
Jan Magnus Aronsen
- Researcher; MD, PhD
Publications 2022
Cardiomyocyte-specific overexpression of syndecan-4 in mice results in activation of calcineurin-NFAT signalling and exacerbated cardiac hypertrophy
Mol Biol Rep, 49 (12), 11795-11809
DOI 10.1007/s11033-022-07985-y, PubMed 36205855
CNP regulates cardiac contractility and increases cGMP near both SERCA and TnI: difference from BNP visualized by targeted cGMP biosensors
Cardiovasc Res, 118 (6), 1506-1519
DOI 10.1093/cvr/cvab167, PubMed 33970224
MSK-Mediated Phosphorylation of Histone H3 Ser28 Couples MAPK Signalling with Early Gene Induction and Cardiac Hypertrophy
Cells, 11 (4)
DOI 10.3390/cells11040604, PubMed 35203255
Regulation of Cardiac Contractility by the Alpha 2 Subunit of the Na+/K+-ATPase
Front Physiol, 13, 827334
DOI 10.3389/fphys.2022.827334, PubMed 35812308
The female syndecan-4-/- heart has smaller cardiomyocytes, augmented insulin/pSer473-Akt/pSer9-GSK-3β signaling, and lowered SCOP, pThr308-Akt/Akt and GLUT4 levels
Front Cell Dev Biol, 10, 908126
DOI 10.3389/fcell.2022.908126, PubMed 36092718
Publications 2021
AKAP18δ Anchors and Regulates CaMKII Activity at Phospholamban-SERCA2 and RYR
Circ Res, 130 (1), 27-44
DOI 10.1161/CIRCRESAHA.120.317976, PubMed 34814703
Exercise Training Stabilizes RyR2-Dependent Ca2+ Release in Post-infarction Heart Failure
Front Cardiovasc Med, 7, 623922
DOI 10.3389/fcvm.2020.623922, PubMed 33569394
Etiology-Dependent Impairment of Diastolic Cardiomyocyte Calcium Homeostasis in Heart Failure With Preserved Ejection Fraction
J Am Coll Cardiol, 77 (4), 405-419
DOI 10.1016/j.jacc.2020.11.044, PubMed 33509397
Design of a Proteolytically Stable Sodium-Calcium Exchanger 1 Activator Peptide for In Vivo Studies
Front Pharmacol, 12, 638646
DOI 10.3389/fphar.2021.638646, PubMed 34163352
Publications 2020
Absence of NLRP3 Inflammasome in Hematopoietic Cells Reduces Adverse Remodeling After Experimental Myocardial Infarction
JACC Basic Transl Sci, 5 (12), 1210-1224
DOI 10.1016/j.jacbts.2020.09.013, PubMed 33426377
Syndecan-4-/- Mice Have Smaller Muscle Fibers, Increased Akt/mTOR/S6K1 and Notch/HES-1 Pathways, and Alterations in Extracellular Matrix Components
Front Cell Dev Biol, 8, 730
DOI 10.3389/fcell.2020.00730, PubMed 32850844
Coupling of the Na+/K+-ATPase to Ankyrin B controls Na+/Ca2+ exchanger activity in cardiomyocytes
Cardiovasc Res, 116 (1), 78-90
DOI 10.1093/cvr/cvz087, PubMed 30949686
Hypokalemia Promotes Arrhythmia by Distinct Mechanisms in Atrial and Ventricular Myocytes
Circ Res, 126 (7), 889-906
DOI 10.1161/CIRCRESAHA.119.315641, PubMed 32070187
Publications 2019
Regional right ventricular function in rats: a novel magnetic resonance imaging method for measurement of right ventricular strain
Am J Physiol Heart Circ Physiol, 318 (1), H143-H153
DOI 10.1152/ajpheart.00357.2019, PubMed 31774693
Cardiomyocyte substructure reverts to an immature phenotype during heart failure
J Physiol, 597 (7), 1833-1853
DOI 10.1113/JP277273, PubMed 30707448
The cardiac syndecan-4 interactome reveals a role for syndecan-4 in nuclear translocation of muscle LIM protein (MLP)
J Biol Chem, 294 (22), 8717-8731
DOI 10.1074/jbc.RA118.006423, PubMed 30967474
Accelerated magnetic resonance imaging tissue phase mapping of the rat myocardium using compressed sensing with iterative soft-thresholding
PLoS One, 14 (7), e0218874
DOI 10.1371/journal.pone.0218874, PubMed 31276508
