Publications 2021

Hildrestrand GA, Rolseth V, Kunath N, Suganthan R, Jensen V, Bugaj AM, Fernandez-Berrocal MS, Sikko SB, Vetlesen S, Kuśnierczyk A, Olsen AK, Gützkow KB, Rowe AD, Wang W, Moldestad O, Syrstad MD, Slupphaug G, Eide L, Klungland A, Sætrom P, Luna L, Ye J, Scheffler K, Bjørås M (2021)
NEIL1 and NEIL2 DNA glycosylases modulate anxiety and learning in a cooperative manner in mice
Commun Biol, 4 (1), 1354
DOI 10.1038/s42003-021-02864-x, PubMed 34857879

Mengeste AM, Lund J, Katare P, Ghobadi R, Bakke HG, Lunde PK, Eide L, Mahony GO, Göpel S, Peng XR, Kase ET, Thoresen GH, Rustan AC (2021)
The small molecule SERCA activator CDN1163 increases energy metabolism in human skeletal muscle cells
Curr Res Pharmacol Drug Discov, 2, 100060
DOI 10.1016/j.crphar.2021.100060, PubMed 34909682

Yuzefovych LV, Kahn AG, Schuler MA, Eide L, Arora R, Wilson GL, Tan M, Rachek LI (2021)
Correction: Mitochondrial DNA Repair through OGG1 Activity Attenuates Breast Cancer Progression and Metastasis
Cancer Res, 81 (11), 3144
DOI 10.1158/0008-5472.CAN-21-1000, PubMed 34087783

Publications 2020

Yang M, Lin X, Segers F, Suganthan R, Hildrestrand GA, Rinholm JE, Aas PA, Sousa MML, Holm S, Bolstad N, Warren D, Berge RK, Johansen RF, Yndestad A, Kristiansen E, Klungland A, Luna L, Eide L, Halvorsen B, Aukrust P, Bjørås M (2020)
OXR1A, a Coactivator of PRMT5 Regulating Histone Arginine Methylation
Cell Rep, 30 (12), 4165-4178.e7
DOI 10.1016/j.celrep.2020.02.063, PubMed 32209476

Publications 2019

Rodinova M, Krizova J, Stufkova H, Bohuslavova B, Askeland G, Dosoudilova Z, Juhas S, Juhasova J, Ellederova Z, Zeman J, Eide L, Motlik J, Hansikova H (2019)
Deterioration of mitochondrial bioenergetics and ultrastructure impairment in skeletal muscle of a transgenic minipig model in the early stages of Huntington's disease
Dis Model Mech, 12 (7)
DOI 10.1242/dmm.038737, PubMed 31278192

Smatlikova P, Askeland G, Vaskovicova M, Klima J, Motlik J, Eide L, Ellederová Z (2019)
Age-Related Oxidative Changes in Primary Porcine Fibroblasts Expressing Mutated Huntingtin
Neurodegener Dis, 19 (1), 22-34
DOI 10.1159/000500091, PubMed 31167196

Publications 2018

Askeland G, Dosoudilova Z, Rodinova M, Klempir J, Liskova I, Kuśnierczyk A, Bjørås M, Nesse G, Klungland A, Hansikova H, Eide L (2018)
Increased nuclear DNA damage precedes mitochondrial dysfunction in peripheral blood mononuclear cells from Huntington's disease patients
Sci Rep, 8 (1), 9817
DOI 10.1038/s41598-018-27985-y, PubMed 29959348

Askeland G, Rodinova M, Štufková H, Dosoudilova Z, Baxa M, Smatlikova P, Bohuslavova B, Klempir J, Nguyen TD, Kuśnierczyk A, Bjørås M, Klungland A, Hansikova H, Ellederova Z, Eide L (2018)
A transgenic minipig model of Huntington's disease shows early signs of behavioral and molecular pathologies
Dis Model Mech, 11 (10)
DOI 10.1242/dmm.035949, PubMed 30254085

Bousquet PA, Meltzer S, Sønstevold L, Esbensen Y, Dueland S, Flatmark K, Sitter B, Bathen TF, Seierstad T, Redalen KR, Eide L, Ree AH (2018)
Markers of Mitochondrial Metabolism in Tumor Hypoxia, Systemic Inflammation, and Adverse Outcome of Rectal Cancer
Transl Oncol, 12 (1), 76-83
DOI 10.1016/j.tranon.2018.09.010, PubMed 30273860

