Jan Magnus Aronsen
- Researcher; MD, PhD
Publications 2022
AKAP18 delta Anchors and Regulates CaMKII Activity at Phospholamban-SERCA2 and RYR
Circ.Res., 130 (1), 27-44
DOI 10.1161/CIRCRESAHA.120.317976
Publications 2021
Exercise Training Stabilizes RyR2-Dependent Ca2+ Release in Post-infarction Heart Failure
Front. Cardiovasc. Med., 7, 623922
DOI 10.3389/fcvm.2020.623922
Etiology-Dependent Impairment of Diastolic Cardiomyocyte Calcium Homeostasis in Heart Failure With Preserved Ejection Fraction
J. Am. Coll. Cardiol., 77 (4), 405-419
DOI 10.1016/j.jacc.2020.11.044
Design of a Proteolytically Stable Sodium-Calcium Exchanger 1 Activator Peptide for In Vivo Studies
Front. Pharmacol., 12, 638646
DOI 10.3389/fphar.2021.638646
Publications 2020
Regional right ventricular function in rats: a novel magnetic resonance imaging method for measurement of right ventricular strain
Am. J. Physiol.-Heart Circul. Physiol., 318 (1), H143-H153
DOI 10.1152/ajpheart.00357.2019
Absence of NLRP3 Inflammasome in Hematopoietic Cells Reduces Adverse Remodeling After Experimental Myocardial Infarction
JACC-Basic Transl. Sci., 5 (12), 1210-1224
DOI 10.1016/j.jacbts.2020.09.013
Syndecan-4(-/-)Mice Have Smaller Muscle Fibers, Increased Akt/mTOR/S6K1 and Notch/HES-1 Pathways, and Alterations in Extracellular Matrix Components
Front. Cell. Dev. Biol., 8, 730
DOI 10.3389/fcell.2020.00730
Coupling of the Na+/K+-ATPase to Ankyrin B controls Na+/Ca2+ exchanger activity in cardiomyocytes
Cardiovasc. Res., 116 (1), 78-90
DOI 10.1093/cvr/cvz087
Hypokalemia Promotes Arrhythmia by Distinct Mechanisms in Atrial and Ventricular Myocytes
Circ.Res., 126 (7), 889-906
DOI 10.1161/CIRCRESAHA.119.315641
Publications 2019
Cardiomyocyte substructure reverts to an immature phenotype during heart failure
J. Physiol.-London, 597 (7), 1833-1853
DOI 10.1113/JP277273
The cardiac syndecan-4 interactome reveals a role for syndecan-4 in nuclear translocation of muscle LIM protein (MLP)
J. Biol. Chem., 294 (22), 8717-8731
DOI 10.1074/jbc.RA118.006423
Accelerated magnetic resonance imaging tissue phase mapping of the rat myocardium using compressed sensing with iterative soft-thresholding
PLoS One, 14 (7), e0218874
DOI 10.1371/journal.pone.0218874
The extracellular matrix proteoglycan lumican improves survival and counteracts cardiac dilatation and failure in mice subjected to pressure overload
Sci Rep, 9, 9206
DOI 10.1038/s41598-019-45651-9
Regional diastolic dysfunction in post-infarction heart failure: role of local mechanical load and SERCA expression
Cardiovasc. Res., 115 (4), 752-764
DOI 10.1093/cvr/cvy257
Evidence for heterogeneous subsarcolemmal Na+ levels in rat ventricular myocytes
Am. J. Physiol.-Heart Circul. Physiol., 316 (5), H941-H957
DOI 10.1152/ajpheart.00637.2018
NLRP3 Inflammasome Promotes Myocardial Remodeling During Diet-Induced Obesity
Front. Immunol., 10, 1621
DOI 10.3389/fimmu.2019.01621
Publications 2018
The extracellular matrix proteoglycan fibromodulin is upregulated in clinical and experimental heart failure and affects cardiac remodeling
PLoS One, 13 (7), e0201422
DOI 10.1371/journal.pone.0201422
Ryanodine receptor dispersion disrupts Ca2+ release in failing cardiac myocytes
eLife, 7, e39427
DOI 10.7554/eLife.39427
A novel method for high precision aortic constriction that allows for generation of specific cardiac phenotypes in mice
Cardiovasc. Res., 114 (12), 1680-1690
DOI 10.1093/cvr/cvy141
Overexpression of integrin alpha 11 induces cardiac fibrosis in mice
Acta Physiol., 222 (2), e12932
DOI 10.1111/apha.12932
