-restricted inhibition of G protein-coupled receptor kinase-3 attenuates cardiac dysfunction after chronic pressure overload
Am. J. Physiol.-Heart Circul. Physiol., 303 (1), H66-H74
DOI 10.1152/ajpheart.00724.2011
Publications 2011
Mechanisms of novel cardioprotective functions of CCN2/CTGF in myocardial ischemia-reperfusion injury
Am. J. Physiol.-Heart Circul. Physiol., 300 (4), H1291-H1302
DOI 10.1152/ajpheart.00604.2010
Collagen isoform shift during the early phase of reverse left ventricular remodelling after relief of pressure overload
Eur. Heart J., 32 (2), 236-245
DOI 10.1093/eurheartj/ehq166
Gene therapy with hypoxia-inducible factor 1 alpha in skeletal muscle is cardioprotective in vivo
Life Sci., 88 (11-12), 543-550
DOI 10.1016/j.lfs.2011.01.006
Lack of Chemokine Signaling through CXCR5 Causes Increased Mortality, Ventricular Dilatation and Deranged Matrix during Cardiac Pressure Overload
PLoS One, 6 (4), e18668
DOI 10.1371/journal.pone.0018668
Publications 2010
Plasma CCN2/connective tissue growth factor is associated with right ventricular dysfunction in patients with neuroendocrine tumors
BMC Cancer, 10, 6
DOI 10.1186/1471-2407-10-6
Separate mechanisms cause anemia in ischemic vs. nonischemic murine heart failure
Am. J. Physiol.-Regul. Integr. Comp. Physiol., 298 (3), R808-R814
DOI 10.1152/ajpregu.00250.2009
Adrenomedullin is increased in alveolar macrophages and released from the lungs into the circulation in severe heart failure
Basic Res. Cardiol., 105 (1), 89-98
DOI 10.1007/s00395-009-0070-y
Activation of Notch signaling in cardiomyocytes during post-infarction remodeling
Scand. Cardiovasc. J., 44 (6), 359-366
DOI 10.3109/14017431.2010.511256
Publications 2009
Prokineticins and the heart: diverging actions elicited by signalling through prokineticin receptor-1 or -2
Cardiovasc. Res., 81 (1), 3-4
DOI 10.1093/cvr/cvn306
Hypertension Are We beta ARKing Up the Right Tree?
Hypertension, 54 (1), 27-28
DOI 10.1161/HYPERTENSIONAHA.109.131904
Publications 2007
Induction of pulmonary connective tissue growth factor in heart failure is associated with pulmonary parenchymal and vascular remodeling
Cardiovasc. Res., 74 (2), 323-333
DOI 10.1016/j.cardiores.2006.12.010
The TGF beta superfamily in cardiovascular biology
Cardiovasc. Res., 74 (2), 181-183
DOI 10.1016/j.cardiores.2007.03.011
Substrate specificities of G protein-coupled receptor kinase-2 and -3 at cardiac myocyte receptors provide basis for distinct roles in regulation of myocardial function
Mol. Pharmacol., 72 (3), 582-591
DOI 10.1124/mol.107.035766
Publications 2006
Thalidomide attenuates the development of fibrosis during post-infarction myocardial remodelling in rats
Eur. J. Heart Fail., 8 (8), 790-796
DOI 10.1016/j.ejheart.2006.02.007
Publications 2005
Induction of myocardial connective tissue growth factor in pacing-induced heart failure in pigs
Acta Physiol. Scand., 184 (1), 27-36
DOI 10.1111/j.1365-201X.2005.01416.x
