Finn Olav Levy
- Professor, group leader
- +47 22840237
Publications 2024
Statins: 50 years old and with new surprises in store
Tidsskr Nor Laegeforen, 144 (8)
DOI 10.4045/tidsskr.24.0165, PubMed 38934304
Publications 2023
Novel enhancers of guanylyl cyclase-A activity acting via allosteric modulation
Br J Pharmacol, 180 (24), 3254-3270
DOI 10.1111/bph.16203, PubMed 37522273
Can acetate via FFA receptors contribute to the diabetogenic effect of statins?
Naunyn Schmiedebergs Arch Pharmacol, 397 (2), 1245-1248
DOI 10.1007/s00210-023-02647-7, PubMed 37642662
Publications 2022
Phosphodiesterases and Compartmentation of cAMP and cGMP Signaling in Regulation of Cardiac Contractility in Normal and Failing Hearts
Int J Mol Sci, 23 (4)
DOI 10.3390/ijms23042145, PubMed 35216259
CNP regulates cardiac contractility and increases cGMP near both SERCA and TnI: difference from BNP visualized by targeted cGMP biosensors
Cardiovasc Res, 118 (6), 1506-1519
DOI 10.1093/cvr/cvab167, PubMed 33970224
Publications 2021
International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function
Pharmacol Rev, 73 (1), 310-520
DOI 10.1124/pr.118.015552, PubMed 33370241
Exercise Training Stabilizes RyR2-Dependent Ca2+ Release in Post-infarction Heart Failure
Front Cardiovasc Med, 7, 623922
DOI 10.3389/fcvm.2020.623922, PubMed 33569394
Publications 2020
An inactive receptor-G protein complex maintains the dynamic range of agonist-induced signaling
Proc Natl Acad Sci U S A, 117 (48), 30755-30762
DOI 10.1073/pnas.2010801117, PubMed 33199589
Publications 2019
Constitutive inhibitory G protein activity upon adenylyl cyclase-dependent cardiac contractility is limited to adenylyl cyclase type 6
PLoS One, 14 (6), e0218110
DOI 10.1371/journal.pone.0218110, PubMed 31173603
FRET-based cyclic GMP biosensors measure low cGMP concentrations in cardiomyocytes and neurons
Commun Biol, 2, 394
DOI 10.1038/s42003-019-0641-x, PubMed 31701023
Knockout of adenylyl cyclase isoform 5 or 6 differentially modifies the β1-adrenoceptor-mediated inotropic response
J Mol Cell Cardiol, 131, 132-145
DOI 10.1016/j.yjmcc.2019.04.017, PubMed 31009605
Reduced ambient temperature exacerbates SIRS-induced cardiac autonomic dysregulation and myocardial dysfunction in mice
Basic Res Cardiol, 114 (3), 26
DOI 10.1007/s00395-019-0734-1, PubMed 31016449
Publications 2018
Related GPCRs couple differently to Gs: preassociation between G protein and 5-HT7 serotonin receptor reveals movement of Gαs upon receptor activation
FASEB J, 32 (2), 1059-1069
DOI 10.1096/fj.201700486R, PubMed 29079700
Hypothermia elongates the contraction-relaxation cycle in explanted human failing heart decreasing the time for ventricular filling during diastole
Am J Physiol Heart Circ Physiol, 315 (5), H1137-H1147
DOI 10.1152/ajpheart.00208.2018, PubMed 30004809
Preassociation between the 5-HT7 serotonin receptor and G protein Gs: molecular determinants and association with low potency activation of adenylyl cyclase
FASEB J, 33 (3), 3870-3886
DOI 10.1096/fj.201800805RR, PubMed 30508496
Publications 2017
Synthesis, Enzyme Assays and Molecular Docking Studies of Fluorinated Bioisosteres of Santacruzamate A as Potential HDAC Tracers
Lett. Drug Des. Discov., 14 (7), 787-797
DOI 10.2174/1570180813666161101152943
PDE3 inhibition by C-type natriuretic peptide-induced cGMP enhances cAMP-mediated signaling in both non-failing and failing hearts
Eur J Pharmacol, 812, 174-183
DOI 10.1016/j.ejphar.2017.07.014, PubMed 28697992
Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications : Bamberg, Germany. 23-25 June, 2017
BMC Pharmacol Toxicol, 18 (Suppl 1), 64
DOI 10.1186/s40360-017-0170-5, PubMed 29035170
Publications 2016
Low β₂-adrenergic receptor level may promote development of castration resistant prostate cancer and altered steroid metabolism
Oncotarget, 7 (2), 1878-94
DOI 10.18632/oncotarget.6479, PubMed 26646591
CaMKII in addition to MLCK contributes to phosphorylation of regulatory light chain in cardiomyocytes
Biochem Biophys Res Commun, 471 (1), 219-25
DOI 10.1016/j.bbrc.2016.01.132, PubMed 26809094
CaMKII and at least two unidentified kinases phosphorylate regulatory light chain in non-contracting cardiomyocytes
