Publications 2024

Calzoni E, Cerrotti G, Sagini K, Delo F, Buratta S, Pellegrino RM, Alabed HBR, Fratini F, Emiliani C, Urbanelli L (2024)
Evidence of Lysosomal β-Hexosaminidase Enzymatic Activity Associated with Extracellular Vesicles: Potential Applications for the Correction of Sandhoff Disease
J Funct Biomater, 15 (6)
DOI 10.3390/jfb15060153, PubMed 38921527

Llorente A, Brokāne A, Mlynska A, Puurand M, Sagini K, Folkmane S, Hjorth M, Martin-Gracia B, Romero S, Skorinkina D, Čampa M, Cešeiko R, Romanchikova N, Kļaviņa A, Käämbre T, Linē A (2024)
From sweat to hope: The role of exercise-induced extracellular vesicles in cancer prevention and treatment
J Extracell Vesicles, 13 (8), e12500
DOI 10.1002/jev2.12500, PubMed 39183543

Publications 2023

Hessvik NP, Sagini K, Romero S, Ramirez-Garrastacho M, Rodriguez M, Tutturen AEV, Kvalvaag A, Stang E, Brech A, Sandvig K, Llorente A (2023)
siRNA screening reveals that SNAP29 contributes to exosome release
Cell Mol Life Sci, 80 (7), 177
DOI 10.1007/s00018-023-04822-8, PubMed 37285022

Nunzi E, Mezzasoma L, Bellezza I, Zelante T, Orvietani P, Coata G, Giardina I, Sagini K, Manni G, Di Michele A, Gargaro M, Talesa VN, Di Renzo GC, Fallarino F, Romani R (2023)
Microbiota-Associated HAF-EVs Regulate Monocytes by Triggering or Inhibiting Inflammasome Activation
Int J Mol Sci, 24 (3)
DOI 10.3390/ijms24032527, PubMed 36768851

Sagini K, Urbanelli L, Buratta S, Emiliani C, Llorente A (2023)
Lipid Biomarkers in Liquid Biopsies: Novel Opportunities for Cancer Diagnosis
Pharmaceutics, 15 (2)
DOI 10.3390/pharmaceutics15020437, PubMed 36839759

Publications 2022

Mezzasoma L, Bellezza I, Orvietani P, Manni G, Gargaro M, Sagini K, Llorente A, Scarpelli P, Pascucci L, Cellini B, Talesa VN, Fallarino F, Romani R (2022)
Amniotic fluid stem cell-derived extracellular vesicles are independent metabolic units capable of modulating inflammasome activation in THP-1 cells
FASEB J, 36 (4), e22218
DOI 10.1096/fj.202101657R, PubMed 35218567

Zendrini A, Guerra G, Sagini K, Vagner T, Di Vizio D, Bergese P (2022)
On the surface-to-bulk partition of proteins in extracellular vesicles
Colloids Surf B Biointerfaces, 218, 112728
DOI 10.1016/j.colsurfb.2022.112728, PubMed 35969923

Publications 2021

Buratta S, Shimanaka Y, Costanzi E, Ni S, Urbanelli L, Kono N, Morena F, Sagini K, Giovagnoli S, Romani R, Gargaro M, Arai H, Emiliani C (2021)
Lipotoxic stress alters the membrane lipid profile of extracellular vesicles released by Huh-7 hepatocarcinoma cells
Sci Rep, 11 (1), 4613
DOI 10.1038/s41598-021-84268-9, PubMed 33633289

Guerriero I, Ramberg H, Sagini K, Ramirez-Garrastacho M, Taskén KA, Llorente A (2021)
Implication of β2-adrenergic receptor and miR-196a correlation in neurite outgrowth of LNCaP prostate cancer cells
PLoS One, 16 (6), e0253828
DOI 10.1371/journal.pone.0253828, PubMed 34191854

Sagini K, Buratta S, Delo F, Pellegrino RM, Giovagnoli S, Urbanelli L, Emiliani C (2021)
Drug-Induced Lysosomal Impairment Is Associated with the Release of Extracellular Vesicles Carrying Autophagy Markers
Int J Mol Sci, 22 (23)
DOI 10.3390/ijms222312922, PubMed 34884727

