Jørgen A. Gravning

  • Senior Cardiologist, Associate Professor; MD, PhD
  • +47 950 75 310

More information from UiO home page

Education:

  • 2005: M.D. (Cand. Med.), Faculty of Medicine, University of Oslo
  • 2013: Ph.D., Faculty of Medicine, University of Oslo, Norway. Thesis: “Cardioprotective Mechanisms in Ischemia-Reperfusion Injury and Heart Failure”
  • 2016: Board certified in Internal Medicine
  • 2018: Board certified in Cardiology

Work record (selected)

  • 2016-t.d.: Senior Consultant, Dept. of Cardiology, Oslo University Hospital, Ullevål, 
  • 2021-t.d.: Associate Professor, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo
  • 2019-2021: Head of section for Resident Fellows, Dept. of Cardiology, Oslo University Hospital, Ullevål
  • 2008-2016: Resident Fellow, Østfold Hospital Trust and Akershus University Hospital
  • 2005-2008: Ph.D. Fellow, Institute for Surgical Research / Dept. of Cardiology, Oslo University Hospital, Rikshospitalet

Memberships:

  • The Norwegian Medical Association
  • Norwegian Society of Cardiology
  • American Health Association
  • European Society of Cardiology

Research areas:

  • Cardiac imaging
  • Cardiac biomarkers
  • Cardiovascular heamodynamics
  • Translational cardiovascular research

Teaching:

  • Lecturer in clinical cardiology for medical Students at University of Oslo

Other:

  • Author of the popular science book “Ditt fantastiske hjerte” (H. Aschehoug & co 2018)
 

Publications 2021

Marcks N, Aimo A, Januzzi JL, Vergaro G, Clerico A, Latini R, Meessen J, Anand IS, Cohn JN, Gravning J, Ueland T, Bayes-Genis A, Lupón J, de Boer RA, Yoshihisa A, Takeishi Y, Egstrup M, Gustafsson I, Gaggin HK, Eggers KM, Huber K, Tentzeris I, Ripoli A, Passino C, Sanders-van Wijk S et al. (2021)
Re-appraisal of the obesity paradox in heart failure: a meta-analysis of individual data
Clin Res Cardiol, 110 (8), 1280-1291
DOI 10.1007/s00392-021-01822-1, PubMed 33704552

Publications 2019

Aimo A, Januzzi JL, Vergaro G, Clerico A, Latini R, Meessen J, Anand IS, Cohn JN, Gravning J, Ueland T, Nymo SH, Brunner-La Rocca HP, Bayes-Genis A, Lupón J, de Boer RA, Yoshihisa A, Takeishi Y, Egstrup M, Gustafsson I, Gaggin HK, Eggers KM, Huber K, Tentzeris I, Ripoli A, Passino C et al. (2019)
Revisiting the obesity paradox in heart failure: Per cent body fat as predictor of biomarkers and outcome
Eur J Prev Cardiol, 26 (16), 1751-1759
DOI 10.1177/2047487319852809, PubMed 31154828

Kvisvik B, Aagaard EN, Mørkrid L, Røsjø H, Lyngbakken M, Smedsrud MK, Eek C, Bendz B, Haugaa KH, Edvardsen T, Gravning J (2019)
Mechanical dispersion as a marker of left ventricular dysfunction and prognosis in stable coronary artery disease
Int J Cardiovasc Imaging, 35 (7), 1265-1275
DOI 10.1007/s10554-019-01583-z, PubMed 31165941

Publications 2018

Aimo A, Januzzi JL, Vergaro G, Ripoli A, Latini R, Masson S, Magnoli M, Anand IS, Cohn JN, Tavazzi L, Tognoni G, Gravning J, Ueland T, Nymo SH, Brunner-La Rocca HP, Bayes-Genis A, Lupón J, de Boer RA, Yoshihisa A, Takeishi Y, Egstrup M, Gustafsson I, Gaggin HK, Eggers KM, Huber K et al. (2018)
Prognostic Value of High-Sensitivity Troponin T in Chronic Heart Failure: An Individual Patient Data Meta-Analysis
Circulation, 137 (3), 286-297
DOI 10.1161/CIRCULATIONAHA.117.031560, PubMed 29335288

Aimo A, Januzzi JL, Vergaro G, Ripoli A, Latini R, Masson S, Magnoli M, Anand IS, Cohn JN, Tavazzi L, Tognoni G, Gravning J, Ueland T, Nymo SH, Rocca HB, Bayes-Genis A, Lupón J, de Boer RA, Yoshihisa A, Takeishi Y, Egstrup M, Gustafsson I, Gaggin HK, Eggers KM, Huber K et al. (2018)
High-sensitivity troponin T, NT-proBNP and glomerular filtration rate: A multimarker strategy for risk stratification in chronic heart failure
Int J Cardiol, 277, 166-172
DOI 10.1016/j.ijcard.2018.10.079, PubMed 30416028