Biochem Biophys Res Commun, 477 (1), 14-19
DOI 10.1016/j.bbrc.2016.05.138, PubMed 27237977
Brain penetrant small molecule (18)F-GnRH receptor (GnRH-R) antagonists: Synthesis and preliminary positron emission tomography imaging in rats
Nucl Med Biol, 43 (8), 478-89
DOI 10.1016/j.nucmedbio.2016.05.003, PubMed 27236283
Functional pharmacological characterization of SER100 in cardiovascular health and disease
Br J Pharmacol, 173 (23), 3386-3401
DOI 10.1111/bph.13634, PubMed 27667485
Publications 2015
The atypical antipsychotics clozapine and olanzapine promote down-regulation and display functional selectivity at human 5-HT7 receptors
Br J Pharmacol, 172 (15), 3846-60
DOI 10.1111/bph.13169, PubMed 25884989
Identification of essential residues for binding and activation in the human 5-HT7(a) serotonin receptor by molecular modeling and site-directed mutagenesis
Front Behav Neurosci, 9, 92
DOI 10.3389/fnbeh.2015.00092, PubMed 26005408
Downregulation of 5-HT7 Serotonin Receptors by the Atypical Antipsychotics Clozapine and Olanzapine. Role of Motifs in the C-Terminal Domain and Interaction with GASP-1
ACS Chem Neurosci, 6 (7), 1206-18
DOI 10.1021/cn500339p, PubMed 25706089
Radiosynthesis of high affinity fluorine-18 labeled GnRH peptide analogues: in vitro studies and in vivo assessment of brain uptake in rats
MedChemComm, 6 (4), 708-714
DOI 10.1039/c4md00486h
The inotropic effect of the active metabolite of levosimendan, OR-1896, is mediated through inhibition of PDE3 in rat ventricular myocardium
PLoS One, 10 (3), e0115547
DOI 10.1371/journal.pone.0115547, PubMed 25738589
Publications 2014
Discovery and pharmacological profile of new hydrophilic 5-HT(4) receptor antagonists
Bioorg Med Chem Lett, 24 (18), 4598-4602
DOI 10.1016/j.bmcl.2014.06.083, PubMed 25149506
Disheveled regulates precoupling of heterotrimeric G proteins to Frizzled 6
FASEB J, 28 (5), 2293-305
DOI 10.1096/fj.13-246363, PubMed 24500924
Non-classical regulation of β1- and β 2-adrenoceptor-mediated inotropic responses in rat heart ventricle by the G protein Gi
Naunyn Schmiedebergs Arch Pharmacol, 387 (12), 1177-86
DOI 10.1007/s00210-014-1036-7, PubMed 25216690
Gi proteins regulate adenylyl cyclase activity independent of receptor activation
PLoS One, 9 (9), e106608
DOI 10.1371/journal.pone.0106608, PubMed 25203113
Different compartmentation of responses to brain natriuretic peptide and C-type natriuretic peptide in failing rat ventricle
J Pharmacol Exp Ther, 350 (3), 681-90
DOI 10.1124/jpet.114.214882, PubMed 25022512
Differential regulation of C-type natriuretic peptide-induced cGMP and functional responses by PDE2 and PDE3 in failing myocardium
Naunyn Schmiedebergs Arch Pharmacol, 387 (5), 407-17
DOI 10.1007/s00210-013-0953-1, PubMed 24424715
Synthesis and in vitro evaluation of small-molecule [18F] labeled gonadotropin-releasing hormone (GnRH) receptor antagonists as potential PET imaging agents for GnRH receptor expression
Bioorg Med Chem Lett, 24 (7), 1846-50
DOI 10.1016/j.bmcl.2014.02.002, PubMed 24613701
Inhibition of phosphodiesterase-3 by levosimendan is sufficient to account for its inotropic effect in failing human heart
Br J Pharmacol, 171 (23), 5169-81
DOI 10.1111/bph.12647, PubMed 24547784
In memory of Guro Valen (1960-2014)
J Mol Cell Cardiol, 79, 254-5
DOI 10.1016/j.yjmcc.2014.11.026, PubMed 25490150
Publications 2013
Identification of small molecule NPR-B antagonists by high throughput screening--potential use in heart failure
Naunyn Schmiedebergs Arch Pharmacol, 387 (1), 5-14
DOI 10.1007/s00210-013-0940-6, PubMed 24297249
Acidic biphenyl derivatives: synthesis and biological activity of a new series of potent 5-HT(4) receptor antagonists
Bioorg Med Chem, 21 (22), 7134-45
DOI 10.1016/j.bmc.2013.09.004, PubMed 24113240
Synthesis and pharmacological properties of a new hydrophilic and orally bioavailable 5-HT4 antagonist
Eur J Med Chem, 64, 629-37
DOI 10.1016/j.ejmech.2013.03.060, PubMed 23711770
The serotonin 5-HT7 receptors: two decades of research
Exp Brain Res, 230 (4), 555-68
DOI 10.1007/s00221-013-3694-y, PubMed 24042216