The extracellular matrix proteoglycan lumican improves survival and counteracts cardiac dilatation and failure in mice subjected to pressure overload
Sci Rep, 9 (1), 9206
DOI 10.1038/s41598-019-45651-9, PubMed 31235849
Regional diastolic dysfunction in post-infarction heart failure: role of local mechanical load and SERCA expression
Cardiovasc Res, 115 (4), 752-764
DOI 10.1093/cvr/cvy257, PubMed 30351410
Evidence for heterogeneous subsarcolemmal Na+ levels in rat ventricular myocytes
Am J Physiol Heart Circ Physiol, 316 (5), H941-H957
DOI 10.1152/ajpheart.00637.2018, PubMed 30657726
NLRP3 Inflammasome Promotes Myocardial Remodeling During Diet-Induced Obesity
Front Immunol, 10, 1621
DOI 10.3389/fimmu.2019.01621, PubMed 31379826
Publications 2018
The extracellular matrix proteoglycan fibromodulin is upregulated in clinical and experimental heart failure and affects cardiac remodeling
PLoS One, 13 (7), e0201422
DOI 10.1371/journal.pone.0201422, PubMed 30052659
Ryanodine receptor dispersion disrupts Ca2+ release in failing cardiac myocytes
Elife, 7
DOI 10.7554/eLife.39427, PubMed 30375974
A novel method for high precision aortic constriction that allows for generation of specific cardiac phenotypes in mice
Cardiovasc Res, 114 (12), 1680-1690
DOI 10.1093/cvr/cvy141, PubMed 29878127
Hypokalemia-Induced Arrhythmias and Heart Failure: New Insights and Implications for Therapy
Front Physiol, 9, 1500
DOI 10.3389/fphys.2018.01500, PubMed 30464746
Contractile responses to endothelin-1 are regulated by PKC phosphorylation of cardiac myosin binding protein-C in rat ventricular myocytes
J Mol Cell Cardiol, 117, 1-18
DOI 10.1016/j.yjmcc.2018.02.012, PubMed 29470978
Publications 2017
Noninvasive stratification of postinfarction rats based on the degree of cardiac dysfunction using magnetic resonance imaging and echocardiography
Am J Physiol Heart Circ Physiol, 312 (5), H932-H942
DOI 10.1152/ajpheart.00668.2016, PubMed 28188213
Toll-Like Receptor 9 Promotes Survival in SERCA2a KO Heart Failure Mice
Mediators Inflamm, 2017, 9450439
DOI 10.1155/2017/9450439, PubMed 28490840
Regional Dysfunction After Myocardial Infarction in Rats
Circ Cardiovasc Imaging, 10 (9)
DOI 10.1161/CIRCIMAGING.116.005997, PubMed 28838960
Compensatory and decompensatory alterations in cardiomyocyte Ca2+ dynamics in hearts with diastolic dysfunction following aortic banding
J Physiol, 595 (12), 3867-3889
DOI 10.1113/JP273879, PubMed 28542952
Genome-wide profiling of DNA 5-hydroxymethylcytosine during rat Sertoli cell maturation
Cell Discov, 3, 17013
DOI 10.1038/celldisc.2017.13, PubMed 28529766
PDE3 inhibition by C-type natriuretic peptide-induced cGMP enhances cAMP-mediated signaling in both non-failing and failing hearts
Eur J Pharmacol, 812, 174-183
DOI 10.1016/j.ejphar.2017.07.014, PubMed 28697992
Overexpression of integrin α11 induces cardiac fibrosis in mice
Acta Physiol (Oxf), 222 (2)
DOI 10.1111/apha.12932, PubMed 28771943
Increased passive stiffness promotes diastolic dysfunction despite improved Ca2+ handling during left ventricular concentric hypertrophy
Cardiovasc Res, 113 (10), 1161-1172
DOI 10.1093/cvr/cvx087, PubMed 28472418
Publications 2016
Cardiomyocyte Ca2+ dynamics: clinical perspectives
Scand Cardiovasc J, 50 (2), 65-77
DOI 10.3109/14017431.2015.1136079, PubMed 26729487
A semiautomatic method for rapid segmentation of velocity-encoded myocardial magnetic resonance imaging data