Emdin M, Aimo A, Vergaro G, Bayes-Genis A, Lupón J, Latini R, Meessen J, Anand IS, Cohn JN, Gravning J, Gullestad L, Broch K, Ueland T, Nymo SH, Brunner-La Rocca HP, de Boer RA, Gaggin HK, Ripoli A, Passino C, Januzzi JL (2018)
sST2 Predicts Outcome in Chronic Heart Failure Beyond NT-proBNP and High-Sensitivity Troponin T
J Am Coll Cardiol, 72 (19), 2309-2320
DOI 10.1016/j.jacc.2018.08.2165, PubMed 30384887

Publications 2017

Kvisvik B, Morkrid L, Rosjo H, Cvancarova M, Rowe AD, Eek C, Bendz B, Edvardsen T, Gravning J (2017)
High-Sensitivity Troponin T vs I in Acute Coronary Syndrome: Prediction of Significant Coronary Lesions and Long-term Prognosis
Acta Bioquim. Clin. Latinoam., 51 (3), 395-407

Nymo SH, Aukrust P, Kjekshus J, McMurray JJ, Cleland JG, Wikstrand J, Muntendam P, Wienhues-Thelen U, Latini R, Askevold ET, Gravning J, Dahl CP, Broch K, Yndestad A, Gullestad L, Ueland T, CORONA Study Group (2017)
Limited Added Value of Circulating Inflammatory Biomarkers in Chronic Heart Failure
JACC Heart Fail, 5 (4), 256-264
DOI 10.1016/j.jchf.2017.01.008, PubMed 28359413

Rutkovskiy A, Sagave J, Czibik G, Baysa A, Zihlavnikova Enayati K, Hillestad V, Dahl CP, Fiane A, Gullestad L, Gravning J, Ahmed S, Attramadal H, Valen G, Vaage J (2017)
Connective tissue growth factor and bone morphogenetic protein 2 are induced following myocardial ischemia in mice and humans
Scand J Clin Lab Invest, 77 (5), 321-331
DOI 10.1080/00365513.2017.1318447, PubMed 28460577

Publications 2016

Kvisvik B, Mørkrid L, Røsjø H, Cvancarova M, Rowe AD, Eek C, Bendz B, Edvardsen T, Gravning J (2016)
High-Sensitivity Troponin T vs I in Acute Coronary Syndrome: Prediction of Significant Coronary Lesions and Long-term Prognosis
Clin Chem, 63 (2), 552-562
DOI 10.1373/clinchem.2016.261107, PubMed 27974383

Publications 2015

Smedsrud MK, Gravning J, Omland T, Eek C, Mørkrid L, Skulstad H, Aaberge L, Bendz B, Kjekshus J, Edvardsen T (2015)
Sensitive cardiac troponins and N-terminal pro-B-type natriuretic peptide in stable coronary artery disease: correlation with left ventricular function as assessed by myocardial strain
Int J Cardiovasc Imaging, 31 (5), 967-73
DOI 10.1007/s10554-015-0646-6, PubMed 25788439

Publications 2013

Gravning J, Ahmed MS, Qvigstad E, Krobert K, Edvardsen T, Moe IT, Hagelin EM, Sagave J, Valen G, Levy FO, Osnes JB, Skomedal T, Attramadal H (2013)
Connective tissue growth factor/CCN2 attenuates β-adrenergic receptor responsiveness and cardiotoxicity by induction of G protein-coupled receptor kinase-5 in cardiomyocytes
Mol Pharmacol, 84 (3), 372-83
DOI 10.1124/mol.113.087312, PubMed 23778361

Gravning J, Ahmed MS, von Lueder TG, Edvardsen T, Attramadal H (2013)
CCN2/CTGF attenuates myocardial hypertrophy and cardiac dysfunction upon chronic pressure-overload
Int J Cardiol, 168 (3), 2049-56
DOI 10.1016/j.ijcard.2013.01.165, PubMed 23452880

Gravning J, Askevold ET, Nymo SH, Ueland T, Wikstrand J, McMurray JJ, Aukrust P, Gullestad L, Kjekshus J, CORONA Study Group (2013)
Prognostic effect of high-sensitive troponin T assessment in elderly patients with chronic heart failure: results from the CORONA trial
Circ Heart Fail, 7 (1), 96-103
DOI 10.1161/CIRCHEARTFAILURE.113.000450, PubMed 24284025

Gravning J, Smedsrud MK, Omland T, Eek C, Skulstad H, Aaberge L, Bendz B, Kjekshus J, Mørkrid L, Edvardsen T (2013)
Sensitive troponin assays and N-terminal pro-B-type natriuretic peptide in acute coronary syndrome: prediction of significant coronary lesions and long-term prognosis
Am Heart J, 165 (5), 716-24
DOI 10.1016/j.ahj.2013.02.008, PubMed 23622908