RAMP2 and RAMP3 rnRNA levels are increased in failing rat cardiomyocytes and associated with increased responsiveness to adrenomedullin
J. Mol. Cell. Cardiol., 38 (1), 145-151
DOI 10.1016/j.yjmcc.2004.10.009
Subtype-specific sorting of the ETA endothelin receptor by a novel endocytic recycling signal for G protein-coupled receptors
Mol. Pharmacol., 67 (5), 1581-1590
DOI 10.1124/mol.104.007013
Publications 2004
Connective-tissue growth factor - a novel mediator of angiotensin II-stimulated cardiac fibroblast activation in heart failure in rats
J. Mol. Cell. Cardiol., 36 (3), 393-404
DOI 10.1016/j.yjmcc.2003.12.004
Mechanisms of elevated plasma endothelin-1 in CHF: congestion increases pulmonary synthesis and secretion of endothelin-1
Cardiovasc. Res., 63 (1), 41-50
DOI 10.1016/j.cardiores.2004.03.016
Elevated levels of activin A in heart failure - Potential role in myocardial remodeling
Circulation, 109 (11), 1379-1385
DOI 10.1161/01.CIR.0000120704.97934.41
Publications 2003
Induction of myocardial biglycan in heart failure in rats - an extracellular matrix component targeted by AT(1) receptor antagonism
Cardiovasc. Res., 60 (3), 557-568
DOI 10.1016/j.cardiores.2003.08.017
Publications 2002
Early intervention with a potent endothelin-A/endothelin-B receptor antagonist aggravates left ventricular remodeling after myocardial infarction in rats
Basic Res. Cardiol., 97 (3), 239-247
DOI 10.1007/s003950200017
Endothelin receptor antagonism attenuates cardiomyocyte apoptosis after induction of ischemia in rats
Scand. Cardiovasc. J., 36 (2), 108-116
Publications 2001
Myocardial gene expression of leukaemia inhibitory factor, interleukin-6 and glycoprotein 130 in end-stage human heart failure
Eur. J. Clin. Invest., 31 (5), 389-397
DOI 10.1046/j.1365-2362.2001.00795.x
Regional cardiac expression and concentration of natriuretic peptides in patients with severe chronic heart failure
Acta Physiol. Scand., 171 (4), 395-403
DOI 10.1046/j.1365-201X.2001.00805.x
Gene expression of natriuretic peptides and their receptors type-A and -C after myocardial infarction in rats
Scand. J. Clin. Lab. Invest., 61 (2), 139-150
Mechanisms of endothelin receptor subtype-specific targeting to distinct intracellular trafficking pathways
J. Biol. Chem., 276 (36), 34041-34050
DOI 10.1074/jbc.M103243200
Myocardial distribution and regulation of GRK and beta-arrestin isoforms in congestive heart failure in rats
Am. J. Physiol.-Heart Circul. Physiol., 281 (6), H2490-H2499
DOI 10.1152/ajpheart.2001.281.6.H2490
Publications 2000
Regulation and intracellular trafficking pathways of the endothelin receptors
J. Biol. Chem., 275 (23), 17596-17604
DOI 10.1074/jbc.M000142200
Myocardial expression of CC- and CXC-chemokines and their receptors in human end-stage heart failure
Cardiovasc. Res., 47 (4), 778-787
DOI 10.1016/S0008-6363(00)00142-5
Contrasting cardiac regional responses of A-type and B-type natriuretic peptide to experimental chronic heart failure