Publications 2017

Jackson CJ, Reppe S, Eidet JR, Eide L, Tønseth KA, Bergersen LH, Dartt DA, Griffith M, Utheim TP (2017)
Optimization of Storage Temperature for Retention of Undifferentiated Cell Character of Cultured Human Epidermal Cell Sheets
Sci Rep, 7 (1), 8206
DOI 10.1038/s41598-017-08586-7, PubMed 28811665

Kassahun H, SenGupta T, Schiavi A, Maglioni S, Skjeldam HK, Arczewska K, Brockway NL, Estes S, Eide L, Ventura N, Nilsen H (2017)
Constitutive MAP-kinase activation suppresses germline apoptosis in NTH-1 DNA glycosylase deficient C. elegans
DNA Repair (Amst), 61, 46-55
DOI 10.1016/j.dnarep.2017.11.009, PubMed 29202295

Li X, Lu J, Kan Q, Li X, Fan Q, Li Y, Huang R, Slipicevic A, Dong HP, Eide L, Wang J, Zhang H, Berge V, Goscinski MA, Kvalheim G, Nesland JM, Suo Z (2017)
Metabolic reprogramming is associated with flavopiridol resistance in prostate cancer DU145 cells
Sci Rep, 7 (1), 5081
DOI 10.1038/s41598-017-05086-6, PubMed 28698547

Li X, Zhong Y, Lu J, Axcrona K, Eide L, Syljuåsen RG, Peng Q, Wang J, Zhang H, Goscinski MA, Kvalheim G, Nesland JM, Suo Z (2017)
Correction: MtDNA depleted PC3 cells exhibit Warburg effect and cancer stem cell features
Oncotarget, 8 (4), 7208-7213
DOI 10.18632/oncotarget.14800, PubMed 28179591

Pawar T, Bjørås M, Klungland A, Eide L (2017)
Metabolism and DNA repair shape a specific modification pattern in mitochondrial DNA
Mitochondrion, 40, 16-28
DOI 10.1016/j.mito.2017.09.002, PubMed 28893634

Scheffler K, Rachek L, You P, Rowe AD, Wang W, Kuśnierczyk A, Kittelsen L, Bjørås M, Eide L (2017)
8-oxoguanine DNA glycosylase (Ogg1) controls hepatic gluconeogenesis
DNA Repair (Amst), 61, 56-62
DOI 10.1016/j.dnarep.2017.11.008, PubMed 29207315

Publications 2016

Distante S, Eikeland J, Pawar T, Skinnes R, Høie K, You P, Mørkrid L, Eide L (2016)
Blood removal therapy in hereditary hemochromatosis induces a stress response resulting in improved genome integrity
Transfusion, 56 (6), 1435-41
DOI 10.1111/trf.13588, PubMed 27045387

Khuu C, Sehic A, Eide L, Osmundsen H (2016)
Anti-proliferative Properties of miR-20b and miR-363 from the miR-106a-363 Cluster on Human Carcinoma Cells
Microrna, 5 (1), 19-35
DOI 10.2174/2211536605666160322151813, PubMed 27001184

Li X, Zhong Y, Lu J, Axcrona K, Eide L, Syljuåsen RG, Peng Q, Wang J, Zhang H, Goscinski MA, Kvalheim G, Nesland JM, Suo Z (2016)
MtDNA depleted PC3 cells exhibit Warburg effect and cancer stem cell features
Oncotarget, 7 (26), 40297-40313
DOI 10.18632/oncotarget.9610, PubMed 27248169

Pawar T, Eide L (2016)
Pitfalls in mitochondrial epigenetics
Mitochondrial DNA A DNA Mapp Seq Anal, 28 (5), 762-768
DOI 10.1080/24701394.2016.1180514, PubMed 27246961

Skarpengland T, Dahl TB, Skjelland M, Scheffler K, de Sousa MML, Gregersen I, Kuśnierczyk A, Sharma A, Slupphaug G, Eide L, Segers FM, Skagen KR, Dahl CP, Russell D, Folkersen L, Krohg-Sørensen K, Holm S, Bjørås M, Aukrust P, Halvorsen B (2016)
Enhanced base excision repair capacity in carotid atherosclerosis may protect nuclear DNA but not mitochondrial DNA
Free Radic Biol Med, 97, 386-397
DOI 10.1016/j.freeradbiomed.2016.07.001, PubMed 27381496

