Andreas Romaine

  • Group leader, Senior Scientist; PhD, M. Sc.

Andreas Romaine joined the Institute of Surgical Research in 2024 as a group leader and senior scientist, focusing on understanding, diagnosing, and treating cardiac disease. 

In particular, he is interested in the molecular and cellular alterations that occur during heart failure which include impaired function of cardiac myocytes and disturbances to the homeostatic balance of the extracellular matrix (ECM). Cardiac fibrosis, a pathological state of ECM imbalance, is a strong indicator of poor outcome for several cardiovascular conditions, yet the key molecular players driving this maladaptation in the heart remain unidentified. 

Andreas completed his PhD in cardiac research in 2020 at the Institute for Experimental Medical Research, Oslo. He holds a Masters degree (MSc.) in immunology from Imperial College London, England.

He has developed and lectures on the UiO course MF9250: Methods in Cardiac Research, and is a member of the K.G. Jebsen Academy for Young Medical Researchers.

 

Publications 2023

Sasi A, Romaine A, Erusappan PM, Melleby AO, Hasic A, Dahl CP, Broch K, Almaas VM, Puertas RD, Roderick HL, Lunde IG, Sjaastad I, Vistnes M, Christensen G (2023)
Temporal expression and spatial distribution of the proteoglycan versican during cardiac fibrosis development
Matrix Biol Plus, 19-20, 100135
DOI 10.1016/j.mbplus.2023.100135, PubMed 38076279

Vistnes M, Erusappan PM, Sasi A, Nordén ES, Bergo KK, Romaine A, Lunde IG, Zhang L, Olsen MB, Øgaard J, Carlson CR, Wang CH, Riise J, Dahl CP, Fiane AE, Hauge-Iversen IM, Espe E, Melleby AO, Tønnessen T, Aronsen JM, Sjaastad I, Christensen G (2023)
Inhibition of the extracellular enzyme A disintegrin and metalloprotease with thrombospondin motif 4 prevents cardiac fibrosis and dysfunction
Cardiovasc Res, 119 (10), 1915-1927
DOI 10.1093/cvr/cvad078, PubMed 37216909

Publications 2022

Romaine A, Melleby AO, Alam J, Lobert VH, Lu N, Lockwood FE, Hasic A, Lunde IG, Sjaastad I, Stenmark H, Herum KM, Gullberg D, Christensen G (2022)
Integrin α11β1 and syndecan-4 dual receptor ablation attenuate cardiac hypertrophy in the pressure overloaded heart
Am J Physiol Heart Circ Physiol, 322 (6), H1057-H1071
DOI 10.1152/ajpheart.00635.2021, PubMed 35522553

Publications 2020

Alam J, Musiime M, Romaine A, Sawant M, Melleby AO, Lu N, Eckes B, Christensen G, Gullberg D (2020)
Generation of a novel mouse strain with fibroblast-specific expression of Cre recombinase
Matrix Biol Plus, 8, 100045
DOI 10.1016/j.mbplus.2020.100045, PubMed 33543038

Herum KM, Romaine A, Wang A, Melleby AO, Strand ME, Pacheco J, Braathen B, Dunér P, Tønnessen T, Lunde IG, Sjaastad I, Brakebusch C, McCulloch AD, Gomez MF, Carlson CR, Christensen G (2020)
Syndecan-4 Protects the Heart From the Profibrotic Effects of Thrombin-Cleaved Osteopontin
J Am Heart Assoc, 9 (3), e013518
DOI 10.1161/JAHA.119.013518, PubMed 32000579

Publications 2019

Mathiesen SB, Lunde M, Aronsen JM, Romaine A, Kaupang A, Martinsen M, de Souza GA, Nyman TA, Sjaastad I, Christensen G, Carlson CR (2019)
The cardiac syndecan-4 interactome reveals a role for syndecan-4 in nuclear translocation of muscle LIM protein (MLP)
J Biol Chem, 294 (22), 8717-8731
DOI 10.1074/jbc.RA118.006423, PubMed 30967474

Publications 2018

Melleby AO, Romaine A, Aronsen JM, Veras I, Zhang L, Sjaastad I, Lunde IG, Christensen G (2018)
A novel method for high precision aortic constriction that allows for generation of specific cardiac phenotypes in mice
Cardiovasc Res, 114 (12), 1680-1690
DOI 10.1093/cvr/cvy141, PubMed 29878127

Publications 2016

Melleby AO, Strand ME, Romaine A, Herum KM, Skrbic B, Dahl CP, Sjaastad I, Fiane AE, Filmus J, Christensen G, Lunde IG (2016)
The Heparan Sulfate Proteoglycan Glypican-6 Is Upregulated in the Failing Heart, and Regulates Cardiomyocyte Growth through ERK1/2 Signaling
PLoS One, 11 (10), e0165079
DOI 10.1371/journal.pone.0165079, PubMed 27768722

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