Connective tissue growth factor/CCN2 attenuates β-adrenergic receptor responsiveness and cardiotoxicity by induction of G protein-coupled receptor kinase-5 in cardiomyocytes
Mol Pharmacol, 84 (3), 372-83
DOI 10.1124/mol.113.087312, PubMed 23778361
NSC23766, a widely used inhibitor of Rac1 activation, additionally acts as a competitive antagonist at muscarinic acetylcholine receptors
J Pharmacol Exp Ther, 347 (1), 69-79
DOI 10.1124/jpet.113.207266, PubMed 23887096
Cardiac PDEs and crosstalk between cAMP and cGMP signalling pathways in the regulation of contractility
Naunyn Schmiedebergs Arch Pharmacol, 386 (8), 665-70
DOI 10.1007/s00210-013-0874-z, PubMed 23649864
PDE3, but not PDE4, reduces β₁ - and β₂-adrenoceptor-mediated inotropic and lusitropic effects in failing ventricle from metoprolol-treated patients
Br J Pharmacol, 169 (3), 528-38
DOI 10.1111/bph.12167, PubMed 23489141
SERCA2 activity is involved in the CNP-mediated functional responses in failing rat myocardium
Br J Pharmacol, 170 (2), 366-79
DOI 10.1111/bph.12282, PubMed 23808942
Publications 2012
Retinoic acid signalling is activated in the postischemic heart and may influence remodelling
PLoS One, 7 (9), e44740
DOI 10.1371/journal.pone.0044740, PubMed 23028599
The cardiac ventricular 5-HT4 receptor is functional in late foetal development and is reactivated in heart failure
PLoS One, 7 (9), e45489
DOI 10.1371/journal.pone.0045489, PubMed 23029047
Biochemical and pharmacological study of N-linked glycosylation of the human serotonin 5-HT₇a receptor
FEBS J, 279 (11), 1994-2003
DOI 10.1111/j.1742-4658.2012.08581.x, PubMed 22448645
The functional activity of inhibitory G protein (G(i)) is not increased in failing heart ventricle
J Mol Cell Cardiol, 56, 129-38
DOI 10.1016/j.yjmcc.2012.11.015, PubMed 23220156
Prostanoid-mediated inotropic responses are attenuated in failing human and rat ventricular myocardium
Eur J Pharmacol, 686 (1-3), 66-73
DOI 10.1016/j.ejphar.2012.04.022, PubMed 22546232
Prostaglandin E1 facilitates inotropic effects of 5-HT4 serotonin receptors and β-adrenoceptors in failing human heart
Basic Res Cardiol, 107 (5), 295
DOI 10.1007/s00395-012-0295-z, PubMed 22923058
Cardiomyocyte-restricted inhibition of G protein-coupled receptor kinase-3 attenuates cardiac dysfunction after chronic pressure overload
Am J Physiol Heart Circ Physiol, 303 (1), H66-74
DOI 10.1152/ajpheart.00724.2011, PubMed 22542621
Publications 2011
Differential regulation of β2 -adrenoceptor-mediated inotropic and lusitropic response by PDE3 and PDE4 in failing and non-failing rat cardiac ventricle
Br J Pharmacol, 162 (1), 54-71
DOI 10.1111/j.1476-5381.2010.00890.x, PubMed 21133887
Agents increasing cyclic GMP amplify 5-HT4-elicited positive inotropic response in failing rat cardiac ventricle
Naunyn Schmiedebergs Arch Pharmacol, 384 (6), 543-53
DOI 10.1007/s00210-011-0670-6, PubMed 21901315
Novel benzo[b]thiophene derivatives as new potential antidepressants with rapid onset of action
J Med Chem, 54 (8), 3086-90
DOI 10.1021/jm2000773, PubMed 21469694
Quantification of GPCR mRNA using real-time RT-PCR
Methods Mol Biol, 746, 165-93
DOI 10.1007/978-1-61779-126-0_9, PubMed 21607857
Cyclic AMP-dependent inotropic effects are differentially regulated by muscarinic G(i)-dependent constitutive inhibition of adenylyl cyclase in failing rat ventricle
Br J Pharmacol, 162 (4), 908-16
DOI 10.1111/j.1476-5381.2010.01097.x, PubMed 21039419
Publications 2010
Reference gene alternatives to Gapdh in rodent and human heart failure gene expression studies
BMC Mol Biol, 11, 22
DOI 10.1186/1471-2199-11-22, PubMed 20331858
Synthesis and pharmacological properties of novel hydrophilic 5-HT4 receptor antagonists
Bioorg Med Chem, 18 (24), 8600-13
DOI 10.1016/j.bmc.2010.10.011, PubMed 21075638
Publications 2009
Activation of muscarinic receptors elicits inotropic responses in ventricular muscle from rats with heart failure through myosin light chain phosphorylation
Br J Pharmacol, 156 (4), 575-86
DOI 10.1111/j.1750-3639.2009.00016.x, PubMed 19159405
Effect of piboserod, a 5-HT4 serotonin receptor antagonist, on left ventricular function in patients with symptomatic heart failure