Scand. J. Clin. Lab. Invest., 60 (4), 299-309
DOI 10.1080/003655100750046468
Regulation of ET: pulmonary release of ET contributes to increased plasma ET levels and vasoconstriction in CHF
Am. J. Physiol.-Heart Circul. Physiol., 278 (4), H1299-H1310
DOI 10.1152/ajpheart.2000.278.4.H1299
Cyclosporin A inhibits cardiac hypertrophy and enhances cardiac dysfunction during postinfarction failure in rats
Am. J. Physiol.-Heart Circul. Physiol., 278 (6), H2115-H2123
Induction of a myocardial adrenomedullin signaling system during ischemic heart failure in rats
Circulation, 101 (4), 415-422
Publications 1999
Gene expression of the renal endothelin system in renal transplant recipients on cyclosporine a based immunosuppression
Transplantation, 67 (7), 1056-1060
DOI 10.1097/00007890-199904150-00020
Publications 1998
Quantification of mRNA levels of endothelin receptor subtypes and preproEndothelin-1 in renal needle biopsies by competitive reverse transcriptase polymerase chain reaction
Scand. J. Clin. Lab. Invest., 58 (4), 299-306
DOI 10.1080/00365519850186472
Endothelin-1 is upregulated during skeletal muscle ischemia and reperfusion
J. Orthop. Res., 16 (1), 128-135
DOI 10.1002/jor.1100160122
ET-receptor antagonism, myocardial gene expression, and ventricular remodeling during CHF in rats
Am. J. Physiol.-Heart Circul. Physiol., 275 (3), H868-H877
Publications 1997
Transient, isopeptide-specific induction of myocardial endothelin-1 mRNA in congestive heart failure in rats
Am. J. Physiol.-Heart Circul. Physiol., 273 (4), H1727-H1736
Increased cardiac expression of endothelin-1 mRNA in ischemic heart failure in rats
Cardiovasc. Res., 33 (3), 601-610
DOI 10.1016/S0008-6363(96)00266-0
Publications 1995
MODULATION OF GONADOTROPIC AND PURINERGIC RESPONSIVENESS BY ISLET ACTIVATING PROTEIN IN SERTOLI CELLS FROM IMMATURE RATS
J. Steroid. Biochem. Mol. Biol., 52 (5), 431-436
DOI 10.1016/0960-0760(95)00002-H
Publications 1993
BETA-ADRENOCEPTOR MEDIATED RESPONSES AND SUBTYPES OF BETA-ADRENOCEPTORS IN CULTURED RAT SERTOLI CELLS
J. Steroid Biochem. Mol. Biol., 44 (1), 85-91
DOI 10.1016/0960-0760(93)90155-P
Publications 1991
DIFFERENT MECHANISMS ARE INVOLVED IN CAMP-MEDIATED INDUCTION OF MESSENGER-RNAS FOR SUBUNITS OF CAMP-DEPENDENT PROTEIN-KINASES
Mol. Endocrinol., 5 (1), 21-28
DOI 10.1210/mend-5-1-21
Publications 1989
Hormonal regulation of Sertoli cell adenylate cyclase: mechanisms of agonist-induced desensitization
Institute of Pathology, Rikshospitalet, [Oslo], 1 b. (flere pag.)
BIBSYS 890195730, ISBN 82-991940-0-8
Publications 1988
MECHANISMS OF GLUCAGON-INDUCED HOMOLOGOUS AND HETEROLOGOUS DESENSITIZATION OF ADENYLATE-CYCLASE IN MEMBRANES AND WHOLE SERTOLI CELLS OF THE RAT
Endocrinology, 123 (2), 1060-1068
DOI 10.1210/endo-123-2-1060
Publications 1986
A TRANSPLANTABLE RAT LEYDIG-CELL TUMOR .3. ISOPROTERENOL AND PROSTAGLANDIN-E1 (PGE1) RESPONSIVE ADENYLYL CYCLASE (AC) - REGULATORY EFFECTS OF NUCLEOTIDES AND MAGNESIUM