Skarpengland T, Holm S, Scheffler K, Gregersen I, Dahl TB, Suganthan R, Segers FM, Østlie I, Otten JJ, Luna L, Ketelhuth DF, Lundberg AM, Neurauter CG, Hildrestrand G, Skjelland M, Bjørndal B, Svardal AM, Iversen PO, Hedin U, Nygård S, Olstad OK, Krohg-Sørensen K, Slupphaug G, Eide L, Kuśnierczyk A et al. (2016)
Neil3-dependent base excision repair regulates lipid metabolism and prevents atherosclerosis in Apoe-deficient mice
Sci Rep, 6, 28337
DOI 10.1038/srep28337, PubMed 27328939

Skjellegrind HK, Fayzullin A, Johnsen EO, Eide L, Langmoen IA, Moe MC, Vik-Mo EO (2016)
Short-Term Differentiation of Glioblastoma Stem Cells Induces Hypoxia Tolerance
Neurochem Res, 41 (7), 1545-58
DOI 10.1007/s11064-016-1868-2, PubMed 26915110

Sokolova M, Vinge LE, Alfsnes K, Olsen MB, Eide L, Kaasbøll OJ, Attramadal H, Torp MK, Fosshaug LE, Rashidi A, Lien E, Finsen AV, Sandanger Ø, Aukrust P, Ranheim T, Yndestad A (2016)
Palmitate promotes inflammatory responses and cellular senescence in cardiac fibroblasts
Biochim Biophys Acta Mol Cell Biol Lipids, 1862 (2), 234-245
DOI 10.1016/j.bbalip.2016.11.003, PubMed 27845246

Wang W, Scheffler K, Esbensen Y, Eide L (2016)
Quantification of DNA Damage by Real-Time qPCR
Methods Mol Biol, 1351, 27-32
DOI 10.1007/978-1-4939-3040-1_3, PubMed 26530672

Publications 2015

Bjørge MD, Hildrestrand GA, Scheffler K, Suganthan R, Rolseth V, Kuśnierczyk A, Rowe AD, Vågbø CB, Vetlesen S, Eide L, Slupphaug G, Nakabeppu Y, Bredy TW, Klungland A, Bjørås M (2015)
Synergistic Actions of Ogg1 and Mutyh DNA Glycosylases Modulate Anxiety-like Behavior in Mice
Cell Rep, 13 (12), 2671-8
DOI 10.1016/j.celrep.2015.12.001, PubMed 26711335

Lauritzen KH, Kleppa L, Aronsen JM, Eide L, Carlsen H, Haugen ØP, Sjaastad I, Klungland A, Rasmussen LJ, Attramadal H, Storm-Mathisen J, Bergersen LH (2015)
Impaired dynamics and function of mitochondria caused by mtDNA toxicity leads to heart failure
Am J Physiol Heart Circ Physiol, 309 (3), H434-49
DOI 10.1152/ajpheart.00253.2014, PubMed 26055793

Wang W, Esbensen Y, Scheffler K, Eide L (2015)
Analysis of mitochondrial DNA and RNA integrity by a real-time qPCR-based method
Methods Mol Biol, 1264, 97-106
DOI 10.1007/978-1-4939-2257-4_10, PubMed 25631007

Yang M, Lin X, Rowe A, Rognes T, Eide L, Bjørås M (2015)
Transcriptome analysis of human OXR1 depleted cells reveals its role in regulating the p53 signaling pathway
Sci Rep, 5, 17409
DOI 10.1038/srep17409, PubMed 26616534

Yuzefovych LV, Kahn AG, Schuler MA, Eide L, Arora R, Wilson GL, Tan M, Rachek LI (2015)
Mitochondrial DNA Repair through OGG1 Activity Attenuates Breast Cancer Progression and Metastasis
Cancer Res, 76 (1), 30-4
DOI 10.1158/0008-5472.CAN-15-0692, PubMed 26586787

Publications 2014

Bliksøen M, Baysa A, Eide L, Bjørås M, Suganthan R, Vaage J, Stensløkken KO, Valen G (2014)
Mitochondrial DNA damage and repair during ischemia-reperfusion injury of the heart
J Mol Cell Cardiol, 78, 9-22
DOI 10.1016/j.yjmcc.2014.11.010, PubMed 25446179