Eur J Heart Fail, 11 (8), 771-8
DOI 10.1093/eurjhf/hfp087, PubMed 19567409
Natriuretic peptides increase beta1-adrenoceptor signalling in failing hearts through phosphodiesterase 3 inhibition
Cardiovasc Res, 85 (4), 763-72
DOI 10.1093/cvr/cvp364, PubMed 19900965
Publications 2008
5-HT4-elicited positive inotropic response is mediated by cAMP and regulated by PDE3 in failing rat and human cardiac ventricles
Br J Pharmacol, 155 (7), 1005-14
DOI 10.1038/bjp.2008.339, PubMed 18846035
Calculating reaction rate constants and estimating the efficacy of selective enzyme inhibitors
Anal Biochem, 383 (2), 323-5
DOI 10.1016/j.ab.2008.09.011, PubMed 18831958
Cloning, genomic organization and functionality of 5-HT(7) receptor splice variants from mouse brain
Gene, 426 (1-2), 23-31
DOI 10.1016/j.gene.2008.08.011, PubMed 18793707
EBV infection renders B cells resistant to growth inhibition via adenylyl cyclase
Cell Signal, 20 (6), 1169-78
DOI 10.1016/j.cellsig.2008.02.007, PubMed 18406106
Diastolic dysfunction in alveolar hypoxia: a role for interleukin-18-mediated increase in protein phosphatase 2A
Cardiovasc Res, 80 (1), 47-54
DOI 10.1093/cvr/cvn180, PubMed 18599478
Effects of serotonin in failing cardiac ventricle: signalling mechanisms and potential therapeutic implications
Neuropharmacology, 55 (6), 1066-71
DOI 10.1016/j.neuropharm.2008.07.010, PubMed 18675829
The heterotrimeric G-protein alpha-subunit Galphaq regulates TCR-mediated immune responses through an Lck-dependent pathway
Eur J Immunol, 38 (11), 3208-18
DOI 10.1002/eji.200838195, PubMed 18991294
Hormonal regulation of beta2-adrenergic receptor level in prostate cancer
Prostate, 68 (10), 1133-42
DOI 10.1002/pros.20778, PubMed 18454446
Prostanoid F receptors elicit an inotropic effect in rat left ventricle by enhancing myosin light chain phosphorylation
Cardiovasc Res, 80 (3), 407-15
DOI 10.1093/cvr/cvn216, PubMed 18703533
Publications 2007
Serotonin increases L-type Ca2+ current and SR Ca2+ content through 5-HT4 receptors in failing rat ventricular cardiomyocytes
Am J Physiol Heart Circ Physiol, 293 (4), H2367-76
DOI 10.1152/ajpheart.01375.2006, PubMed 17660386
Serotonin responsiveness through 5-HT2A and 5-HT4 receptors is differentially regulated in hypertrophic and failing rat cardiac ventricle
J Mol Cell Cardiol, 43 (6), 767-79
DOI 10.1016/j.yjmcc.2007.08.019, PubMed 17936780
Expression of mRNA encoding G protein-coupled receptors involved in congestive heart failure--a quantitative RT-PCR study and the question of normalisation
Basic Res Cardiol, 102 (3), 198-208
DOI 10.1007/s00395-007-0648-1, PubMed 17370034
Novel aspects of G-protein-coupled receptor signalling--different ways to achieve specificity
Acta Physiol (Oxf), 190 (1), 33-8
DOI 10.1111/j.1365-201X.2007.01696.x, PubMed 17428230
Substrate specificities of g protein-coupled receptor kinase-2 and -3 at cardiac myocyte receptors provide basis for distinct roles in regulation of myocardial function
Mol Pharmacol, 72 (3), 582-91
DOI 10.1124/mol.107.035766, PubMed 17573483
Publications 2006
Effects of treatment with a 5-HT4 receptor antagonist in heart failure
Br J Pharmacol, 150 (2), 143-52
DOI 10.1038/sj.bjp.0706966, PubMed 17160012
Fading of 5-HT4 receptor-mediated inotropic responses to 5-hydroxytryptamine is caused by phosphodiesterase activity in porcine atrium
Br J Pharmacol, 147 (2), 128-30
DOI 10.1038/sj.bjp.0706501, PubMed 16331292
5-hydroxytryptamine receptors in the human cardiovascular system
Pharmacol Ther, 111 (3), 674-706
DOI 10.1016/j.pharmthera.2005.12.004, PubMed 16960982
Heterologous desensitization is evoked by both agonist and antagonist stimulation of the human 5-HT(7) serotonin receptor
Eur J Pharmacol, 532 (1-2), 1-10
DOI 10.1016/j.ejphar.2005.11.039, PubMed 16487959
Epac- and Rap- independent ERK1/2 phosphorylation induced by Gs-coupled receptor stimulation in HEK293 cells
FEBS Lett, 581 (1), 15-20
DOI 10.1016/j.febslet.2006.11.069, PubMed 17174312
Publications 2005
Activation of adenylyl cyclase by endogenous G(s)-coupled receptors in human embryonic kidney 293 cells is attenuated by 5-HT(7) receptor expression
Mol Pharmacol, 69 (1), 207-15