Publications 2020

Botti V, Urbanelli L, Sagini K, Tarpani L, Cesaretti A, Fortuna CG, Elisei F (2020)
Quaternized styryl-azinium fluorophores as cellular RNA-binders
Photochem Photobiol Sci, 19 (3), 362-370
DOI 10.1039/c9pp00465c, PubMed 32147676

Buratta S, Tancini B, Sagini K, Delo F, Chiaradia E, Urbanelli L, Emiliani C (2020)
Lysosomal Exocytosis, Exosome Release and Secretory Autophagy: The Autophagic- and Endo-Lysosomal Systems Go Extracellular
Int J Mol Sci, 21 (7)
DOI 10.3390/ijms21072576, PubMed 32276321

Caponi S, Mattana S, Mattarelli M, Alunni Cardinali M, Urbanelli L, Sagini K, Emiliani C, Fioretto D (2020)
Correlative Brillouin and Raman spectroscopy data acquired on single cells
Data Brief, 29, 105223
DOI 10.1016/j.dib.2020.105223, PubMed 32090158

Parfejevs V, Sagini K, Buss A, Sobolevska K, Llorente A, Riekstina U, Abols A (2020)
Adult Stem Cell-Derived Extracellular Vesicles in Cancer Treatment: Opportunities and Challenges
Cells, 9 (5)
DOI 10.3390/cells9051171, PubMed 32397238

Skotland T, Sagini K, Sandvig K, Llorente A (2020)
An emerging focus on lipids in extracellular vesicles
Adv Drug Deliv Rev, 159, 308-321
DOI 10.1016/j.addr.2020.03.002, PubMed 32151658

Tancini B, Buratta S, Delo F, Sagini K, Chiaradia E, Pellegrino RM, Emiliani C, Urbanelli L (2020)
Lysosomal Exocytosis: The Extracellular Role of an Intracellular Organelle
Membranes (Basel), 10 (12)
DOI 10.3390/membranes10120406, PubMed 33316913

Urbanelli L, Buratta S, Logozzi M, Mitro N, Sagini K, Raimo RD, Caruso D, Fais S, Emiliani C (2020)
Lipidomic analysis of cancer cells cultivated at acidic pH reveals phospholipid fatty acids remodelling associated with transcriptional reprogramming
J Enzyme Inhib Med Chem, 35 (1), 963-973
DOI 10.1080/14756366.2020.1748025, PubMed 32308048

Publications 2019

Tancini B, Buratta S, Sagini K, Costanzi E, Delo F, Urbanelli L, Emiliani C (2019)
Insight into the Role of Extracellular Vesicles in Lysosomal Storage Disorders
Genes (Basel), 10 (7)
DOI 10.3390/genes10070510, PubMed 31284546

Urbanelli L, Buratta S, Tancini B, Sagini K, Delo F, Porcellati S, Emiliani C (2019)
The Role of Extracellular Vesicles in Viral Infection and Transmission
Vaccines (Basel), 7 (3)
DOI 10.3390/vaccines7030102, PubMed 31466253

Publications 2018

Mattana S, Mattarelli M, Urbanelli L, Sagini K, Emiliani C, Serra MD, Fioretto D, Caponi S (2018)
Non-contact mechanical and chemical analysis of single living cells by microspectroscopic techniques
Light Sci Appl, 7, 17139
DOI 10.1038/lsa.2017.139, PubMed 30839528

Sagini K, Costanzi E, Emiliani C, Buratta S, Urbanelli L (2018)
Extracellular Vesicles as Conveyors of Membrane-Derived Bioactive Lipids in Immune System
Int J Mol Sci, 19 (4)
DOI 10.3390/ijms19041227, PubMed 29670015

Sagini K, Urbanelli L, Costanzi E, Mitro N, Caruso D, Emiliani C, Buratta S (2018)
Oncogenic H-Ras Expression Induces Fatty Acid Profile Changes in Human Fibroblasts and Extracellular Vesicles
Int J Mol Sci, 19 (11)
DOI 10.3390/ijms19113515, PubMed 30413053

