Leif Erik Vinge

  • Consultant Cardiologist, MD, PhD
 

Publications 2020

Arain F, Abraityte A, Bogdanova M, Solberg OG, Michelsen AE, Lekva T, Aakhus S, Holm S, Halvorsen B, Finsen AV, Vinge LE, Nymo S, Espeland T, Ranheim T, Aukrust P, Vaage IJ, Auensen A, Gullestad L, Ueland T (2020)
YKL-40 (Chitinase-3-Like Protein 1) Serum Levels in Aortic Stenosis
Circ.-Heart Fail., 13 (10), e006643
DOI 10.1161/CIRCHEARTFAILURE.119.006643

Hamre CFB, Kvammen EMH, Vinge LE, Skeie AT, Hompland I (2020)
Sarcoma of the heart
Tidsskr. Nor. Laegeforen., 140 (6), 582-583

Publications 2019

Fosshaug LE, Colas RA, Anstensrud AK, Gregersen I, Nymo S, Sagen EL, Michelsen A, Vinge LE, Oie E, Gullestad L, Halvorsen B, Hansen TV, Aukrust P, Dalli J, Yndestad A (2019)
Early increase of specialized pro-resolving lipid mediators in patients with ST-elevation myocardial infarction
EBioMedicine, 46, 264-273
DOI 10.1016/j.ebiom.2019.07.024

Torp MK, Yang K, Ranheim T, Lauritzen KH, Alfsnes K, Vinge LE, Aukrust P, Stenslokken KO, Yndestad A, Sandanger O (2019)
Mammalian Target of Rapamycin (mTOR) and the Proteasome Attenuates IL-1 beta Expression in Primary Mouse Cardiac Fibroblasts
Front. Immunol., 10, 1285
DOI 10.3389/fimmu.2019.01285

Publications 2017

Abraityte A, Vinge LE, Askevold ET, Lekva T, Michelsen AE, Ranheim T, Alfsnes K, Fiane A, Aakhus S, Lunde IG, Dahl CP, Aukrust P, Christensen G, Gullestad L, Yndestad A, Ueland T (2017)
Wnt5a is elevated in heart failure and affects cardiac fibroblast function
J. Mol. Med., 95 (7), 767-777
DOI 10.1007/s00109-017-1529-1

Dhondup Y, Sjaastad I, Sandanger O, Aronsen JM, Ahmed MS, Attramadal H, Finsen AV, Zhang LL, Ranheim T, Alfsnes K, Aukrust P, Christensen G, Yndestad A, Vinge LE (2017)
Toll-Like Receptor 9 Promotes Survival in SERCA2a KO Heart Failure Mice
Mediat. Inflamm., 2017, 9450439
DOI 10.1155/2017/9450439

Olsen MB, Hildrestrand GA, Scheffler K, Vinge LE, Alfsnes K, Palibrk V, Wang JB, Neurauter CG, Luna L, Johansen J, Ogaard JDS, Ohm IK, Slupphaug G, Kusnierczyk A, Fiane AE, Brorson SH, Zhang LL, Gullestad L, Louch WE, Iversen PO, Ostlie I, Klungland A, Christensen G, Sjaastad I, Saetrom P et al. (2017)
NEIL3-Dependent Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture
Cell Reports, 18 (1), 82-92
DOI 10.1016/j.celrep.2016.12.009

Sokolova M, Vinge LE, Alfsnes K, Olsen MB, Eide L, Kaasboll OJ, Attramadal H, Torp MK, Fosshaug LE, Rashidi A, Lien E, Finsen AV, Sandanger O, Aukrust P, Ranheim T, Yndestad A (2017)
Palmitate promotes inflammatory responses and cellular senescence in cardiac fibroblasts
Biochim. Biophys. Acta Mol. Cell Biol. Lipids, 1862 (2), 234-245
DOI 10.1016/j.bbalip.2016.11.003

Publications 2016

Dhondup Y, Ueland T, Dahl CP, Askevold ET, Sandanger O, Fiane A, Ohm IK, Sjaastad I, Finsen AV, Waehre A, Gullestad L, Aukrust P, Yndestad A, Vinge LE (2016)
Low Circulating Levels of Mitochondrial and High Levels of Nuclear DNA Predict Mortality in Chronic Heart Failure
J. Card. Fail., 22 (10), 823-828
DOI 10.1016/j.cardfail.2016.06.013