Magn Reson Med, 78 (3), 1199-1207
DOI 10.1002/mrm.26486, PubMed 27699840
Elevated ventricular wall stress disrupts cardiomyocyte t-tubule structure and calcium homeostasis
Cardiovasc Res, 112 (1), 443-51
DOI 10.1093/cvr/cvw111, PubMed 27226008
Exercise training increases protein O-GlcNAcylation in rat skeletal muscle
Physiol Rep, 4 (18)
DOI 10.14814/phy2.12896, PubMed 27664189
Beta-Adrenoceptor Stimulation Reveals Ca2+ Waves and Sarcoplasmic Reticulum Ca2+ Depletion in Left Ventricular Cardiomyocytes from Post-Infarction Rats with and without Heart Failure
PLoS One, 11 (4), e0153887
DOI 10.1371/journal.pone.0153887, PubMed 27096943
Three-Directional Evaluation of Mitral Flow in the Rat Heart by Phase-Contrast Cardiovascular Magnetic Resonance
PLoS One, 11 (3), e0150536
DOI 10.1371/journal.pone.0150536, PubMed 26930073
The H3K9 dimethyltransferases EHMT1/2 protect against pathological cardiac hypertrophy
J Clin Invest, 127 (1), 335-348
DOI 10.1172/JCI88353, PubMed 27893464
Publications 2015
Sustained Toll-Like Receptor 9 Activation Promotes Systemic and Cardiac Inflammation, and Aggravates Diastolic Heart Failure in SERCA2a KO Mice
PLoS One, 10 (10), e0139715
DOI 10.1371/journal.pone.0139715, PubMed 26461521
Assessment of regional myocardial work in rats
Circ Cardiovasc Imaging, 8 (2), e002695
DOI 10.1161/CIRCIMAGING.114.002695, PubMed 25673647
Protein Phosphatase 1c Associated with the Cardiac Sodium Calcium Exchanger 1 Regulates Its Activity by Dephosphorylating Serine 68-phosphorylated Phospholemman
J Biol Chem, 291 (9), 4561-79
DOI 10.1074/jbc.M115.677898, PubMed 26668322
Exhausting treadmill running causes dephosphorylation of sMLC2 and reduced level of myofilament MLCK2 in slow twitch rat soleus muscle
Physiol Rep, 3 (2)
DOI 10.14814/phy2.12285, PubMed 25713325
Impaired dynamics and function of mitochondria caused by mtDNA toxicity leads to heart failure
Am J Physiol Heart Circ Physiol, 309 (3), H434-49
DOI 10.1152/ajpheart.00253.2014, PubMed 26055793
Secretoneurin is a novel prognostic cardiovascular biomarker associated with cardiomyocyte calcium handling
J Am Coll Cardiol, 65 (4), 339-351
DOI 10.1016/j.jacc.2014.10.065, PubMed 25634832
Shedding of syndecan-4 promotes immune cell recruitment and mitigates cardiac dysfunction after lipopolysaccharide challenge in mice
J Mol Cell Cardiol, 88, 133-44
DOI 10.1016/j.yjmcc.2015.10.003, PubMed 26449522
Cardiac Hypertrophy Is Inhibited by a Local Pool of cAMP Regulated by Phosphodiesterase 2
Circ Res, 117 (8), 707-19
DOI 10.1161/CIRCRESAHA.114.305892, PubMed 26243800
Publications 2014
Hypokalaemia induces Ca²⁺ overload and Ca²⁺ waves in ventricular myocytes by reducing Na⁺,K⁺-ATPase α₂ activity
J Physiol, 593 (6), 1509-21
DOI 10.1113/jphysiol.2014.279893, PubMed 25772299
Impaired left ventricular mechanical and energetic function in mice after cardiomyocyte-specific excision of Serca2
Am J Physiol Heart Circ Physiol, 306 (7), H1018-24
DOI 10.1152/ajpheart.00741.2013, PubMed 24486508
Computational modeling of Takotsubo cardiomyopathy: effect of spatially varying β-adrenergic stimulation in the rat left ventricle
Am J Physiol Heart Circ Physiol, 307 (10), H1487-96
DOI 10.1152/ajpheart.00443.2014, PubMed 25239804
Non-classical regulation of β1- and β 2-adrenoceptor-mediated inotropic responses in rat heart ventricle by the G protein Gi
