- Consultant cardiologist; MD, PhD
Mette-Elise Estensen, MD, PhD, Consultant Cardiologist, Department of Cardiology, Oslo University Hospital, Rikshospitalet
Dr. Estensen defended her PhD thesis "Left ventricular function and systemic arterial properties in normal and preeclamptic pregnancy" in January 2013.
Preeclampsia occurs in 3-8% of all pregnancies and can have serious consequences for the mother and child. Research has shown that women who have undergone preeclampsia have a significantly increased risk of developing cardiovascular disease later in life.
Cardiologist and researcher Mette-Elise Estensen studied how the heart and the large vessels function during normal pregnancies in healthy women, and compared the change in healthy women with the changes that occur in women who develop preeclampsia.
In her dissertation, Estensen and colleagues found that the pumping function of the heart reduced somewhat during pregnancy, both in healthy subjects and in those with preeclampsia. Heart function is normalized in both groups after childbirth. However, Estensen found that during pregnancy women with preeclampsia have more rigid vessels compared to healthy women, this is persistent even after pregnancy and is shown in women who are controlled 3 years after undergone preeclampsia.
Estensen concluded that women who have undergone preeclampsia have persistent cardiovascular changes that last up to three years after childbirth, which can help explain the increased incidence of cardiovascular disease in these women.
Elevated levels of the secreted wingless agonist R-spondin 3 in preeclamptic pregnancies
J Hypertens (in press)
Number of pregnancies and subsequent phenotype in a cross-sectional cohort of women with arrhythmogenic cardiomyopathy
Eur Heart J Cardiovasc Imaging, 20 (2), 192-198
Arterial properties in adults with long-lasting active juvenile idiopathic arthritis compared to healthy controls
Pediatr Rheumatol Online J, 16 (1), 85
Survival in patients with univentricular hearts: the impact of right versus left ventricular morphology
Open Heart, 5 (2), e000902
Subclinical atherosclerosis in patients with cyanotic congenital heart disease
Int J Cardiol, 277, 97-103
Clinical diagnosis of Larsen syndrome, Stickler syndrome and Loeys-Dietz syndrome in a 19-year old male: a case report
BMC Med Genet, 19 (1), 155
Past and current cause-specific mortality in Eisenmenger syndrome
Eur Heart J, 38 (26), 2060-2067
Epidemiological changes in Eisenmenger syndrome in the Nordic region in 1977-2012
Heart, 103 (17), 1353-1358
Predictors of Death in Contemporary Adult Patients With Eisenmenger Syndrome: A Multicenter Study
Circulation, 135 (15), 1432-1440
Elevated inflammatory markers in preeclamptic pregnancies, but no relation to systemic arterial stiffness
Pregnancy Hypertens, 5 (4), 325-9
Cardiac Function in Adult Patients with Juvenile Idiopathic Arthritis
J Rheumatol, 42 (9), 1716-23
Heart failure in pregnant women with cardiac disease: data from the ROPAC
Heart, 100 (3), 231-8
Altered maternal left ventricular contractility and function during normal pregnancy
Ultrasound Obstet Gynecol, 41 (6), 659-66
Increased arterial stiffness in pre-eclamptic pregnancy at term and early and late postpartum: a combined echocardiographic and tonometric study
Am J Hypertens, 26 (4), 549-56
Systemic arterial response and ventriculo-arterial interaction during normal pregnancy
Am J Hypertens, 25 (6), 672-7
Changes in blood pressure during healthy pregnancy: a longitudinal cohort study
J Hypertens, 30 (2), 342-50
Changes in pulmonary function during pregnancy: a longitudinal cohort study
BJOG, 119 (1), 94-101
Pregnancy in heart- and heart/lung recipients can be problematic
Scand Cardiovasc J, 45 (6), 349-53
Prognostic value of plasma chromogranin A levels in patients with complicated myocardial infarction
Am Heart J, 152 (5), 927.e1-6
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