Hypokalemia-Induced Arrhythmias and Heart Failure: New Insights and Implications for Therapy
Front. Physiol., 9, 1500
DOI 10.3389/fphys.2018.01500
Contractile responses to endothelin-1 are regulated by PKC phosphorylation of cardiac myosin binding protein-C in rat ventricular myocytes
J. Mol. Cell. Cardiol., 117, 1-18
DOI 10.1016/j.yjmcc.2018.02.012
Publications 2017
Noninvasive stratification of postinfarction rats based on the degree of cardiac dysfunction using magnetic resonance imaging and echocardiography
Am. J. Physiol.-Heart Circul. Physiol., 312 (5), H932-H942
DOI 10.1152/ajpheart.00668.2016
Toll-Like Receptor 9 Promotes Survival in SERCA2a KO Heart Failure Mice
Mediat. Inflamm., 2017, 9450439
DOI 10.1155/2017/9450439
Regional Dysfunction After Myocardial Infarction in Rats
Circ.-Cardiovasc. Imaging, 10 (9), e005997
DOI 10.1161/CIRCIMAGING.116.005997
A semiautomatic method for rapid segmentation of velocity-encoded myocardial magnetic resonance imaging data
Magn. Reson. Med., 78 (3), 1199-1207
DOI 10.1002/mrm.26486
Compensatory and decompensatory alterations in cardiomyocyte Ca2+ dynamics in hearts with diastolic dysfunction following aortic banding
J. Physiol.-London, 595 (12), 3867-3889
DOI 10.1113/JP273879
Genome-wide profiling of DNA 5-hydroxymethylcytosine during rat Sertoli cell maturation
Cell Discov., 3, 170013
DOI 10.1038/celldisc.2017.13
PDE3 inhibition by C-type natriuretic peptide-induced cGMP enhances cAMP-mediated signaling in both non-failing and failing hearts
Eur. J. Pharmacol., 812, 174-183
DOI 10.1016/j.ejphar.2017.07.014
Increased passive stiffness promotes diastolic dysfunction despite improved Ca2+ handling during left ventricular concentric hypertrophy
Cardiovasc. Res., 113 (10), 1161-1172
DOI 10.1093/cvr/cvx087
The H3K9 dimethyltransferases EHMT1/2 protect against pathological cardiac hypertrophy
J. Clin. Invest., 127 (1), 335-348
Publications 2016
Cardiomyocyte Ca2+ dynamics: clinical perspectives
Scand. Cardiovasc. J., 50 (2), 65-77
DOI 10.3109/14017431.2015.1136079
Elevated ventricular wall stress disrupts cardiomyocyte t-tubule structure and calcium homeostasis
Cardiovasc. Res., 112 (1), 443-451
DOI 10.1093/cvr/cvw111
Protein Phosphatase 1c Associated with the Cardiac Sodium Calcium Exchanger 1 Regulates Its Activity by Dephosphorylating Serine 68-phosphorylatedPhospholemman
J. Biol. Chem., 291 (9), 4561-4579
DOI 10.1074/jbc.M115.677898
Exercise training increases protein O-GlcNAcylation in rat skeletal muscle
PHYSIOL. REP., 4 (18), e12896
DOI 10.14814/phy2.12896
Beta-Adrenoceptor Stimulation Reveals Ca2+ Waves and Sarcoplasmic Reticulum Ca2+ Depletion in Left Ventricular Cardiomyocytes from Post-Infarction Rats with and without Heart Failure
PLoS One, 11 (4), e0153887
DOI 10.1371/journal.pone.0153887
Three-Directional Evaluation of Mitral Flow in the Rat Heart by Phase-Contrast Cardiovascular Magnetic Resonance
PLoS One, 11 (3), e0150536
DOI 10.1371/journal.pone.0150536
Publications 2015
Hypokalaemia induces Ca2+ overload and Ca2+ waves in ventricular myocytes by reducing Na+, K+-ATPase alpha(2) activity
J. Physiol.-London, 593 (6), 1509-1521
DOI 10.1113/jphysiol.2014.279893
Sustained Toll-Like Receptor 9 Activation Promotes Systemic and Cardiac Inflammation, and Aggravates Diastolic Heart Failure in SERCA2a KO Mice
PLoS One, 10 (10), e0139715
DOI 10.1371/journal.pone.0139715
Assessment of Regional Myocardial Work in Rats
Circ.-Cardiovasc. Imaging, 8 (2), e002695
DOI 10.1161/CIRCIMAGING.114.002695