Naunyn Schmiedebergs Arch Pharmacol, 387 (12), 1177-86
DOI 10.1007/s00210-014-1036-7, PubMed 25216690
Different compartmentation of responses to brain natriuretic peptide and C-type natriuretic peptide in failing rat ventricle
J Pharmacol Exp Ther, 350 (3), 681-90
DOI 10.1124/jpet.114.214882, PubMed 25022512
Differential regulation of C-type natriuretic peptide-induced cGMP and functional responses by PDE2 and PDE3 in failing myocardium
Naunyn Schmiedebergs Arch Pharmacol, 387 (5), 407-17
DOI 10.1007/s00210-013-0953-1, PubMed 24424715
A computational pipeline for quantification of mouse myocardial stiffness parameters
Comput Biol Med, 53, 65-75
DOI 10.1016/j.compbiomed.2014.07.013, PubMed 25129018
Pentosan polysulfate decreases myocardial expression of the extracellular matrix enzyme ADAMTS4 and improves cardiac function in vivo in rats subjected to pressure overload by aortic banding
PLoS One, 9 (3), e89621
DOI 10.1371/journal.pone.0089621, PubMed 24595230
Molecular basis of calpain cleavage and inactivation of the sodium-calcium exchanger 1 in heart failure
J Biol Chem, 289 (49), 33984-98
DOI 10.1074/jbc.M114.602581, PubMed 25336645
Publications 2013
Cardiac sodium transport and excitation-contraction coupling
J Mol Cell Cardiol, 61, 11-9
DOI 10.1016/j.yjmcc.2013.06.003, PubMed 23774049
Novel insight into the detailed myocardial motion and deformation of the rodent heart using high-resolution phase contrast cardiovascular magnetic resonance
J Cardiovasc Magn Reson, 15 (1), 82
DOI 10.1186/1532-429X-15-82, PubMed 24034168
Beta-adrenergic stimulation maintains cardiac function in Serca2 knockout mice
Biophys J, 104 (6), 1349-56
DOI 10.1016/j.bpj.2013.01.042, PubMed 23528094
SERCA2 activity is involved in the CNP-mediated functional responses in failing rat myocardium
Br J Pharmacol, 170 (2), 366-79
DOI 10.1111/bph.12282, PubMed 23808942
Deletion of mouse Alkbh7 leads to obesity
J Mol Cell Biol, 5 (3), 194-203
DOI 10.1093/jmcb/mjt012, PubMed 23572141
Publications 2012
Mutual antagonism between IP(3)RII and miRNA-133a regulates calcium signals and cardiac hypertrophy
J Cell Biol, 199 (5), 783-98
DOI 10.1083/jcb.201111095, PubMed 23166348
Improved MR phase-contrast velocimetry using a novel nine-point balanced motion-encoding scheme with increased robustness to eddy current effects
Magn Reson Med, 69 (1), 48-61
DOI 10.1002/mrm.24226, PubMed 22392844
The functional activity of inhibitory G protein (G(i)) is not increased in failing heart ventricle
J Mol Cell Cardiol, 56, 129-38
DOI 10.1016/j.yjmcc.2012.11.015, PubMed 23220156
An analysis of deformation-dependent electromechanical coupling in the mouse heart
J Physiol, 590 (18), 4553-69
DOI 10.1113/jphysiol.2012.231928, PubMed 22615436
Sodium accumulation in SERCA knockout-induced heart failure
Biophys J, 102 (9), 2039-48
DOI 10.1016/j.bpj.2012.03.045, PubMed 22824267
Publications 2011
Differential regulation of β2 -adrenoceptor-mediated inotropic and lusitropic response by PDE3 and PDE4 in failing and non-failing rat cardiac ventricle
Br J Pharmacol, 162 (1), 54-71
DOI 10.1111/j.1476-5381.2010.00890.x, PubMed 21133887
Agents increasing cyclic GMP amplify 5-HT4-elicited positive inotropic response in failing rat cardiac ventricle
Naunyn Schmiedebergs Arch Pharmacol, 384 (6), 543-53
DOI 10.1007/s00210-011-0670-6, PubMed 21901315
Repeter!: farmakologi
Gyldendal akademisk, Oslo, 207 s.