DOI 10.1124/mol.105.015396, PubMed 16189297
Prucalopride is a partial agonist through human and porcine atrial 5-HT4 receptors: comparison with recombinant human 5-HT4 splice variants
Naunyn Schmiedebergs Arch Pharmacol, 371 (6), 473-9
DOI 10.1007/s00210-005-1068-0, PubMed 16012870
Endogenous expression and protein kinase A-dependent phosphorylation of the guanine nucleotide exchange factor Ras-GRF1 in human embryonic kidney 293 cells
FEBS J, 272 (9), 2304-16
DOI 10.1111/j.1742-4658.2005.04658.x, PubMed 15853814
Appearance of a ventricular 5-HT4 receptor-mediated inotropic response to serotonin in heart failure
Cardiovasc Res, 65 (4), 869-78
DOI 10.1016/j.cardiores.2004.11.017, PubMed 15721867
Dual serotonergic regulation of ventricular contractile force through 5-HT2A and 5-HT4 receptors induced in the acute failing heart
Circ Res, 97 (3), 268-76
DOI 10.1161/01.RES.0000176970.22603.8d, PubMed 16002744
Publications 2004
Cloning, pharmacological characterisation and tissue distribution of a novel 5-HT4 receptor splice variant, 5-HT4(i)
Naunyn Schmiedebergs Arch Pharmacol, 369 (6), 616-28
DOI 10.1007/s00210-004-0919-4, PubMed 15118808
Functional serotonin 5-HT4 receptors in porcine and human ventricular myocardium with increased 5-HT4 mRNA in heart failure
Naunyn Schmiedebergs Arch Pharmacol, 370 (3), 157-66
DOI 10.1007/s00210-004-0963-0, PubMed 15365689
Beta2-adrenergic receptor regulation in prostate cancer upon androgen deprivation
In European urology supplements, Elsevier Science, Oxford, 3(2004)2, Abstrakt 581
BIBSYS 052053962
The effect of cleaning on dust and the health of office workers: an intervention study
Epidemiology, 15 (1), 71-8
DOI 10.1097/01.ede.0000101020.72399.37, PubMed 14712149
Functional 5-HT receptors in human occipital artery
Naunyn Schmiedebergs Arch Pharmacol, 369 (4), 391-401
DOI 10.1007/s00210-004-0878-9, PubMed 15007537
RAMP2 and RAMP3 mRNA levels are increased in failing rat cardiomyocytes and associated with increased responsiveness to adrenomedullin
J Mol Cell Cardiol, 38 (1), 145-51
DOI 10.1016/j.yjmcc.2004.10.009, PubMed 15623431
Publications 2003
Alpha1-AR-mediated activation of NKCC in rat cardiomyocytes involves ERK-dependent phosphorylation of the cotransporter
Am J Physiol Heart Circ Physiol, 286 (4), H1354-60
DOI 10.1152/ajpheart.00549.2003, PubMed 14630635
Unaltered agonist potency upon inducible 5-HT7(a) but not 5-HT4(b) receptor expression indicates agonist-independent association of 5-HT7(a) receptor and Gs
Recept Channels, 9 (2), 107-16
DOI 10.1080/10606820308245, PubMed 12916471
Publications 2002
The human 5-HT7 serotonin receptor splice variants: constitutive activity and inverse agonist effects
Br J Pharmacol, 135 (6), 1563-71
DOI 10.1038/sj.bjp.0704588, PubMed 11906971
Ras-dependent ERK activation by the human G(s)-coupled serotonin receptors 5-HT4(b) and 5-HT7(a)
J Biol Chem, 278 (5), 3098-104
DOI 10.1074/jbc.M206237200, PubMed 12446729
Cholesterol is important in control of EGF receptor kinase activity but EGF receptors are not concentrated in caveolae
J Cell Sci, 115 (Pt 6), 1331-40
DOI 10.1242/jcs.115.6.1331, PubMed 11884532
Publications 2001
5HT4(a) and 5-HT4(b) receptors have nearly identical pharmacology and are both expressed in human atrium and ventricle
Naunyn Schmiedebergs Arch Pharmacol, 363 (2), 146-60
DOI 10.1007/s002100000299, PubMed 11218067
The cloned human 5-HT7 receptor splice variants: a comparative characterization of their pharmacology, function and distribution
Naunyn Schmiedebergs Arch Pharmacol, 363 (6), 620-32
DOI 10.1007/s002100000369, PubMed 11414657
Activation of the COOH-terminal Src kinase (Csk) by cAMP-dependent protein kinase inhibits signaling through the T cell receptor
J Exp Med, 193 (4), 497-507
DOI 10.1084/jem.193.4.497, PubMed 11181701
Publications 2000
Identification of the adenylyl cyclase-activating 5-hydroxytryptamine receptor subtypes expressed in the rat submandibular gland
Br J Pharmacol, 130 (1), 104-8
DOI 10.1038/sj.bjp.0703303, PubMed 10781004
Prosjektrapport Innemiljø og trivsel i skolen: "Lørenskogprosjektet"
Institutt for plantefag, Norges landbrukshøgskole, [Ås], 36 s.