Sandanger O, Gao E, Ranheim T, Bilksoen M, Kaasboll OJ, Alfnes K, Nymo SH, Rashidi A, Ohm IK, Attramadal H, Aukrust P, Vinge LE, Yndestad A (2016)
NLRP3 inflammasome activation during myocardial ischemia reperfusion is cardioprotective
Biochem. Biophys. Res. Commun., 469 (4), 1012-1020
DOI 10.1016/j.bbrc.2015.12.051

Publications 2015

Dhondup Y, Sjaastad I, Scott H, Sandanger O, Zhang LL, Haugstad SB, Aronsen JM, Ranheim T, Holmen SD, Alfsnes K, Ahmed MS, Attramadal H, Gullestad L, Aukrust P, Christensen G, Yndestad A, Vinge LE (2015)
Sustained Toll-Like Receptor 9 Activation Promotes Systemic and Cardiac Inflammation, and Aggravates Diastolic Heart Failure in SERCA2a KO Mice
PLoS One, 10 (10), e0139715
DOI 10.1371/journal.pone.0139715

Fosshaug LE, Dahl CP, Risnes I, Bohov P, Berge RK, Nymo S, Geiran O, Yndestad A, Gullestad L, Aukrust P, Vinge LE, Oie E (2015)
Altered Levels of Fatty Acids and Inflammatory and Metabolic Mediators in Epicardial Adipose Tissue in Patients With Systolic Heart Failure
J. Card. Fail., 21 (11), 916-923
DOI 10.1016/j.cardfail.2015.07.014

Publications 2014

Askevold ET, Aukrust P, Nymo SH, Lunde IG, Kaasboll OJ, Aakhus S, Florholmen G, Ohm IK, Strand ME, Attramadal H, Fiane A, Dahl CP, Finsen AV, Vinge LE, Christensen G, Yndestad A, Gullestad L, Latini R, Masson S, Tavazzi L, Ueland T, GISSI-HF Investigators (2014)
The cardiokine secreted Frizzled-related protein 3, a modulator of Wnt signalling, in clinical and experimental heart failure
J. Intern. Med., 275 (6), 621-630
DOI 10.1111/joim.12175

Kaikkonen L, Magga J, Ronkainen VP, Koivisto E, Perjes A, Chuprun JK, Vinge LE, Kilpio T, Aro J, Ulvila J, Alakoski T, Bibb JA, Szokodi I, Koch WJ, Ruskoaho H, Kerkela R (2014)
p38 alpha regulates SERCA2a function
J. Mol. Cell. Cardiol., 67, 86-93
DOI 10.1016/j.yjmcc.2013.12.005

Ohm IK, Alfsnes K, Olsen MB, Ranheim T, Sandanger O, Dahl TB, Aukrust P, Finsen AV, Yndestad A, Vinge LE (2014)
Toll-Like Receptor 9 Mediated Responses in Cardiac Fibroblasts
PLoS One, 9 (8), e104398
DOI 10.1371/journal.pone.0104398

Ohm IK, Gao E, Olsen MB, Alfsnes K, Bliksoen M, Ogaard J, Ranheim T, Nymo SH, Holmen YD, Aukrust P, Yndestad A, Vinge LE (2014)
Toll-Like Receptor 9-Activation during Onset of Myocardial Ischemia Does Not Influence Infarct Extension
PLoS One, 9 (8), e104407
DOI 10.1371/journal.pone.0104407

Publications 2013

Sandanger O, Ranheim T, Vinge LE, Bliksoen M, Alfsnes K, Finsen AV, Dahl CP, Askevold ET, Florholmen G, Christensen G, Fitzgerald KA, Lien E, Valen G, Espevik T, Aukrust P, Yndestad A (2013)
The NLRP3 inflammasome is up-regulated in cardiac fibroblasts and mediates myocardial ischaemiareperfusion injury
Cardiovasc. Res., 99 (1), 164-174
DOI 10.1093/cvr/cvt091

Sandanger O, Ranheim T, Vinge LE, Bliksoen M, Valen G, Aukrust P, Yndestad A (2013)
A role for NLRP3 inflammasome in acute myocardial ischaemia-reperfusion injury? Reply
Cardiovasc. Res., 99 (1), 226-227
DOI 10.1093/cvr/cvt130

Publications 2012

Bliksoen M, Mariero LH, Ohm IK, Haugen F, Yndestad A, Solheim S, Seljeflot I, Ranheim T, Andersen GO, Aukrust P, Valen G, Vinge LE (2012)
Increased circulating mitochondrial DNA after myocardial infarction
Int. J. Cardiol., 158 (1), 132-134
DOI 10.1016/j.ijcard.2012.04.047