BIBSYS 110553365, ISBN 978-82-05-40130-3
Cyclic AMP-dependent inotropic effects are differentially regulated by muscarinic G(i)-dependent constitutive inhibition of adenylyl cyclase in failing rat ventricle
Br J Pharmacol, 162 (4), 908-16
DOI 10.1111/j.1476-5381.2010.01097.x, PubMed 21039419
Cardiac O-GlcNAc signaling is increased in hypertrophy and heart failure
Physiol Genomics, 44 (2), 162-72
DOI 10.1152/physiolgenomics.00016.2011, PubMed 22128088
Attenuated fatigue in slow twitch skeletal muscle during isotonic exercise in rats with chronic heart failure
PLoS One, 6 (7), e22695
DOI 10.1371/journal.pone.0022695, PubMed 21799933
Publications 2010
[No title]
In Repeter!: sykdomslære, Gyldendal akademisk, Oslo, 2, 235 s.
BIBSYS 102187355, ISBN 978-82-05-40079-5
Repeter!: sykdomslære
Gyldendal akademisk, Oslo, 2 b.
BIBSYS 102381445
Cre-loxP DNA recombination is possible with only minimal unspecific transcriptional changes and without cardiomyopathy in Tg(alphaMHC-MerCreMer) mice
Am J Physiol Heart Circ Physiol, 299 (5), H1671-8
DOI 10.1152/ajpheart.01155.2009, PubMed 20802136
Publications 2009
Sodium accumulation promotes diastolic dysfunction in end-stage heart failure following Serca2 knockout
J Physiol, 588 (Pt 3), 465-78
DOI 10.1113/jphysiol.2009.183517, PubMed 20008467
Natriuretic peptides increase beta1-adrenoceptor signalling in failing hearts through phosphodiesterase 3 inhibition
Cardiovasc Res, 85 (4), 763-72
DOI 10.1093/cvr/cvp364, PubMed 19900965
Temporary fatigue and altered extracellular matrix in skeletal muscle during progression of heart failure in rats
Am J Physiol Regul Integr Comp Physiol, 297 (1), R26-33
DOI 10.1152/ajpregu.90617.2008, PubMed 19339678
Cardiomyocytes from postinfarction failing rat hearts have improved ischemia tolerance
Am J Physiol Heart Circ Physiol, 296 (3), H787-95
DOI 10.1152/ajpheart.00796.2008, PubMed 19136604
Publications 2008
5-HT4-elicited positive inotropic response is mediated by cAMP and regulated by PDE3 in failing rat and human cardiac ventricles
Br J Pharmacol, 155 (7), 1005-14
DOI 10.1038/bjp.2008.339, PubMed 18846035
Slow contractions characterize failing rat hearts
Basic Res Cardiol, 103 (4), 328-44
DOI 10.1007/s00395-008-0719-y, PubMed 18347833
Altered Na+/Ca2+-exchanger activity due to downregulation of Na+/K+-ATPase alpha2-isoform in heart failure
Cardiovasc Res, 78 (1), 71-8
DOI 10.1093/cvr/cvn013, PubMed 18203708
Altered Na(+)/Ca(2+)-exchanger activity due to downregulation of Na(+)/K(+)-ATPase alpha(2)-isoform in heart failure (vol 78, pg 71, 2008)
Cardiovasc. Res., 79 (2), 352
DOI 10.1093/cvr/cvn147