J. Steroid Biochem. Mol. Biol., 24 (3), 761-768
DOI 10.1016/0022-4731(86)90855-1
CHANGES IN GERM-CELL ADENYLATE-CYCLASE AND PROTEIN CARBOXYL METHYLASE ACTIVITIES IN RAT TESTICULAR TISSUE DURING BILATERAL CRYPTORCHIDISM AND AFTER ORCHIDOPEXY
J. Reprod. Fertil., 77 (2), 317-320
HORMONAL ACTIVATION OF THE ADENYLYL CYCLASES OF THE RAT AND HUMAN-PROSTATE GLAND
Prostate, 8 (1), 11-24
DOI 10.1002/pros.2990080104
Publications 1985
GLUCAGON-STIMULATED CYCLIC-AMP PRODUCTION AND FORMATION OF ESTRADIOL IN SERTOLI-CELL CULTURES FROM IMMATURE RATS
Mol. Cell. Endocrinol., 39 (2), 107-113
DOI 10.1016/0303-7207(85)90126-1
STUDIES ON THE MECHANISM OF FOLLICLE-STIMULATING HORMONE-INDUCED DESENSITIZATION OF SERTOLI-CELL ADENYLYL CYCLASE INVITRO
Biol. Reprod., 32 (4), 916-924
DOI 10.1095/biolreprod32.4.916
Publications 1984
FSH AND CATECHOLAMINE REGULATION OF SERTOLI-CELL ADENYLYL CYCLASE - REQUIREMENTS FOR DESENSITIZATION IN A CELL-FREE SYSTEM
Ann.NY Acad.Sci., 438 (DEC), 551-553
DOI 10.1111/j.1749-6632.1984.tb38333.x
REGULATION OF HORMONE-RESPONSIVE SERTOLI-CELL ADENYLYL CYCLASE IN A CELL-FREE SYSTEM
Mol. Cell. Endocrinol., 34 (3), 221-228
DOI 10.1016/0303-7207(84)90178-3
BETA-ADRENERGIC REGULATION OF SERTOLI-CELL ADENYLYL CYCLASE - DESENSITIZATION BY HOMOLOGOUS HORMONE
Mol. Cell. Endocrinol., 34 (1), 1-6
DOI 10.1016/0303-7207(84)90152-7
GLUCAGON-STIMULATED CYCLIC-AMP FORMATION IN RAT SERTOLI CELLS - INHIBITORY EFFECTS OF ADENOSINE
Ann.NY Acad.Sci., 438 (DEC), 563-565
DOI 10.1111/j.1749-6632.1984.tb38337.x
A TRANSPLANTABLE RAT LEYDIG-CELL TUMOR - BINDING-PROPERTIES, HORMONAL RESPONSIVENESS, AND TUMOR-GROWTH
Ann.NY Acad.Sci., 438 (DEC), 655-658
DOI 10.1111/j.1749-6632.1984.tb38365.x
A TRANSPLANTABLE RAT LEYDIG-CELL TUMOR .2. ADENYLYL CYCLASE ACTIVATION BY PROSTAGLANDIN-E1, ISOPROTERENOL AND GLUCAGON
J. Steroid Biochem. Mol. Biol., 21 (5), 545-548
DOI 10.1016/0022-4731(84)90329-7
CATECHOLAMINE RESPONSIVE ADENYLATE-CYCLASE IN HUMAN MYOCARDIAL PREPARATIONS - PROPERTIES AND OPTIMALIZATION OF ASSAY CONDITIONS
Scand. J. Clin. Lab. Invest., 44 (4), 317-327
DOI 10.3109/00365518409083814
CHANGES IN GONADOTROPIN AND ISOPROTERENOL STIMULATED ADENYLATE-CYCLASE ACTIVITIES IN RAT TESTICULAR TISSUE DURING CRYPTORCHIDISM
Ann.NY Acad.Sci., 438 (DEC), 606-608
DOI 10.1111/j.1749-6632.1984.tb38350.x
CHANGES IN ISOPROTERENOL-STIMULATED ADENYLATE-CYCLASE ACTIVITY IN RAT TESTICULAR TISSUE DURING CRYPTORCHIDISM AND AFTER ORCHIDOPEXY
J. Reprod. Fertil., 70 (2), 443-448
SOLUBLE MN-2+-DEPENDENT ADENYLATE-CYCLASE ACTIVITY IN THE TESTIS OF THE BLUE FOX (ALOPEX-LAGOPUS)
Arch. Androl., 12 (2-3), 225-230
DOI 10.3109/01485018409161180
Publications 1983
EFFECTS OF FSH, ISOPROTERENOL, AND CYCLIC-AMP ON THE PRODUCTION OF LACTATE AND PYRUVATE BY CULTURED SERTOLI CELLS
Arch. Androl., 10 (2), 149-154
Publications 1982
RAT SPERM ENZYMES DURING EPIDIDYMAL TRANSIT
J. Reprod. Fertil., 65 (2), 381-387