Exhausting treadmill running causes dephosphorylation of sMLC2 and reduced level of myofilament MLCK2 in slow twitch rat soleus muscle
PHYSIOL. REP., 3 (2), e12285
DOI 10.14814/phy2.12285
Impaired dynamics and function of mitochondria caused by mtDNA toxicity leads to heart failure
Am. J. Physiol.-Heart Circul. Physiol., 309 (3), H434-H449
DOI 10.1152/ajpheart.00253.2014
Secretoneurin Is a Novel Prognostic Cardiovascular Biomarker Associated With Cardiomyocyte Calcium Handling
J. Am. Coll. Cardiol., 65 (4), 339-351
DOI 10.1016/j.jacc.2014.10.065
Shedding of syndecan-4 promotes immune cell recruitment and mitigates cardiac dysfunction after lipopolysaccharide challenge in mice
J. Mol. Cell. Cardiol., 88, 133-144
DOI 10.1016/j.yjmcc.2015.10.003
Cardiac Hypertrophy Is Inhibited by a Local Pool of cAMP Regulated by Phosphodiesterase 2
Circ.Res., 117 (8), 707-719
DOI 10.1161/CIRCRESAHA.114.305892
Publications 2014
Impaired left ventricular mechanical and energetic function in mice after cardiomyocyte-specific excision of Serca2
Am. J. Physiol.-Heart Circul. Physiol., 306 (7), H1018-H1024
DOI 10.1152/ajpheart.00741.2013
Computational modeling of Takotsubo cardiomyopathy: effect of spatially varying beta-adrenergic stimulation in the rat left ventricle
Am. J. Physiol.-Heart Circul. Physiol., 307 (10), H1487-H1496
DOI 10.1152/ajpheart.00443.2014
Non-classical regulation of beta(1)- and beta(2)-adrenoceptor-mediated inotropic responses in rat heart ventricle by the G protein G(i)
Naunyn-Schmiedebergs Arch. Pharmacol., 387 (12), 1177-1186
DOI 10.1007/s00210-014-1036-7
Different Compartmentation of Responses to Brain Natriuretic Peptide and C-Type Natriuretic Peptide in Failing Rat Ventricle
J. Pharmacol. Exp. Ther., 350 (3), 681-690
DOI 10.1124/jpet.114.214882
Differential regulation of C-type natriuretic peptide-induced cGMP and functional responses by PDE2 and PDE3 in failing myocardium
Naunyn-Schmiedebergs Arch. Pharmacol., 387 (5), 407-417
DOI 10.1007/s00210-013-0953-1
A computational pipeline for quantification of mouse myocardial stiffness parameters
Comput. Biol. Med., 53, 65-75
DOI 10.1016/j.compbiomed.2014.07.013
Pentosan Polysulfate Decreases Myocardial Expression of the Extracellular Matrix Enzyme ADAMTS4 and Improves Cardiac Function In Vivo in Rats Subjected to Pressure Overload by Aortic Banding
PLoS One, 9 (3), e89621
DOI 10.1371/journal.pone.0089621
Molecular Basis of Calpain Cleavage and Inactivation of the Sodium-Calcium Exchanger 1 in Heart Failure
J. Biol. Chem., 289 (49), 33984-33998
DOI 10.1074/jbc.M114.602581
Publications 2013
Cardiac sodium transport and excitation-contraction coupling
J. Mol. Cell. Cardiol., 61, 11-19
DOI 10.1016/j.yjmcc.2013.06.003
Novel insight into the detailed myocardial motion and deformation of the rodent heart using high-resolution phase contrast cardiovascular magnetic resonance
J. Cardiov. Magn. Reson., 15, 82
DOI 10.1186/1532-429X-15-82
Improved MR phase-contrast velocimetry using a novel nine-point balanced motion-encoding scheme with increased robustness to eddy current effects
Magn. Reson. Med., 69 (1), 48-61
DOI 10.1002/mrm.24226
The functional activity of inhibitory G protein (G(i)) is not increased in failing heart ventricle
J. Mol. Cell. Cardiol., 56, 129-138
DOI 10.1016/j.yjmcc.2012.11.015
Beta-Adrenergic Stimulation Maintains Cardiac Function in Serca2 Knockout Mice
Biophys. J., 104 (6), 1349-1356
DOI 10.1016/j.bpj.2013.01.042
SERCA2 activity is involved in the CNP-mediated functional responses in failing rat myocardium
Br. J. Pharmacol., 170 (2), 366-379
DOI 10.1111/bph.12282
