Andreas Romaine

  • Group leader, Senior Scientist; PhD, M. Sc.

Andreas Romaine joined the Institute of Surgical Research in 2024 as a group leader and senior scientist, focusing on understanding, diagnosing, and treating cardiac disease. 

In particular, he is interested in the molecular and cellular alterations that occur during heart failure which include impaired function of cardiac myocytes and disturbances to the homeostatic balance of the extracellular matrix (ECM). Cardiac fibrosis, a pathological state of ECM imbalance, is a strong indicator of poor outcome for several cardiovascular conditions, yet the key molecular players driving this maladaptation in the heart remain unidentified. 

Andreas completed his PhD in cardiac research in 2020 at the Institute for Experimental Medical Research, Oslo. He holds a Masters degree (MSc.) in immunology from Imperial College London, England.

He has developed and lectures on the UiO course MF9250: Methods in Cardiac Research, and is a member of the K.G. Jebsen Academy for Young Medical Researchers.

 

Publications 2020

Herum KM, Romaine A, Wang A, Melleby AO, Strand ME, Pacheco J, Braathen B, Duner P, Tonnessen T, Lunde IG, Sjaastad I, Brakebusch C, McCulloch AD, Gomez MF, Carlson CR, Christensen G (2020)
Syndecan-4 Protects the Heart From the Profibrotic Effects of Thrombin-Cleaved Osteopontin
J. Am. Heart Assoc., 9 (3), e013518
DOI 10.1161/JAHA.119.013518

Publications 2019

Mathiesen SB, Lunde M, Aronsen JM, Romaine A, Kaupang A, Martinsen M, de Souza GA, Nyman TA, Sjaastad I, Christensen G, Carlson CR (2019)
The cardiac syndecan-4 interactome reveals a role for syndecan-4 in nuclear translocation of muscle LIM protein (MLP)
J. Biol. Chem., 294 (22), 8717-8731
DOI 10.1074/jbc.RA118.006423

Publications 2018

Melleby AO, Romaine A, Aronsen JM, Veras I, Zhang LL, Sjaastad I, Lunde IG, Christensen G (2018)
A novel method for high precision aortic constriction that allows for generation of specific cardiac phenotypes in mice
Cardiovasc. Res., 114 (12), 1680-1690
DOI 10.1093/cvr/cvy141

Publications 2016

Melleby AO, Strand ME, Romaine A, Herum KM, Skrbic B, Dahl CP, Sjaastad I, Fiane AE, Filmus J, Christensen G, Lunde IG (2016)
The Heparan Sulfate Proteoglycan Glypican-6 Is Upregulated in the Failing Heart, and Regulates Cardiomyocyte Growth through ERK1/2 Signaling
PLoS One, 11 (10), e0165079
DOI 10.1371/journal.pone.0165079

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