Gullestad L, Ueland T, Vinge LE, Finsen A, Yndestad A, Aukrust P (2012)
Inflammatory Cytokines in Heart Failure: Mediators and Markers
Cardiology, 122 (1), 23-35
DOI 10.1159/000338166

von Lueder TG, Gravning J, How OJ, Vinge LE, Ahmed MS, Krobert KA, Levy FO, Larsen TS, Smiseth OA, Aasum E, Attramadal H (2012)
Cardiomyocyte-restricted inhibition of G protein-coupled receptor kinase-3 attenuates cardiac dysfunction after chronic pressure overload
Am. J. Physiol.-Heart Circul. Physiol., 303 (1), H66-H74
DOI 10.1152/ajpheart.00724.2011

Waehre A, Vistnes M, Sjaastad I, Nygard S, Husberg C, Lunde IG, Aukrust P, Yndestad A, Vinge LE, Behmen D, Neukamm C, Brun H, Thaulow E, Christensen G (2012)
Chemokines regulate small leucine-rich proteoglycans in the extracellular matrix of the pressure-overloaded right ventricle
J. Appl. Physiol., 112 (8), 1372-1382
DOI 10.1152/japplphysiol.01350.2011

Yndestad A, Finsen AV, Ueland T, Husberg C, Dahl CP, Oie E, Vinge LE, Sjaastad I, Sandanger O, Ranheim T, Dickstein K, Kjekshus J, Damas JK, Fiane AE, Hilfiker-Kleiner D, Lipp M, Gullestad L, Christensen G, Aukrust P (2012)
The Homeostatic Chemokine CCL21 Predicts Mortality and May Play a Pathogenic Role in Heart Failure
PLoS One, 7 (3), e33038
DOI 10.1371/journal.pone.0033038

Publications 2011

Ahmed MS, Gravning J, Martinov VN, von Lueder TG, Edvardsen T, Czibik G, Moe IT, Vinge LE, Oie E, Valen G, Attramadal H (2011)
Mechanisms of novel cardioprotective functions of CCN2/CTGF in myocardial ischemia-reperfusion injury
Am. J. Physiol.-Heart Circul. Physiol., 300 (4), H1291-H1302
DOI 10.1152/ajpheart.00604.2010

Aukrust P, Sandberg WJ, Otterdal K, Vinge LE, Gullestad L, Yndestad A, Halvorsen B, Ueland T (2011)
Tumor necrosis factor superfamily molecules in acute coronary syndromes
Ann. Med., 43 (2), 90-103
DOI 10.3109/07853890.2010.523711

Fosshaug LE, Berge RK, Beitnes JO, Berge K, Vik H, Aukrust P, Gullestad L, Vinge LE, Oie E (2011)
Krill oil attenuates left ventricular dilatation after myocardial infarction in rats
Lipids Health Dis., 10, 245
DOI 10.1186/1476-511X-10-245

Waehre A, Halvorsen B, Yndestad A, Husberg C, Sjaastad I, Nygard S, Dahl CP, Ahmed MS, Finsen AV, Reims H, Louch WE, Hilfiker-Kleiner D, Vinge LE, Roald B, Attramadal H, Lipp M, Gullestad L, Aukrust P, Christensen G (2011)
Lack of Chemokine Signaling through CXCR5 Causes Increased Mortality, Ventricular Dilatation and Deranged Matrix during Cardiac Pressure Overload
PLoS One, 6 (4), e18668
DOI 10.1371/journal.pone.0018668

Publications 2010

Oie E, Ahmed MS, Ueland T, Sikkeland LIB, Dahl CP, Hagelin EMV, von Lueder T, Edvardsen T, Andreassen AK, Gullestad L, Aukrust P, Yndestad A, Vinge LE, Attramadal H (2010)
Adrenomedullin is increased in alveolar macrophages and released from the lungs into the circulation in severe heart failure
Basic Res. Cardiol., 105 (1), 89-98
DOI 10.1007/s00395-009-0070-y

Publications 2009

Dahl CP, Husberg C, Gullestad L, Waehre A, Damas JK, Vinge LE, Finsen AV, Ueland T, Florholmen G, Aakhus S, Halvorsen B, Aukrust P, Oie E, Yndestad A, Christensen G (2009)
Increased Production of CXCL16 in Experimental and Clinical Heart Failure A Possible Role in Extracellular Matrix Remodeling
Circ.-Heart Fail., 2 (6), 624-632
DOI 10.1161/CIRCHEARTFAILURE.108.821074

Yndestad A, Landro L, Ueland T, Dahl CP, Flo TH, Vinge LE, Espevik T, Froland SS, Husberg C, Christensen G, Dickstein K, Kjekshus J, Oie E, Gullestad L, Aukrust P (2009)
Increased systemic and myocardial expression of neutrophil gelatinase-associated lipocalin in clinical and experimental heart failure
Eur. Heart J., 30 (10), 1229-1236
DOI 10.1093/eurheartj/ehp088