Publications 2012

Askevold ET, Nymo S, Ueland T, Gravning J, Wergeland R, Kjekshus J, Yndestad A, Cleland JG, McMurray JJ, Aukrust P, Gullestad L (2012)
Soluble glycoprotein 130 predicts fatal outcomes in chronic heart failure: analysis from the Controlled Rosuvastatin Multinational Trial in Heart Failure (CORONA)
Circ Heart Fail, 6 (1), 91-8
DOI 10.1161/CIRCHEARTFAILURE.112.972653, PubMed 23230311

Bilbija D, Gravning JA, Haugen F, Attramadal H, Valen G (2012)
Protecting the heart through delivering DNA encoding for heme oxygenase-1 into skeletal muscle
Life Sci, 91 (17-18), 828-36
DOI 10.1016/j.lfs.2012.08.014, PubMed 22917518

Gravning J, Ørn S, Kaasbøll OJ, Martinov VN, Manhenke C, Dickstein K, Edvardsen T, Attramadal H, Ahmed MS (2012)
Myocardial connective tissue growth factor (CCN2/CTGF) attenuates left ventricular remodeling after myocardial infarction
PLoS One, 7 (12), e52120
DOI 10.1371/journal.pone.0052120, PubMed 23284892

von Lueder TG, Gravning J, How OJ, Vinge LE, Ahmed MS, Krobert KA, Levy FO, Larsen TS, Smiseth OA, Aasum E, Attramadal H (2012)
Cardiomyocyte-restricted inhibition of G protein-coupled receptor kinase-3 attenuates cardiac dysfunction after chronic pressure overload
Am J Physiol Heart Circ Physiol, 303 (1), H66-74
DOI 10.1152/ajpheart.00724.2011, PubMed 22542621

Publications 2011

Czibik G, Gravning J, Martinov V, Ishaq B, Knudsen E, Attramadal H, Valen G (2011)
Gene therapy with hypoxia-inducible factor 1 alpha in skeletal muscle is cardioprotective in vivo
Life Sci, 88 (11-12), 543-50
DOI 10.1016/j.lfs.2011.01.006, PubMed 21238463

Publications 2010

Ahmed MS, Gravning J, Martinov VN, von Lueder TG, Edvardsen T, Czibik G, Moe IT, Vinge LE, Øie E, Valen G, Attramadal H (2010)
Mechanisms of novel cardioprotective functions of CCN2/CTGF in myocardial ischemia-reperfusion injury
Am J Physiol Heart Circ Physiol, 300 (4), H1291-302
DOI 10.1152/ajpheart.00604.2010, PubMed 21186275

Bergestuen DS, Gravning J, Haugaa KH, Sahakyan LG, Aakhus S, Thiis-Evensen E, Øie E, Aukrust P, Attramadal H, Edvardsen T (2010)
Plasma CCN2/connective tissue growth factor is associated with right ventricular dysfunction in patients with neuroendocrine tumors
BMC Cancer, 10, 6
DOI 10.1186/1471-2407-10-6, PubMed 20053285

Publications 2008

Gravning J, Kjekshus J (2008)
The perfect biomarker in acute coronary syndrome: a challenge for diagnosis, prognosis, and treatment
Eur Heart J, 29 (23), 2827-8
DOI 10.1093/eurheartj/ehn489, PubMed 18957473

Gravning J, Ueland T, Mørkrid L, Endresen K, Aaberge L, Kjekshus J (2008)
Different prognostic importance of elevated troponin I after percutaneous coronary intervention in acute coronary syndrome and stable angina pectoris
Scand Cardiovasc J, 42 (3), 214-21
DOI 10.1080/14017430801932824, PubMed 18569954

Publications 2007

Vinge LE, von Lueder TG, Aasum E, Qvigstad E, Gravning JA, How OJ, Edvardsen T, Bjørnerheim R, Ahmed MS, Mikkelsen BW, Oie E, Attramadal T, Skomedal T, Smiseth OA, Koch WJ, Larsen TS, Attramadal H (2007)
Cardiac-restricted expression of the carboxyl-terminal fragment of GRK3 Uncovers Distinct Functions of GRK3 in regulation of cardiac contractility and growth: GRK3 controls cardiac alpha1-adrenergic receptor responsiveness
J Biol Chem, 283 (16), 10601-10
DOI 10.1074/jbc.M708912200, PubMed 18165681

Publications 2006

Gravning J, Vege A, Kjekshus J (2006)
[Unexpected sudden death after percutaneous coronary intervention]
Tidsskr Nor Laegeforen, 126 (16), 2111-3
PubMed 16960998

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