Hereng TH, Elgstøen KB, Eide L, Rosendal KR, Skålhegg BS (2014)
Serum albumin and HCO3- regulate separate pools of ATP in human spermatozoa
Hum Reprod, 29 (5), 918-30
DOI 10.1093/humrep/deu028, PubMed 24578478

Strand JM, Scheffler K, Bjørås M, Eide L (2014)
The distribution of DNA damage is defined by region-specific susceptibility to DNA damage formation rather than repair differences
DNA Repair (Amst), 18, 44-51
DOI 10.1016/j.dnarep.2014.03.003, PubMed 24685126

Strand JM, Skinnes R, Scheffler K, Rootvelt T, Woldseth B, Bjørås M, Eide L (2014)
Genome instability in Maple Syrup Urine Disease correlates with impaired mitochondrial biogenesis
Metabolism, 63 (8), 1063-70
DOI 10.1016/j.metabol.2014.05.003, PubMed 24928662

Wang W, Scheffler K, Esbensen Y, Strand JM, Stewart JB, Bjørås M, Eide L (2014)
Addressing RNA integrity to determine the impact of mitochondrial DNA mutations on brain mitochondrial function with age
PLoS One, 9 (5), e96940
DOI 10.1371/journal.pone.0096940, PubMed 24819950

Yang M, Luna L, Sørbø JG, Alseth I, Johansen RF, Backe PH, Danbolt NC, Eide L, Bjørås M (2014)
Human OXR1 maintains mitochondrial DNA integrity and counteracts hydrogen peroxide-induced oxidative stress by regulating antioxidant pathways involving p21
Free Radic Biol Med, 77, 41-8
DOI 10.1016/j.freeradbiomed.2014.09.003, PubMed 25236744

Publications 2013

Hystad EM, Amdam GV, Eide L (2013)
Mitochondrial DNA integrity changes with age but does not correlate with learning performance in honey bees
Exp Gerontol, 49, 12-8
DOI 10.1016/j.exger.2013.10.013, PubMed 24211425

Jalland CM, Benestad SL, Ersdal C, Scheffler K, Suganthan R, Nakabeppu Y, Eide L, Bjørås M, Tranulis MA (2013)
Accelerated clinical course of prion disease in mice compromised in repair of oxidative DNA damage
Free Radic Biol Med, 68, 1-7
DOI 10.1016/j.freeradbiomed.2013.11.013, PubMed 24296244

Yuzefovych LV, Schuler AM, Chen J, Alvarez DF, Eide L, Ledoux SP, Wilson GL, Rachek LI (2013)
Alteration of mitochondrial function and insulin sensitivity in primary mouse skeletal muscle cells isolated from transgenic and knockout mice: role of ogg1
Endocrinology, 154 (8), 2640-9
DOI 10.1210/en.2013-1076, PubMed 23748360

Publications 2011

Halsne R, Esbensen Y, Wang W, Scheffler K, Suganthan R, Bjørås M, Eide L (2011)
Lack of the DNA glycosylases MYH and OGG1 in the cancer prone double mutant mouse does not increase mitochondrial DNA mutagenesis
DNA Repair (Amst), 11 (3), 278-85
DOI 10.1016/j.dnarep.2011.12.001, PubMed 22209780

Hereng TH, Elgstøen KB, Cederkvist FH, Eide L, Jahnsen T, Skålhegg BS, Rosendal KR (2011)
Exogenous pyruvate accelerates glycolysis and promotes capacitation in human spermatozoa
Hum Reprod, 26 (12), 3249-63
DOI 10.1093/humrep/der317, PubMed 21946930

Kaarbø M, Ager-Wick E, Osenbroch PØ, Kilander A, Skinnes R, Müller F, Eide L (2011)
Human cytomegalovirus infection increases mitochondrial biogenesis
Mitochondrion, 11 (6), 935-45
DOI 10.1016/j.mito.2011.08.008, PubMed 21907833

Wang W, Esbensen Y, Kunke D, Suganthan R, Rachek L, Bjørås M, Eide L (2011)
Mitochondrial DNA damage level determines neural stem cell differentiation fate
J Neurosci, 31 (26), 9746-51
DOI 10.1523/JNEUROSCI.0852-11.2011, PubMed 21715639