Publications 2017

Buratta S, Urbanelli L, Sagini K, Giovagnoli S, Caponi S, Fioretto D, Mitro N, Caruso D, Emiliani C (2017)
Extracellular vesicles released by fibroblasts undergoing H-Ras induced senescence show changes in lipid profile
PLoS One, 12 (11), e0188840
DOI 10.1371/journal.pone.0188840, PubMed 29182668

Magini A, Polchi A, Di Meo D, Mariucci G, Sagini K, De Marco F, Cassano T, Giovagnoli S, Dolcetta D, Emiliani C (2017)
TFEB activation restores migration ability to Tsc1-deficient adult neural stem/progenitor cells
Hum Mol Genet, 26 (17), 3303-3312
DOI 10.1093/hmg/ddx214, PubMed 28637240

Sadovska L, Zandberga E, Sagini K, Jēkabsons K, Riekstiņa U, Kalniņa Z, Llorente A, Linē A (2017)
A novel 3D heterotypic spheroid model for studying extracellular vesicle-mediated tumour and immune cell communication
Biochem Biophys Res Commun, 495 (2), 1930-1935
DOI 10.1016/j.bbrc.2017.12.072, PubMed 29248729

Publications 2016

Urbanelli L, Buratta S, Sagini K, Tancini B, Emiliani C (2016)
Extracellular Vesicles as New Players in Cellular Senescence
Int J Mol Sci, 17 (9)
DOI 10.3390/ijms17091408, PubMed 27571072

Publications 2015

Boukhari A, Alhosin M, Bronner C, Sagini K, Truchot C, Sick E, Schini-Kerth VB, André P, Mély Y, Mousli M, Gies JP (2015)
CD47 activation-induced UHRF1 over-expression is associated with silencing of tumor suppressor gene p16INK4A in glioblastoma cells
Anticancer Res, 35 (1), 149-57
PubMed 25550546

Buratta S, Urbanelli L, Ferrara G, Sagini K, Goracci L, Emiliani C (2015)
A role for the autophagy regulator Transcription Factor EB in amiodarone-induced phospholipidosis
Biochem Pharmacol, 95 (3), 201-9
DOI 10.1016/j.bcp.2015.03.017, PubMed 25881747

Caponi S, Mattana S, Ricci M, Sagini K, Urbanelli L, Sassi P, Morresi A, Emiliani C, Dalla Serra M, Iannotta S, Musio C, Fioretto D (2015)
Raman micro-spectroscopy study of living SH-SY5Y cells adhering on different substrates
Biophys Chem, 208, 48-53
DOI 10.1016/j.bpc.2015.07.009, PubMed 26256426

Urbanelli L, Buratta S, Sagini K, Ferrara G, Lanni M, Emiliani C (2015)
Exosome-based strategies for Diagnosis and Therapy
Recent Pat CNS Drug Discov, 10 (1), 10-27
DOI 10.2174/1574889810666150702124059, PubMed 26133463

Publications 2014

Urbanelli L, Magini A, Ercolani L, Sagini K, Polchi A, Tancini B, Brozzi A, Armeni T, Principato G, Emiliani C (2014)
Oncogenic H-Ras up-regulates acid β-hexosaminidase by a mechanism dependent on the autophagy regulator TFEB
PLoS One, 9 (2), e89485
DOI 10.1371/journal.pone.0089485, PubMed 24586816

Publications 2013

Urbanelli L, Magini A, Buratta S, Brozzi A, Sagini K, Polchi A, Tancini B, Emiliani C (2013)
Signaling pathways in exosomes biogenesis, secretion and fate
Genes (Basel), 4 (2), 152-70
DOI 10.3390/genes4020152, PubMed 24705158

Urbanelli L, Sagini K, Polidoro M, Brozzi A, Magini A, Emiliani C (2013)
Therapeutic approaches for lysosomal storage diseases: a patent update
Recent Pat CNS Drug Discov, 8 (2), 91-109
DOI 10.2174/15748898113089990002, PubMed 23713988