BIBSYS 000200867
Ephrin-B2 is a candidate ligand for the Eph receptor, EphB6
FEBS Lett, 466 (1), 169-74
DOI 10.1016/s0014-5793(99)01793-7, PubMed 10648835
Publications 1999
Activation of the cAMP signaling pathway increases apoptosis in human B-precursor cells and is associated with downregulation of Mcl-1 expression
J Cell Physiol, 180 (1), 71-80
DOI 10.1002/(SICI)1097-4652(199907)180:1<71::AID-JCP8>3.0.CO;2-N, PubMed 10362019
Publications 1998
High-affinity binding of epidermal growth factor (EGF) to EGF receptor is disrupted by overexpression of mutant dynamin (K44A)
J Biol Chem, 273 (27), 16639-42
DOI 10.1074/jbc.273.27.16639, PubMed 9642213
Isozymes of cyclic AMP-dependent protein kinases (PKA) in human lymphoid cell lines: levels of endogenous cAMP influence levels of PKA subunits and growth in lymphoid cell lines
J Cell Physiol, 177 (1), 85-93
DOI 10.1002/(SICI)1097-4652(199810)177:1<85::AID-JCP9>3.0.CO;2-A, PubMed 9731748
Kinetic properties of the C-terminal Src kinase, p50csk
Biochim Biophys Acta, 1384 (2), 285-93
DOI 10.1016/s0167-4838(97)00202-1, PubMed 9659389
Publications 1997
CDw78--a determinant on a major histocompatibility complex class II subpopulation that can be induced to associate with the cytoskeleton
Eur J Immunol, 27 (12), 3206-13
DOI 10.1002/eji.1830271218, PubMed 9464807
Structure, function, and regulation of human cAMP-dependent protein kinases
Adv Second Messenger Phosphoprotein Res, 31, 191-204
DOI 10.1016/s1040-7952(97)80019-5, PubMed 9344252
Selective activation of cAMP-dependent protein kinase type I inhibits rat natural killer cell cytotoxicity
J Biol Chem, 272 (9), 5495-500
DOI 10.1074/jbc.272.9.5495, PubMed 9038153
Hus og helse: hva legen vet om innemiljø
Cappelen, [Oslo] (4. [rev.] oppl.), 182 s.
BIBSYS 970726627, ISBN 82-02-17021-4
Publications 1996
Betong i bygninger - konsekvenser for inneklima: forp[r]osjekt
In Prosjektrapport, Instituttet., Oslo, 193-1996, 32 s.
BIBSYS 960288899, ISBN 82-536-0506-4
Cyclic AMP-dependent protein kinase (cAK) in human B cells: co-localization of type I cAK (RI alpha 2 C2) with the antigen receptor during anti-immunoglobulin-induced B cell activation
Eur J Immunol, 26 (6), 1290-6
DOI 10.1002/eji.1830260617, PubMed 8647207
Report on the 9th European Workshop on the Molecular and Cellular Endocrinology of the Testis
Mol Cell Endocrinol, 122 (1), 1-13
DOI 10.1016/0303-7207(96)03883-x, PubMed 8898343
Hus og helse: hva legen vet om innemiljø
Pensumtjeneste, Oslo, 175 s.
BIBSYS 96228811x, ISBN 82-13-00740-9
Publications 1995
Modulation of gonadotropic and purinergic responsiveness by islet activating protein in sertoli cells from immature rats
J Steroid Biochem Mol Biol, 52 (5), 431-6
DOI 10.1016/0960-0760(95)00002-h, PubMed 7748808
Publications 1994
Studies on the intrinsic activity (efficacy) of human adrenergic receptors. Co-expression of beta 1 and beta 2 reveals a lower efficacy for the beta 1 receptor
Tex Heart Inst J, 21 (1), 16-21
PubMed 8180506
Assignment of the gene encoding the 5-HT1E serotonin receptor (S31) (locus HTR1E) to human chromosome 6q14-q15
Genomics, 22 (3), 637-40
DOI 10.1006/geno.1994.1439, PubMed 8001977
Publications 1993
Human S31 serotonin receptor clone encodes a 5-hydroxytryptamine1E-like serotonin receptor
Mol Pharmacol, 43 (3), 412-8
PubMed 8450834
Efficacy of beta 1-adrenergic receptors is lower than that of beta 2-adrenergic receptors
Proc Natl Acad Sci U S A, 90 (22), 10798-802
DOI 10.1073/pnas.90.22.10798, PubMed 8248173
Publications 1992
Omfanget av inneklimaproblemer i Norge
In Prosjektrapport, Instituttet., Oslo, 97, 44 s.