Publications 2010

Brodtkorb E, Strand J, Backe PH, Lund AM, Bjørås M, Rootwelt T, Rootwelt H, Woldseth B, Eide L (2010)
Four novel mutations identified in Norwegian patients result in intermittent maple syrup urine disease when combined with the R301C mutation
Mol Genet Metab, 100 (4), 324-32
DOI 10.1016/j.ymgme.2010.04.017, PubMed 20570198

Lauritzen KH, Moldestad O, Eide L, Carlsen H, Nesse G, Storm JF, Mansuy IM, Bergersen LH, Klungland A (2010)
Mitochondrial DNA toxicity in forebrain neurons causes apoptosis, neurodegeneration, and impaired behavior
Mol Cell Biol, 30 (6), 1357-67
DOI 10.1128/MCB.01149-09, PubMed 20065039

Wang W, Osenbroch P, Skinnes R, Esbensen Y, Bjørås M, Eide L (2010)
Mitochondrial DNA integrity is essential for mitochondrial maturation during differentiation of neural stem cells
Stem Cells, 28 (12), 2195-204
DOI 10.1002/stem.542, PubMed 20954243

Publications 2009

Osenbroch PØ, Auk-Emblem P, Halsne R, Strand J, Forstrøm RJ, van der Pluijm I, Eide L (2009)
Accumulation of mitochondrial DNA damage and bioenergetic dysfunction in CSB defective cells
FEBS J, 276 (10), 2811-21
DOI 10.1111/j.1742-4658.2009.07004.x, PubMed 19389114

Sejersted Y, Aasland AL, Bjørås M, Eide L, Saugstad OD (2009)
Accumulation of 8-oxoguanine in liver DNA during hyperoxic resuscitation of newborn mice
Pediatr Res, 66 (5), 533-8
DOI 10.1203/PDR.0b013e3181ba1a42, PubMed 19668103

Yndestad A, Neurauter CG, Oie E, Forstrøm RJ, Vinge LE, Eide L, Luna L, Aukrust P, Bjørås M (2009)
Up-regulation of myocardial DNA base excision repair activities in experimental heart failure
Mutat Res, 666 (1-2), 32-8
DOI 10.1016/j.mrfmmm.2009.03.008, PubMed 19481677

Publications 2007

Ringvoll J, Uldal L, Roed MA, Reite K, Baynton K, Klungland A, Eide L (2007)
Mutations in the RAD27 and SGS1 genes differentially affect the chronological and replicative lifespan of yeast cells growing on glucose and glycerol
FEMS Yeast Res, 7 (6), 848-59
DOI 10.1111/j.1567-1364.2007.00248.x, PubMed 17506834

Publications 2005

Eide L, McMurray CT (2005)
Culture of adult mouse neurons
Biotechniques, 38 (1), 99-104
DOI 10.2144/05381RR02, PubMed 15679091

Publications 2004

Trushina E, Dyer RB, Badger JD, Ure D, Eide L, Tran DD, Vrieze BT, Legendre-Guillemin V, McPherson PS, Mandavilli BS, Van Houten B, Zeitlin S, McNiven M, Aebersold R, Hayden M, Parisi JE, Seeberg E, Dragatsis I, Doyle K, Bender A, Chacko C, McMurray CT (2004)
Mutant huntingtin impairs axonal trafficking in mammalian neurons in vivo and in vitro
Mol Cell Biol, 24 (18), 8195-209
DOI 10.1128/MCB.24.18.8195-8209.2004, PubMed 15340079

Ulbert S, Eide L, Seeberg E, Borst P (2004)
Base J, found in nuclear DNA of Trypanosoma brucei, is not a target for DNA glycosylases
DNA Repair (Amst), 3 (2), 145-54
DOI 10.1016/j.dnarep.2003.10.009, PubMed 14706348

Publications 2003

Moe A, Ringvoll J, Nordstrand LM, Eide L, Bjørås M, Seeberg E, Rognes T, Klungland A (2003)
Incision at hypoxanthine residues in DNA by a mammalian homologue of the Escherichia coli antimutator enzyme endonuclease V
Nucleic Acids Res, 31 (14), 3893-900
DOI 10.1093/nar/gkg472, PubMed 12853604