Deletion of mouse Alkbh7 leads to obesity
J. Mol. Cell Biol., 5 (3), 194-203
DOI 10.1093/jmcb/mjt012
Publications 2012
Mutual antagonism between IP3RII and miRNA-133a regulates calcium signals and cardiac hypertrophy
J. Cell Biol., 199 (5), 783-798
DOI 10.1083/jcb.201111095
An analysis of deformation-dependent electromechanical coupling in the mouse heart
J. Physiol.-London, 590 (18), 4553-4569
DOI 10.1113/jphysiol.2012.231928
Sodium Accumulation in SERCA Knockout-Induced Heart Failure
Biophys. J., 102 (9), 2039-2048
DOI 10.1016/j.bpj.2012.03.045
Cardiac O-GlcNAc signaling is increased in hypertrophy and heart failure
Physiol. Genomics, 44 (2), 162-172
DOI 10.1152/physiolgenomics.00016.2011
Publications 2011
Differential regulation of beta(2)-adrenoceptor-mediated inotropic and lusitropic response by PDE3 and PDE4 in failing and non-failing rat cardiac ventricle
Br. J. Pharmacol., 162 (1), 54-71
DOI 10.1111/j.1476-5381.2010.00890.x
Agents increasing cyclic GMP amplify 5-HT4-elicited positive inotropic response in failing rat cardiac ventricle
Naunyn-Schmiedebergs Arch. Pharmacol., 384 (6), 543-553
DOI 10.1007/s00210-011-0670-6
Repeter!: farmakologi
Gyldendal akademisk, Oslo, 207 s.
BIBSYS 110553365, ISBN 978-82-05-40130-3
Cyclic AMP-dependent inotropic effects are differentially regulated by muscarinic G(i)-dependent constitutive inhibition of adenylyl cyclase in failing rat ventricle
Br. J. Pharmacol., 162 (4), 908-916
DOI 10.1111/j.1476-5381.2010.01097.x
Attenuated Fatigue in Slow Twitch Skeletal Muscle during Isotonic Exercise in Rats with Chronic Heart Failure
PLoS One, 6 (7), e22695
DOI 10.1371/journal.pone.0022695
Publications 2010
[No title]
In Repeter!: sykdomslære, Gyldendal akademisk, Oslo, 2, 235 s.
BIBSYS 102187355, ISBN 978-82-05-40079-5
Repeter!: sykdomslære
Gyldendal akademisk, Oslo, 2 b.
BIBSYS 102381445
Cre-loxP DNA recombination is possible with only minimal unspecific transcriptional changes and without cardiomyopathy in Tg(alpha MHC-MerCreMer) mice
Am. J. Physiol.-Heart Circul. Physiol., 299 (5), H1671-H1678
DOI 10.1152/ajpheart.01155.2009
Sodium accumulation promotes diastolic dysfunction in end-stage heart failure following Serca2 knockout
J. Physiol.-London, 588 (3), 465-478
DOI 10.1113/jphysiol.2009.183517
Natriuretic peptides increase beta(1)-adrenoceptor signalling in failing hearts through phosphodiesterase 3 inhibition
Cardiovasc. Res., 85 (4), 763-772
DOI 10.1093/cvr/cvp364
Publications 2009
Temporary fatigue and altered extracellular matrix in skeletal muscle during progression of heart failure in rats
Am. J. Physiol.-Regul. Integr. Comp. Physiol., 297 (1), R26-R33
DOI 10.1152/ajpregu.90617.2008
Cardiomyocytes from postinfarction failing rat hearts have improved ischemia tolerance
Am. J. Physiol.-Heart Circul. Physiol., 296 (3), H787-H795
DOI 10.1152/ajpheart.00796.2008
Publications 2008
5-HT4-elicited positive inotropic response is mediated by cAMP and regulated by PDE3 in failing rat and human cardiac ventricles
Br. J. Pharmacol., 155 (7), 1005-1014
DOI 10.1038/bjp.2008.339
Slow contractions characterize failing rat hearts
Basic Res. Cardiol., 103 (4), 328-344
DOI 10.1007/s00395-008-0719-y
Altered Na+/Ca2+-exchanger activity due to downregulation of Na+/K+-ATPase alpha(2)-isoform in heart failure
Cardiovasc. Res., 78 (1), 71-78
DOI 10.1093/cvr/cvn013
Altered Na(+)/Ca(2+)-exchanger activity due to downregulation of Na(+)/K(+)-ATPase alpha(2)-isoform in heart failure (vol 78, pg 71, 2008)
Cardiovasc. Res., 79 (2), 352
DOI 10.1093/cvr/cvn147