BIBSYS 920675034, ISBN 82-536-0381-9
Ca2+ mobilization by the LH receptor expressed in Xenopus oocytes independent of 3',5'-cyclic adenosine monophosphate formation: evidence for parallel activation of two signaling pathways
Mol Endocrinol, 6 (2), 272-8
DOI 10.1210/mend.6.2.1314958, PubMed 1314958
Molecular cloning of a human gene (S31) encoding a novel serotonin receptor mediating inhibition of adenylyl cyclase
FEBS Lett, 296 (2), 201-6
DOI 10.1016/0014-5793(92)80379-u, PubMed 1733778
Molecular cloning of a human serotonin receptor (S12) with a pharmacological profile resembling that of the 5-HT1D subtype
J Biol Chem, 267 (11), 7553-62
PubMed 1559993
Publications 1991
Cellular localization of mRNAs for retinoic acid receptor-alpha, cellular retinol-binding protein, and cellular retinoic acid-binding protein in rat testis: evidence for germ cell-specific mRNAs
Biol Reprod, 44 (1), 53-61
DOI 10.1095/biolreprod44.1.53, PubMed 1849753
Hus og helse: hva legen vet om innemiljø
Cappelen, [Oslo], 175 s.
BIBSYS 91100663x, ISBN 82-02-12821-8
Publications 1989
Inneklima: en orientering om klimafaktorer og forurensninger
In Publikasjon, HD, Arbeidsmiljøinstituttet, Oslo, 992/89 (4. rev. utg.), 34 s.
BIBSYS 890244308
Glucocorticoid receptors and glucocorticoid effects in rat Sertoli cells
Endocrinology, 124 (1), 430-6
DOI 10.1210/endo-124-1-430, PubMed 2909375
Autologous down-regulation of messenger ribonucleic acid and protein levels for estrogen receptors in MCF-7 cells: an inverse correlation to progesterone receptor levels
Endocrinology, 124 (5), 2577-83
DOI 10.1210/endo-124-5-2577, PubMed 2651098
Publications 1988
A transplantable rat Leydig cell tumor--5. Cellular localization of beta-adrenergic and prostaglandin receptors and their effects on testosterone production
J Steroid Biochem, 31 (1), 41-8
DOI 10.1016/0022-4731(88)90203-8, PubMed 2840532
Luftionisering og mikroklimaforskning i Ungarn: rapport fra en studiereise i Budapest
In AMY publikasjon, HD, AMY, Oslo, 978/88 FOU, 11, 2, 4 bl.
BIBSYS 882106724
Helseforhold ved kontorarbeidsplasser: en undersøkelse over sammenheng mellom belastningssymptomer fra øyne og muskulatur i relasjon til bruk av skjermterminaler og tradisjonelle kontormaskiner
In Publikasjon, HD, Arbeidsmiljøinstituttet, Oslo, 985/88 FOU, 99 s.
BIBSYS 894043234
Testicular receptors for 1,25-dihydroxyvitamin D3 and glucocorticoids: a study of cellular localization, developmental changes, and receptor-mediated effects
Institute of Medical Biochemistry, University of Oslo, Oslo, 1 b. (flere pag.)
BIBSYS 894049461
Molecular cloning, complementary deoxyribonucleic acid structure and predicted full-length amino acid sequence of the hormone-inducible regulatory subunit of 3'-5'-cyclic adenosine monophosphate-dependent protein kinase from human testis
Mol Endocrinol, 2 (12), 1364-73
DOI 10.1210/mend-2-12-1364, PubMed 2851102
Differential regulation of messenger ribonucleic acids for specific subunits of cyclic adenosine 3',5'-monophosphate (cAMP)-dependent protein kinase by cAMP in rat Sertoli cells
Endocrinology, 122 (6), 2658-66
DOI 10.1210/endo-122-6-2658, PubMed 2836170
Molecular cloning and cell-specific expression of newly discovered subunits of cAMP-dependent protein kinases. Implications for different cellular responses to cAMP
APMIS Suppl, 2, 238-50
PubMed 2846017
Molecular cloning, cDNA structure and deduced amino acid sequence for the hormone-induced regulatory subunit (RII beta) of cAMP-dependent protein kinase from rat ovarian granulosa cells
Biochem Biophys Res Commun, 154 (2), 705-11
DOI 10.1016/0006-291x(88)90197-0, PubMed 3401231
Publications 1987
Biologiske faktorer: helserisiko
In AMY publikasjon, HD, AMY, Oslo, 969/87 FOU, 20 s.