Rogers PA, Eide L, Klungland A, Ding H (2003)
Reversible inactivation of E. coli endonuclease III via modification of its [4Fe-4S] cluster by nitric oxide
DNA Repair (Amst), 2 (7), 809-17
DOI 10.1016/s1568-7864(03)00065-x, PubMed 12826281

Publications 2001

de Souza-Pinto NC, Eide L, Hogue BA, Thybo T, Stevnsner T, Seeberg E, Klungland A, Bohr VA (2001)
Repair of 8-oxodeoxyguanosine lesions in mitochondrial dna depends on the oxoguanine dna glycosylase (OGG1) gene and 8-oxoguanine accumulates in the mitochondrial dna of OGG1-defective mice
Cancer Res, 61 (14), 5378-81
PubMed 11454679

Eide L, Fosberg E, Hoff E, Seeberg E (2001)
Overexpression of endonuclease III protects Escherichia coli mutants defective in alkylation repair against lethal effects of methylmethanesulphonate
FEBS Lett, 491 (1-2), 59-62
DOI 10.1016/s0014-5793(01)02156-1, PubMed 11226419

Eide L, Luna L, Gustad EC, Henderson PT, Essigmann JM, Demple B, Seeberg E (2001)
Human endonuclease III acts preferentially on DNA damage opposite guanine residues in DNA
Biochemistry, 40 (22), 6653-9
DOI 10.1021/bi0028901, PubMed 11380260

Publications 2000

Seeberg E, Luna L, Morland I, Eide L, Johnsen B, Larsen E, Alseth I, Dantzer F, Baynton K, Aamodt R, Kristiansen KI, Rognes T, Klungland A, Bjørås M (2000)
Base removers and strand scissors: different strategies employed in base excision and strand incision at modified base residues in DNA
Cold Spring Harb Symp Quant Biol, 65, 135-42
DOI 10.1101/sqb.2000.65.135, PubMed 12760028

Publications 1999

Alseth I, Eide L, Pirovano M, Rognes T, Seeberg E, Bjørås M (1999)
The Saccharomyces cerevisiae homologues of endonuclease III from Escherichia coli, Ntg1 and Ntg2, are both required for efficient repair of spontaneous and induced oxidative DNA damage in yeast
Mol Cell Biol, 19 (5), 3779-87
DOI 10.1128/MCB.19.5.3779, PubMed 10207101

Luna L, Bjoras M, Berdal KG, Alseth I, Eide L, Rognes T, Seeberg E (1999)
Genes and enzymes for the removal of oxidative DNA base damage
ALFRED BENZON SYMP S, 44, 272-283

Publications 1996

Eide L (1996)
Base excision of DNA damage by DNA glycosylases containing the helix-hairpin-helix domain
Biotechnology Centre of Oslo, University of Oslo, Oslo, 1 b. (flere pag.)
BIBSYS 971092192, ISBN 82-90934-51-3

Eide L, Bjørås M, Pirovano M, Alseth I, Berdal KG, Seeberg E (1996)
Base excision of oxidative purine and pyrimidine DNA damage in Saccharomyces cerevisiae by a DNA glycosylase with sequence similarity to endonuclease III from Escherichia coli
Proc Natl Acad Sci U S A, 93 (20), 10735-40
DOI 10.1073/pnas.93.20.10735, PubMed 8855249

Publications 1995

Bjelland S, Eide L, Time RW, Stote R, Eftedal I, Volden G, Seeberg E (1995)
Oxidation of thymine to 5-formyluracil in DNA: mechanisms of formation, structural implications, and base excision by human cell free extracts
Biochemistry, 34 (45), 14758-64
DOI 10.1021/bi00045a017, PubMed 7578084

Seeberg E, Eide L, Bjørås M (1995)
The base excision repair pathway
Trends Biochem Sci, 20 (10), 391-7
DOI 10.1016/s0968-0004(00)89086-6, PubMed 8533150

Publications 1992

Pines G, Danbolt NC, Bjørås M, Zhang Y, Bendahan A, Eide L, Koepsell H, Storm-Mathisen J, Seeberg E, Kanner BI (1992)
Cloning and expression of a rat brain L-glutamate transporter
Nature, 360 (6403), 464-7
DOI 10.1038/360464a0, PubMed 1448170