Yndestad A, Neurauter CG, Oie E, Forstrom RJ, Vinge LE, Eide L, Luna L, Aukrust P, Bjoras M (2009)
Up-regulation of myocardial DNA base excision repair activities in experimental heart failure
Mutat. Res.-Fundam. Mol. Mech. Mutagen., 666 (1-2), 32-38
DOI 10.1016/j.mrfmmm.2009.03.008

Publications 2008

Dahl CP, Gullestad L, Fevang B, Holm AM, Landro L, Vinge LE, Fiane AE, Sandberg WJ, Otterdal K, Froland SS, Damas JK, Halvorsen B, Aukrust P, Oie E, Yndestad A (2008)
Increased expression of LIGHT/TNFSF 14 and its receptors in experimental and clinical heart failure
Eur. J. Heart Fail., 10 (4), 352-359
DOI 10.1016/j.ejheart.2008.02.010

DeGeorge BR, Gao E, Boucher M, Vinge LE, Martini JS, Raake PW, Chuprun JK, Harris DM, Kim GW, Soltys S, Eckhart AD, Koch WJ (2008)
Targeted inhibition of cardiomyocyte Gi signaling enhances susceptibility to apoptotic cell death in response to ischemic stress
Circulation, 117 (11), 1378-1387
DOI 10.1161/CIRCULATIONAHA.107.752618

Pleger ST, Harris DM, Shan CG, Vinge LE, Chuprun JK, Berzins B, Pleger W, Druckman C, Volkers M, Heierhorst J, Oie E, Remppis A, Katus HA, Scalia R, Eckhart AD, Koch WJ, Most P (2008)
Endothelial S100A1 modulates vascular function via nitric oxide
Circ.Res., 102 (7), 786-794
DOI 10.1161/CIRCRESAHA.108.172031

Vinge LE, Von Lueder TG, Aasum E, Qvigstad E, Gravning JA, How OJ, Edvardsen T, Bjornerheim R, Ahmed MS, Mikkelsen BW, Oie E, Attramadal T, Skomedal T, Smiseth OA, Koch WJ, Larsen TS, Havard Attramadal (2008)
Cardiac-restricted expression of the carboxyl-terminal fragment of GRK3 uncovers distinct functions of GRK3 in regulation of cardiac contractility and growth - GRK3 controls cardiac alpha(1)-adrenergic receptor responsiveness
J. Biol. Chem., 283 (16), 10601-10610
DOI 10.1074/jbc.M708912200

Publications 2007

Ahmed MS, Oie E, Vinge LE, von Lueder TG, Attramadal T, Attramadal H (2007)
Induction of pulmonary connective tissue growth factor in heart failure is associated with pulmonary parenchymal and vascular remodeling
Cardiovasc. Res., 74 (2), 323-333
DOI 10.1016/j.cardiores.2006.12.010

Vinge LE, Andressen KW, Attramadal T, Andersen GO, Ahmed MS, Peppel K, Koch WJ, Freedman NJ, Levy FO, Skomedal T, Osnes JB, Attramadal H (2007)
Substrate specificities of G protein-coupled receptor kinase-2 and -3 at cardiac myocyte receptors provide basis for distinct roles in regulation of myocardial function
Mol. Pharmacol., 72 (3), 582-591
DOI 10.1124/mol.107.035766

Publications 2006

Andersen GO, Oie E, Vinge LE, Yndestad A, Attramadal H, Skomedal T, Osnes JB (2006)
Increased expression and function of the myocardial Na-K-2Cl cotransporter in failing rat hearts
Basic Res. Cardiol., 101 (6), 471-478
DOI 10.1007/s00395-006-0604-5

Vinge LE (2006)
Myocardial G protein-coupled receptor kinases: distinct isoform specificities at receptors as basis for diverse roles in regulation of cardiac function
In Series of dissertations submitted to the Faculty of Medicine, University of Oslo, Unipub, Oslo, no. 362, 1 b. (flere pag.)
BIBSYS 05229658x, ISBN 82-8072-661-6

Yndestad A, Vinge LE, Bjornerheim R, Ueland T, Wang JE, Froland SS, Attramadal H, Aukrust P, Oie E (2006)
Thalidomide attenuates the development of fibrosis during post-infarction myocardial remodelling in rats
Eur. J. Heart Fail., 8 (8), 790-796
DOI 10.1016/j.ejheart.2006.02.007