BIBSYS 884065472
Effects of cryptorchidism and orchidopexy on deoxyribonucleoside-activated nucleotidase (DAN) in the rat testis
Int J Biochem, 19 (11), 1023-7
DOI 10.1016/0020-711x(87)90302-8, PubMed 2892698
Inneklima: en orientering om klimafaktorer og forurensninger
In AMY publikasjon, HD, AMY, Oslo, 966/87 FOU (3. rev. utg.), ii, 26, 5 s.
BIBSYS 874151112
Sykdommer assosiert med bygninger: foredrag holdt ved seminaret "Det sunda huset", arrangertav Bygghälsan og Statens miljömedicinska laboratorium, Stockholm 31/3-1/4-87
In AMY publikasjon, HD, AMY, Oslo, 973/87 FOU, 12 s.
BIBSYS 884065502
Publications 1986
Helseeffekter av muggsoppsporer og trestøv i to sorterverk og innflytelse av driftsbetingelser på eksponeringen
In YHI publikasjon, HD, Yrkeshygienisk institutt, Arbeidsforskningsinstituttene., [Oslo], 915/85, 26, 6 s.
BIBSYS 862091276
Inneklima: en orientering om klimafaktorer og forurensninger
In YHI publikasjon, HD, Yrkeshygienisk institutt, Arbeidsforskningsinstituttene., [Oslo], 927/86 (2. utg.), 27, [11] s.
BIBSYS 862054028
Løsemiddelmålinger og virkning av løsemiddeleksponering ved produksjon og arbeid med maling og lakk: sammenheng mellom eksponeringsforhold og symptomer
In YHI publikasjon, HD, Yrkeshygienisk institutt, Arbeidsforskningsinstituttene., [Oslo], 938/86, 34 s.
BIBSYS 872029174
Publications 1985
Glucagon-stimulated cyclic AMP production and formation of estradiol in Sertoli cell cultures from immature rats
Mol Cell Endocrinol, 39 (2), 107-13
DOI 10.1016/0303-7207(85)90126-1, PubMed 2984057
Effects of adenosine analogs on glucagon-stimulated adenosine 3',5'-monophosphate formation in Sertoli cell cultures from immature rats
Endocrinology, 117 (2), 488-91
DOI 10.1210/endo-117-2-488, PubMed 2990852
Metabolism of palmitate in cultured rat Sertoli cells
J Reprod Fertil, 73 (2), 497-503
DOI 10.1530/jrf.0.0730497, PubMed 4039365
Inneklima: en orientering om klimafaktorer og forurensninger
In YHI publikasjon, HD, Yrkeshygienisk institutt, Arbeidsforskningsinstituttene., [Oslo], 923, 24 s., [10] bl.
BIBSYS 862019516
Rapport fra Inneklimat - ett forskarseminarium Esbo, Finland, 6.-7. mai 1985
In YHI publikasjon, HD, Yrkeshygienisk institutt, Arbeidsforskningsinstituttene., [Oslo], 906/85, 10 bl.
BIBSYS 852129106
Trestøv - helseeffekter
In YHI publikasjon, HD, Yrkeshygienisk institutt, Arbeidsforskningsinstituttene., [Oslo], HD 922/85, 17 s.
BIBSYS 862026687
"Differential displacement"--a simple method to study receptors for 1,25-dihydroxyvitamin D3 in the presence of contaminating serum vitamin D binding protein
Biochem Biophys Res Commun, 130 (3), 1020-6
DOI 10.1016/0006-291x(85)91717-6, PubMed 2992493
Appearance of the rat testicular receptor for calcitriol (1,25-dihydroxyvitamin D3) during development
J Steroid Biochem, 23 (1), 51-6
DOI 10.1016/0022-4731(85)90259-6, PubMed 2991662
Properties and compartmentalization of the testicular receptor for 1,25-dihydroxyvitamin D3
J Steroid Biochem, 22 (4), 453-60
DOI 10.1016/0022-4731(85)90162-1, PubMed 2987614
Yrkesmedisinsk og nervopsykologisk undersøkelse av løsemiddeleksponerte arbeidstakere: årsrapport 1984 fra Yrkeshygienisk institutt, Medisinsk avdeling
In YHI publikasjon, HD, Yrkeshygienisk institutt, Arbeidsforskningsinstituttene., [Oslo], 909/85, ii, 29 s.
BIBSYS 852164130
Publications 1984
Kartlegging og kontroll av kvikksølveksponering i oljeindustrien: retningslinjer for bruk av urinanalyser
In YHI publikasjon, HD, Yrkeshygienisk institutt, Arbeidsforskningsinstituttene., [Oslo], 900/84, 17 bl.
BIBSYS 852092989
Publications 1983
Kontroll av kvikksølvopptak ved tannklinikker: Finn Levy, John Selstad og Nils Wandel
In YHI publikasjon, HD, Yrkeshygienisk institutt, Arbeidsforskningsinstituttene., [Oslo], 890/83, 9 bl.
BIBSYS 842209913